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Cited by 344

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Caffeine Use in Sports, Pharmacokinetics in Man, and Cellular Mechanisms of Action

Magkos, Faidon, Kavouras, Stavros A.·2005·Critical Reviews in Food Science and Nutrition
DOI 10.1080/1040-830491379245
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Abstract

Caffeine is the most widely consumed psychoactive 'drug' in the world and probably one of the most commonly used stimulants in sports. This is not surprising, since it is one of the few ergogenic aids with documented efficiency and minimal side effects. Caffeine is rapidly and completely absorbed by the gastrointestinal tract and is readily distributed throughout all tissues of the body. Peak plasma concentrations after normal consumption are usually around 50 microM, and half-lives for elimination range between 2.5-10 h. The parent compound is extensively metabolized in the liver microsomes to more than 25 derivatives, while considerably less than 5% of the ingested dose is excreted unchanged in the urine. There is, however, considerable inter-individual variability in the handling of caffeine by the body, due to both environmental and genetic factors. Evidence from in vitro studies provides a wealth of different cellular actions that could potentially contribute to the observed effects of caffeine in humans in vivo. These include potentiation of muscle contractility via induction of sarcoplasmic reticulum calcium release, inhibition of phosphodiesterase isoenzymes and concomitant cyclic monophosphate accumulation, inhibition of glycogen phosphorylase enzymes in liver and muscle, non-selective adenosine receptor antagonism, stimulation of the cellular membrane sodium/potassium pump, impairment of phosphoinositide metabolism, as well as other, less thoroughly characterized actions. Not all, however, seem to account for the observed effects in vivo, although a variable degree of contribution cannot be readily discounted on the basis of experimental data. The most physiologically relevant mechanism of action is probably the blockade of adenosine receptors, but evidence suggests that, at least under certain conditions, other biochemical mechanisms may also be operational.

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Metadata

Authors
Magkos, F., & Kavouras, S. A.
Venue
Critical Reviews in Food Science and Nutrition
Publisher
Informa UK Limited
Published
2005-10
Volume
45
Issue
7-8
Pages
535-562
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
DOI
10.1080/1040-830491379245
OpenAlex
W2017880868
Cited by
344
References
30
FWCI
4.02
Type
journal article
Language
en
Open access
closed

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