Can dynamic in vitro digestion systems mimic the physiological reality?

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775

A Multicompartmental Dynamic Computer-controlled Model Simulating the Stomach and Small Intestine

Minekus, M., Marteau, P., Havenaar, R., & Veld, J. H. J. H. I. (1995) · Alternatives to Laboratory Animals · doi:10.1177/026119299502300205 · Cited by 686

Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem

Molly, K., Vande Woestyne, M., & Verstraete, W. (1993) · Applied Microbiology and Biotechnology · doi:10.1007/bf00228615 · Cited by 672

Butyrate-producingClostridiumcluster XIVa species specifically colonize mucins in anin vitrogut model

den Abbeele, P. V., Belzer, C., Goossens, M., Kleerebezem, M., de Vos, W. M., Thas, O., Weirdt, R. D., Kerckhof, F., & de Wiele, T. V. (2012) · The ISME Journal · doi:10.1038/ismej.2012.158 · Cited by 656

Disintegration of Solid Foods in Human Stomach

Kong, F., & Singh, R. P. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00766.x · Cited by 629

Relevance and challenges in modeling human gastric and small intestinal digestion

Guerra, A., Etienne‐Mesmin, L., Livrelli, V., Denis, S., Blanquet‐Diot, S., & Alric, M. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.08.001 · Cited by 612

Analysis of Gastric Emptying Data

ELASHOFF, J. D., Reedy, T. J., & Meyer, J. H. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80145-5 · Cited by 534

Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI

Marciani, L., Gowland, P. A., Spiller, R. C., Manoj, P., Moore, R. J., Young, P., & Fillery-Travis, A. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.6.g1227 · Cited by 502

Survival of Lactic Acid Bacteria in a Dynamic Model of the Stomach and Small Intestine: Validation and the Effects of Bile

Marteau, P., Minekus, M., Havenaar, R., & Huis In’t Veld, J. H. J. (1997) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(97)76027-2 · Cited by 488

A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products

Minekus, M., Smeets-Peeters, M. J. E., Bernalier, A., Marol-Bonnin, S., Havenaar, R., Marteau, P. R., Alric, M., Fonty, G., & Veld, J. H. J. H. I. (1999) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051622 · Cited by 459

A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach

Kong, F., & Singh, R. P. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01856.x · Cited by 428

Biphasic nature of gastric emptying.

Siegel, J. A., Urbain, J., Adler, L., Charkes, N., Maurer, A. H., Krevsky, B., Knight, L. C., Fisher, R. S., & Malmud, L. (1988) · Gut · doi:10.1136/gut.29.1.85 · Cited by 380

Microbial Community Development in a Dynamic Gut Model Is Reproducible, Colon Region Specific, and Selective forBacteroidetesandClostridiumCluster IX

den Abbeele, P. V., Grootaert, C., Marzorati, M., Possemiers, S., Verstraete, W., Gérard, P., Rabot, S., Bruneau, A., Aidy, S. E., Derrien, M., et al. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00759-10 · Cited by 359

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

den Abbeele, P. V., Roos, S., Eeckhaut, V., MacKenzie, D. A., Derde, M., Verstraete, W., Marzorati, M., Possemiers, S., Vanhoecke, B. W. A., Immerseel, F. V., et al. (2011) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2011.00308.x · Cited by 300

Modeling the Fluid Dynamics in a Human Stomach to Gain Insight of Food Digestion

Ferrua, M. J., & Singh, R. P. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01748.x · Cited by 294

Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin‐degradation in humanized rats

den Abbeele, P. V., Gérard, P., Rabot, S., Bruneau, A., Aidy, S. E., Derrien, M., Kleerebezem, M., Zoetendal, E. G., Smidt, H., Verstraete, W., et al. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02533.x · Cited by 267

Validation of a new in vitro dynamic system to simulate infant digestion

Ménard, O., Cattenoz, T., Guillemin, H., Souchon, I., Deglaire, A., Dupont, D., & Picque, D. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.09.036 · Cited by 263

PCR-DGGE-based quantification of stability of the microbial community in a simulator of the human intestinal microbial ecosystem

Possemiers, S., Verthé, K., Uyttendaele, S., & Verstraete, W. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.05.002 · Cited by 259

The Prenylflavonoid Isoxanthohumol from Hops (Humulus lupulus L.) Is Activated into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in the Human Intestine

Possemiers, S., Bolca, S., Grootaert, C., Heyerick, A., Decroos, K., Dhooge, W., Keukeleire, D. D., Rabot, S., Verstraete, W., & de Wiele, T. V. (2006) · Journal of Nutrition · doi:10.1093/jn/136.7.1862 · Cited by 258

Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities

Molly, K., Woestyne, M. V., Smet, I. D., & Verstraete, W. (1994) · Microbial Ecology in Health and Disease · doi:10.3109/08910609409141354 · Cited by 241

Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem

de Wiele, T. V., Boon, N., Possemiers, S., Jacobs, H., & Verstraete, W. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.07.014 · Cited by 217

Assessment of antral grinding of a model solid meal with echo-planar imaging

Marciani, L., Gowland, P. A., Fillery‐Travis, A., et al. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g844 · Cited by 210

Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo

Anson, N. M., Aura, A., Nordlund, E., Mattila, I. M., Poutanen, K. S., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. R. M. M. (2010) · Journal of Nutrition · doi:10.3945/jn.110.127720 · Cited by 208

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

Marzorati, M., Vanhoecke, B. W. A., Ryck, T. D., Sadabad, M. S., Pinheiro, I., Possemiers, S., den Abbeele, P. V., Derycke, L., Bracke, M., Pieters, J., et al. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-133 · Cited by 208

Comparison of five in vitro digestion models to in vivo experimental results: Lead bioaccessibility in the human gastrointestinal tract

de Wiele, T. V., Oomen, A. G., Wragg, J., et al. (2007) · Journal of Environmental Science and Health Part A · doi:10.1080/10934520701434919 · Cited by 191

Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities

Molly, K., Woestyne, M. V., & Smet, I. D. (1994) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v7i4.8295 · Cited by 190

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

Ribnicky, D., Roopchand, D. E., Oren, A., Grace, M. H., Poulev, A., Lila, M. A., Havenaar, R., & Raskin, I. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.07.073 · Cited by 188

Of the Major Phenolic Acids Formed during Human Microbial Fermentation of Tea, Citrus, and Soy Flavonoid Supplements, Only 3,4-Dihydroxyphenylacetic Acid Has Antiproliferative Activity ,

Gao, K., Xu, A., Krul, C. A. M., Venema, K., Liu, Y., Niu, Y., Lu, J., Bensoussan, L., Seeram, N. P., Heber, D., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.52 · Cited by 183

Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity

Smet, I. D., Boever, P. D., & Verstraete, W. (1998) · British Journal Of Nutrition · doi:10.1079/bjn19980030 · Cited by 182

Linking phylogenetic identities of bacteria to starch fermentation in an in vitro model of the large intestine by RNA‐based stable isotope probing

Kovatcheva‐Datchary, P., Egert, M., Maathuis, A. J. H., Rajilić-Stojanović, M. D., de Graaf, A. A., Smidt, H., de Vos, W. M., & Venema, K. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01815.x · Cited by 174

Effect of gel structure on the gastric digestion of whey protein emulsion gels

Guo, Q. Q., Ye, A., Lad, M., Dalgleish, D. G., & Singh, H. (2014) · Soft Matter · doi:10.1039/c3sm52758a · Cited by 173

Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety

Marciani, L., Faulks, R. M., Wickham, M. S. J., Bush, D., Pick, B., Wright, J. W., Cox, E. F., Fillery‐Travis, A., Gowland, P. A., & Spiller, R. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508039986 · Cited by 170

The Protein Digestibility-Corrected Amino Acid Score (PDCAAS)—A Concept for Describing Protein Quality in Foods and Food Ingredients: A Critical Review

Schaafsma, G. (2005) · Journal of AOAC International · doi:10.1093/jaoac/88.3.988 · Cited by 166

Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data

Vardakou, M., Mercuri, A., Barker, S. A., Craig, D. Q. M., Faulks, R. M., & Wickham, M. S. J. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9616-z · Cited by 162

To pool or not to pool? Impact of the use of individual and pooled fecal samples for in vitro fermentation studies

Aguirre, M., Ramiro‐Garcia, J., Koenen, M. E., & Venema, K. (2014) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2014.08.022 · Cited by 147

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

Westerhout, J., van de Steeg, E., Grossouw, D., Zeijdner, E. E., Krul, C. A. M., Verwei, M., & Wortelboer, H. M. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.07.003 · Cited by 135

The Design, Operation, and Application of a Dynamic Gastric Model

Wickham, M. J. S., Faulks, R. M., Mann, J., et al. (2012) · Dissolution Technologies · doi:10.14227/dt190312p15 · Cited by 135

A level A in vitro/in vivo correlation in fasted and fed states using different methods: Applied to solid immediate release oral dosage form

Souliman, S., Blanquet, S., Beyssac, E., & Cardot, J. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.006 · Cited by 132

Different Human Gut Models Reveal the Distinct Fermentation Patterns of Arabinoxylan versus Inulin

den Abbeele, P. V., Venema, K., de Wiele, T. V., Verstraete, W., & Possemiers, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4021784 · Cited by 127

Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment

Vermeiren, J., den Abbeele, P. V., Laukens, D., Vigsnæs, L. K., Vos, M. D., Boon, N., & de Wiele, T. V. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01252.x · Cited by 126

Development of an advanced in vitro model of the stomach and its evaluation versus human gastric physiology

Bellmann, S., Lelieveld, J., Gorissen, T., Minekus, M., & Havenaar, R. (2016) · Food Research International · doi:10.1016/j.foodres.2016.01.030 · Cited by 122

Eubacterium limosum Activates Isoxanthohumol from Hops (Humulus lupulus L.) into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in Rat Intestine3

Possemiers, S., Rabot, S., Espı́n, J. C., Bruneau, A., Philippe, C., González‐Sarrías, A., Heyerick, A., Tomás-Barberán, F. A., Keukeleire, D. D., & Verstraete, W. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1310 · Cited by 120

Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms

Verwei, M., Minekus, M., Zeijdner, E. E., et al. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.11.048 · Cited by 118

Antral motility measurements by magnetic resonance imaging

Marciani, L., Young, P. G., Wright, J. W., et al. (2001) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2001.00285.x · Cited by 114

Development of human colonic microbiota in the computer-controlled dynamic SIMulator of the GastroIntestinal tract SIMGI

Barroso, E., Cueva, C., Peláez, C., Martínez‐Cuesta, M. C., & Requena, T. (2014) · LWT · doi:10.1016/j.lwt.2014.12.014 · Cited by 113

Tracking the in vivo release of bioactive peptides in the gut during digestion: Mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs

Barbé, F., Feunteun, S. L., Rémond, D., Ménard, O., Jardin, J., Henry, G., Laroche, B., & Dupont, D. (2014) · Food Research International · doi:10.1016/j.foodres.2014.02.015 · Cited by 113

In Vitro Characterization of the Impact of Different Substrates on Metabolite Production, Energy Extraction and Composition of Gut Microbiota from Lean and Obese Subjects

Aguirre, M., Jonkers, D. M. A. E., Troost, F. J., Roeselers, G., & Venema, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113864 · Cited by 112

Combining the Dynamic TNO-Gastrointestinal Tract System with a Caco-2 Cell Culture Model: Application to the Assessment of Lycopene and α-Tocopherol Bioavailability from a Whole Food

Déat, E., Blanquet‐Diot, S., Jarrige, J.-F., et al. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902392a · Cited by 108

Profiling of Microbial-Derived Phenolic Metabolites in Human Feces after Moderate Red Wine Intake

Muñoz‐González, I., Jiménez-Girón, A., Martín‐Álvarez, P. J., Bartolomé, B., & Moreno-Arribas, M. V. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4025135 · Cited by 107

Holder pasteurization impacts the proteolysis, lipolysis and disintegration of human milk under in vitro dynamic term newborn digestion

de Oliveira, S. C., Deglaire, A., Ménard, O., Bellanger, A., Rousseau, F., Henry, G., Dirson, E., Carrière, F., Dupont, D., & Bourlieu‐Lacanal, C. (2015) · Food Research International · doi:10.1016/j.foodres.2015.11.022 · Cited by 106

Evaluating the microbial diversity of an in vitro model of the human large intestine by phylogenetic microarray analysis

Rajilić-Stojanović, M. D., Maathuis, A. J. H., Heilig, H. G. H. J., Venema, K., de Vos, W. M., & Smidt, H. (2010) · Microbiology · doi:10.1099/mic.0.042044-0 · Cited by 99

Assessment of the Multi-mycotoxin-Binding Efficacy of a Carbon/Aluminosilicate-Based Product in an in Vitro Gastrointestinal Model

Avantaggiato, G., Havenaar, R., & Visconti, A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0702803 · Cited by 97

Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women

Bolca, S., Possemiers, S., Maervoet, V. E. T., Huybrechts, I., Heyerick, A., Vervarcke, S., Depypere, H. T., Keukeleire, D. D., Bracke, M., Henauw, S. D., et al. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507749243 · Cited by 95

Dynamic In Vitro Models of the Human Gastrointestinal Tract as Relevant Tools to Assess the Survival of Probiotic Strains and Their Interactions with Gut Microbiota

Cordonnier, C., Thévenot, J., Etienne‐Mesmin, L., Denis, S., Alric, M., Livrelli, V., & Blanquet‐Diot, S. (2015) · Microorganisms · doi:10.3390/microorganisms3040725 · Cited by 94

Estimation of the Bioavailability of Iron and Phosphorus in Cereals using a DynamicIn Vitro Gastrointestinal Model

Larsson, M., Minekus, M., & Havenaar, R. (1997) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(199705)74:1 · Cited by 94

Gastric emptying rate and chyme characteristics for cooked brown and white rice meals in vivo

Bornhorst, G. M., Chang, L. Q., Rutherfurd, S. M., Moughan, P. J., & Singh, R. P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6160 · Cited by 91

Digestion of cooked meat proteins is slightly affected by age as assessed using the dynamic gastrointestinal TIM model and mass spectrometry

Denis, S., Sayd, T., Georges, A. D. J., Chambon, C., Chalançon, S., Santé-Lhoutellier, V., & Blanquet‐Diot, S. (2016) · Food & Function · doi:10.1039/c6fo00120c · Cited by 88

Impact of pasteurization of human milk on preterm newborn in vitro digestion: Gastrointestinal disintegration, lipolysis and proteolysis

de Oliveira, S. C., Bourlieu‐Lacanal, C., Ménard, O., et al. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.028 · Cited by 88

Evaluation of an optimal preparation of human standardized fecal inocula for in vitro fermentation studies

Aguirre, M., Eck, A., Koenen, M. E., Savelkoul, P. H. M., Budding, A. E., & Venema, K. (2015) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2015.07.019 · Cited by 86

In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?

Havenaar, R., Anneveld, B., Hanff, L. M., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.07.053 · Cited by 85

Peptide mapping during dynamic gastric digestion of heated and unheated skimmed milk powder

Sánchez‐Rivera, L., Ménard, O., Recio, I., & Dupont, D. (2015) · Food Research International · doi:10.1016/j.foodres.2015.08.001 · Cited by 82

Starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease

Rose, D. J., Venema, K., Keshavarzian, A., & Hamaker, B. R. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509993515 · Cited by 78

Gastric pH Distribution and Mixing of Soft and Rigid Food Particles in the Stomach using a Dual-Marker Technique

Bornhorst, G. M., Rutherfurd, S. M., Roman, M. J., et al. (2014) · Food Biophysics · doi:10.1007/s11483-014-9354-3 · Cited by 77

Use of Artificial Digestive Systems to Investigate the Biopharmaceutical Factors Influencing the Survival of Probiotic Yeast During Gastrointestinal Transit in Humans

Blanquet‐Diot, S., Denis, S., Chalançon, S., Chaira, F., Cardot, J., & Alric, M. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0620-5 · Cited by 70

Development and validation of a new dynamic computer‐controlled model of the human stomach and small intestine

Guerra, A., Denis, S., le Goff, O., Sicardi, V., François, O., Yao, A., Garrait, G., Manzi, A. P., Beyssac, E., Alric, M., et al. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25890 · Cited by 70

Application of a new Dynamic Gastrointestinal Simulator (SIMGI) to study the impact of red wine in colonic metabolism

Cueva, C., Jiménez-Girón, A., Muñoz‐González, I., et al. (2015) · Food Research International · doi:10.1016/j.foodres.2015.03.003 · Cited by 69

The Effect of Lactulose on the Composition of the Intestinal Microbiota and Short-chain Fatty Acid Production in Human Volunteers and a Computer-controlled Model of the Proximal Large Intestine

Venema, K., van Nuenen, M. H. M. C., van den Heuvel, E. G. H. M., et al. (2003) · Microbial Ecology in Health and Disease · doi:10.1080/08910600310019895 · Cited by 64

Antioxidant and anti-inflammatory capacity of bioaccessible compounds from wheat fractions after gastrointestinal digestion

Anson, N. M., Havenaar, R., Bast, A., et al. (2009) · Journal of Cereal Science · doi:10.1016/j.jcs.2009.10.005 · Cited by 60

Investigation of the Biopharmaceutical Behavior of Theophylline Hydrophilic Matrix Tablets Using USP Methods and an Artificial Digestive System

Souliman, S., Beyssac, E., Cardot, J., Denis, S., & Alric, M. (2007) · Drug Development and Industrial Pharmacy · doi:10.1080/03639040601128654 · Cited by 60

D-Tagatose increases butyrate production by the colonic microbiota in healthy men and women

Venema, K., Vermunt, S. H. F., & Brink, E. J. (2005) · Microbial Ecology in Health and Disease · doi:10.1080/08910600510035093 · Cited by 59

Rheological Properties and Textural Attributes of Cooked Brown and White Rice During Gastric Digestion in Vivo

Bornhorst, G. M., Ferrua, M. J., Rutherfurd, S. M., Heldman, D. R., & Singh, R. P. (2013) · Food Biophysics · doi:10.1007/s11483-013-9288-1 · Cited by 58

Predicted Serum Folate Concentrations Based on In Vitro Studies and Kinetic Modeling are Consistent with Measured Folate Concentrations in Humans

Verwei, M., Freidig, A. P., Havenaar, R., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.12.3074 · Cited by 58

Metabolite Production during in Vitro Colonic Fermentation of Dietary Fiber: Analysis and Comparison of Two European Diets

Tabernero, M., Venema, K., Maathuis, A. J. H., & Saura-Calixto, F. D. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201777w · Cited by 58

Enterohemorrhagic Escherichia coli infection has donor-dependent effect on human gut microbiota and may be antagonized by probiotic yeast during interaction with Peyer’s patches

Thévenot, J., Cordonnier, C., Rougeron, A., Goff, O. L., Nguyen, H. T. T., Denis, S., Alric, M., Livrelli, V., & Blanquet‐Diot, S. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6704-0 · Cited by 57

Herring roe protein has a high digestible indispensable amino acid score (DIAAS) using a dynamic in vitro gastrointestinal model

Havenaar, R., Maathuis, A. J. H., de Jong, A., Mancinelli, D., Berger, A., & Bellmann, S. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.05.004 · Cited by 56

Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus

Vigsnæs, L. K., den Abbeele, P. V., Sulek, K., Frandsen, H. L., Steenholdt, C., Brynskov, J., Vermeiren, J., de Wiele, T. V., & Licht, T. R. (2013) · Scientific Reports · doi:10.1038/srep01110 · Cited by 55

Dynamic gastric digestion of a commercial whey protein concentrate†

Miralles, B., del Barrio, R., Cueva, C., Recio, I., & Amigo, L. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8668 · Cited by 52

Enterohemorrhagic Escherichia coli O157:H7 Survival in an In Vitro Model of the Human Large Intestine and Interactions with Probiotic Yeasts and Resident Microbiota

Thévenot, J., Etienne‐Mesmin, L., Denis, S., Chalançon, S., Alric, M., Livrelli, V., & Blanquet‐Diot, S. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.03303-12 · Cited by 48

The Journal of Science of Food and Agriculture

(2018) · The Journal of the Science of Food and Agriculture · doi:10.26855/jsfa · Cited by 45

Preparation and characterization of a packed bead immobilized trypsin reactor integrated into a PDMS microfluidic chip for rapid protein digestion

Kecskeméti, Á., & Gáspár, A. (2017) · Talanta · doi:10.1016/j.talanta.2017.01.060 · Cited by 44

The Computer-Controlled Multicompartmental Dynamic Model of the Gastrointestinal System SIMGI

Barroso, E., Cueva, C., Peláez, C., Martínez‐Cuesta, M. C., & Requena, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-16104-4_28 · Cited by 43

Digestibility of Transglutaminase Cross-Linked Caseinate versus Native Caseinate in an In Vitro Multicompartmental Model Simulating Young Child and Adult Gastrointestinal Conditions

Havenaar, R., de Jong, A., Koenen, M. E., et al. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf402824u · Cited by 41

Effect of galactooligosaccharides andBifidobacterium animalisBb-12 on growth ofLactobacillus amylovorusDSM 16698, microbial community structure, and metabolite production in anin vitrocolonic model set up with human or pig microbiota

Martinez, R. C. R., Cardarelli, H. R., Borst, W., Albrecht, S., Schols, H. A., Gutiérrez, O. P., Maathuis, A. J. H., Franco, B. D. G. D. M., Martinis, E. C. P. D., Zoetendal, E. G., et al. (2012) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12041 · Cited by 40

A microfluidic device to study the digestion of trapped lipid droplets

Marze, S., Algaba, H., & Marquis, M. (2014) · Food & Function · doi:10.1039/c4fo00010b · Cited by 39

Every slow-wave impulse is associated with motor activity of the human stomach

Hocke, M., Schöne, U., Richert, H., Görnert, P., Keller, J., Layer, P., & Stallmach, A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90318.2008 · Cited by 37

Description of a Dynamic In Vitro Model of the Dog Gastrointestinal Tract and an Evaluation of Various Transit Times for Protein and Calcium

Smeets-Peeters, M. J. E., Minekus, M., Havenaar, R., et al. (1999) · Alternatives to Laboratory Animals · doi:10.1177/026119299902700608 · Cited by 36

Increased EHEC survival and virulence gene expression indicate an enhanced pathogenicity upon simulated pediatric gastrointestinal conditions

Roussel, C., Cordonnier, C., Galia, W., Goff, O. L., Thévenot, J., Chalançon, S., Alric, M., Thévenot-Sergentet, D., Leriche, F., de Wiele, T. V., et al. (2016) · Pediatric Research · doi:10.1038/pr.2016.144 · Cited by 36

Effect of bioprocessing of wheat bran in wholemeal wheat breads on the colonic SCFA production in vitro and postprandial plasma concentrations in men

Anson, N. M., Havenaar, R., Vaes, W. H. J., Coulier, L., Venema, K., Nordlund, E., Bast, A., & Haenen, G. R. M. M. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.03.043 · Cited by 34

Impact of human milk pasteurization on the kinetics of peptide release during in vitro dynamic term newborn digestion

Deglaire, A., de Oliveira, S. C., Jardin, J., Briard‐Bion, V., Emily, M., Ménard, O., Bourlieu‐Lacanal, C., & Dupont, D. (2016) · Electrophoresis · doi:10.1002/elps.201500573 · Cited by 34

Gastric digestion of α-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling

Sullivan, L. M., Kehoe, J., Barry, L., Buckley, M. J. M., Shanahan, F., Mok, K. H., & Brodkorb, A. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001196 · Cited by 32

Use of a gastro-intestinal model and gastroplus[tm] for the prediction of in vivo performance

Naylor, T., Connolly, P., Martini, L., et al. (2006) · TNO Repository · Cited by 28

Survival of cheese-ripening microorganisms in a dynamic simulator of the gastrointestinal tract

Adouard, N., Magne, L., Cattenoz, T., Guillemin, H., Foligné, B., Picque, D. D., & Bonnarme, P. (2015) · Food Microbiology · doi:10.1016/j.fm.2015.03.002 · Cited by 28

Digestion of barley malt porridges in a gastrointestinal model: Iron dialysability, iron uptake by Caco-2 cells and degradation of β-glucan

Haraldsson, A., Rimsten, L., Alminger, M., et al. (2005) · Journal of Cereal Science · doi:10.1016/j.jcs.2005.04.002 · Cited by 24

Geigy scientific tables : 1 : units of measurement - body fluids - composition of the body - nutrition

Lentner, C. (1981) · Cited by 24

Development and Validation of a Continuous In Vitro System Reproducing Some Biotic and Abiotic Factors of the Veal Calf Intestine

Gérard-Champod, M., Blanquet‐Diot, S., Cardot, J., Bravo, D., & Alric, M. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00524-10 · Cited by 18

Microfluidic Flow Cell for Sequential Digestion of Immobilized Proteoliposomes

Jansson, E. T., Trkulja, C. L., Olofsson, J., et al. (2012) · Analytical Chemistry · doi:10.1021/ac300519q · Cited by 14

TIM-Carbo: a rapid, cost-efficient and reliable in vitro method for glycemic response after carbohydrate ingestion

Bellmann, S., Minekus, M., Zeijdner, E. E., et al. (2010) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-692-2_033 · Cited by 6

INFOGEST static in vitro simulation of gastrointestinal food digestion

Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0119-1 · Cited by 5,199

Progress in microencapsulation of probiotics: A review

Yao, M., Xie, J., Du, H., McClements, D. J., Xiao, H., & Li, L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12532 · Cited by 571

Influence of In Vitro Digestion on Composition, Bioaccessibility and Antioxidant Activity of Food Polyphenols—A Non-Systematic Review

Wojtunik‐Kulesza, K. A., Oniszczuk, A., Oniszczuk, T., Combrzyński, M., Nowakowska, D., & Matwijczuk, A. P. (2020) · Nutrients · doi:10.3390/nu12051401 · Cited by 464

A review on the food digestion in the digestive tract and the used in vitro models

Şensoy, İ. (2021) · Current Research in Food Science · doi:10.1016/j.crfs.2021.04.004 · Cited by 362

PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion

Tamargo, A., Molinero, N., Reinosa, J. J., Alcolea-Rodriguez, V., Portela, R., Bañares, M. Á., Fernández, J. F., & Moreno-Arribas, M. V. (2022) · Scientific Reports · doi:10.1038/s41598-021-04489-w · Cited by 348

[Measurement of the digestion of dietary nitrogen in different parts of the sheep digestive tract using the nylon bag technic].

Wz, Y., & Poncet, C. (1988) · PubMed

Expression of pro‐apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract

Dempsey, C. E., Dive, C., Fletcher, D. J., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.050 · Cited by 19

[Modern views on digestion and absorption from digestive tract with particular reference to contact digestion].

Ziemlański, Ś. (1970) · PubMed

Studies on the Digestion of nucleic acids in the Digestive Tract of Sheep.

Arias, M. (1974)

Digestion of Proteins and Absorption of Amino Acids in the Digestive Tract of Pigs

Buraczewski, S. (1980) · Archiv für Tierernaehrung · doi:10.1080/17450398009441177 · Cited by 7