Cited by 345Food composition and propertiesGastrointestinal motility and disordersDigestive system and related health

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Can dynamic in vitro digestion systems mimic the physiological reality?

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Dupont, D., Alric, M., Blanquet-Diot, S., Bornhorst, G., Cueva, C., Deglaire, A., Denis, S., Ferrua, M., Havenaar, R., Lelieveld, J., Mackie, A. R., Marzorati, M., Menard, O., Minekus, M., Miralles, B., Recio, I., Van den Abbeele, P.·2019·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2017.1421900

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Abstract

During the last decade, there has been a growing interest in understanding the fate of food during digestion in the gastrointestinal tract in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore simple static in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments but these models are quite basic and hardly recreate the complexity of the digestive tract. In contrast, dynamic models that allow pH regulation, flow of the food and injection in real time of digestive enzymes in the different compartments of the gastrointestinal tract are more promising to accurately mimic the digestive process. Most of the systems developed so far have been compared for their performances to in vivo data obtained on animals and/or humans. The objective of this article is to review the validation towards in vivo data of some of the dynamic digestion systems currently available in order to determine what aspects of food digestion they are able to mimic. Eight dynamic digestion systems are presented as well as their validation towards in vivo data. Advantages and limits of each simulator is discussed. This is the result of a cooperative international effort made by some of the scientists involved in Infogest, an international network on food digestion

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In vitro dynamic digestion of model infant formulae containing lactoferrin and medium chain triacylglycerols
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Authors: Dupont, D., Alric, M., Blanquet-Diot, S., Bornhorst, G., Cueva, C., Deglaire, A., Denis, S., Ferrua, M., Havenaar, R., Lelieveld, J., Mackie, A. R., Marzorati, M., Menard, O., Minekus, M., Miralles, B., Recio, I., & Van den Abbeele, P.
Affiliations: Institut Agro Rennes-Angers (FR)
Université Clermont Auvergne (FR)
Université Clermont Auvergne, Clermont-Ferrand, France
University of California, Davis (US)
Consejo Superior de Investigaciones Científicas (ES)
Fonterra (New Zealand) (NZ)
Triskelion, Zeist, The Netherlands
University of Leeds (GB)
Ghent University (BE)
INRA Agrocampus Ouest, STLO, Rennes, France
ProDigest BVBA, Gent, Belgium
Corresponding author: Dupont, D.
ORCID: Dupont, D.
Bornhorst, G.
Deglaire, A.
Denis, S.
Havenaar, R.
Mackie, A. R.
Marzorati, M.
Miralles, B.
Recio, I.
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2018-01-23
Volume: 59
Issue: 10
Pages: 1546-1562
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2017.1421900
OpenAlex: W2789386374
Semantic Scholar: 6214d2a33898583215c63c2e095f1c86b1a8aab5
Cited by: 345
References: 100
Citations by year: 2026: 29 · 2025: 41 · 2024: 48 · 2023: 48 · 2022: 57 · 2021: 57 · 2020: 40 · 2019: 20 · 2018: 5
FWCI: 3.90
Type: journal article
Language: en
Open access: green
institut-agro-rennes-angers.hal.science
Licence: other-oa
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
HAL (submittedVersion, other-oa)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Digestive system and related health
Keywords: gastrointestinal tract simulation, food digestion, digestive enzymes, pH control, food flows
MeSH terms: Nutrients, Animals, Digestion, Fermentation, Food, Humans, Hydrogen-Ion Concentration, Models, Biological, Biomimetics, Gastrointestinal Tract, In Vitro Techniques

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Can dynamic in vitro digestion systems mimic the physiological reality?

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