Microbial signatures in post-infectious irritable bowel syndrome--toward patient stratification for improved diagnostics and treatment
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Irritable bowel syndrome (IBS) is a multifactorial and heterogeneous disorder estimated to affect over 10% of the Western population. A subset of the patients reports the start of the disease after an episode of gastroenteritis. The alterations in the intestinal microbiota of the post-infectious IBS (PI-IBS) patients were recently investigated in a British cohort and shown to differentiate from the healthy controls and resemble that of diarrhea-predominant IBS (IBS-D) patients. The altered 27 genus-like groups created a microbial signature, which could be used to objectively stratify patients and healthy controls. In this addendum, we combine the microbiota data derived from the British cohort with that of a recently reported Swedish PI-IBS cohort. Remarkably, robust and reproducible microbiota signatures were observed in these PI-IBS patients. We discuss these results with attention on the emerging role of microbiota in the classification, development and treatment of PI-IBS.
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Approximately 10% of IBS cases begin after an episode of infectious gastroenteritis.
“An estimated 10% of IBS cases begin after an episode of infectious gastroenteritis3.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [3]
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- Authors
- Jalanka, J., Salonen, A., Fuentes, S., & de Vos, W. M.
- Affiliations
- University of Helsinki (FI)
- Wageningen University & Research (NL)
- Department of Veterinary Biosciences; Microbiology; University of Helsinki; Helsinki, Finland
- Corresponding author
- Jalanka, Jonna
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2015-10-29
- Volume
- 6
- Issue
- 6
- Pages
- 364-369
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4826089
- OpenAlex
- W2098202807
- Cited by
- 61
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 10
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- post-infectious irritable bowel syndrome, gut microbiota, microbial signatures, patient stratification, diarrhea-predominant irritable bowel syndrome, gastroenteritis
- MeSH terms
- Feces, Humans, Intestinal Mucosa, Gene Expression, Irritable Bowel Syndrome, Microbiota
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