The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma
Open accessAbstract
Extracellular vesicles (EVs), including exosomes and microvesicles, are secreted from all cells, and convey messages between cells in health and disease. However, the diversity of EV subpopulations is only beginning to be explored. Since EVs have been implicated in tumour microenvironmental communication, we started to determine the diversity of EVs specifically in this tissue. To do this, we isolated EVs directly from patient melanoma metastatic tissues. Using EV membrane isolation and mass spectrometry analysis, we discovered enrichment of mitochondrial membrane proteins in the melanoma tissue‐derived EVs, compared to non‐melanoma‐derived EVs. Interestingly, two mitochondrial inner membrane proteins MT‐CO2 (encoded by the mitochondrial genome) and COX6c (encoded by the nuclear genome) were highly prevalent in the plasma of melanoma patients, as well as in ovarian and breast cancer patients. Furthermore, this subpopulation of EVs contains active mitochondrial enzymes. In summary, tumour tissues are enriched in EVs with mitochondrial membrane proteins and these mitochondrial membrane proteins can be detected in plasma and are increased in melanoma, ovarian cancer as well as breast cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855
Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426
Membrane transporters in drug development
The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3028 · Cited by 3,340
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Self-citationIslam, M. N., Das, S. R., Emin, M. T., Wei, M., Sun, L., Westphalen, K., Rowlands, D. J., Quadri, S. K., Bhattacharya, S., & Bhattacharya, J. (2012) · Nature Medicine · doi:10.1038/nm.2736 · Cited by 1,585
Transfer of mitochondria from astrocytes to neurons after stroke
Hayakawa, K., Esposito, E., Wang, X., Terasaki, Y., Liu, Y., Xing, C., Ji, X., & Lo, E. H. (2016) · Nature · doi:10.1038/nature18928 · Cited by 1,423
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Phinney, D. G., Di Giuseppe, M., Njah, J., Sala, E., Shiva, S., St Croix, C. M., Stolz, D. B., Watkins, S. C., Di, Y. P., Leikauf, G. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9472 · Cited by 1,007
Boudreau, L. H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Paré, A., Rousseau, M., Naika, G. S., Lévesque, T., et al. (2014) · Blood · doi:10.1182/blood-2014-05-573543 · Cited by 703
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
Fais, S., O’Driscoll, L., Borras, F. E., Buzas, E., Camussi, G., Cappello, F., Carvalho, J., Cordeiro da Silva, A., Del Portillo, H., El Andaloussi, S., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b08015 · Cited by 481
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes
Sugiura, A., Mattie, S., Prudent, J., & McBride, H. M. (2017) · Nature · doi:10.1038/nature21375 · Cited by 386 · cited 1×
“It has been described that mitochondria can releasee vesicles inside of cells, and these vesicles seem to be either fusing with lysosomes to undergo degradation [46] or can fusing with ER-derived preperoxisomes to generate the peroxisomes [47].”
Background
Research works printed but not linked: 40
- 10.1146/annurev-cellbio-101512-122326 · DOI · Paper page
- Xiao H, 2014, Mast cell exosomes promote lung adenocarcinoma cell proliferation ‐ role of KIT‐stem cell factor signaling, Cell Commun Signal, 12, 64
- 10.1038/ncb1596 · DOI · Paper page
- Kim CW, 2002, Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin, Cancer Res, 62, 6312
- 10.1016/j.jprot.2012.05.031 · DOI
- Saraswat M, 2015, N‐linked (N‐) Glycoproteomics of Urinary Exosomes, Mol Cell Proteomics, 14, 2298, 10.1074/mcp.A114.040345 · DOI
- 10.3402/jev.v4.28680 · DOI · Paper page
- 10.4049/jimmunol.179.3.1969 · DOI · Paper page
- 10.1038/nbt.2886 · DOI · Paper page
- 10.1074/jbc.C113.532267 · DOI · Paper page
- 10.3402/jev.v4.27522 · DOI · Paper page
- 10.1074/mcp.M900152-MCP200 · DOI · Paper page
- Wang Y, 2016, Diagnostic potential of tumor DNA from ovarian cyst fluid, Elife, 5, 15175, 10.7554/eLife.15175 · DOI
- 10.3402/jev.v3.24783 · DOI · Paper page
- 10.7554/eLife.01479 · DOI
- 10.1111/j.1365-2818.2007.01767.x · DOI
- 10.1007/978-1-62703-453-1_9 · DOI
- 10.3402/jev.v2i0.20677 · DOI · Paper page
- 10.1038/srep22519 · DOI · Paper page
- 10.1002/pmic.201300452 · DOI · Paper page
- 10.3402/jev.v2i0.20384 · DOI · Paper page
- 10.1186/s13024-016-0108-1 · DOI
- 10.3402/jev.v3.26913 · DOI · Paper page
- 10.1093/nar/gku989 · DOI · Paper page
- 10.1038/ncb3039 · DOI · Paper page
- 10.7554/eLife.10769 · DOI · Paper page
- 10.1510/icvts.2008.177006 · DOI
- 10.1016/j.cmet.2014.12.003 · DOI · Paper page
- 10.1038/282189a0 · DOI · Paper page
- 10.1007/s00018-018-2773-4 · DOI · Paper page
- 10.1038/s41551-017-0058 · DOI · Paper page
- 10.1038/nrclinonc.2013.110 · DOI · Paper page
- 10.1186/1471-2407-14-962 · DOI
- 10.1073/pnas.1310501111 · DOI · Paper page
- 10.1038/nm.2753 · DOI · Paper page
- 10.1074/jbc.M112.404467 · DOI · Paper page
- 10.1016/j.cub.2011.11.057 · DOI · Paper page
- 10.1038/ncomms10582 · DOI · Paper page
- 10.1186/1471-2407-12-225 · DOI
- 10.1038/ncomms5004 · DOI · Paper page
Cited by
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663
Self-citationAdvances in therapeutic applications of extracellular vesicles
Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & EL Andaloussi, S. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav8521 · Cited by 1,039
Self-citationThe Machinery of Exosomes: Biogenesis, Release, and Uptake
Krylova, S. V., & Feng, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021337 · Cited by 678
Formation of a protein corona on the surface of extracellular vesicles in blood plasma
Tóth, E. Á., Turiák, L., Visnovitz, T., Cserép, C., Mázló, A., Sódar, B. W., Försönits, A. I., Petővári, G., Sebestyén, A., Komlósi, Z., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12140 · Cited by 522
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
Metadata
- Authors
- Jang, S. C., Crescitelli, R., Cvjetkovic, A., Belgrano, V., Bagge, R. O., Sundfeldt, K., Ochiya, T., Kalluri, R., & Lötvall, J.
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2019-08-27
- Volume
- 8
- Issue
- 1
- Pages
- 1635420-1635420
- ISSN
- 2001-3078 (ISSN-L)
- OpenAlex
- W2970195272
- Cited by
- 197
- References
- 10
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- gold
- Funders
- Vetenskapsrådet (K2014-85X-22504-01-3)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma. https://app.cochat.ai/papers/10.1080/20013078.2019.1635420
- The paper
- Jang, S. C., Crescitelli, R., Cvjetkovic, A., Belgrano, V., Bagge, R. O., Sundfeldt, K., Ochiya, T., Kalluri, R., & Lötvall, J. (2019). Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma. Journal of Extracellular Vesicles. https://doi.org/10.1080/20013078.2019.1635420
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
