Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation
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miR-9 regulates NSC proliferation, differentiation, and neuronal integration, with context-dependent functional effects in AD-relevant contexts.
“Among these, miR-9 is one of the more extensively studied regulators of NSC proliferation, differentiation, and neuronal integration, and it displays context-dependent functional effects in AD-relevant contexts (Chang et al., 2014; Liu et al., 2020; Roese-Koerner et al., 2017; Xie et al., 2017).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Roese-Koerner et al., 2017
miR-9 directly targets Notch-pathway components Hes1 and Notch2 to promote differentiation.
“by directly targeting Notch-pathway components (Hes1, Notch2) to promote differentiation (Roese-Koerner et al., 2017)”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Roese-Koerner et al., 2017
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Direct conversion of fibroblasts to functional neurons by defined factors
Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017 · see citing works
A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040 · see citing works
Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562 · see citing works
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis
Kawaguchi, A., Ikawa, T., Kasukawa, T., Ueda, H. R., Kurimoto, K., Saitou, M., & Matsuzaki, F. (2008) · Development · doi:10.1242/dev.022616 · Cited by 193 · see citing works
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Sorted by citations
Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease
Donepudi, K., Eadha, S., Rodarte, D., Sharma, B., & Kumar, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103211
- Authors
- Roese-Koerner, B., Stappert, L., & Brüstle, O.
- Affiliations
- Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn Medical Faculty, Bonn, Germany
- Venue
- Neurogenesis
- Publisher
- Informa UK Limited
- Published
- 2017-01
- Volume
- 4
- Issue
- 1
- Pages
- e1313647
- ISSN
- 2326-2133
- PMC
- PMC5443189
- Cited by
- 46
- References
- 4
- Language
- en
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