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Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation

Roese-Koerner, Beate, Stappert, Laura, Brüstle, Oliver·2017·Neurogenesis

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  • miR-9 regulates NSC proliferation, differentiation, and neuronal integration, with context-dependent functional effects in AD-relevant contexts.

    “Among these, miR-9 is one of the more extensively studied regulators of NSC proliferation, differentiation, and neuronal integration, and it displays context-dependent functional effects in AD-relevant contexts (Chang et al., 2014; Liu et al., 2020; Roese-Koerner et al., 2017; Xie et al., 2017).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Roese-Koerner et al., 2017

  • miR-9 directly targets Notch-pathway components Hes1 and Notch2 to promote differentiation.

    “by directly targeting Notch-pathway components (Hes1, Notch2) to promote differentiation (Roese-Koerner et al., 2017)”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Roese-Koerner et al., 2017

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Cited by

Sorted by citations

Authors
Roese-Koerner, B., Stappert, L., & Brüstle, O.
Affiliations
Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn Medical Faculty, Bonn, Germany
Venue
Neurogenesis
Published
2017-01
Volume
4
Issue
1
Pages
e1313647
ISSN
2326-2133
Cited by
46
References
4
Language
en

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