Association Mapping in Structured Populations

Maximum Likelihood from Incomplete Data Via the EM Algorithm

Dempster, A. P., Laird, N. M., & Rubin, D. B. (1977) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1977.tb01600.x · Cited by 50,444

Genomic Control for Association Studies

Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 1×

Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies

Pritchard, J. K., & Rosenberg, N. A. (1999) · The American Journal of Human Genetics · doi:10.1086/302449 · Cited by 1,198

Estimating African American Admixture Proportions by Use of Population-Specific Alleles

Parra, E. J., Marcini, A., Akey, J., Martinson, J., Batzer, M. A., Cooper, R., Forrester, T., Allison, D. B., Deka, R., Ferrell, R. E., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/302148 · Cited by 771 · cited 4×

Principal components analysis corrects for stratification in genome-wide association studies

Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248

Variance component model to account for sample structure in genome-wide association studies

Kang, H. M., Sul, J. H., Service, S. K., Zaitlen, N. A., Kong, S.-Y., Freimer, N. B., Sabatti, C., & Eskin, E. (2010) · Nature Genetics · doi:10.1038/ng.548 · Cited by 2,817

A new multipoint method for genome-wide association studies by imputation of genotypes

Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Naj, A. C., Jun, G., Beecham, G. W., Wang, L.-S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., et al. (2011) · Nature Genetics · doi:10.1038/ng.801 · Cited by 1,901

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines

Atwell, S., Huang, Y. S., Vilhjálmsson, B. J., Willems, G., Horton, M., Li, Y., Meng, D., Platt, A., Tarone, A. M., Hu, T. T., et al. (2010) · Nature · doi:10.1038/nature08800 · Cited by 1,780

A comprehensive review of genetic association studies

Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674

Convergent adaptation of human lactase persistence in Africa and Europe

Tishkoff, S. A., Reed, F. A., Ranciaro, A., Voight, B. F., Babbitt, C. C., Silverman, J. S., Powell, K., Mortensen, H. M., Hirbo, J. B., Osman, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1946 · Cited by 1,615

The Genetic Structure and History of Africans and African Americans

Tishkoff, S. A., Reed, F. A., Friedlaender, F. R., Ehret, C., Ranciaro, A., Froment, A., Hirbo, J. B., Awomoyi, A. A., Bodo, J.-M., Doumbo, O., et al. (2009) · Science · doi:10.1126/science.1172257 · Cited by 1,573

The effects of human population structure on large genetic association studies

Marchini, J., Cardon, L. R., Phillips, M. S., & Donnelly, P. (2004) · Nature Genetics · doi:10.1038/ng1337 · Cited by 869

Association mapping: critical considerations shift from genotyping to experimental design

Myles, S., Peiffer, J., Brown, P. J., Ersoz, E. S., Zhang, Z., Costich, D. E., & Buckler, E. S. (2009) · The Plant Cell · doi:10.1105/tpc.109.068437 · Cited by 857

Functional markers in plants

Andersen, J. R., & Lübberstedt, T. (2003) · Trends in Plant Science · doi:10.1016/j.tplants.2003.09.010 · Cited by 796

A common variant associated with prostate cancer in European and African populations

Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1808 · Cited by 787

Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

Rosenberg, N. A., & Nordborg, M. (2002) · Nature Reviews Genetics · doi:10.1038/nrg795 · Cited by 750

Copy-number variation and association studies of human disease

McCarroll, S. A., & Altshuler, D. M. (2007) · Nature Genetics · doi:10.1038/ng2080 · Cited by 622

Combining population genomics and quantitative genetics: Finding the genes underlying ecologically important traits

Stinchcombe, J. R., & Hoekstra, H. E. (2008) · Heredity · doi:10.1038/sj.hdy.6800937 · Cited by 622

Control of confounding of genetic associations in stratified populations

Hoggart, C. J., Parra, E. J., Shriver, M. D., Bonilla, C., Kittles, R. A., Clayton, D. G., & McKeigue, P. M. (2003) · The American Journal of Human Genetics · doi:10.1086/375613 · Cited by 490

Demonstrating stratification in a European American population

Campbell, C. D., Ogburn, E. L., Lunetta, K. L., Lyon, H. N., Freedman, M. L., Groop, L. C., Altshuler, D., Ardlie, K. G., & Hirschhorn, J. N. (2005) · Nature Genetics · doi:10.1038/ng1607 · Cited by 444

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

Jun, G. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.201 · Cited by 422

Theory and practice in quantitative genetics

Posthuma, D., Beem, A. L., de Geus, E. J. C., van Baal, G. C. M., von Hjelmborg, J. B., Iachine, I., & Boomsma, D. I. (2003) · Twin Research · doi:10.1375/136905203770326367 · Cited by 416

Discerning the ancestry of European Americans in genetic association studies

Price, A. L., Butler, J., Patterson, N., Capelli, C., Pascali, V. L., Scarnicci, F., Ruiz-Linares, A., Groop, L., Saetta, A. A., Korkolopoulou, P., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0030236 · Cited by 327

PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations

Paschou, P., Ziv, E., Burchard, E. G., Choudhry, S., Rodriguez-Cintron, W., Mahoney, M. W., & Drineas, P. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030160 · Cited by 302

The FKBP5 gene in depression and treatment response – an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) cohort

Lekman, M., Laje, G., Charney, D., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R., Wisniewski, S. R., Manji, H., McMahon, F. J., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.026 · Cited by 284

What makes a good case–control study?

Zondervan, K. T., Cardon, L. R., & Kennedy, S. H. (2002) · Human Reproduction · doi:10.1093/humrep/17.6.1415 · Cited by 271

Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease

Beecham, G. W., Martin, E. R., Li, Y.-J., Slifer, M. A., Gilbert, J. R., Haines, J. L., & Pericak-Vance, M. A. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.008 · Cited by 260

Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders

Stein, M. B., Schork, N. J., & Gelernter, J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301422 · Cited by 247

Analysis and application of European genetic substructure using 300 K SNP information

Tian, C., Plenge, R. M., Ransom, M., Lee, A., Villoslada, P., Selmi, C., Klareskog, L., Pulver, A. E., Qi, L., Gregersen, P. K., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040004 · Cited by 247

The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia

Yunusbayev, B., Metspalu, M., Metspalu, E., Valeev, A., Litvinov, S., Valiev, R., Akhmetova, V., Balanovska, E., Balanovsky, O., Turdikulova, S., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005068 · Cited by 176

Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects

Margolis, D. J., Gupta, J., Apter, A. J., Ganguly, T., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., & Mitra, N. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.015 · Cited by 175

Nicotinic acetylcholine receptor β2 subunit gene implicated in a systems-based candidate gene study of smoking cessation

Conti, D. V., Lee, W., Li, D., Liu, J., Van Den Berg, D., Thomas, P. D., Bergen, A. W., Swan, G. E., Tyndale, R. F., Benowitz, N. L., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn181 · Cited by 136

Genetic approaches to stature, pubertal timing, and other complex traits

Palmert, M. R., & Hirschhorn, J. N. (2003) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(03)00107-0 · Cited by 135

Genetics of posttraumatic stress disorder: review and recommendations for future studies

Koenen, K. C. (2007) · Journal of Traumatic Stress · doi:10.1002/jts.20205 · Cited by 116

Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder

Li, D., Sulovari, A., Cheng, C., Zhao, H., Kranzler, H. R., & Gelernter, J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.291 · Cited by 103

Measuring and using admixture to study the genetics of complex diseases

Halder, I., & Shriver, M. D. (2003) · Human Genomics · doi:10.1186/1479-7364-1-1-52 · Cited by 93

Argentine population genetic structure: Large variance in Amerindian contribution

Seldin, M. F., Tian, C., Shigeta, R., Scherbarth, H. R., Silva, G., Belmont, J. W., Kittles, R., Gamron, S., Allevi, A., Palatnik, S. A., et al. (2007) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20534 · Cited by 90

Pharmacogenetics Studies in STAR*D: Strengths, Limitations, and Results

Laje, G., Perlis, R. H., Rush, A. J., & McMahon, F. J. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.11.1446 · Cited by 89

A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits

Stein, M. B., Yang, B.-Z., Chavira, D. A., Hitchcock, C. A., Sung, S. C., Shipon-Blum, E., & Gelernter, J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.008 · Cited by 89

Admixture analysis of a rural population of the state of Guerrero, Mexico

Bonilla, C., Gutiérrez, G., Parra, E. J., Kline, C., & Shriver, M. D. (2005) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20227 · Cited by 88

Linkage Disequilibrium Analysis of Biallelic DNA Markers, Human Quantitative Trait Loci, and Threshold-Defined Case and Control Subjects

Schork, N. J., Nath, S. K., Fallin, D., & Chakravarti, A. (2000) · The American Journal of Human Genetics · doi:10.1086/321201 · Cited by 86

Consistent long-range linkage disequilibrium generated by admixture in a Bantu-Semitic hybrid population.

Wilson, J. F., & Goldstein, D. B. (2000) · The American Journal of Human Genetics · doi:10.1086/303083 · Cited by 64

Measurement of admixture proportions and description of admixture structure in different U.S. populations

Halder, I., Yang, B.-Z., Kranzler, H. R., Stein, M. B., Shriver, M. D., & Gelernter, J. (2009) · Human Mutation · doi:10.1002/humu.21045 · Cited by 63

Serotonin Transporter Promoter Polymorphism Genotype Is Associated With Behavioral Disinhibition and Negative Affect in Children of Alcoholics

Twitchell, G. R., Hanna, G. L., Cook, E. H., Stoltenberg, S. F., Fitzgerald, H. E., & Zucker, R. A. (2001) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02302.x · Cited by 60

Candidate gene studies of bipolar disorder

Jones, I., & Craddock, N. (2001) · Annals of Medicine · doi:10.3109/07853890108998753 · Cited by 44

Genotyping-by-sequencing (GBS) detects genetic structure and confirms behavioral QTL in tame and aggressive foxes (Vulpes vulpes)

Johnson, J. L., Wittgenstein, H., Mitchell, S. E., Hyma, K. E., Temnykh, S. V., Kharlamova, A. V., Gulevich, R. G., Vladimirova, A. V., Fong, H. W. F., Acland, G. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127013 · Cited by 38