Cited by 38Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Role of hypohalous acids in basement membrane homeostasis

Open access
Colon, Selene, Page-McCaw, Patrick, Bhave, Gautam·2017·Antioxidants & Redox Signaling

Abstract

Significance: Basement membranes (BMs) are sheet-like structures of specialized extracellular matrix that underlie nearly all tissue cell layers including epithelial, endothelial, and muscle cells. BMs not only provide structural support but are also critical for the development, maintenance, and repair of organs. Animal heme peroxidases generate highly reactive hypohalous acids extracellularly and, therefore, target BMs for oxidative modification. Given the importance of BMs in tissue structure and function, hypohalous acid-mediated oxidative modifications of BM proteins represent a key mechanism in normal development and pathogenesis of disease. Recent Advances: Peroxidasin (PXDN), a BM-associated animal heme peroxidase, generates hypobromous acid (HOBr) to form sulfilimine cross-links within the collagen IV network of BM. These cross-links stabilize BM and are critical for animal tissue development. These findings highlight a paradoxical anabolic role for HOBr, which typically damages protein structure leading to dysfunction. Critical Issues: The molecular mechanism whereby PXDN uses HOBr as a reactive intermediate to cross-link collagen IV, yet avoid collateral damage to nearby BM proteins, remains unclear. Future Directions: The exact identification and functional impact of specific hypohalous acid-mediated modifications of BM proteins need to be addressed to connect these modifications to tissue development and pathogenesis of disease. As seen with the sulfilimine cross-link of collagen IV, hypohalous acid oxidative events may be beneficial in select situations rather than uniformly deleterious. Antioxid. Redox Signal . 27, 839–854.

Integrity signals

Registry

Crossref · 10.1089/ars.2017.7245

Cites

167 of 167 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Myeloperoxidase produces HOCl and other hypohalous acids such as HOBr, HOI, and HOSCN as an essential component of antimicrobial innate immunity.

    “Myeloperoxidase produces HOCl and yet other hypohalous acids such as hypobromous acid HOBr, hypoiodous acid HOI, and hypothiocyanous acid HOSCN as an essential component of antimicrobial innate immunity [159].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [159]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Colon, S., Page-McCaw, P., & Bhave, G.
Affiliations
  • Tennessee State University (US)
  • Vanderbilt University Medical Center (US)
  • Vanderbilt University (US)
Corresponding author
Bhave, Gautam
Venue
Antioxidants & Redox Signaling
Published
2017-10
Volume
27
Issue
12
Pages
839-854
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W2729249620
Cited by
38
References
167
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 2
FWCI
0.48
Type
journal article
Language
en
Open access
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Burroughs Wellcome Fund
  • Vanderbilt University Medical Center
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (K08DK097306)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
hypohalous acids, hypobromous acid, basement membrane, peroxidasin, heme peroxidase, type IV collagen, protein oxidation, extracellular matrix, histogenesis
MeSH terms
Peroxidasin, Animals, Basement Membrane, Bromates, Homeostasis, Peroxidase, Extracellular Matrix Proteins, Oxidative Stress, Collagen Type IV

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review