Cited by 72Dialysis and Renal Disease ManagementNatural Products and Biological ResearchFatty Acid Research and Health

Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities

Khalatbari Soltani, Saman, Jamaluddin, Rosita, Tabibi, Hadi, Mohd Yusof, Barakatun Nisak, Atabak, Shahnaz, Loh, Su‐Peng, Rahmani, Leila·2013·Hemodialysis International

Abstract

Inflammation and lipid abnormalities are two important risk factors for cardiovascular disease in hemodialysis (HD) patients. The present study was designed to investigate the effects of flaxseed consumption on systemic inflammation and serum lipid profile in HD patients with lipid abnormalities. This was an unblinded, randomized clinical trial. Thirty HD patients with dyslipidemia (triglyceride >200 mg/dL and/or high‐density lipoprotein‐cholesterol (HDL‐C) <40 mg/dL) were randomly assigned to either a flaxseed or control group. Patients in the flaxseed group received 40 g/day ground flaxseed for 8 weeks, whereas patients in the control group received their usual diet, without any flaxseed. At baseline and at the end of week 8, 7 mL of blood was collected after a 12‐ to 14‐hour fast and serum concentrations of triglyceride, total cholesterol, low‐density lipoprotein‐cholesterol (LDL‐C), HDL‐C, and C‐reactive protein (CRP) were measured. Serum concentrations of triglyceride (P < 0.01), total cholesterol (P < 0.01), LDL‐C (P < 0.01), and CRP (P < 0.05) decreased significantly in the flaxseed group at the end of week 8 compared with baseline, whereas serum HDL‐C showed a significant increase (P < 0.01). These changes in the flaxseed group were significant in comparison with the control group. The study indicates that flaxseed consumption improves lipid abnormalities and reduces systemic inflammation in HD patients with lipid abnormalities.

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Crossref · 10.1111/j.1542-4758.2012.00754.x

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Authors
Khalatbari Soltani, S., Jamaluddin, R., Tabibi, H., Mohd Yusof, B. N., Atabak, S., Loh, S., & Rahmani, L.
Affiliations
  • Department of Nutrition and Dietetics Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia
  • Universiti Putra Malaysia (MY)
  • National Nutrition and Food Technology Research Institute (IR)
  • Shahid Beheshti University (IR)
Corresponding author
Jamaluddin, Rosita
Venue
Hemodialysis International
Publisher
Wiley
Published
2012-09-24
Volume
17
Issue
2
Pages
275-281
ISSN
  • 1492-7535 (ISSN-L)
  • 1542-4758
OpenAlex
W1517129380
Cited by
72
References
34
Citations by year
2025: 5 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 16 · 2020: 3 · 2019: 10 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 1 · 2013: 1
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Hemodialysis International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
flaxseed, hemodialysis patients, dyslipidemia, systemic inflammation, lipid profile, triglycerides, LDL cholesterol, HDL cholesterol, total cholesterol, C-reactive protein, cardiovascular risk factors
MeSH terms
Cardiovascular Diseases, Diet, Female, Renal Dialysis, Humans, Inflammation, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Flax

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