Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities
Abstract
Inflammation and lipid abnormalities are two important risk factors for cardiovascular disease in hemodialysis (HD) patients. The present study was designed to investigate the effects of flaxseed consumption on systemic inflammation and serum lipid profile in HD patients with lipid abnormalities. This was an unblinded, randomized clinical trial. Thirty HD patients with dyslipidemia (triglyceride >200 mg/dL and/or high‐density lipoprotein‐cholesterol (HDL‐C) <40 mg/dL) were randomly assigned to either a flaxseed or control group. Patients in the flaxseed group received 40 g/day ground flaxseed for 8 weeks, whereas patients in the control group received their usual diet, without any flaxseed. At baseline and at the end of week 8, 7 mL of blood was collected after a 12‐ to 14‐hour fast and serum concentrations of triglyceride, total cholesterol, low‐density lipoprotein‐cholesterol (LDL‐C), HDL‐C, and C‐reactive protein (CRP) were measured. Serum concentrations of triglyceride (P < 0.01), total cholesterol (P < 0.01), LDL‐C (P < 0.01), and CRP (P < 0.05) decreased significantly in the flaxseed group at the end of week 8 compared with baseline, whereas serum HDL‐C showed a significant increase (P < 0.01). These changes in the flaxseed group were significant in comparison with the control group. The study indicates that flaxseed consumption improves lipid abnormalities and reduces systemic inflammation in HD patients with lipid abnormalities.
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Six RCTs had low risk of bias for random sequence generation, three had high risk, and the remaining had unclear risk.
“Six RCTs indicated the method for random sequence generation was low risk [29, 34, 44, 47, 48, 52], three other studies indicated high risk [21, 41, 53], and the remaining studies have unclear risk of bias.”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [53]
Findings regarding serum lipid, inflammatory and anthropometric parameters basically remained robust in the sensitivity analysis when excluding a trial carrying a high risk of bias.
“Findings regarding serum lipid, inflammatory and anthropometric parameters basically remained robust in the sensitivity analysis when excluding a trial carrying a high risk of bias [53].”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [53]
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- Authors
- Khalatbari Soltani, S., Jamaluddin, R., Tabibi, H., Mohd Yusof, B. N., Atabak, S., Loh, S., & Rahmani, L.
- Affiliations
- Department of Nutrition and Dietetics Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia
- Universiti Putra Malaysia (MY)
- National Nutrition and Food Technology Research Institute (IR)
- Shahid Beheshti University (IR)
- Corresponding author
- Jamaluddin, Rosita
- Venue
- Hemodialysis International
- Publisher
- Wiley
- Published
- 2012-09-24
- Volume
- 17
- Issue
- 2
- Pages
- 275-281
- ISSN
- 1492-7535 (ISSN-L)
- 1542-4758
- OpenAlex
- W1517129380
- Cited by
- 72
- References
- 34
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 16 · 2020: 3 · 2019: 10 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hemodialysis International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- flaxseed, hemodialysis patients, dyslipidemia, systemic inflammation, lipid profile, triglycerides, LDL cholesterol, HDL cholesterol, total cholesterol, C-reactive protein, cardiovascular risk factors
- MeSH terms
- Cardiovascular Diseases, Diet, Female, Renal Dialysis, Humans, Inflammation, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Flax
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