Therapeutic Strategies and Enhanced Production of Stem Cell-Derived Exosomes for Tissue Regeneration

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583 · see citing works

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Doyle, L. M., & Wang, M. Z. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,271 · see citing works

Osteoarthritis: A disease of the joint as an organ

Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,129 · see citing works

Exosomes: biogenesis, biologic function and clinical potential

Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell &amp; Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119 · see citing works

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works

Three-dimensional cell culture: the missing link in drug discovery

Breslin, S., & O’Driscoll, L. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2012.10.003 · Cited by 1,332 · see citing works

&lt;p&gt;Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications&lt;/p&gt;

Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323 · see citing works

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,135 · see citing works

Hypoxic enhancement of exosome release by breast cancer cells

King, H. W., Michael, M. Z., & Gleadle, J. M. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-421 · Cited by 1,045 · see citing works

Stem cells in tissue engineering

Bianco, P., & Robey, P. G. (2001) · Nature · doi:10.1038/35102181 · Cited by 969 · see citing works

Exosomes and Ectosomes in Intercellular Communication

Meldolesi, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.059 · Cited by 944 · see citing works

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

Zhang, S., Chuah, S. J., Lai, R. C., Hui, J. H. P., Lim, S. K., & Toh, W. S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.028 · Cited by 919 · see citing works

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2018) · Theranostics · doi:10.7150/thno.29766 · Cited by 914 · see citing works

Exosomes in tumor microenvironment influence cancer progression and metastasis

Kahlert, C., & Kalluri, R. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1020-6 · Cited by 869 · see citing works

Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells

Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M., & Baglio, S. R. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.013 · Cited by 815 · see citing works

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

Pathan, M., Fonseka, P., Chitti, S. V., Kang, T., Sanwlani, R., Deun, J. V., Hendrix, A., & Mathivanan, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1029 · Cited by 769 · see citing works

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0485-1 · Cited by 744 · see citing works

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

Tao, S., Yuan, T., Zhang, Y.-L., Yin, W., Guo, S., & Zhang, C. (2016) · Theranostics · doi:10.7150/thno.17133 · Cited by 734 · see citing works

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

Kourembanas, S. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071641 · Cited by 655 · see citing works

Exosome Processing and Characterization Approaches for Research and Technology Development

Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623 · see citing works

Review on Strategies and Technologies for Exosome Isolation and Purification

Chen, J., Li, P., Zhang, T., Xu, Z., Huang, X., Wang, R., & Du, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.811971 · Cited by 585 · see citing works

Exosomes: New players in cell–cell communication

Bang, C., & Thum, T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.007 · Cited by 509 · see citing works

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

Li, J., Liu, K., Liu, Y., Xu, Y., Zhang, F., Yang, H., Liu, J., Pan, T., Chen, J., Wu, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2647 · Cited by 508 · see citing works

Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1β-Primed Mesenchymal Stem Cells Against Sepsis

Song, Y., Dou, H., Li, X., Zhao, X., Li, Y., Liu, D., Ji, J., Liu, F., Ding, L., Ni, Y., et al. (2017) · Stem Cells · doi:10.1002/stem.2564 · Cited by 490 · see citing works

Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration

Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 459 · see citing works

Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing

Shiekh, P. A., Singh, A., & Kumar, A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120020 · Cited by 443 · see citing works

Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, I. L., Corteling, R. L., Bracewell, D. G., & Wall, I. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.006 · Cited by 414 · see citing works

Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury

Li, L., Zhang, Y., Mu, J., Chen, J., Zhang, C., Cao, H., & Gao, J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c00929 · Cited by 406 · see citing works

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

Kim, D. H., Kim, H., Choi, Y. J., Kim, S. Y., Lee, J.-E., Sung, K. J., Sung, Y. H., Pack, C., Jung, M., Han, B., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0295-2 · Cited by 381 · see citing works

Exosomes as biomimetic tools for stem cell differentiation: Applications in dental pulp tissue regeneration

Huang, C.-C., Narayanan, R., Alapati, S. B., & Ravindran, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.029 · Cited by 324 · see citing works

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

Li, Z., Zhou, X., Wei, M., Gao, X., Zhao, L., Shi, R., Sun, W., Duan, Y., Yang, G., & Yuan, L. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b02689 · Cited by 318 · see citing works

Exosomes Derived from Akt -Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D

Ma, J., Zhao, Y., Sun, L., Sun, X., Zhao, X., Sun, X., Qian, H., Xu, W., & Zhu, W. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0038 · Cited by 312 · see citing works

Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism

Shen, Z., Kuang, S., Zhang, Y., Yang, M., Qin, W., Shi, X., & Lin, Z. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.07.002 · Cited by 295 · see citing works

Human mesenchymal stem cell derived exosomes enhance cell‐free bone regeneration by altering their miRNAs profiles

Zhai, M., Zhu, Y., Yang, M., & Mao, C. (2020) · Advanced Science · doi:10.1002/advs.202001334 · Cited by 277 · see citing works

Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis

Zhang, Y., Xie, Y., Hao, Z., Zhou, P., Wang, P., Fang, S., Lu, L., Xu, S., & Xia, Y. Q. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c22671 · Cited by 275 · see citing works

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

Zhu, J., Lü, K., Zhang, N., Zhao, Y. F., Ma, Q., Shen, J., Lin, Y., Xiang, P., Tang, Y., Hu, X., et al. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1388249 · Cited by 264 · see citing works

Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes

Domenis, R., Cifù, A., Quaglia, S., Pistis, C., Moretti, M., Vicario, A., Parodi, P. C., Fabris, M., Niazi, K., Soon‐Shiong, P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31707-9 · Cited by 245 · see citing works

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity

Yan, L., & Wu, X. (2019) · Cell Biology and Toxicology · doi:10.1007/s10565-019-09504-5 · Cited by 244 · see citing works

Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis

You, D. G., Lim, G. T., Kwon, S., Um, W., Oh, B. H., Song, S. H., Lee, J., Jo, D., Cho, Y. W., & Park, J. H. (2021) · Science Advances · doi:10.1126/sciadv.abe0083 · Cited by 240 · see citing works

Bone marrow mesenchymal stem cell-derived exosomes promote tendon regeneration by facilitating the proliferation and migration of endogenous tendon stem/progenitor cells

Yu, H., Cheng, J., Shi, W., Ren, B., Zhao, F., Shi, Y., Yang, P., Duan, X., Zhang, J., Fu, X., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.01.051 · Cited by 232 · see citing works

Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury

Bucan, V., Vaslaitis, D., Peck, C., Strauß, S., Vogt, P. M., & Radtke, C. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1172-z · Cited by 230 · see citing works

Low pH increases the yield of exosome isolation

Ban, J.-J., Lee, M., Im, W., & Kim, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.172 · Cited by 225 · see citing works

Generation of Small RNA-Modulated Exosome Mimetics for Bone Regeneration

Fan, J., Lee, C., Kim, S., Chen, C., Aghaloo, T. L., & Lee, M. (2020) · ACS Nano · doi:10.1021/acsnano.0c05122 · Cited by 224 · see citing works

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

Asgarpour, K., Shojaei, Z., Amiri, F., Ai, J., Mahjoubin‐Tehran, M., Ghasemi, F., Arefnezhad, R., Hamblin, M. R., & Mirzaei, H. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00650-6 · Cited by 221 · see citing works

Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration

Kim, W., Gwon, Y., Park, S., Kim, H., & Kim, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.039 · Cited by 211 · see citing works

The crosstalk: exosomes and lipid metabolism

Wang, W., Zhu, N., Yan, T., Shi, Y.-N., Chen, J., Zhang, C.-J., Xie, X.-J., Liao, D.-F., & Qin, L. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00581-2 · Cited by 203 · see citing works

Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway

Yan, B., Zhang, Y., Liang, C., Liu, B., Ding, F., Wang, Y., Zhu, B. T., Zhao, R., Yu, X., & Li, Y. (2020) · Theranostics · doi:10.7150/thno.42259 · Cited by 202 · see citing works

Dental pulp and dentin tissue engineering and regeneration advancement and challenge

Huang, G. T. ‐. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e286 · Cited by 200 · see citing works

Priming Adipose Stem Cells with Tumor Necrosis Factor-Alpha Preconditioning Potentiates Their Exosome Efficacy for Bone Regeneration

Lu, Z., Chen, Y., Dunstan, C. R., Roohani‐Esfahani, S., & Zreiqat, H. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0548 · Cited by 200 · see citing works

Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration

Qing, L., Chen, H. A., Tang, J., & Jia, X. (2018) · Neurorehabilitation and neural repair · doi:10.1177/1545968318798955 · Cited by 180 · see citing works

Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine

Miceli, V., Bulati, M., Iannolo, G., Zito, G., Gallo, A., & Conaldi, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020763 · Cited by 176 · see citing works

Technological advances towards extracellular vesicles mass production

Grangier, A., Branchu, J., Volatron, J., Piffoux, M., Gazeau, F., Wilhelm, C., & Silva, A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113843 · Cited by 175 · see citing works

Advancing cartilage tissue engineering: the application of stem cell technology

Raghunath, J., Salacinski, H. J., Sales, K. M., Butler, P. E. M., & Seifalian, A. M. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.08.004 · Cited by 168 · see citing works

Progress and challenges in large-scale expansion of human pluripotent stem cells

Kropp, C., Massai, D., & Zweigerdt, R. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2016.09.032 · Cited by 167 · see citing works

Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway

Jiang, T., Wang, Z., & Sun, J. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01723-6 · Cited by 167 · see citing works

Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes

Kim, H., Yun, N., Mun, D., Kang, J.-Y., Lee, S., Park, H., Park, H., & Joung, B. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.227 · Cited by 166 · see citing works

Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing

Hu, Y., Wu, B., Xiong, Y., Tao, R., Panayi, A. C., Chen, L., Tian, W., Xue, H., Shi, L., Zhang, X., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130634 · Cited by 164 · see citing works

Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells

Kim, M., Yun, H., Park, D. Y., Choi, B. H., & Min, B. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0139-5 · Cited by 163 · see citing works

Trabecular bone organoid model for studying the regulation of localized bone remodeling

Park, Y., Cheong, E., Kwak, J., Carpenter, R., Shim, J., & Lee, J. (2021) · Science Advances · doi:10.1126/sciadv.abd6495 · Cited by 157 · see citing works

Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia

Yang, J., Wu, S., Hou, L., Zhu, D., Yin, S., Yang, G., & Wang, Y. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.06.013 · Cited by 154 · see citing works

Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function

Chen, J., Ren, S., Duscher, D., Kang, Y., Liu, Y., Wang, C., Yuan, M., Guo, G., Xiong, H., Zhan, P., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28873 · Cited by 145 · see citing works

Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon

Zhang, M., Liu, H., Cui, Q., Han, P., Yang, S., Shi, M., Zhang, T., Zhang, Z., & Li, Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01918-x · Cited by 145 · see citing works

Exosome manufacturing status.

Whitford, W., & Guterstam, P. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0417 · Cited by 145 · see citing works

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

Yao, J., Huang, K., Zhu, D., Chen, T., Jiang, Y., Zhang, J., Mi, L., He, X., Hu, S., Li, J., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c00628 · Cited by 140 · see citing works

Cellular senescence in aging and osteoarthritis

Toh, W. S., Brittberg, M., Farr, J., Foldager, C. B., Gomoll, A. H., Hui, J. H. P., Richardson, J. B., Roberts, S., & Spector, M. (2016) · Acta Orthopaedica · doi:10.1080/17453674.2016.1235087 · Cited by 130 · see citing works

High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism

Ambattu, L. A., Ramesan, S., Dekiwadia, C. D., Hanssen, E. G., Li, H., & Yeo, L. Y. (2020) · Communications Biology · doi:10.1038/s42003-020-01277-6 · Cited by 128 · see citing works

Overcome the barriers of the skin: exosome therapy

Yang, G. H., Lee, Y. B., Kang, D., Choi, E.-J., Nam, Y., Lee, K. H., You, H., Kang, H. J., An, S., & Jeon, H. (2021) · Biomaterials Research · doi:10.1186/s40824-021-00224-8 · Cited by 123 · see citing works

Stem cells in the hood: the skeletal muscle niche

Pannérec, A., Marazzi, G., & Sassoon, D. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.07.004 · Cited by 122 · see citing works

Exosomes from adipose‑derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR‑145 and miR‑221

Zhao, C., Chen, J., Peng, W., Yuan, B., Bi, Q., & Xu, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10982 · Cited by 119 · see citing works

The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment

Malekpour, K., Hazrati, A., Zahar, M., Markov, A. A., Zekiy, A. O., Navashenaq, J. G., Roshangar, L., & Ahmadi, M. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10185-z · Cited by 119 · see citing works

Exosome therapeutics for lung regenerative medicine

Popowski, K. D., Lutz, H., Hu, S., George, A., Dinh, P., & Cheng, K. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1785161 · Cited by 116 · see citing works

Spheroids as vascularization units: From angiogenesis research to tissue engineering applications

Laschke, M. W., & Menger, M. D. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.07.002 · Cited by 104 · see citing works

Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury

Zhao, J., Ding, Y., He, R., Huang, K., Liu, L., Jiang, C., Liu, Z., Wang, Y., Yan, X., Cao, F., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01872-8 · Cited by 103 · see citing works

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

Haraszti, R. Á., Miller, R., Dubuke, M. L., Rockwell, H. E., Coles, A. H., Sapp, E., Didiot, M.-C., Echeverria, D., Stoppato, M., Sere, Y. Y., et al. (2019) · iScience · doi:10.1016/j.isci.2019.05.029 · Cited by 103 · see citing works

Bioglass enhances the production of exosomes and improves their capability of promoting vascularization

Wu, Z., He, D., & Li, H. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.011 · Cited by 101 · see citing works

Exploring the Application of Stem Cells in Tendon Repair and Regeneration

Ahmad, Z., Wardale, J., Brooks, R. A., HENSON, F. M. D., Noorani, A. M., & Rushton, N. (2012) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2011.12.009 · Cited by 100 · see citing works

A review of manufacturing capabilities of cell spheroid generation technologies and future development

Liu, D., Chen, S., & Naing, M. W. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27620 · Cited by 96 · see citing works

Development and regulation of exosome‐based therapy products

Batrakova, E. V., & Kim, M. S. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1395 · Cited by 94 · see citing works

Biomimetic nerve guidance conduit containing engineered exosomes of adipose-derived stem cells promotes peripheral nerve regeneration

Yang, Z., Yang, Y., Xu, Y., Jiang, W., Shao, Y., Xing, J., Chen, Y., & Han, Y. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02528-x · Cited by 94 · see citing works

Multiscale patterned transplantable stem cell patches for bone tissue regeneration

Kim, J., Bae, W., Choung, H., Lim, K., Seonwoo, H., Jeong, H. E., Suh, K.-Y., Jeon, N. L., Choung, P., & Chung, J. H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.036 · Cited by 88 · see citing works

Mitochondrial‐derived vesicles: Recent insights

Popov, L. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17391 · Cited by 87 · see citing works

Mesenchymal Stem Cell Exosomes for Cartilage Regeneration: A Systematic Review of Preclinical In Vivo Studies

Tan, S. H. S., Tjio, C. K. E., Wong, J. R. Y., Wong, K. L., Chew, R. J. J., Hui, J. H. P., & Toh, W. S. (2020) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0326 · Cited by 84 · see citing works

Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19

Yan, L., Liu, G., & Wu, X. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.03.005 · Cited by 83 · see citing works

Improvement of stem cell-derived exosome release efficiency by surface-modified nanoparticles

Park, D. J., Yun, W. S., Kim, W. C., Park, J., Lee, S. H., Ha, S., Choi, J. S., Key, J., & Seo, Y. J. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00739-7 · Cited by 82 · see citing works

Improvement, scaling-up, and downstream analysis of exosome production

Jafari, D., Malih, S., Eini, M., Jafari, R., Gholipourmalekabadi, M., Sadeghizadeh, M., & Samadikuchaksaraei, A. (2020) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1805406 · Cited by 81 · see citing works

Exosome redux

Zipkin, M. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0326-5 · Cited by 78 · see citing works

Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior

Park, S., Park, H., Sun, K., Gwon, Y., Seong, M., Kim, S., Park, T., Hyun, H., Choung, Y., Kim, J., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b04109 · Cited by 76 · see citing works

Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling

Bagheri, H. S., Mousavi, M., Rezabakhsh, A., Rezaie, J., Rasta, S. H., Nourazarian, A., Avcı, Ç. B., Tajalli, H., Talebi, M., Oryan, A., et al. (2018) · Lasers in Medical Science · doi:10.1007/s10103-018-2495-8 · Cited by 75 · see citing works

Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

Dunn, A. J., Talovic, M., Patel, K. H., Patel, A., Marcinczyk, M., & Garg, K. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24212 · Cited by 73 · see citing works

Exosomes in disease and regeneration: biological functions, diagnostics, and beneficial effects

Lin, Y., Anderson, J. D., Rahnama, L. M. A., Gu, S. V., & Knowlton, A. A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00075.2020 · Cited by 73 · see citing works

Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction

Shiekh, P. A., Mohammed, S. A., Gupta, S. V., Das, A., Meghwani, H., Maulik, S. K., Banerjee, S., & Kumar, A. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132490 · Cited by 71 · see citing works

Current strategies in tailoring methods for engineered exosomes and future avenues in biomedical applications

Mishra, A., Singh, P., Qayoom, I., Prasad, A., & Kumar, A. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01088c · Cited by 68 · see citing works

Stem cell engineering in bioreactors for large‐scale bioprocessing

Liu, N., Zang, R., Yang, S., & Li, Y. (2013) · Engineering in Life Sciences · doi:10.1002/elsc.201300013 · Cited by 66 · see citing works

Exosomes from tendon derived stem cells promote tendon repair through miR-144-3p-regulated tenocyte proliferation and migration

Song, K., Jiang, T., Pan, P. H., Yao, Y., & Jiang, Q. Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02723-4 · Cited by 66 · see citing works

Mitochondrial-Derived Vesicles Protect Cardiomyocytes Against Hypoxic Damage

Li, B., Zhao, H., Wu, Y., Zhu, Y., Zhang, J., Yang, G., Yan, Q., Li, J., Li, T., & Liu, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00214 · Cited by 55 · see citing works

The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration

Yao, X., Yan, Z., Wang, X., Jiang, H., Qian, Y., & Fan, C. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbab032 · Cited by 52 · see citing works

Skeletal Muscle Regeneration by the Exosomes of Adipose Tissue-Derived Mesenchymal Stem Cells

Byun, S., Sim, C., Chung, Y., Kim, H. K., Park, S., Kim, H. K., Cho, S., & Lee, S. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030104 · Cited by 49 · see citing works

Aptamer decorated magnetic graphene oxide nanoparticles for effective capture of exosomes

Huang, W., Yu, Y., Yang, C., Zhang, X., Shang, L., Zu, Y., & Shi, K. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.133849 · Cited by 46 · see citing works

Umbilical cord mesenchymal stem cells as well as their released exosomes suppress proliferation of activated PBMCs in multiple sclerosis

Baharlooi, H., Nouraei, Z., Azimi, M., Moghadasi, A. N., Tavassolifar, M. J., Moradi, B., Sahraian, M. A., & Izad, M. H. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.13013 · Cited by 46 · see citing works

Low-intensity ultrasound radiation increases exosome yield for efficient drug delivery

Zhao, Z. X., Qu, L., Shuang, T., Wu, S., Su, Y., Fan, L., Wang, D., Chen, B., & Hao, Q. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101713 · Cited by 44 · see citing works

Endometrial Mesenchymal Stem Cell-Derived Exosome Promote Endothelial Cell Angiogenesis in a Dose Dependent Manner: A New Perspective on Regenerative Medicine and Cell-Free Therapy

Nooshabadi, V. T., Verdi, J., Ebrahimi‐Barough, S., Mowla, S. J., Atlasi, M. A., Mazoochi, T., Valipour, E., Shafiei, S., Ai, J., & Banafshe, H. R. (2019) · Archives of Neuroscience · doi:10.5812/ans.94041 · Cited by 42 · see citing works

Exosomes: a tool for bone tissue engineering

Huber, J., Griffin, M. F., Longaker, M. T., & Quarto, N. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2020.0246 · Cited by 41 · see citing works

Exosome derived from mesenchymal stem cells mediates hypoxia-specific BMP2 gene delivery and enhances bone regeneration

Liang, Z., Yang, L., & Lv, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130084 · Cited by 35 · see citing works

Tendon-Inspired Nanotopographic Scaffold for Tissue Regeneration in Rotator Cuff Injuries

Kim, W., Kim, G., Abdou, M. A., Kim, S., Kim, D., Park, S., Kim, Y.-K., Gwon, Y., Jeong, S.-E., Kim, M., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c01328 · Cited by 35 · see citing works

Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration

Kim, W., Gwon, Y., Kim, Y.-K., Park, S., Kang, S.-J., Park, H., Kim, M., & Kim, J. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00162-y · Cited by 26 · see citing works

Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models

Gwon, Y., Kim, W., Park, S., Kim, Y., Kim, H., Kim, M., & Kim, J. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10376 · Cited by 16 · see citing works

Engineered exosomes and composite biomaterials for tissue regeneration

Hu, W., Wang, W., Chen, Z., Chen, Y., & Wang, Z. (2024) · Theranostics · doi:10.7150/thno.93088 · Cited by 85 · see citing works

Biomaterials in tissue repair and regeneration: key insights from extracellular matrix biology

Abolhasani, S., Ahmadi, Y., Rostami, Y., Baravar, E., & Fattahi, D. (2025) · Frontiers in Medical Technology · doi:10.3389/fmedt.2025.1565810 · Cited by 60 · see citing works

Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration

Pisheh, H. R., & Sani, M. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04123-2 · Cited by 54 · see citing works

Curcumin-encapsulated exosomes in bisphosphonate-modified hydrogel microspheres promote bone repair through macrophage polarization and DNA damage mitigation

Si, Y., Dong, S., Li, M., Gu, J., Luo, M., Wang, X., Wang, Z., Li, X., & Zhang, C. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101874 · Cited by 34 · see citing works

Advances in Purification, Modification, and Application of Extracellular Vesicles for Novel Clinical Treatments

Matsuzaka, Y., & Yashiro, R. (2022) · Membranes · doi:10.3390/membranes12121244 · Cited by 28 · see citing works

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works

DNA Nano‐Biomaterials Based Futuristic Technologies for Tissue Engineering and Regenerative Therapeutics

Kansara, K., Mansuri, A., Kumar, A., & Bhatia, D. D. (2025) · Small · doi:10.1002/smll.202504361 · Cited by 13 · see citing works

Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

Choi, S., Kang, B. S., Choi, G., Kang, M., Park, H., Kim, N., Chang, P., Kwak, M. K., Jeong, H. E., & Jung, H. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300044 · Cited by 9 · see citing works

High‐Yield Extruded Nanovesicles From Adipose Stem Cells Promote High‐Quality Healing of Diabetic Wound Through WNT /β‐Catenin Pathway Activation

Yao, T., Liu, L., Miao, Y., Li, X., Yu, Y., Sun, R., Zhang, Y., Cui, L., & Ma, X. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70877 · Cited by 3 · see citing works

Possibilities of using cellular secretome to stimulate soft tissue regeneration: a review

Eremin, P. S., Rozhkova, E. A., & Ринатовна, Г. И. (2025) · Bulletin of Rehabilitation Medicine · doi:10.38025/2078-1962-2025-24-5-106-112 · Cited by 2 · see citing works

Polydopamine-functionalized nanohydroxyapatite coated exosomes with enhanced cytocompatibility and osteogenesis for bone regeneration

Xiang, M., Zhang, G., Liu, Y., Liao, C., Xiao, L., Xiang, M., Guan, X., & Liu, J. (2024) · Bio-Medical Materials and Engineering · doi:10.1177/09592989241301662 · Cited by 2 · see citing works

Exosome-targeted injectable hydrogels for sustained DEPTOR delivery and delay of IDD via the mTORC1/SASP pathway

Lu, H., Liu, Z., Han, S., Wang, Y., Zhang, X., Tao, H., Liu, R., Guo, Z., & Ma, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148758 · Cited by 1 · see citing works

Research progress on exosomes in the otology field: a systematic review

Hao, Z., Zhang, C., Li, Z., Zhao, H., Wang, Y., Wang, Y., Wang, H., Liu, D., Cui, L., & Sun, Y. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04816-2 · Cited by 1 · see citing works

The emerging role of exosomes derived from induced pluripotent stem cells (iPSCs) in cardioprotection: Potential applications in ischemic heart disease

Muduli, P. P. (2024) · doi:10.61577/ijcri.2024.1000010

Bioinspired and Biomimetic Materials/Architecture in Cardiovascular Regeneration

Fathi‐karkan, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-87744-5_20

Mechanisms and clinical prospects of mesenchymal stem cells and their derivatives in treating hypothyroidism-induced injuries: A focus on cardiovascular, skeletal muscle, and nervous systems

Wang, Y., Zhu, J., Li, Z., Yu, F., Fu, Y., Gao, H., Wang, M., Yuan, L., Zheng, L., & He, Q. (2026) · Cell Transplantation · doi:10.1177/09636897261418754

Exosome Therapy: A Novel Investigational Approach in Acute Myocardial Infarction

Joshi, A., Gupta, R., Sangdup, T., Jacob, J., & Aggarwal, A. (2026) · Cardiology in Review · doi:10.1097/crd.0000000000001365

Exosomes in tissue engineering and cell-free therapy: A comprehensive review

Zhang, L., Yang, F. F., Liu, J. B., Li, M., Mao, F., Ocansey, D. K. W., & Wu, Y. B. (2026) · European Cells and Materials · doi:10.22203/ecm.v055a06 · Cited by 5 · see citing works

Exosomal therapy is a luxury area for regenerative medicine

Hassaan, N. A., & Mansour, H. A. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102570 · Cited by 15 · see citing works

Stem-cell‑derived exosomes: a comprehensive review from basic biology to clinical translation challenges

Hasan, M. T., Hossain, M. B., Rahman, M. M., Hasan, M. S., Hasan, M., & Mithu, M. M. (2024) · New medicine. · doi:10.1097/nm9.0000000000000004 · Cited by 1 · see citing works

Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications

Roszkowski, S. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01282-z · Cited by 120 · see citing works

Molecular mechanisms governing exosome biogenesis, engineering strategies, and emerging role as cell-free therapeutics

Raza, M. H., Ilyas, J., Shahid, K., Urooj, Z., Baig, M. T., & Shahid, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12040-1