The DOI matches its Crossref record; 42 of the 45 references it cites were found in a registry or an index.
Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials
Open accessAbstract
Background Soluble fibers, including those from psyllium husk, have been shown to augment the cholesterol-lowering effects of a low-fat diet in persons with hypercholesterolemia. As evidence of this, the US Food and Drug Administration recently authorized the use of health claims on food products containing soluble fiber from psyllium that state that they are associated with a decreased risk of coronary heart disease. Objective This meta-analysis was conducted to more precisely define the hypolipidemic effects and safety of psyllium when used adjunctive to a low-fat diet in men and women with hypercholesterolemia. Design The 8 studies in the meta-analysis included a total of 384 and 272 subjects receiving psyllium or cellulose placebo, respectively. All studies evaluated the hypocholesterolemic effects of 10.2 g psyllium/d adjunctive to a low-fat diet for >/=8 wk in individuals with mild-to-moderate hypercholesterolemia after a low-fat diet lead-in phase lasting >/=8 wk. The safety and adverse events associated with psyllium consumption were summarized from pooled data of 19 clinical studies ranging from 6 wk to 6 mo in duration. Results Consumption of 10.2 g psyllium/d lowered serum total cholesterol by 4% (P < 0.0001), LDL cholesterol by 7% (P < 0.0001), and the ratio of apolipoprotein (apo) B to apo A-I by 6% (P < 0.05) relative to placebo in subjects already consuming a low-fat diet, with no effect on serum HDL or triacylglycerol concentrations. Conclusions Psyllium supplementation significantly lowered serum total and LDL-cholesterol concentrations in subjects consuming a low-fat diet. Psyllium is well tolerated and safe when used adjunctive to a low-fat diet in individuals with mild-to-moderate hypercholesterolemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These data provide confirmation that the LDL-C lowering effect of 5-10% [14][15][16][17][18] of each of the 4 core food components can be considered additive, [8][9][10][11][12][13]”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [15]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Controlled feeding trials of the portfolio dietary pattern demonstrated that each of the components had a low-density lipoprotein cholesterol (LDL-C) lowering effect of 5-10% [14][15][16][17][18] and that the effect was additive when combined as part of this dietary pattern.[8][9][10][11][12][13]”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Discrete Multivariate Analysis: Theory and Practice.
Beniger, J. R., Bishop, Y. M. M., Feinberg, S. E., Holland, P. W., Light, R. J., & Mosteller, F. C. (1975) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2063625 · Cited by 5,119
Meta-Analyses of Randomized Controlled Trials
Sacks, H. S., Berrier, J., Reitman, D., Ancona-Berk, V. A., & Chalmers, T. C. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702193160806 · Cited by 1,257
Guidelines for Meta-analyses Evaluating Diagnostic Tests
Irwig, L., Tosteson, A. N. A., Gatsonis, C., Lau, J., Colditz, G. A., Chalmers, T. C., & Mosteller, F. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-8-199404150-00008 · Cited by 754
Chen, W.-J. L., Anderson, J. W., & Jennings, D. (1984) · Experimental Biology and Medicine · doi:10.3181/00379727-175-41791 · Cited by 439
Self-citationPhysiological and Clinical Aspects of Short-Chain Fatty Acids
Cummings, J. H., Rombeau, J. L., & 坂田, 隆. (2004) · Medical Entomology and Zoology · Cited by 313
Effect on Blood Lipids of Very High Intakes of Fiber in Diets Low in Saturated Fat and Cholesterol
Jenkins, D., Wolever, T. M. S., Rao, A. V., Hegele, R. A., Mitchell, S. J., Ransom, T. P. P., Boctor, D. L., Spadafora, P. J., Jenkins, A. L., Mehling, C. C., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307013290104 · Cited by 301
Soluble fiber and serum lipids: A literature review
Glore, S. R., Treeck, D. V., KNEHANS, A. W., & Guild, M. (1994) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(94)90099-x · Cited by 289
Prevalence of High Blood Cholesterol Among US Adults
Sempos, C. T. (1993) · JAMA · doi:10.1001/jama.1993.03500230091035 · Cited by 239
Flagged first, then by citations
3 of the 45 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Weingand, 1997, Effects of psyllium on cholesterol and low-density lipoprotein metabolism in subjects with hypercholesterolemia, Endocrinol Metab, 4, 141
- 1998, Food labeling: health claims; soluble fiber from certain foods and corouary heart disease, Fed Regist, 63, 8103
Cited by
Sorted by citations
Health benefits of dietary fiber
Anderson, J. W., Baird, P., Davis Jr, R. H., Ferreri, S., Knudtson, M., Koraym, A., Waters, V., & Williams, C. L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00189.x · Cited by 2,239
Self-citationDietary fibre in gastrointestinal health and disease
Gill, S. K., Rossi, M., Bajka, B., & Whelan, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00375-4 · Cited by 979
Diet and risk of type II diabetes: the role of types of fat and carbohydrate
Hu, F. B., Liu, S., & van Dam, R. M. (2001) · Diabetologia · doi:10.1007/s001250100547 · Cited by 758
JBS3 Board (2014) · Heart · doi:10.1136/heartjnl-2014-305693 · Cited by 608
McRorie, J. W., & McKeown, N. M. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.09.021 · Cited by 602
Tungland, B. C., & Meyer, D. (2002) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2002.tb00009.x · Cited by 525
Psyllium as therapeutic and drug delivery agent
SINGH, B. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.01.028 · Cited by 375
“…in children and adolescents (Pittler and Ernst, 2004), high holesterol (Rodriguez-Moran et al., 1998; Moreyra et al., 2005; omero et al., 2002; Anderson et al., 1995, 1999, 2000a,b) nd diabetes (Anderson et al., 1999; Florholmen et al., 1982; agerberg, 1982; Gupta et al., 1994; Fukagawa et…”
BackgroundThe gel-forming polysaccharide of psyllium husk (Plantago ovata Forsk)
Fischer, M. H., Yu, N., Gray, G. R., Ralph, J., Anderson, L., & Marlett, J. A. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2004.05.023 · Cited by 366
Anderson, J. W., Randles, K. M., Kendall, C. W. C., & Jenkins, D. J. A. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719338 · Cited by 350
Self-citationThe link between dietary fibre and human health
Kendall, C. W. C., Esfahani, A., & Jenkins, D. J. A. (2009) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2009.08.002 · Cited by 361
Papathanasopoulos, A. A., & Camilleri, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.045 · Cited by 342
Functional and therapeutic potential of inulin: A comprehensive review
Ahmed, W., & Rashid, S. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1355775 · Cited by 347
“© 2017 Taylor & Francis Group, LLC economic disparities exist (Anderson et al., 2000).”
BackgroundDietary Fruits and Vegetables and Cardiovascular Diseases Risk
Alissa, E. M., & Ferns, G. A. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1040487 · Cited by 322
Cicero, A. F. G., Colletti, A., Bajraktari, G., Descamps, O. S., Djuric, D. M., Владиславович, Е. М., Fras, Z., Katsiki, N., Langlois, M. R., Latkovskis, G., et al. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux047 · Cited by 303
Cicero, A. F. G., Colletti, A., Bajraktari, G., Descamps, O., Djuric, D. M., Ezhov, M., Fras, Z., Katsiki, N., Langlois, M., Latkovskis, G., et al. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.69326 · Cited by 281
“However, in some cases minor gastrointestinal side effects were reported (especially with micronized fibers) that might slightly reduce the adherence to this nutraceutical [64].”
BackgroundAnderson, J. W., & Major, A. W. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002716 · Cited by 281
“Habitual intakes of large amounts of dietary fibre or of vegetables are associated with significantly lower rates of CHD (Anderson et al. 2000 b ).”
InfluentialSelf-citationChawla, R., & Patil, G. R. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00099.x · Cited by 281
Torres, N., Guevara‐Cruz, M., Velázquez‐Villegas, L. A., & Tovar, A. R. (2015) · Archives of Medical Research · doi:10.1016/j.arcmed.2015.05.010 · Cited by 289
Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review
Ioniță-Mîndrican, C.-B., Ziani, K., Mititelu, M., Oprea, E., Neacșu, S. M., Moroșan, E., Dumitrescu, D. E., Roșca, A. C., Drăgănescu, D., & Negrei, C. (2022) · Nutrients · doi:10.3390/nu14132641 · Cited by 300
Jenkins, D. J., Kendall, C. W., Vuksan, V., Vidgen, E., Parker, T., Faulkner, D., Mehling, C. C., Garsetti, M., Testolin, G., Cunnane, S. C., et al. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.834 · Cited by 250
Whole grains protect against atherosclerotic cardiovascular disease
Anderson, J. W. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002222 · Cited by 250
Self-citationChiavaroli, L., Nishi, S. K., Khan, T. A., Braunstein, C. R., Glenn, A. J., Mejia, S. B., Rahelić, D., Kahleová, H., Salas-Salvadó, J., Jenkins, D. J. A., et al. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.05.004 · Cited by 226
Functional foods and dietary supplements for the management of dyslipidaemia
Hunter, P. M., & Hegele, R. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.210 · Cited by 233
Jenkins, D. J. A., Jones, P. J. H., Lamarche, B., Kendall, C. W. C., Faulkner, D., Cermakova, L., Gigleux, I., Ramprasath, V., de Souza, R., Ireland, C., et al. (2011) · JAMA · doi:10.1001/jama.2011.1202 · Cited by 218
Type 2 diabetes and the vegetarian diet
Jenkins, D. J., Kendall, C. W., Marchie, A., Jenkins, A. L., Augustin, L. S., Ludwig, D. S., Barnard, N. D., & Anderson, J. W. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.610s · Cited by 209
Self-citationChamp, M. M. J., Langkilde, A.-M., Brouns, F. J. P. H., Kettlitz, B., & Bail-Collet, Y. L. (2003) · Nutrition Research Reviews · doi:10.1079/nrr200254 · Cited by 203
Role of Fiber in Cardiovascular Diseases: A Review
Viuda‐Martos, M., López-Marcos, M. C., Fernández‐López, J., Sendra, E., Vargas, J. H. L., & Pérez‐Álvarez, J. Á. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00102.x · Cited by 200
Plantago - viel mehr als nur ein Stuhlregulans
Bachmann, C. (2014) · Schweizerische Zeitschrift für Ganzheitsmedizin / Swiss Journal of Integrative Medicine · doi:10.1159/000362776 · Cited by 194
Saltzman, E. J., Das, S. K., Lichtenstein, A. H., Dallal, G. E., Corrales, A. D., Schaefer, E. J., Greenberg, A. S., & Roberts, S. B. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1465 · Cited by 192
“In many circumstances, dietary interventions have been shown to have salutary effects on hypertension and hyperlipidemia (Anderson et al. 2000, Appel et al. 1997, Stevens et al. 1993), but definition of the most beneficial regimens remains controversial.”
BackgroundJones, M. L., Tomaro-Duchesneau, C., Martoni, C. J., & Prakash, S. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.758706 · Cited by 190
“4 [130,131] Soy proteinz 25 3 -- 5 4 -- 6 0.”
Sood, N. A., Baker, W. L., & Coleman, C. I. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1167 · Cited by 184
“Two previous meta-analyses (22, 24) evaluated the hypocholesterolemic effects of pectin, psyllium, oats, and guar gum with reductions in total and LDL cholesterol ranging from 7% to 15% and 7% to 10%, respectively, along with a detrimental but small effect on HDL cholesterol.”
BackgroundMcRae, M. P. (2017) · Journal of Chiropractic Medicine · doi:10.1016/j.jcm.2017.05.005 · Cited by 184
Xie, J., Tang, W., Jin, M., Li, J., & Xie, J. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.03.030 · Cited by 181
Anderson, J. W., Davidson, M. H., Blonde, L., Brown, W. V., Howard, W. J., Ginsberg, H., Allgood, L. D., & Weingand, K. W. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1433 · Cited by 172
Self-citationHydrocolloids in Food Industry
Milani, J. M., & Maleki, G. (2012) · InTech eBooks · doi:10.5772/32358 · Cited by 167
“In men with diabetes and hypercholesterolemia participating in a crossover trial, 8 weeks of psyllium (15 g/day) decreased hemoglobin A1c 6.1% (absolute change, 0.8%), with similar 6% decreases in fasting postprandial glucose (Anderson et al., 1999).”
BackgroundInfluentialThe impact of concentration, temperature and pH on dynamic rheology of psyllium gels
Farahnaky, A., Askari, H., Majzoobi, M., & Mesbahi, G. (2010) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2010.04.012 · Cited by 159
Fibrinolytic enzymes in Asian traditional fermented foods
Mine, Y., Wong, A. H. K., & Jiang, B. (2004) · Food Research International · doi:10.1016/j.foodres.2004.04.008 · Cited by 158
“As part of a low fat diet, 3 g of soluble fiber daily can help reduce blood cholesterol (Anderson et al., 2000; Bell & Goldman, 1999).”
BackgroundDietary fibre, nuts and cardiovascular diseases
Salas‐Salvadó, J., Bulló, M., Pérez-Heras, A., & Ros, E. (2006) · British Journal Of Nutrition · doi:10.1017/bjn20061863 · Cited by 148
“2, S45–S51 DOI: 10.1017/BJN20061863 q The Authors 2006 mass, and as a cholesterol-lowering agent in patients with moderate hypercholesterolemia (Anderson et al. 2000).”
BackgroundInfluentialSoluble fiber and nondigestible carbohydrate effects on plasma lipids and cardiovascular risk
Fernández, M. L. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200102000-00007 · Cited by 149
Ponrasu, T., Kannan, R., Ramachandran, B., Ganeshkumar, M., Suguna, L., & Muthuvijayan, V. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.01.110 · Cited by 147
Potenza, M. V., & Mechanick, J. I. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533609342436 · Cited by 150
“SCFAs enter the portal system directly rather than the lymph system like other fatty acids and are thereby able to suppress both liver glucose and lipid production.(110) The lipid-lowering potential of soluble fiber has been confirmed by many high-quality studies and metaanalyses.”
BackgroundDietary fibre: influence on body weight, glycemic control and plasma cholesterol profile.
Babió, N., Balanzá, R., Basulto, J., Bulló, M., & Salas‐Salvadó, J. (2010) · PubMed · Cited by 140
Psyllium: a useful functional ingredient in food systems
Belorio, M., & Gómez, M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1822276 · Cited by 141
Rideout, T. C. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s3512 · Cited by 137
“…and cardioprotective benefi ts associated with dietary soluble fi ber consumption are abundantly clear from the results of human clinical trials (Anderson et al 1984, 1991, 2000b; Bell et al 1989; Braaten et al 1994; Naumann et al 2006), animal feeding studies (van Bennekum et al 2005;…”
BackgroundSaghir, S., Iqbal, M. S., Hussain, M. A., Koschella, A., & Heinze, T. J. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.02.019 · Cited by 137
Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Faulkner, D., Vidgen, E., Lapsley, K. G., Trautwein, E. A., Parker, T. L., Josse, R. G., Leiter, L. A., et al. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00260-9 · Cited by 131
Health benefits of cereal fibre: a review of clinical trials
Smith, C. E., & Tucker, K. L. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000023 · Cited by 130
Psyllium (Plantago ovata Forsk): From evidence of health benefits to its food application
Franco, E. A. N., Sanches-Silva, A. T., Ribeiro‐Santos, R., & de Melo, N. R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.12.006 · Cited by 136
Salas-Salvadó, J., Farrés, X., Luque, X., Narejos, S., Borrell, M., Basora, J., Anguera, A., Torres, F., Bulló, M., Balanza, R., et al. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507868528 · Cited by 127
“The hypocholesterolaemic effect observed was modest, not dependent on the dose administered, and of the same magnitude as that observed in a meta-analysis where the decrease in total and LDL-cholesterol was estimated to be about 0·05 mmol/l for every gram of soluble fibre added to the diet((21,28)).”
Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets
DiRienzo, D. B. (2013) · Nutrition Reviews · doi:10.1111/nure.12084 · Cited by 120
Effect of combining psyllium fiber with simvastatin in lowering cholesterol
Moreyra, A. E. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.10.1161 · Cited by 117
Dietary fibre and cardiovascular health.
Sánchez-Muniz, F. J. (2012) · PubMed · doi:10.1590/s0212-16112012000100005 · Cited by 113
A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects
Crujeiras, A. B., Parra, D., Abete, I., & Martínez, J. A. (2007) · Free Radical Research · doi:10.1080/10715760601131935 · Cited by 111
“cholesterol without changing HDL fraction [43].”
Major Cereal Grain Fibers and Psyllium in Relation to Cardiovascular Health
Bernstein, A., Titgemeier, B., Kirkpatrick, K., Golubić, M., & Roizen, M. F. (2013) · Nutrients · doi:10.3390/nu5051471 · Cited by 115
“2 g/day of psyllium lowers TC by 4% and LDL by 7% and reduces the ratio of apolipoprotein B to apolipoprotein A1 by 6% [52].”
BackgroundInfluentialFunctional foods and cardiovascular disease
Hasler, C. M., Kundrat, S., & Wool, D. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0045-9 · Cited by 112
Wei, Z.-H., Wang, H., Chen, X.-Y., Wang, B.-S., Rong, Z.-X., Wang, B.-S., Su, B.-H., & Chen, H.-Z. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2008.49 · Cited by 96
“The latest meta-analysis, conducted on individuals with mild-to-moderate hypercholesterolemia, demonstrated that psyllium supplementation could significantly lower serum total and LDL cholesterol concentrations in subjects consuming a low-fat diet (Anderson et al., 2000a).”
BackgroundJovanovski, E., Yashpal, S., Komishon, A., Zurbau, A., Mejía, S. B., Ho, H. V. T., Li, D., Sievenpiper, J. L., Duvnjak, L. S., & Vuksan, V. V. V. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy115 · Cited by 97
Galisteo, M., Sánchez, M., Vera, R., González, M., Anguera, A., Duarte, J., & Zarzuelo, A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2399 · Cited by 100
de Castro, I. A., Barroso, L. P., & Sinnecker, P. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.1.32 · Cited by 95
Fechner, A., Kiehntopf, M., & Jahreis, G. (2014) · Journal of Nutrition · doi:10.3945/jn.113.186858 · Cited by 94
Nutraceuticals for the treatment of hypercholesterolemia
Mannarino, M. R., Ministrini, S., & Pirro, M. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.06.008 · Cited by 92
“2 g psyllium/day lowered serum total cholesterol by 4% and LDL cholesterol by 7% [35].”
BackgroundThe active fraction of psyllium seed husk
Marlett, J. A., & Fischer, M. H. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002201 · Cited by 91
Crujeiras, A. B., Parra, M. D., Rodríguez, M. C., de Morentin, B. E. M., & Martínez, J. A. (2006) · Nutrition · doi:10.1016/j.nut.2006.03.008 · Cited by 90
Mousavi, S. M., Milajerdi, A., Kord‐Varkaneh, H., Gorjipour, M. M., & Esmaillzadeh, A. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1517724 · Cited by 88
Polysaccharide Breakdown by Anaerobic Microorganisms Inhabiting the Mammalian Gut
Flint, H. J. (2004) · Advances in applied microbiology · doi:10.1016/s0065-2164(04)56003-3 · Cited by 86
Does Dietary Fiber Affect the Levels of Nutritional Components after Feed Formulation?
Adams, S., Sello, C. T., Qin, G., Che, D., & Han, R. (2018) · Fibers · doi:10.3390/fib6020029 · Cited by 86
“Most studies support the notion that blood cholesterol levels may be decreased by viscous soluble fiber, that generates high viscosity within the gastrointestinal tract (GIT) [92,93].”
BackgroundLupin kernel fibre-enriched foods beneficially modify serum lipids in men
Hall, R. S., Johnson, S. K., Baxter, A. L., & Ball, M. J. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602077 · Cited by 87
Nonpharmacologic Treatment of Dyslipidemia
Houston, M. C., Fazio, S., Chilton, F. H., Wise, D. E., Jones, K. B., Barringer, T. A., & Bramlet, D. A. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.02.002 · Cited by 85
Role of dietary supplements in lowering low-density lipoprotein cholesterol: A review
Nijjar, P. S., Burke, F. M., Blosch, A. K., & Rader, D. J. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.07.001 · Cited by 86
“12 mg/dL per gram of soluble fiber.(18) Moreyra(19) reported similar LDL-C reductions in subjects taking 15 g/d of psyllium plus 10 mg of simvastatin as compared with those taking 20 mg of simvastatin plus placebo.”
BackgroundConsensus statement on management of dyslipidemia in Indian subjects
Chandra, K. S., Bansal, M., Nair, T., Iyengar, S. S., Gupta, R., Manchanda, S. C., Mohanan, P. P., Rao, V. D., Manjunath, C. N., Sawhney, J. P. S., et al. (2014) · Indian Heart Journal · doi:10.1016/j.ihj.2014.12.001 · Cited by 86
Plantago ovata: genetic diversity, cultivation, utilization and chemistry
Dhar, M. K., Kaul, S., Sareen, S., & Koul, A. K. (2005) · Plant Genetic Resources · doi:10.1079/pgr200582 · Cited by 81
“It has also been demonstrated to lower blood cholesterol levels (Anderson et al., 2000).”
BackgroundFunctional foods for dyslipidaemia and cardiovascular risk prevention
Sirtori, C. R., Galli, C., Anderson, J. W., Sirtori, E., & Arnoldi, A. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990187 · Cited by 79
“This was well confirmed in two meta-analyses((20,21)) and led to health claims for foods or supplements containing these ingredients((22)).”
BackgroundResultSelf-citationRomero, A. L., West, K. L., Zern, T. L., & Fernández, M. L. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1194 · Cited by 80
Characterization of a Novel Polysaccharide from Tetraploid Gynostemma pentaphyllum Makino
Niu, Y., Yan, W., Lv, J., Yao, W., & Yu, L. L. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400236x · Cited by 80
A High Legume Low Glycemic Index Diet Improves Serum Lipid Profiles in Men
Zhang, Z., Lanza, E., Kris‐Etherton, P. M., Colburn, N. H., Bagshaw, D., Rovine, M. J., Ulbrecht, J. S., Bobe, G., Chapkin, R. S., & Hartman, T. J. (2010) · Lipids · doi:10.1007/s11745-010-3463-7 · Cited by 87
“A limitation of legume-related studies is that most recent interventions have been conducted with a single test meal [12–15] or fiber supplement [16, 17] and some of these studies were designed to test short-term effects in hours or days [12, 14, 15].”
BackgroundMellen, P. B., Liese, A. D., Tooze, J. A., Vitolins, M. Z., Wagenknecht, L. E., & Herrington, D. M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1495 · Cited by 78
Hussain, M. A., Muhammad, G., Jantan, I., & Bukhari, S. N. A. (2015) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2015.1078351 · Cited by 79
“7%, respectively.(29) Regular use of PS (before meal for 6 weeks) by individuals suffering from type II diabetes reduces fasting plasma glucose, total cholesterol, LDL cholesterol and triglycerides levels with insignificant change in body weight.”
BackgroundViscous fibers, health claims, and strategies to reduce cardiovascular disease risk
Jenkins, D. J. A., Kendall, C. W. C., & Vuksan, V. V. V. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.401 · Cited by 77
Mead, A., Atkinson, G., Albin, D., Alphey, D., Baic, S., Boyd, O., Cadigan, L., Clutton, L., Craig, L., Flanagan, C., et al. (2006) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2006.00726.x · Cited by 79
Ren, Y., Linter, B. R., Linforth, R., & Foster, T. J. (2020) · Food & Function · doi:10.1039/d0fo00115e · Cited by 75
Ren, Y., Yakubov, G. E., Linter, B. R., MacNaughtan, W., & Foster, T. J. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.105737 · Cited by 73
Viscous dietary fibre and metabolic effects
Jenkins, D. J. A., Marchie, A., Augustin, L. S. A., Ros, E., & Kendall, C. W. C. (2004) · Clinical Nutrition Supplements · doi:10.1016/j.clnu.2004.09.007 · Cited by 74
Dietary fiber prevents carbohydrate-induced hypertriglyceridemia
Anderson, J. W. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0055-7 · Cited by 74
Self-citationSatiety effects of psyllium in healthy volunteers
Brum, J. M., Gibb, R., Peters, J. C., & Mattes, R. D. (2016) · Appetite · doi:10.1016/j.appet.2016.04.041 · Cited by 69
Sánchez‐Infantes, D., Muguerza, B., Moulay, L., Hernández, R., Miguel, M., & Aleixandre, A. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf703598j · Cited by 69
Solà, R., Godàs, G., Ribalta, J., Vallvé, J.-C., Girona, J., Anguera, A., Ostos, M., Recalde, D., Salazar, J., CASLAKE, M. J., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1157 · Cited by 69
“In a controlled, single-blind, crossover study (Figure 1) consisting of a 4-wk dietary adaptation period, the patients were randomly assigned to 2 different fiber-supplement periods of 8 wk each (4, 13).”
MethodJane, M., McKay, J., & Pal, S. (2018) · Nutrition · doi:10.1016/j.nut.2018.05.036 · Cited by 68
Schwab, U., Louheranta, A. M., Törrönen, A., & Uusitupa, M. I. J. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602421 · Cited by 66
“Previous studies have shown a small decrease by soluble fiber in serum total and LDL-cholesterol concentrations without a decreasing effect on HDL-cholesterol (Brown et al., 1999; Knopp et al., 1999; Anderson et al., 2000; Vuksan et al., 2000).”
BackgroundHermansen, K., Dinesen, B., Høie, L. H., Morgenstern, E. C. A., & Gruenwald, J. (2003) · Advances in Therapy · doi:10.1007/bf02850119 · Cited by 67
Hibi, M., Takase, H., Iwasaki, M., Osaki, N., & Katsuragi, Y. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.03.012 · Cited by 64
Kris‐Etherton, P. M., Taylor, D. S., Smiciklas‐Wright, H., Mitchell, D. C., Bekhuis, T., Olson, B. H., & Slonim, A. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90116-1 · Cited by 62
A Functional Food Product for the Management of Weight
Bell, S. J., & Goodrick, G. K. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690290825501 · Cited by 60
The Impact of Dietary Changes and Dietary Supplements on Lipid Profile
Huang, J., Frohlich, J. J., & Ignaszewski, A. P. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.12.077 · Cited by 60
“Three metaanalyses,(31-33) 1 large multicentre RCT,(34) as well as a number of RCTs-DB(35-44) have shown that a diet containing 5 to 15 g soluble fibre resulted in reductions of TC and LDL-C by 2% to 12% and 5% to 20%, respectively.(31-33,35-44) There was no significant difference in the lipid-lowering effects between…”
BackgroundSequence meets function—microbiota and cardiovascular disease
Kim, M., Huda, M. N., & Bennett, B. J. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab030 · Cited by 62
Pérez-Granados, A. M., Navas‐Carretero, S., Schoppen, S., & Vaquero, M. P. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.07.010 · Cited by 57
“Malabsorption of bile acid leads to a fall in LDL-cholesterol and a tendency to increase HDL-cholesterol [38] without changes in serum TG [39].”
BackgroundPoppitt, S. D., Drunen, J. D. E. V., McGill, A., Mulvey, T. B., & Leahy, F. E. (2007) · PubMed · Cited by 56
Trends in Dietary Fibre Research and Development
Mälkki, Y. (2004) · Acta Alimentaria · doi:10.1556/aalim.33.2004.1.5 · Cited by 55
Motamedi, H., Darabpour, E., Gholipour-Shahraki, M., & Nejad, S. M. S. (2010) · International Journal of Pharmacology · doi:10.3923/ijp.2010.117.122 · Cited by 55
Sex and hormonal status influence plasma lipid responses to psyllium
Vega‐López, S., Vidal‐Quintanar, R. L., & Fernández, M. L. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.435 · Cited by 55
Dietary Fibre and Gastrointestinal Function
Schneeman, B. O. (2000) · doi:10.1002/9780470999615.ch14 · Cited by 55
Metadata
- Authors
- Anderson, J. W., Allgood, L. D., Lawrence, A., Altringer, L. A., Jerdack, G. R., Hengehold, D. A., & Morel, J. G.
- Affiliations
- University of Kentucky (US)
- ORCID
- Anderson, James W
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 71
- Issue
- 2
- Pages
- 472-479
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2134391068
- Cited by
- 337
- References
- 45
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 17 · 2019: 10 · 2018: 14 · 2017: 21 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 15
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Keywords
- psyllium, hypercholesterolemia, LDL cholesterol, total cholesterol, soluble dietary fiber, low-fat diet, dietary supplementation, hypolipidemic effect, safety and tolerability, coronary heart disease prevention
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Hypolipidemic Agents, Combined Modality Therapy, Female, Humans, Hypercholesterolemia, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Psyllium, Sex Factors, Triglycerides, Controlled Clinical Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
