The DOI matches its Crossref record; 156 of the 162 references it cites were found in a registry or an index.
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Open accessAbstract
Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases is emerging. Bioavailability differs greatly from one polyphenol to another, so that the most abundant polyphenols in our diet are not necessarily those leading to the highest concentrations of active metabolites in target tissues. Mean values for the maximal plasma concentration, the time to reach the maximal plasma concentration, the area under the plasma concentration-time curve, the elimination half-life, and the relative urinary excretion were calculated for 18 major polyphenols. We used data from 97 studies that investigated the kinetics and extent of polyphenol absorption among adults, after ingestion of a single dose of polyphenol provided as pure compound, plant extract, or whole food/beverage. The metabolites present in blood, resulting from digestive and hepatic activity, usually differ from the native compounds. The nature of the known metabolites is described when data are available. The plasma concentrations of total metabolites ranged from 0 to 4 mumol/L with an intake of 50 mg aglycone equivalents, and the relative urinary excretion ranged from 0.3% to 43% of the ingested dose, depending on the polyphenol. Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics. The least well-absorbed polyphenols are the proanthocyanidins, the galloylated tea catechins, and the anthocyanins. Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some of the biomarkers listed in Table 1 have half-lives that do not exceed 24 h [polyphenols, alkylresorcinols, and amino acids (34,35)].”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
Williamson, G., & Manach, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.243s · Cited by 1,340
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Setchell, K. D. R., Brown, N. M., Desai, P. B., Zimmer-Nechemias, L., Wolfe, B., Brashear, W. T., Kirschner, A. S., Cassidy, A., & Heubi, J. E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1362s · Cited by 974
Soy Isoflavone Aglycones Are Absorbed Faster and in Higher Amounts than Their Glucosides in Humans
Izumi, T., Osawa, S., Obata, A., Tobe, K., Saito, M., Kataoka, S., Kikuchi, M., Piskuła, M. K., & Kubota, Y. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1695 · Cited by 959
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Hollman, P. C. H., de Vries, J., van Leeuwen, S., Mengelers, M. J. B., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1276 · Cited by 956
Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
Hollman, P. C. H., van Trijp, J. M. P., Buysman, M. N. C. P., van der Gaag, M. S., Mengelers, M. J. B., de Vries, J. H. M., & Katan, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01367-7 · Cited by 782
Lee, M., Maliakal, P. P., Chen, L., Meng, X., Bondoc, F. Y., Prabhu, S., Lambert, G. H., Mohr, S. N., & Yang, C. S. (2002) · PubMed · Cited by 716
Research works printed but not linked: 2
- Tomas-Barberan, 2000, Dietary hydroxybenzoic acid derivatives and their possible role in health protection, J Sci Food Agric, 80, 1024
- Clifford, 2000, Ellagitannins: occurrence in food, bioavailability and cancer prevention, J Food Sci Agric, 80, 1118, 10.1002/(SICI)1097-0010(20000515)80:7<1118::AID-JSFA570>3.0.CO;2-9 · DOI
Cited by
Sorted by citations
Items 201–300 of 1,010
Bondonno, C. P., Yang, X., Croft, K. D., Considine, M. J., Ward, N. C., Rich, L., Puddey, I. B., Swinny, E., Mubarak, A., & Hodgson, J. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.028 · Cited by 292
McKay, D. L., Chen, C. O., Saltzman, E. J., & Blumberg, J. B. (2009) · Journal of Nutrition · doi:10.3945/jn.109.115097 · Cited by 302
Appeldoorn, M. M., Vincken, J., Aura, A., Hollman, P. C. H., & Gruppen, H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803059z · Cited by 293
Quirós-Sauceda, A. E., Palafox-Carlos, H., Sáyago‐Ayerdi, S. G., Ayala-Zavala, J. F., Bello‐Pérez, L. A., Álvarez-Parrilla, E., la Rosa, L. A. D., González-Córdova, A. F., & González-Aguilar, G. A. (2014) · Food & Function · doi:10.1039/c4fo00073k · Cited by 293
Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases
Losada‐Barreiro, S., & Bravo‐Díaz, C. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.061 · Cited by 304
Cancer Chemopreventive Potential of Apples, Apple Juice, and Apple Components
Gerhäuser, C. (2008) · Planta Medica · doi:10.1055/s-0028-1088300 · Cited by 286
Speisky, H., Shahidi, F., de Camargo, A. C., & Fuentes, J. (2022) · Antioxidants · doi:10.3390/antiox11010133 · Cited by 322
Determination of Flavonoids and Phenolics and Their Distribution in Almonds
Milbury, P. E., Chen, C. O., Dolnikowski, G. G., & Blumberg, J. B. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0603937 · Cited by 287
Review: The Potential of the Common Bean (Phaseolus vulgaris) as a Vehicle for Iron Biofortification
Petry, N., Boy, E., Wirth, J. P., & Hurrell, R. F. (2015) · Nutrients · doi:10.3390/nu7021144 · Cited by 302
“However, they need to be present at a sufficiently high concentration and be adequately absorbed if they are to exert biological effects [103].”
BackgroundCentral nervous system depressant action of flavonoid glycosides
Fernández, S. P., Wasowski, C., Loscalzo, L. M., Granger, R. E., Johnston, G. A. R., Paladini, A. C., & Marder, M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.04.004 · Cited by 286
“Small amounts of the aglycones can also be present in the diet (Walle, 2004; Manach et al., 2005).”
BackgroundLoke, W. M., Proudfoot, J. M., Hodgson, J. M., McKinley, A. J., Hime, N. J., Magat, M., Stocker, R., & Croft, K. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.199687 · Cited by 284
Tanase, C., Coşarcă, S., & Muntean, D.-L. (2019) · Molecules · doi:10.3390/molecules24061182 · Cited by 283
Phenolic Compounds from Blueberries Can Inhibit Colon Cancer Cell Proliferation and Induce Apoptosis
Yi, W., Fischer, J. G., Krewer, G. W., & Akoh, C. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051333o · Cited by 280
Khan, J. A., Alexander, A., Ajazuddin, M., Saraf, S., & Saraf, S. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.02.025 · Cited by 288
Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.767221 · Cited by 296
Kwee, E. M., & Niemeyer, E. D. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.04.011 · Cited by 298
Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls
Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 279
Mango peel dietary fibre: Composition and associated bound phenolics
Ajila, C. M., & Prasada Rao, U. J. S. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2012.11.017 · Cited by 271
The Carotenoid Pigment Zeaxanthin—A Review
Sajilata, M. G., Singhal, R. S., & Kamat, M. Y. (2008) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2007.00028.x · Cited by 274
Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME
Yang, Z., Kulkarni, K. H., Zhu, W., & Hu, M. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833107 · Cited by 271
“Genistein was extensively metabolized in intestine after oral administration and several studies showed that intestine is more important than liver on disposition of genistein [30, 70].”
BackgroundMulti-targeted prevention and therapy of cancer by proanthocyanidins
Nandakumar, V., Singh, T., & Katiyar, S. K. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.049 · Cited by 330
“Polymeric proanthocyanidins are not absorbed as such in the gut [54].”
BackgroundAnthocyanins as Antimicrobial Agents of Natural Plant Origin
Cisowska, A., Wojnicz, D., & Hendrich, A. B. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600136 · Cited by 269
“Therefore, the absorption of an anthocyanin glycoside requires either a specific active transport mechanism or hydrolysis of the β-glycoside before absorption [34].”
BackgroundPérez‐Jiménez, J., Diaz-Rubio, M. E., & Saura-Calixto, F. D. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000097 · Cited by 268
“All these aspects have been studied in depth over recent years for EPP((11)), but studies on NEPP are scarce.”
BackgroundTheobroma cacao L., the Food of the Gods: A scientific approach beyond myths and claims
Rusconi, M., & Conti, A. M. F. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.08.008 · Cited by 282
“[34] hypothesizes that some individuals could have better absorption than others, possibly because of particular”
BackgroundBioavailability issues in studying the health effects of plant polyphenolic compounds
Yang, C. S., Sang, S., Lambert, J. D., & Lee, M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700234 · Cited by 271
Özcan, T., Akpinar‐Bayizit, A., Yilmaz‐Ersan, L., & Delikanlı, B. (2014) · International Journal of Chemical Engineering and Applications · doi:10.7763/ijcea.2014.v5.416 · Cited by 267
Serban, M., Sahebkar, A., Zanchetti, A., Mikhailidis, D. P., Howard, G., Antal, D., Andrica, F., Ahmed, A., Aronow, W. S., Muntner, P., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002713 · Cited by 317
“A challenge to the explanation of quercetin bioactivity was represented, until recently, by the contradiction between its extremely low plasma concentration after oral administration and the demonstrable systemic effects.(47) The resolution of this inconsistency, termed the “flavonoid paradox” came with the full compr…”
BackgroundJennings, A., Welch, A. A., Fairweather-Tait, S. J., Kay, C. D., Minihane, A. M., Chowienczyk, P., Jiang, B., Cecelja, M., Spector, T. D., MacGregor, A. J., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042036 · Cited by 266
“These subtle differences in chemical structure can alter absorption, distribution, metabolism, and elimination and bioactivity, which highlight the importance of investigating intake-phenotype associations with subclasses in addition to flavonoid intake as a whole (9, 10).”
BackgroundAnti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities
Boccellino, M., & D’Angelo, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165642 · Cited by 283
“Further nonflavonoids that may be found in nature are gallotannins, ellagitannins, stilbene oligomers, and lignans [28,29].”
BackgroundHPLC-MS Analysis of Proanthocyanidin Oligomers and Other Phenolics in 15 Strawberry Cultivars
Buendía, B., Gil, M. I., Tudela, J. A., Gady, A. L., Medina, J. J., Soria, C., López, J. M. L., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9030597 · Cited by 263
Boesch, C., Łoboda, A., Wagner, A. E., Stachurska, A., Józkowicz, A., Dulak, J., Döring, F., Wolffram, S., & Rimbach, G. H. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.02.008 · Cited by 268
“Onions, apples, tea and red wine are important sources of quercetin in the human diet [1,2].”
BackgroundPolyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review
Chambers, K., Day, P. E. L., Aboufarrag, H. T., & Kroon, P. A. (2019) · Nutrients · doi:10.3390/nu11112588 · Cited by 277
Vasta, V., & Luciano, G. (2011) · Small Ruminant Research · doi:10.1016/j.smallrumres.2011.09.035 · Cited by 262
Plant Betalains: Safety, Antioxidant Activity, Clinical Efficacy, and Bioavailability
Khan, M. I. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12185 · Cited by 280
Common tea formulations modulate in vitro digestive recovery of green tea catechins
Green, R. J., Murphy, A. S., Schulz, B., Watkins, B. A., & Ferruzzi, M. G. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700086 · Cited by 261
Riso, P., Klimis‐Zacas, D. J., Bo’, C. D., Martini, D., Campolo, J., Vendrame, S., Möller, P., Loft, S. H., Maria, R. D., & Porrini, M. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0402-9 · Cited by 270
“It is widely recognized that ACNs are rapidly cleared from plasma after an oral dose of berry fruits with maximum bioavailability between 1 and 3 h [19].”
BackgroundHabauzit, V., & Morand, C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311430006 · Cited by 260
“Circulating levels range between 0.1 and 7 µM for flavonols, flavanones, isoflavones and flavanols, and do not exceed 0.15 µM for anthocyanins [Manach et al. 2005].”
BackgroundInfluentialLucas‐González, R., Viuda‐Martos, M., Pérez‐Álvarez, J. Á., & Fernández‐López, J. (2018) · Food Research International · doi:10.1016/j.foodres.2018.02.055 · Cited by 275
Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine
Zahra, M., Abrahamse, H., & George, B. P. A. (2024) · Antioxidants · doi:10.3390/antiox13080922 · Cited by 330
“Formulating flavonoids into these supplements can improve their bioavailability, which is often low due to poor solubility and rapid metabolism [19].”
BackgroundChen, C. O., Milbury, P. E., Lapsley, K. G., & Blumberg, J. B. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1366 · Cited by 258
Dietary Polyphenols and Human Gut Microbiota: a Review
Hervert-Hernández, D., & Goñi, I. (2010) · Food Reviews International · doi:10.1080/87559129.2010.535233 · Cited by 257
Identification and quantification of polyphenolic compounds from okra seeds and skins
Arapitsas, P. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.03.014 · Cited by 256
Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review
Gemede, H. F. (2015) · Journal of Food Processing & Technology · doi:10.4172/2157-7110.1000458 · Cited by 255
Cassano, A., Conidi, C., Ruby‐Figueroa, R., & Castro‐Muñoz, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020351 · Cited by 255
Saleh, H. A., Yousef, M. H., & Abdelnaser, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606069 · Cited by 269
Gonzales, G. B., Smagghe, G. J., Grootaert, C., Zotti, M. J., Raes, K., & Camp, J. V. (2015) · Drug Metabolism Reviews · doi:10.3109/03602532.2014.1003649 · Cited by 264
“Figure 2 summarizes the findings of a much quoted review involving 97 bioavailability studies (Manach et al., 2005) with regards to bioavailability of flavonoids.”
BackgroundBioavailability of ferulic acid is determined by its bioaccessibility
Anson, N. M., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. R. M. M. (2008) · Journal of Cereal Science · doi:10.1016/j.jcs.2008.12.001 · Cited by 253
“4–98%), in part depending on the food source (Bourne et al., 2000; Karakaya, 2004; Manach et al., 2005).”
BackgroundQuercetin and the mitochondria: A mechanistic view
de Oliveira, M. R., Nabavi, S. M., Braidy, N., Setzer, W. N., Ahmed, T., & Nabavi, S. F. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.014 · Cited by 253
Ferruzzi, M. G., Lobo, J., Janle, E. M., Cooper, B. R., Simon, J. E., Wu, Q., Welch, C., Ho, L., Weaver, C. M., & Pasinetti, G. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1135 · Cited by 250
Hole, A. S., Rud, I., Grimmer, S., Sigl, S., Narvhus, J., & Sahlstrøm, S. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300410h · Cited by 250
Genistein: Its role in metabolic diseases and cancer
Mukund, V., Mukund, D., Sharma, V., Mannarapu, M., & Alam, A. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.09.004 · Cited by 251
Berry Phenolic Antioxidants – Implications for Human Health?
Olas, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00078 · Cited by 266
“However, they also have low bioavailability compared with other phenolic compounds (Manach et al., 2004, 2005; Talavera et al., 2006).”
BackgroundAnthocyanins and heart health.
Mazza, G. (2007) · PubMed · Cited by 248
Proanthocyanidins, anthocyanins and cardiovascular diseases
Kruger, M. J., Davies, N. H., Myburgh, K. H., & Lecour, S. (2014) · Food Research International · doi:10.1016/j.foodres.2014.01.046 · Cited by 257
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Iqbal, I., Wilairatana, P., Saqib, F., Nasir, B., Wahid, M., Latif, M. F., Iqbal, A., Naz, R., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28176403 · Cited by 271
“The highest dietary sources of polyphenols are dark-colored fruits (especially small berries), chocolate, cereals made entirely of whole grains, coffee, and red wine, with the latter three accounting for the lion’s share of overall dietary polyphenol consumption [72].”
BackgroundCrosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
Campbell, C., Kandalgaonkar, M. R., Golonka, R. M., Yeoh, B. S., Vijay–Kumar, M., & Saha, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020294 · Cited by 270
Berghe, W. V. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.03.007 · Cited by 245
García‐Pérez, I., Posma, J. M., Gibson, R., Chambers, E. S., Hansen, T. H., Vestergaard, H., Hansen, T. F., Beckmann, M., Pedersen, O. B., Elliott, P., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30419-3 · Cited by 251
Synthetic and natural iron chelators: Therapeutic potential and clinical use
Hatcher, H. C., Singh, R. N., Torti, F. M., & Torti, S. V. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.121 · Cited by 242
Citrus flavonoids and lipid metabolism
Assini, J. M., Mulvihill, E. E., & Huff, M. W. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835c07fd · Cited by 242
“2 mmol/l after ingestion of 130–220 mg of hesperetin as orange juice [15,16].”
BackgroundHuman studies on the absorption, distribution, metabolism, and excretion of tea polyphenols
Clifford, M. N., van der Hooft, J. J. J., & Crozier, A. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058958 · Cited by 240
Poiroux-Gonord, F., Bidel, L., Fanciullino, A., Gautier, H., Lopez, F., & Urban, L. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1037745 · Cited by 242
Peluso, I., & Serafini, M. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13649 · Cited by 240
“At present the data published on the absorption of green tea phenolics vary considerably and are controversial (Manach et al., 2005).”
BackgroundEstimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study
Grosso, G., Stepaniak, U., Topór‐Mądry, R., Szafraniec, K., & Pająk, A. (2014) · Nutrition · doi:10.1016/j.nut.2014.04.012 · Cited by 244
“Their bioavailability and biologic properties vary to a great extent and are affected by their chemical structure [8].”
BackgroundDenev, P. N., Kratchanov, C. G., Čı́ž, M., Lojek, A., & Kratchanova, M. G. (2012) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2012.00198.x · Cited by 244
Wine Flavonoids in Health and Disease Prevention
Fernandes, I., Pérez-Gregório, R., Soares, S., Mateus, N. F. D. C. B., & de Freitas, V. A. P. (2017) · Molecules · doi:10.3390/molecules22020292 · Cited by 241
“Natural anthocyanins have been reported to have some of the lowest bioavailabilities of all the dietary flavonoid subclasses, below 1% of the ingested amount, so any significant contribution of anthocyanins to health-protective properties of red wine after consumption by healthy volunteers is likely to be questionable…”
Citrus Flavanones: What Is Their Role in Cardiovascular Protection?
Chanet, A., Milenković, D., Manach, C., Mazur, A., & Morand, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300669s · Cited by 233
Bioaccessibility and bioavailability of phenolic compounds
Shahidi, F., & Peng, H. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.4162 · Cited by 253
“As Manach et al. (2005) summarized, the orally administrated anthocyanins presented the lowest gastrointestinal absorbability (0.004–5.1”
BackgroundInfluentialIsolation of catechin-converting human intestinal bacteria
Kutschera, M., Engst, W., Blaut, M., & Braune, A. (2011) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2011.05025.x · Cited by 234
“Because the absorption of monomeric catechins in the small intestine is not complete and greatly impaired by polymerization, these polyphenols reach the colon and are converted by the resident microbiota (Manach et al. 2005).”
BackgroundDietary Flavonoids and the Risk of Colorectal Cancer
Τheodoratou, E., Kyle, J., Cetnarskyj, R., Farrington, S. M., Tenesa, A., Barnetson, R. A., Porteous, M. E., Dunlop, M. G., & Campbell, H. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0785 · Cited by 232
“It has been shown that flavonoids can cross the intestinal barrier and reach concentrations in the blood that have shown to have effects in some in vitro studies (55).”
BackgroundRole of flavonoids in intestinal tight junction regulation
Suzuki, T., & Hara, H. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.08.001 · Cited by 233
“The daily intake of flavonoids in humans is reportedly 20–50 mg for isoflavones, 20–35 mg for flavonols [64–66] and 18–50 mg for catechins [67], and it has been shown that the plasma concentrations of total flavonoid derivatives range from 0 to 4 μM at an intake level of 50 mg aglycone equivalents [68].”
BackgroundQuercetin: a potential drug to reverse multidrug resistance.
Chen, C., Zhou, J., & Ji, C. (2010) · Life Science · doi:10.1016/j.lfs.2010.07.004 · Cited by 240
López‐Fernández, O., Domínguez, R., Pateiro, M., Munekata, P. E. S., Rocchetti, G., & Lorenzo, J. M. (2020) · Antioxidants · doi:10.3390/antiox9060479 · Cited by 232
“These natural compounds constitute a group of molecules that are divided according to their chemical structure [2,4,5], although they can also be classified by their source of origin, natural distribution or biological function.”
BackgroundSmoliga, J. M., & Blanchard, O. L. (2014) · Molecules · doi:10.3390/molecules191117154 · Cited by 236
“Alternatively, the absorption of native quercetin is poor, and may not reach the liver in a concentration that will inhibit SULT in vivo [66].”
BackgroundSerra, A., Macià, A., Romero, M., Reguant, J., Ortega-Olivé, N., & Motilva, M. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.055 · Cited by 231
Blueberry anthocyanins in health promotion: A metabolic overview
Norberto, S., Silva, S., Meireles, M., Faria, A., Pintado, M., & Calhau, C. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.08.015 · Cited by 235
“Nevertheless, the bioavailability of ACNs is low as compared with other BB polyphenols (Manach et al., 2005; McGhie & Walton, 2007) but these low levels of ACNs can be bioavailable and well retained in tissues (Kalt et al., 2008).”
BackgroundNatural antioxidants as stabilizers for polymers
Kirschweng, B., Tátraaljai, D., Földes, E., & Pukánszky, B. (2017) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2017.07.012 · Cited by 239
“A limiting factor of medical applications is the poor bioavailability of flavonoids [84,85].”
BackgroundReview of the Factors Affecting Bioavailability of Soy Isoflavones in Humans
Nielsen, I. L. F., & Williamson, G. (2007) · Nutrition and Cancer · doi:10.1080/01635580701267677 · Cited by 229
“The bioavailability of isoflavones compared with other flavonoids has been reviewed (6).”
BackgroundPhytochemicals in Cancer Prevention and Therapy: Truth or Dare?
Russo, M., Spagnuolo, C., Tedesco, I., & Russo, G. L. (2010) · Toxins · doi:10.3390/toxins2040517 · Cited by 225
“The very low concentrations of free aglycones found in vivo are due to the scarce bioavailability and biotransformation of these molecules discussed in excellent reviews [7,8].”
BackgroundAntioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships
Razzaghi‐Asl, N., Garrido, J., Khazraei, H., Borges, F., & Firuzi, O. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990141 · Cited by 231
“They have been categorized as structural and functional constituents of plant cell walls and also as bioactive ingredi- ents of the diet [40, 41].”
BackgroundIron-binding properties of plant phenolics and cranberry's bio-effects
Guo, M., Perez, C., Wei, Y., Rapoza, E., Su, G. M., Bou‐Abdallah, F., & Chasteen, N. D. (2007) · Dalton Transactions · doi:10.1039/b705136k · Cited by 227
Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management
Vargas, A. J., & Burd, R. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00301.x · Cited by 229
Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin
Iranshahi, M., Rezaee, R., Parhiz, H., Roohbakhsh, A., & Soltani, F. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.07.014 · Cited by 222
“The antibacterial activity and bioavailability of flavonoids are affected by various parameters, such as molecular conformation, hydrophobicity, solubility, presence or absence of sugar moiety and the type of sugar in the chemical backbone (Manach et al., 2005).”
BackgroundA review of the health care potential of bioactive compounds
Hooper, L., & Cassidy, A. (2006) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2599 · Cited by 221
Jennings, A., Welch, A. A., Spector, T. D., MacGregor, A. J., & Cassidy, A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.184358 · Cited by 220
“, procyanidins]; isoflavones; and anthocyanins and other polymeric flavonoids) can alter both bioavailability and bioactivity (14,15), which highlights the importance of investigating each subclass individually.”
BackgroundA Review of the Health Benefits of Cherries
Kelley, D. S., Adkins, Y. C., & Laugero, K. D. (2018) · Nutrients · doi:10.3390/nu10030368 · Cited by 223
“Both anthocyanins and hydoxycinnamates are believed to be rapidly absorbed in humans reaching maximum plasma concentrations in less than 2 h and are quickly eliminated [31,32].”
BackgroundDendrimers in combination with natural products and analogues as anti-cancer agents
Mignani, S. M., Rodrigues, J., Tomás, H., Zabłocka, M., Shi, X., Caminade, A., & Majoral, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00550d · Cited by 222
Eker, M. E., Aaby, K., Budić-Leto, I., Brnčić, S. R., El, S. N., Karakaya, S., Şimşek, Ş., Manach, C., Wiczkowski, W., & de Pascual‐Teresa, S. (2019) · Foods · doi:10.3390/foods9010002 · Cited by 230
“After consumption, a very low proportion (<2%) of the original anthocyanins are retrieved in the circulation (plasma/urine) [39].”
BackgroundAbsorption, metabolism and excretion of Choladi green tea flavan‐3‐ols by humans
Stalmach, A., Troufflard, S., Serafini, M., & Crozier, A. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800169 · Cited by 218
Dower, J. I., Geleijnse, J. M., Gijsbers, L., Zock, P. L., Kromhout, D., & Hollman, P. C. H. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.098590 · Cited by 216
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
Rezai-Zadeh, K. P., Ehrhart, J. C., Bai, Y., Sanberg, P. R., Bickford, P. C., Tan, J. R., & Shytle, R. D. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-41 · Cited by 217
Dietary Intake of Natural Antioxidants: Vitamins and Polyphenols
Landete, J. M. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.555018 · Cited by 229
Curcumin, Gut Microbiota, and Neuroprotection
Meo, F. D., Margarucci, S., Galderisi, U., Crispi, S., & Peluso, G. (2019) · Nutrients · doi:10.3390/nu11102426 · Cited by 217
Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., & Blomhoff, R. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0092-0 · Cited by 216
“A number of the measured polyphenolic compounds have a rapid metabolism and elimination [54].”
BackgroundAbsorption, metabolism, and excretion of green tea flavan‐3‐ols in humans with an ileostomy
Stalmach, A., Mullen, W., Steiling, H., Williamson, G., Lean, M. E. J., & Crozier, A. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900194 · Cited by 216
Piazzon, A., Vrhovšek, U., Masuero, D., Mattivi, F., Mandoj, F., & Nardini, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304076z · Cited by 215
miRNA as molecular target of polyphenols underlying their biological effects
Milenković, D., Jude, B., & Morand, C. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.046 · Cited by 223
Polyphenols in Fruits and Vegetables and Its Effect on Human Health
Lima, G. P. P., Vianello, F., Corrêa, C. R., Campos, R. A. D. S., & Borguini, M. G. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.511117 · Cited by 226
Gorelik, S., Ligumsky, M., Kohen, R., & Kanner, J. (2007) · The FASEB Journal · doi:10.1096/fj.07-9041com · Cited by 213
“It is well accepted that diets rich in polyphenols have health benefits (4, 6–9), but the absorption of polyphenols in humans is limited and the mechanisms of action of these molecules in the human body are not fully understood (1, 8).”
BackgroundMemariani, Z., Abbas, S. Q., Hassan, S. S. U., Ahmadi, A., & Chabra, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105264 · Cited by 219
Metadata
- Authors
- Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut National de la Recherche Agronomique (FR)
- Corresponding author
- Manach, Claudine
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 81
- Issue
- 1
- Pages
- 230S-242S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2119331100
- Cited by
- 4,219
- References
- 162
- Citations by year
- 2026: 201 · 2025: 170 · 2024: 170 · 2023: 170 · 2022: 189 · 2021: 215 · 2020: 241 · 2019: 216 · 2018: 224 · 2017: 242 · 2016: 235 · 2015: 211 · 2014: 246 · 2013: 257 · 2012: 266
- FWCI
- 78.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- polyphenols, bioavailability, bioefficacy, plasma concentration, urinary excretion, polyphenol metabolism, absorption kinetics, gallic acid, isoflavones, catechins, flavanones, quercetin glucosides, proanthocyanidins, anthocyanins, hydroxycinnamic acids, degenerative disease prevention
- MeSH terms
- Adult, Anthocyanins, Biological Availability, Female, Flavonoids, Food Analysis, Half-Life, Humans, Intestinal Absorption, Isoflavones, Male, Phenols, Area Under Curve, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
