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Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Open accessAbstract
Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases is emerging. Bioavailability differs greatly from one polyphenol to another, so that the most abundant polyphenols in our diet are not necessarily those leading to the highest concentrations of active metabolites in target tissues. Mean values for the maximal plasma concentration, the time to reach the maximal plasma concentration, the area under the plasma concentration-time curve, the elimination half-life, and the relative urinary excretion were calculated for 18 major polyphenols. We used data from 97 studies that investigated the kinetics and extent of polyphenol absorption among adults, after ingestion of a single dose of polyphenol provided as pure compound, plant extract, or whole food/beverage. The metabolites present in blood, resulting from digestive and hepatic activity, usually differ from the native compounds. The nature of the known metabolites is described when data are available. The plasma concentrations of total metabolites ranged from 0 to 4 mumol/L with an intake of 50 mg aglycone equivalents, and the relative urinary excretion ranged from 0.3% to 43% of the ingested dose, depending on the polyphenol. Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics. The least well-absorbed polyphenols are the proanthocyanidins, the galloylated tea catechins, and the anthocyanins. Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols.
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“Some of the biomarkers listed in Table 1 have half-lives that do not exceed 24 h [polyphenols, alkylresorcinols, and amino acids (34,35)].”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [34]
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BackgroundPhenol‐Based Antioxidants and the In Vitro Methods Used for Their Assessment
Craft, B. D., Kerrihard, A. L., Amarowicz, R., & Pegg, R. B. (2012) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2011.00173.x · Cited by 329
Green tea (Camellia sinensis) for the prevention of cancer
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“005, significant difference between the DMSO- and the flavonoid-treated cells at t consumption [31].”
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“Average catechin intake is approximately 18 to 50 mg/day [204], and this can be raised with increased consumption of green tea.”
BackgroundBioactive potential of fruit and vegetable wastes
Coman, V., Teleky, B., Mitrea, L., Martău, G. A., Szabo, K., Călinoiu, L. F., & Vodnar, D. C. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.07.001 · Cited by 339
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“(24), who observed that besides b-glucuronidase and sulfatase activities, this type of extract contains other esterases able to degrade CGA into caffeic acid.”
BackgroundThe Chemical Reactivity of Anthocyanins and Its Consequences in Food Science and Nutrition
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“…pivotal in controlling neuronal resistance to neurotoxins, including oxidants (‘indirect’ antioxidant nature) (Levites et al., 2001) and inflammatory mediators (Spencer, 2009a), or through their chelation of transition metal ions such as iron (Levites et al., 2002; Mandel et al., 2005, 2006).”
BackgroundFecal microbial metabolism of polyphenols and its effects on human gut microbiota
Parkar, S. G., Trower, T. M., & Stevenson, D. E. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.07.009 · Cited by 316
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“Dietary polyphenols differ widely in their physico-chemical properties, bioavailability, biological properties and health effects [9,10].”
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Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
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Holá, K., Bourlinos, A. B., Kozák, O., Berka, K., Šišková, K., Havrdová, M., Tuček, J., Šafářová, K., Otyepka, M., Giannelis, E. P., et al. (2014) · Carbon · doi:10.1016/j.carbon.2014.01.008 · Cited by 303
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Isoflavones: Anti-Inflammatory Benefit and Possible Caveats
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Metadata
- Authors
- Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut National de la Recherche Agronomique (FR)
- Corresponding author
- Manach, Claudine
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 81
- Issue
- 1
- Pages
- 230S-242S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2119331100
- Cited by
- 4,219
- References
- 162
- Citations by year
- 2026: 201 · 2025: 170 · 2024: 170 · 2023: 170 · 2022: 189 · 2021: 215 · 2020: 241 · 2019: 216 · 2018: 224 · 2017: 242 · 2016: 235 · 2015: 211 · 2014: 246 · 2013: 257 · 2012: 266
- FWCI
- 78.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- polyphenols, bioavailability, bioefficacy, plasma concentration, urinary excretion, polyphenol metabolism, absorption kinetics, gallic acid, isoflavones, catechins, flavanones, quercetin glucosides, proanthocyanidins, anthocyanins, hydroxycinnamic acids, degenerative disease prevention
- MeSH terms
- Adult, Anthocyanins, Biological Availability, Female, Flavonoids, Food Analysis, Half-Life, Humans, Intestinal Absorption, Isoflavones, Male, Phenols, Area Under Curve, Polyphenols
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