Cited by 955Cardiac Health and Mental HealthHeart Rate Variability and Autonomic ControlCardiovascular Health and Risk Factors

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State of the Art Review: Depression, Stress, Anxiety, and Cardiovascular Disease

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Cohen, Beth E., Edmondson, Donald, Kronish, Ian M.·2015·American Journal of Hypertension

DOI 10.1093/ajh/hpv047PMC PMC4612342

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Abstract

The notion that psychological states can influence physical health is hardly new, and perhaps nowhere has the mind-body connection been better studied than in cardiovascular disease (CVD). Recently, large prospective epidemiologic studies and smaller basic science studies have firmly established a connection between CVD and several psychological conditions, including depression, chronic psychological stress, posttraumatic stress disorder (PTSD), and anxiety. In addition, numerous clinical trials have been conducted to attempt to prevent or lessen the impact of these conditions on cardiovascular health. In this article, we review studies connecting depression, stress/PTSD, and anxiety to CVD, focusing on findings from the last 5 years. For each mental health condition, we first examine the epidemiologic evidence establishing a link with CVD. We then describe studies of potential underlying mechanisms and finally discuss treatment trials and directions for future research.

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Authors: Cohen, B. E., Edmondson, D., & Kronish, I. M.
Affiliations: San Francisco VA Medical Center (US)
Columbia University Irving Medical Center (US)
ORCID: Cohen, Beth E.
Edmondson, Donald
Kronish, Ian M.
Venue: American Journal of Hypertension
Publisher: Oxford University Press (OUP)
Published: 2015-04-24
Volume: 28
Issue: 11
Pages: 1295-1302
ISSN: 0895-7061 (ISSN-L)
1941-7225
DOI: 10.1093/ajh/hpv047
PMC: PMC4612342
OpenAlex: W2017141822
Cited by: 955
References: 97
Citations by year: 2026: 51 · 2025: 93 · 2024: 99 · 2023: 150 · 2022: 128 · 2021: 128 · 2020: 115 · 2019: 72 · 2018: 67 · 2017: 27 · 2016: 22 · 2015: 3
FWCI: 6.81
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
Locations: American Journal of Hypertension (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Heart Association (UL1 TR000040)
National Institutes of Health (UL1TR000040)
National Heart, Lung, and Blood Institute (K23HL094765, HL117832, K23HL098359, R01HL117832)
National Center for Advancing Translational Sciences (TR000040)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: depression, psychological stress, post-traumatic stress disorder, anxiety, cardiovascular disease, mind-body problem, psychocardiology, cardiovascular risk factors
MeSH terms: Anxiety, Cardiovascular Diseases, Depression, Humans, Psychological Techniques, Psychotropic Drugs, Risk Factors, Stress Disorders, Post-Traumatic, Stress, Psychological, Comorbidity

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