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From One-Cell to Tissue: Reprogramming, Cell Differentiation and Tissue Engineering
Abstract
Adult somatic cells can be reprogrammed into pluripotent stem cells, which can indefinitely proliferate in a dish and differentiate into almost all the cell types that constitute the human body. These cells hold great promise for cell therapy and regenerative medicine, as well as drug screening and disease modeling. Theoretically, we can create a source of versatile, therapeutic cells that could be genetically matched to any patient. These pluripotent stem cells can be differentiated into desired cell types and eventually used to reconstruct a tissue or an organ with insights gained from tissue engineering. Inspired by the pioneering work in stem cells, particularly the remarkable reprogramming technique, the fields of regenerative medicine and tissue engineering have advanced rapidly in the past several years. Here recent progress in the fields of induced pluripotent stem cells and tissue engineering is reviewed, with a focus on applications in medicine.
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“Direct reprogramming of primary and passaged cells towards specific terminally differentiated cell derivatives has also been shown to be a promising approach to obtain cell cultures of interest (Zhang and Jiang, 2015) while avoiding the need to establish stable PSC lines and develop differentiation protocols.”
From Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0) (2021) · cites this paper as Zhang and Jiang, 2015
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Self-citationDeterministic direct reprogramming of somatic cells to pluripotency
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Cited by
Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0)
Pamies, D. (2021) · ALTEX · doi:10.14573/altex.2111011 · Cited by 100
Hill, N. J., Tobin, A. J., Reside, A. E., Pepperell, J. G., & Bridge, T. C. L. (2016) · Global Change Biology · doi:10.1111/gcb.13129 · Cited by 74
Metadata
- Authors
- Zhang, D., & Jiang, W.
- Venue
- BioScience
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-02-28
- Volume
- 65
- Issue
- 5
- Pages
- 468-475
- ISSN
- 1525-3244
- 0006-3568
- Cited by
- 12
- References
- 5
- Language
- en
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