Neuroimaging in Parkinson’s disease dementia: connecting the dots
Open accessAbstract
Dementia is a common and devastating symptom of Parkinson’s disease but the anatomical substrate remains unclear. Some evidence points towards hippocampal involvement but neuroimaging abnormalities have been reported throughout the brain and are largely inconsistent across studies. Here, we test whether these disparate neuroimaging findings for Parkinson’s disease dementia localize to a common brain network. We used a literature search to identify studies reporting neuroimaging correlates of Parkinson’s dementia (11 studies, 385 patients). We restricted our search to studies of brain atrophy and hypometabolism that compared Parkinson’s patients with dementia to those without cognitive involvement. We used a standard coordinate-based activation likelihood estimation meta-analysis to assess for consistency in the neuroimaging findings. We then used a new approach, coordinate-based network mapping, to test whether neuroimaging findings localized to a common brain network. This approach uses resting-state functional connectivity from a large cohort of normative subjects (n = 1000) to identify the network of regions connected to a reported neuroimaging coordinate. Activation likelihood estimation meta-analysis failed to identify any brain regions consistently associated with Parkinson’s dementia, showing major heterogeneity across studies. In contrast, coordinate-based network mapping found that these heterogeneous neuroimaging findings localized to a specific brain network centred on the hippocampus. Next, we tested whether this network showed symptom specificity and stage specificity by performing two further analyses. We tested symptom specificity by examining studies of Parkinson’s hallucinations (9 studies, 402 patients) that are frequently co-morbid with Parkinson’s dementia. We tested for stage specificity by using studies of mild cognitive impairment in Parkinson’s disease (15 studies, 844 patients). Coordinate-based network mapping revealed that correlates of visual hallucinations fell within a network centred on bilateral lateral geniculate nucleus and correlates of mild cognitive impairment in Parkinson’s disease fell within a network centred on posterior default mode network. In both cases, the identified networks were distinct from the hippocampal network of Parkinson’s dementia. Our results link heterogeneous neuroimaging findings in Parkinson’s dementia to a common network centred on the hippocampus. This finding was symptom and stage-specific, with implications for understanding Parkinson’s dementia and heterogeneity of neuroimaging findings in general.
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Self-citationGoetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez‐Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., et al. (2008) · Movement Disorders · doi:10.1002/mds.22340 · Cited by 7,536 · see citing works
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304 · see citing works
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946 · see citing works
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781 · see citing works
Overdependence on degraded gist memory in Alzheimer's disease.
Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,756 · see citing works
Large-scale automated synthesis of human functional neuroimaging data.
Yarkoni, T., Poldrack, R. A., Nichols, T. E., Van Essen, D. C., & Wager, T. D. (2011) · Nature Methods · doi:10.1038/nmeth.1635 · Cited by 3,686 · cited 1× · see citing works
“We added these seeds together to produce one combined seed for each study (Eickhoff et al., 2009; Yarkoni et al., 2011; Darby et al., 2019).”
MethodCluster failure: why fMRI inferences for spatial extent have inflated false-positive rates
Eklund, A., Nichols, T. E., & Knutsson, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602413113 · Cited by 3,487 · see citing works
Adams, J., Dinesh, K., Xiong, M., Tarolli, C. G., Sharma, S., Sheth, N., Aranyosi, A. J., Zhu, W. Y., Goldenthal, S. B., Biglan, K., et al. (2017) · Digital Biomarkers · doi:10.1159/000479018 · Cited by 3,190 · see citing works
Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027 · see citing works
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862 · see citing works
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822 · see citing works
Litvan, I., Goldman, J. G., Tröster, A. I., Schmand, B. A., Weintraub, D., Petersen, R. C., Mollenhauer, B., Adler, C. H., Marder, K., Williams‐Gray, C. H., et al. (2012) · Movement Disorders · doi:10.1002/mds.24893 · Cited by 2,609 · see citing works
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350 · see citing works
The Neuropsychiatric Inventory
Cummings, J. L. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.10s · Cited by 2,017 · see citing works
Eickhoff, S. B., Laird, A. R., Grefkes, C., Wang, L. E., Zilles, K., & Fox, P. T. (2009) · Human Brain Mapping · doi:10.1002/hbm.20718 · Cited by 1,924 · see citing works
Activation Likelihood Estimation meta-analysis revisited
Eickhoff, S., Bzdok, D., Laird, A., Kurth, F., & Fox, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.017 · Cited by 1,448 · see citing works
Scanning the horizon: towards transparent and reproducible neuroimaging research
Poldrack, R. A., Baker, C. I., Durnez, J., Gorgolewski, K. J., Matthews, P. M., Munafò, M. R., Nichols, T. E., Poline, J.-B., Vul, E., & Yarkoni, T. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.167 · Cited by 1,410 · see citing works
Amunts, K., Kedo, O., Kindler, M., Pieperhoff, P., Mohlberg, H., Shah, N. J., Habel, U., Schneider, F., & Zilles, K. (2005) · Anatomy and Embryology · doi:10.1007/s00429-005-0025-5 · Cited by 1,264 · see citing works
The hubs of the human connectome are generally implicated in the anatomy of brain disorders
Crossley, N. A., Mechelli, A., Scott, J., Carletti, F., Fox, P. T., McGuire, P., & Bullmore, E. T. (2014) · Brain · doi:10.1093/brain/awu132 · Cited by 1,166 · see citing works
Hallucinations in Parkinson's disease: Prevalence, phenomenology and risk factors
Fénelon, G. (2000) · Brain · doi:10.1093/brain/123.4.733 · Cited by 1,035 · see citing works
Cognitive decline in Parkinson disease
Aarsland, D., Creese, B., Politis, M., Chaudhuri, K. R., ffytche, D. H., Weintraub, D., & Ballard, C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.27 · Cited by 1,027 · see citing works
Connectivity Predicts deep brain stimulation outcome in <scp>P</scp> arkinson disease
Horn, A., Reich, M., Vorwerk, J., Li, N., Wenzel, G., Fang, Q., Schmitz‐Hübsch, T., Nickl, R., Kupsch, A., Volkmann, J., et al. (2017) · Annals of Neurology · doi:10.1002/ana.24974 · Cited by 711 · see citing works
Self-citationPredicting Regional Neurodegeneration from the Healthy Brain Functional Connectome
Zhou, J., Gennatas, E. D., Kramer, J. H., Miller, B. L., & Seeley, W. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.004 · Cited by 706 · see citing works
The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort
Williams‐Gray, C. H., Mason, S., Evans, J., Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. A. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305277 · Cited by 683 · see citing works
Bursting of Thalamic Neurons and States of Vigilance
Llinás, R. R., & Steriade, M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00166.2006 · Cited by 682 · see citing works
Presymptomatic hippocampal atrophy in Alzheimer's disease: A longitudinal MRI study
Fox, N. C., Warrington, E. K., Freeborough, P. A., Hartikainen, P., Kennedy, A. M., Stevens, J. M., & Rossor, M. N. (1996) · Brain · doi:10.1093/brain/119.6.2001 · Cited by 656 · see citing works
Burton, E. J. (2004) · Brain · doi:10.1093/brain/awh088 · Cited by 643 · see citing works
Mapping Symptoms to Brain Networks with the Human Connectome.
Fox, M. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1706158 · Cited by 630 · see citing works
Self-citationCriteria for diagnosing Parkinson's disease
Calne, D. B., Snow, B. J., & Lee, C. (1992) · Annals of Neurology · doi:10.1002/ana.410320721 · Cited by 628 · see citing works
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease
Hurtig, H., Trojanowski, J., Galvin, J., Ewbank, D., Schmidt, M., Lee, V., Clark, C., Glosser, G., Stern, M., Gollomp, S., et al. (2000) · Neurology · doi:10.1212/wnl.54.10.1916 · Cited by 596 · see citing works
Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementia
Janvin, C. C., Larsen, J. P., Aarsland, D., & Hugdahl, K. (2006) · Movement Disorders · doi:10.1002/mds.20974 · Cited by 592 · see citing works
Irwin, D. J., Grossman, M., Weintraub, D. A., Hurtig, H. I., Duda, J. E., Xie, S. X., Lee, E. B., Deerlin, V. M. V., López, O. L., Kofler, J., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30291-5 · Cited by 588 · see citing works
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
Compta, Y., Parkkinen, L., O’Sullivan, S. S., Vandrovcová, J., Holton, J. L., Collins, C., Lashley, T., Kallis, C., Williams, D. R., de Silva, R., et al. (2011) · Brain · doi:10.1093/brain/awr031 · Cited by 585 · see citing works
Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2012) · Neurodegenerative Diseases · doi:10.1159/000341998 · Cited by 574 · see citing works
Cognitive status correlates with neuropathologic stage in Parkinson disease
Braak, H., Rüb, U., Steur, E. N. H. J., Tredici, K. D., & de Vos, R. A. I. (2005) · Neurology · doi:10.1212/01.wnl.0000158422.41380.82 · Cited by 555 · see citing works
Network localization of neurological symptoms from focal brain lesions
Boes, A. D., Prasad, S., Liu, H., Liu, Q., Pascual‐Leone, Á., Caviness, V. S., & Fox, M. (2015) · Brain · doi:10.1093/brain/awv228 · Cited by 537 · see citing works
Self-citationDiagnostic criteria for psychosis in Parkinson's disease: Report of an NINDS, NIMH work group
Ravina, B., Marder, K., Fernandez, H. H., Friedman, J. H., McDonald, W., Murphy, D., Aarsland, D., Babcock, D., Cummings, J., Endicott, J., et al. (2007) · Movement Disorders · doi:10.1002/mds.21382 · Cited by 528 · see citing works
Neuropathologic substrates of Parkinson disease dementia
Irwin, D. J., White, M. T., Toledo, J. B., Xie, S. X., Robinson, J. L., Van Deerlin, V., Lee, V. M. ‐., Leverenz, J. B., Montine, T. J., Duda, J. E., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23659 · Cited by 518 · see citing works
Weigand, A., Horn, A., Caballero, R., Cooke, D. L., Stern, A. P., Taylor, S. F., Press, D. Z., Pascual‐Leone, Á., & Fox, M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.028 · Cited by 492 · see citing works
Self-citationHolmes, A. J., Hollinshead, M. O., O’Keefe, T. M., Petrov, V. I., Fariello, G., Wald, L. L., Fischl, B. R., Rosen, B. R., Mair, R. W., Roffman, J. L., et al. (2015) · Scientific Data · doi:10.1038/sdata.2015.31 · Cited by 436 · see citing works
Bürgel, U., Amunts, K., Hömke, L., Mohlberg, H., Gilsbach, J. M., & Zilles, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.040 · Cited by 425 · see citing works
Parkinson Disease Neuropathology
Apaydın, H., Ahlskog, J. E., Parisi, J. E., Boeve, B. F., & Dickson, D. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.102 · Cited by 397 · see citing works
Leroi, I., McDonald, K., Pantula, H., & Harbishettar, V. (2012) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988712464823 · Cited by 378 · see citing works
Metabolic brain networks associated with cognitive function in Parkinson's disease
Huang, C. C., Mattis, P. J., Tang, C., Perrine, K. R., Carbon, M., & Eidelberg, D. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.003 · Cited by 357 · see citing works
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
Klein, J. C., Eggers, C., Kalbe, E., Weisenbach, S., Hohmann, C., Vollmar, S., Baudrexel, S., Diederich, N. J., Heiß, W.-D., & Hilker, R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d55f61 · Cited by 355 · see citing works
Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study
Aarsland, D., Perry, R., Brown, A. D., Larsen, J. O., & Ballard, C. G. (2005) · Annals of Neurology · doi:10.1002/ana.20635 · Cited by 347 · see citing works
Visual hallucinations in Parkinson's disease: a review and phenomenological survey
Barnes, J. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.6.727 · Cited by 341 · see citing works
Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease
Tessitore, A., Esposito, F., Vitale, C., Santangelo, G., Amboni, M., Russo, A., Corbo, D., Cirillo, G., Barone, P., & Tedeschi, G. (2012) · Neurology · doi:10.1212/wnl.0b013e31827689d6 · Cited by 326 · see citing works
Hall, H., Reyes, S., Landeck, N., Bye, C. R., Leanza, G., Double, K. L., Thompson, L. H., Halliday, G. M., & Kirik, D. (2014) · Brain · doi:10.1093/brain/awu193 · Cited by 306 · see citing works
Cortical Lewy body pathology in the diagnosis of dementia
Harding, A. J., & Halliday, G. M. (2001) · Acta Neuropathologica · doi:10.1007/s004010100390 · Cited by 296 · see citing works
Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia
Noé, E., Marder, K. S., Bell, K. L., Jacobs, D. M., Manly, J. J., & Stern, Y. (2004) · Movement Disorders · doi:10.1002/mds.10633 · Cited by 267 · see citing works
Mak, E., Su, L., Williams, G. B., Firbank, M., Lawson, R. A., Yarnall, A. J., Duncan, G. W., Owen, A. M., Khoo, T. K., Brooks, D. J., et al. (2015) · Brain · doi:10.1093/brain/awv211 · Cited by 261 · see citing works
Grey matter atrophy in cognitively impaired Parkinson's disease
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple‐Alford, J. C., & Anderson, T. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-300828 · Cited by 244 · see citing works
Minor hallucinations occur in drug‐naive Parkinson's disease patients, even from the premotor phase
Pagonabarraga, J., Martinez‐Horta, S., Fernández de Bobadilla, R., Pérez, J., Ribosa‐Nogué, R., Marín, J., Pascual‐Sedano, B., García, C., Gironell, A., & Kulisevsky, J. (2016) · Movement Disorders · doi:10.1002/mds.26432 · Cited by 236 · see citing works
Synchrony in the Interconnected Circuitry of the Thalamus and Cerebral Cortex
Jones, E. G. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04534.x · Cited by 234 · see citing works
Neurodegeneration Across Stages of Cognitive Decline in Parkinson Disease
Weintraub, D. A. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.725 · Cited by 217 · see citing works
Finding the imposter: brain connectivity of lesions causing delusional misidentifications
Darby, R. R., Laganiere, S. E., Pascual‐Leone, Á., Prasad, S., & Fox, M. (2016) · Brain · doi:10.1093/brain/aww288 · Cited by 216 · see citing works
Self-citationInitial cognitive decline is associated with cortical thinning in early Parkinson disease
Pereira, J. B., Svenningsson, P., Weintraub, D. A., Brønnick, K., Lebedev, A. V., Westman, E., & Aarsland, D. (2014) · Neurology · doi:10.1212/wnl.0000000000000483 · Cited by 198 · see citing works
Dickerson, B. C., & Sperling, R. A. (2009) · Behavioural Neurology · doi:10.1155/2009/610392 · Cited by 197 · see citing works
Gray matter asymmetries in aging and neurodegeneration: a review and meta-analysis.
Minkova, L., Habich, A., Peter, J., Kaller, C. P., Eickhoff, S. B., & Klöppel, S. (2017) · Human Brain Mapping · doi:10.1002/hbm.23772 · Cited by 194 · see citing works
Cortical thinning is associated with disease stages and dementia in Parkinson's disease
Zarei, M., Ibarretxe‐Bilbao, N., Compta, Y., Hough, M., Junqué, C., Bargalló, N., Tolosa, E., & Martí, M. J. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304126 · Cited by 192 · see citing works
Toledo, J. B., Gopal, P., Raible, K., Irwin, D. J., Brettschneider, J., Sedor, S., Waits, K., Boluda, S., Grossman, M., Van Deerlin, V. M., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1526-9 · Cited by 184 · see citing works
Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
Weintraub, D. A., Dietz, N., Duda, J. E., Wolk, D. A., Doshi, J. J., Xie, S. X., Davatzikos, C. A., Clark, C. M., & Siderowf, A. D. (2011) · Brain · doi:10.1093/brain/awr277 · Cited by 180 · see citing works
Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study)
Reid, W., Hely, M. A., Morris, J. G., Loy, C., & Halliday, G. M. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.232678 · Cited by 179 · see citing works
Larsen, J. O., Dupont, E., & Tandberg, E. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb01674.x · Cited by 176 · see citing works
Ezzati, A., Katz, M. J., Zammit, A. R., Lipton, M. L., Zimmerman, M. E., Sliwinski, M. J., & Lipton, R. B. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.08.016 · Cited by 172 · see citing works
Shibata, N., Motoi, Y., Tomiyama, H., Ohnuma, T., Kuerban, B., Tomson, K., Komatsu, M., Shimazaki, H., Hattori, N., & Arai, H. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000351419 · Cited by 171 · see citing works
Dickerson, B. C., & Sperling, R. A. (2009) · PubMed · doi:10.3233/ben-2009-0227 · Cited by 167 · see citing works
Lesion network localization of free will
Darby, R. R., Joutsa, J., Burke, M. J., & Fox, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814117115 · Cited by 165 · see citing works
Self-citationLocalizing parkinsonism based on focal brain lesions
Joutsa, J., Horn, A., Hsu, J., & Fox, M. (2018) · Brain · doi:10.1093/brain/awy161 · Cited by 160 · see citing works
Self-citationTricks of the mind: Visual hallucinations as disorders of attention
Shine, J. M., O’Callaghan, C., Halliday, G. M., & Lewis, S. J. G. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.01.004 · Cited by 157 · see citing works
Cerebral atrophy in Parkinson's disease patients with visual hallucinations
Ramírez‐Ruiz, B., Martí, M., TOLOSA, E. S., Giménez, M., Bargalló, N., Valldeoriola, F., & Junqué, C. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01768.x · Cited by 154 · see citing works
Network localization of heterogeneous neuroimaging findings
Darby, R. R., Joutsa, J., & Fox, M. (2018) · Brain · doi:10.1093/brain/awy292 · Cited by 152 · see citing works
Self-citationThe default mode network is disrupted in parkinson's disease with visual hallucinations
Yao, N., Chang, R. S., Cheung, C., Pang, S. Y.-Y., Lau, K. K., John Suckling, A., Rowe, J. B., Yu, K., Mak, H. K., Chua, S.-E., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22577 · Cited by 151 · see citing works
Course of cognitive decline in Parkinson's disease: A meta-analysis
Muslimović, D., Schmand, B. A., Speelman, J. D., & de Haan, R. J. (2007) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617707071160 · Cited by 148 · see citing works
The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
Song, S., Lee, J. E., Park, H., Sohn, Y. H., Lee, J. D., & Lee, P. H. (2011) · Movement Disorders · doi:10.1002/mds.23477 · Cited by 147 · see citing works
Cost of Illness and its Predictors for Parkinson??s Disease in Germany
Spottke, A. E., Reuter, M., Machat, O., Bornschein, B., von Campenhausen, S., Berger, K., Köhne-Volland, R., Rieke, J., Simonow, A., Brandstädter, D., et al. (2005) · PharmacoEconomics · doi:10.2165/00019053-200523080-00007 · Cited by 144 · see citing works
Testing an aetiological model of visual hallucinations in Parkinson's disease
Gallagher, D. A., Parkkinen, L., O’Sullivan, S. S., Spratt, A., Shah, A., Davey, C. C., Bremner, F., Révész, T., Williams, D. R., Lees, A. J., et al. (2011) · Brain · doi:10.1093/brain/awr225 · Cited by 140 · see citing works
Pattern of Regional Cortical Thinning Associated with Cognitive Deterioration in Parkinson’s Disease
Pagonabarraga, J., Corcuera‐Solano, I., Vives‐Gilabert, Y., Llebaria, G., García‐Sánchez, C., Pascual‐Sedano, B., Delfino, M., Kulisevsky, J., & Gómez‐Ansón, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054980 · Cited by 138 · see citing works
Janvin, C. C., Larsen, J. P., Salmon, D. P., Galasko, D. R., Hugdahl, K., & Aarsland, D. (2005) · Movement Disorders · doi:10.1002/mds.20726 · Cited by 119 · see citing works
Recognition memory impairment in Parkinson's disease: Power and meta-analyses.
Whittington, C. J., Podd, J., & Kan, M. M. (2000) · Neuropsychology · doi:10.1037//0894-4105.14.2.233 · Cited by 112 · see citing works
Shine, J. M., Muller, A. J., O’Callaghan, C., Hornberger, M., Halliday, G. M., & Lewis, S. J. (2015) · npj Parkinson's Disease · doi:10.1038/npjparkd.2015.3 · Cited by 106 · see citing works
Kalbe, E., Rehberg, S., Heber, I. A., Kronenbuerger, M., Schulz, J. B., Storch, A., Linse, K., Schneider, C. B., Gräber, S., Liepelt‐Scarfone, I., et al. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-313838 · Cited by 106 · see citing works
Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease
Kandiah, N., Zainal, N. H., Narasimhalu, K., Chander, R. J., Ng, A. Y. T., Mak, E., Au, W. L., Sitoh, Y. Y., Nadkarni, N. V., & Tan, L. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.08.024 · Cited by 105 · see citing works
Recognition memory impairment in Parkinson's disease: Power and meta-analyses.
Whittington, C. J., Podd, J., & Kan, M. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.2.233 · Cited by 100 · see citing works
Nerve cell loss in the thalamus in Alzheimer's disease and Parkinson's disease
Xuereb, J. H., Perry, R. H., Candy, J. M., Perry, E. K., Marshall, E., & Bonham, J. R. (1991) · PubMed · doi:10.25405/ncl.34085541 · Cited by 99 · see citing works
Predicting dementia development in Parkinson's disease using Bayesian network classifiers
Morales, D. A., Vives‐Gilabert, Y., Gómez‐Ansón, B., Bengoetxea, E., Larrañaga, P., Bielza, C., Pagonabarraga, J., Kulisevsky, J., Corcuera‐Solano, I., & Delfino, M. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.06.001 · Cited by 94 · see citing works
Brønnick, K., Emre, M., Lane, R. M., Tekin, S., & Aarsland, D. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.108076 · Cited by 89 · see citing works
Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
Rektorová, I., Biundo, R., Mareček, R., Weis, L., Aarsland, D., & Antonini, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085595 · Cited by 81 · see citing works
Identifying therapeutic targets from spontaneous beneficial brain lesions
Joutsa, J., Shih, L. C., Horn, A., Reich, M. M., Wu, O., Rost, N. S., & Fox, M. (2018) · Annals of Neurology · doi:10.1002/ana.25285 · Cited by 80 · see citing works
Self-citationMak, E., Zhou, J. H., Tan, L. C. S., Au, W., Sitoh, Y. Y., & Kandiah, N. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305805 · Cited by 76 · see citing works
Hou, Y., Yang, J., Luo, C., Song, W., Ou, R., Liu, W., Gong, Q., & Shang, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00247 · Cited by 73 · see citing works
Fredericks, D., Norton, J. C., Atchison, C., et al. (2017) · PubMed · Cited by 72 · see citing works
Short‐ and long‐term cost and utilization of health care resources in Parkinson's disease in the UK
Weir, S., Samnaliev, M., Kuo, T., Tierney, T. S., Autiero, S. W., Taylor, R. S., & Schrag, A. E. (2018) · Movement Disorders · doi:10.1002/mds.27302 · Cited by 72 · see citing works
Default mode network differences between rigidity- and tremor-predominant Parkinson's disease
Karunanayaka, P., Lee, E.-Y., Lewis, M. M., Sen, S., Eslinger, P. J., Yang, Q. X., & Huang, X. (2016) · Cortex · doi:10.1016/j.cortex.2016.04.021 · Cited by 70 · see citing works
Are patients with Parkinson’s disease blind to blindsight?
Diederich, N. J., Stebbins, G. T., Schiltz, C., & Goetz, C. G. (2014) · Brain · doi:10.1093/brain/awu094 · Cited by 69 · see citing works
Can neuroimaging predict dementia in Parkinson’s disease?
Lanskey, J. H., McColgan, P., Schrag, A. E., Acosta‐Cabronero, J., Rees, G. E., Morris, H. R., & Weil, R. S. (2018) · Brain · doi:10.1093/brain/awy211 · Cited by 69 · see citing works
Self-citationNetwork correlates of the cognitive response to levodopa in Parkinson disease
Mattis, P. J., Tang, C., Ma, Y., DHAWAN, V. M., & Eidelberg, D. (2011) · Neurology · doi:10.1212/wnl.0b013e31822c6224 · Cited by 66 · see citing works
Progression of subcortical atrophy in mild Parkinson's disease and its impact on cognition
Foo, H., Mak, E., Yong, T. T., Wen, M., Chander, R. J., Au, W., Sitoh, Y. Y., Tan, L. C. S., & Kandiah, N. (2016) · European Journal of Neurology · doi:10.1111/ene.13205 · Cited by 66 · see citing works
On visual hallucinations and cortical networks: a trans-diagnostic review
Carter, R., & Ffytche, D. H. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7687-6 · Cited by 65 · see citing works
Arnold, S. E., Toledo, J. B., Appleby, D. H., Xie, S. X., Wang, W., Baek, Y., Wolk, D. A., Lee, E. B., Miller, B. L., Lee, V. M. ‐., et al. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23430 · Cited by 61 · see citing works
Pan, P. L., Shi, H. C., Zhong, J. G., Xiao, P. R., Shen, Y., Wu, L., Song, Y. Y., He, G. X., & Li, H. L. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1250-3 · Cited by 59 · see citing works
Mihaescu, A. S., Masellis, M., Graff‐Guerrero, A., Kim, J., Criaud, M., Cho, S. S., Ghadery, C., Valli, M., & Strafella, A. P. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9922-0 · Cited by 56 · see citing works
Hippocampal atrophy predicts conversion to dementia after STN-DBS in Parkinson's disease
Aybek, S., Lazeyras, F., Gronchi‐Perrin, A., Burkhard, P. R., Villemure, J., & Vingerhoets, F. J. G. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.01.003 · Cited by 50 · see citing works
Farlow, M. R., & Cummings, J. L. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000119104 · Cited by 50 · see citing works
Functional brain imaging of cognitive dysfunction in Parkinson's disease
Hirano, S., Shinotoh, H., & Eidelberg, D. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301818 · Cited by 49 · see citing works
Mapping Cortical Atrophy in Parkinson's Disease Patients with Dementia
Hwang, K., Beyer, M. K., Green, A. E., Chung, C., Thompson, P. M., Janvin, C. C., Larsen, J. O., Aarsland, D., & Apostolova, L. G. (2013) · Journal of Parkinson s Disease · doi:10.3233/jpd-120151 · Cited by 42 · see citing works
The Cats‐and‐Dogs test: A tool to identify visuoperceptual deficits in Parkinson's disease
Weil, R. S., Pappa, K., Schade, R. N., et al. (2017) · Movement Disorders · doi:10.1002/mds.27176 · Cited by 28 · see citing works
Self-citationRegional volumetric change in Parkinson's disease with cognitive decline
Gee, M., Dukart, J., Draganski, B., Martin, W. R. W., Emery, D. J., & Camicioli, R. M. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.12.030 · Cited by 27 · see citing works
Wang, Y., Tang, B., Yan, X., et al. (2015) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2014.11.030 · Cited by 25 · see citing works
Schneider, C. B., Donix, M., Linse, K., Werner, A., Fauser, M., Klingelhoefer, L., Löhle, M., von Kummer, R., Reichmann, H., & Storch, A. (2017) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317517698794 · Cited by 21 · see citing works
Kiesmann, M., Chanson, J., Godet, J., et al. (2013) · Journal of Neurology · doi:10.1007/s00415-013-7018-8 · Cited by 20 · see citing works
Visual Hallucination and Pattern of Brain Degeneration in Parkinson's Disease
Lee, W., Yoon, E. J., Lee, J., Park, S., & Kim, Y. K. (2016) · Neurodegenerative Diseases · doi:10.1159/000448517 · Cited by 20 · see citing works
Psychosis in parkinsonism: an unorthodox approach
ONOFRJ, M. C., Carrozzino, D., D'Amico, A., Giacomo, R. D., Pizzi, S. D., Thomas, A., Onofrj, V., Taylor, J., & Bonanni, L. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s116116 · Cited by 17 · see citing works
Pedunculopontine Nucleus Stimulation in Parkinson’s Disease Dementia
Ricciardi, L., Piano, C., Bentivoglio, A. R., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.027 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- de Morsier G. Les automatismes visuels. (Hallucinations visuelles retrochiasmatiques). Schweizerische Medizinische Wochenschrift 1936; 66: 700– 3.
- de Morsier G. Les hallucinations: etude Oto-neuro-ophtalmologique. Rev Oto-Neuro-Ophtalmol 1938; 16: 244– 352.
Cited by
Sorted by citations
Beyond the average patient: how neuroimaging models can address heterogeneity in dementia
Verdi, S., Marquand, A. F., Schott, J. M., & Cole, J. H. (2021) · Brain · doi:10.1093/brain/awab165 · Cited by 106 · see citing works
Vignando, M., ffytche, D., Lewis, S. J. G., Lee, P. H., Chung, S. J., Weil, R. S., Hu, M. T., Mackay, C. E., Griffanti, L., Pins, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28087-0 · Cited by 42 · see citing works
Self-citationThomas, G. E. C., Zeidman, P., Sultana, T., Zarkali, A., Razi, A., & Weil, R. S. (2022) · Brain Communications · doi:10.1093/braincomms/fcac329 · Cited by 38 · see citing works
Self-citationZarkali, A., McColgan, P., Leyland, L. A., Lees, A. J., & Weil, R. S. (2022) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-326630 · Cited by 32 · see citing works
Self-citationVisual hallucinations in Parkinson’s disease: spotlight on central cholinergic dysfunction
Ignatavicius, A., Matar, E., & Lewis, S. J. G. (2025) · Brain · doi:10.1093/brain/awae289 · Cited by 32 · see citing works
Vignando, M., Ffytche, D., Mazibuko, N., Palma, G., Bhat, A., Montagnese, M., Dave, S., Tai, Y. F., Batzu, L., Leta, V., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00669-7
“6).”
- Authors
- Weil, R. S., Hsu, J. K., Darby, R. R., Soussand, L., & Fox, M. D.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Vanderbilt University Medical Center (US)
- Corresponding author
- Weil, Rimona S
- Venue
- Brain Communications
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-01-01
- Volume
- 1
- Issue
- 1
- Pages
- fcz006-fcz006
- ISSN
- 2632-1297 (ISSN-L)
- PMC
- PMC6777517
- OpenAlex
- W2958270502
- Cited by
- 71
- References
- 119
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 2
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Brain Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Clinical Research Career Development Fellowship (201567/Z/16/Z)
- Sidney R. Baer, Jr. Foundation
- NIH (R01MH113929)
- Nancy Lurie Marks Foundation
- G. Harold
- Leila Y. Mathers Charitable Foundation
- Alzheimer’s foundation
- Brightfocus foundation
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- Parkinson's disease dementia, hippocampus, brain networks, brain atrophy, hypometabolism, visual hallucinations, lateral geniculate nucleus, mild cognitive impairment, posterior default mode network, symptom specificity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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