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Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
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“This heterogeneity may be related to differences in the developmental trajectories of brain regions, sample composition, methodological approaches (e.g. the use of absolute vs. relative brain volumes), or because of unmeasured moderators such as those reported previously.36,37”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [37]
In the citing paper
“Genetic interactions have also been reported, with increasing household income associated with smaller neonatal amygdala and hippocampus volumes in infants with high genetic risk for depression, but not in a low genetic risk group.37”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [37]
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“In addition to these converging main effects, two studies have reported that socioeconomic factors can moderate effects of other known predictors of brain structure.”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [37]
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“Several studies from the same research group have reported significant gene by maternal psychopathology interactive effects.”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [37]
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“prenatal maternal depression symptoms have been positively associated with right hippocampal volume in infants with high genomic risk for depression (without controlling for total intracranial volume)”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [37]
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Citations
Cites
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Developmental pathways to amygdala–prefrontal function and internalizing symptoms in adolescence
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Carrion, V. G., Weems, C. F., & Reiss, A. L. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2028 · Cited by 327 · cited 2×
“implicating the right hemisphere, notably the right amygdala and right hippocampus in the regulation of stress responses (Abercrombie et al. 1998; Carrion et al. 2007; Hamilton and Gotlib 2008).”
Backgroundvan Marle, H. J. F., Hermans, E. J., Qin, S., & Fernández, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.014 · Cited by 317
Holmes, A. J., Lee, P. H., Hollinshead, M. O., Bakst, L., Roffman, J. L., Smoller, J. W., & Buckner, R. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2531-12.2012 · Cited by 293 · cited 4×
“For example, a higher GPRSMDD associates with cortical thinning in the medial prefrontal cortex (Holmes et al. 2012), a region strongly implicated in the pathophysiology of depression (Kupfer et al. 2012).”
BackgroundInfluentialPrenatal maternal depression associates with microstructure of right amygdala in neonates at birth.
Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B., Sim, L. W., Tint, M. T., Leutscher-Broekman, B., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.019 · Cited by 258
Self-citationEffect of polygenic risk scores on depression in childhood trauma
Peyrot, W. J., Milaneschi, Y., Abdellaoui, A., Sullivan, P. F., Hottenga, J. J., Boomsma, D. I., & Penninx, B. W. J. H. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.143081 · Cited by 209
Wen, D. J., Poh, J. S., Ni, S. N., Chong, Y.-S., Chen, H., Kwek, K., Shek, L. P., Gluckman, P. D., Fortier, M. V., Meaney, M. J., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.74 · Cited by 186 · cited 1×
“Antenatal maternal depression, independent of postnatal maternal mood, influences fetal neurodevelopment, in particular the amygdala, where alterations associate with affective disorders (Rifkin-Graboi et al. 2013; Qiu et al. 2015a; Wen et al. 2017).”
BackgroundSelf-citationCOMT Haplotypes Modulate Associations of Antenatal Maternal Anxiety and Neonatal Cortical Morphology
Qiu, A., Tuan, T. A., Ong, M. L., Li, Y., Chen, H., Rifkin-Graboi, A., Broekman, B. F. P., Kwek, K., Saw, S.-M., Chong, Y.-S., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14030313 · Cited by 100
Self-citation
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Metadata
- Authors
- Qiu, A., Shen, M., Buss, C., Chong, Y.-S., Kwek, K., Saw, S.-M., Gluckman, P. D., Wadhwa, P. D., Entringer, S., Styner, M., Karnani, N., Heim, C. M., O'Donnell, K. J., Holbrook, J. D., Fortier, M. V., Meaney, M. J., & the GUSTO study group
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-18
- Volume
- 27
- Issue
- 5
- Pages
- 3080-3092
- ISSN
- 1047-3211
- 1460-2199
- Cited by
- 114
- References
- 22
- Language
- en
- Funders
- National Institute of Health (R01 MH091351, R01 HD060628)
- National Medical Research Council (NMRC/TCR/004-NUS/2008, NMRC/CBRG/0039/2013)
- Hope for Depression Research Foundation
- Canadian Institutes for Advanced Research
- Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2012-T2-2-130)
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