Cited by 455Child Abuse and TraumaPsychopathy, Forensic Psychiatry, Sexual OffendingNeural and Behavioral Psychology Studies

Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk

Open access
Hanson, Jamie L., Chung, Moo K., Avants, Brian B., Shirtcliff, Elizabeth A., Gee, James C., Davidson, Richard J., Pollak, Seth D.·2010·The Journal of Neuroscience

Abstract

Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.

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Registry

Crossref · 10.1523/jneurosci.0859-10.2010

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49 of 49 references verified0 citation errors · 0 not checkable

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  • Early life trauma is linked to less cortical thickness of the prefrontal cortex.

    “Additionally, early life trauma is linked to less cortical thickness of the prefrontal cortex (Hanson et al., 2010), and in a sample of adolescents exposed to child abuse, a reduction in resting state connectivity between the amygdala and ventral medial PFC (Herringa et al., 2013).”

    From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Hanson et al., 2010

    The Results (Brain Measurements; page unavailable) report smaller right orbitofrontal volumes in children who experienced physical abuse, supporting an association between early trauma and a prefrontal structural difference. The Methods (Symmetric diffeomorphic image normalization and Tensor-based morphometry; page unavailable) describe measuring regional volume changes, not cortical thickness. The cited paper therefore does not establish the claimed reduction in cortical thickness. (LLM, conf=0.90)

    Experimental — accuracy not yet measured
  • Threat exposure in childhood is associated with reduced volume and/or thickness of the vmPFC.

    “threat exposure in childhood is associated with reduced volume and/or thickness of the vmPFC”
  • Earlier studies have explored that exposure to sexual abuse may affect smaller thalamic volume.

    “Earlier studies have explored that exposure to sexual abuse may affect smaller thalamic volume as well [ 70 , 71 ].”

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Authors
Hanson, J. L., Chung, M. K., Avants, B. B., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., & Pollak, S. D.
Affiliations
  • University of Wisconsin–Madison (US)
  • University of Pennsylvania (US)
Venue
The Journal of Neuroscience
Published
2010-06-02
Volume
30
Issue
22
Pages
7466-7472
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1987683287
Cited by
455
References
50
Citations by year
2026: 11 · 2025: 22 · 2024: 30 · 2023: 23 · 2022: 32 · 2021: 26 · 2020: 65 · 2019: 28 · 2018: 33 · 2017: 34 · 2016: 29 · 2015: 35 · 2014: 22 · 2013: 27 · 2012: 26
FWCI
22.55
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (MH61285, MH84051)
  • National Institute of Mental Health (MH84051, MH61285, R01MH068858, MH 68858, P50MH084051, R01MH061285)
  • U.S. Children's Bureau
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
childhood adversity, child abuse, physical abuse, orbitofrontal cortex, brain structure, social behavior, social difficulties, individual differences, behavioral risk, pediatric neuroimaging
MeSH terms
Adaptation, Psychological, Adolescent, Brain Mapping, Child, Child Abuse, Child Behavior Disorders, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Neuropsychological Tests, Stress, Psychological, Diffusion Tensor Imaging

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