Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk
Open accessAbstract
Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.
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Early life trauma is linked to less cortical thickness of the prefrontal cortex.
“Additionally, early life trauma is linked to less cortical thickness of the prefrontal cortex (Hanson et al., 2010), and in a sample of adolescents exposed to child abuse, a reduction in resting state connectivity between the amygdala and ventral medial PFC (Herringa et al., 2013).”
From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Hanson et al., 2010
The Results (Brain Measurements; page unavailable) report smaller right orbitofrontal volumes in children who experienced physical abuse, supporting an association between early trauma and a prefrontal structural difference. The Methods (Symmetric diffeomorphic image normalization and Tensor-based morphometry; page unavailable) describe measuring regional volume changes, not cortical thickness. The cited paper therefore does not establish the claimed reduction in cortical thickness. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThreat exposure in childhood is associated with reduced volume and/or thickness of the vmPFC.
“threat exposure in childhood is associated with reduced volume and/or thickness of the vmPFC”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Hanson et al., 2010
Earlier studies have explored that exposure to sexual abuse may affect smaller thalamic volume.
“Earlier studies have explored that exposure to sexual abuse may affect smaller thalamic volume as well [ 70 , 71 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [71]
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- Authors
- Hanson, J. L., Chung, M. K., Avants, B. B., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., & Pollak, S. D.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Pennsylvania (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-06-02
- Volume
- 30
- Issue
- 22
- Pages
- 7466-7472
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2893146
- OpenAlex
- W1987683287
- Cited by
- 455
- References
- 50
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 30 · 2023: 23 · 2022: 32 · 2021: 26 · 2020: 65 · 2019: 28 · 2018: 33 · 2017: 34 · 2016: 29 · 2015: 35 · 2014: 22 · 2013: 27 · 2012: 26
- FWCI
- 22.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH61285, MH84051)
- National Institute of Mental Health (MH84051, MH61285, R01MH068858, MH 68858, P50MH084051, R01MH061285)
- U.S. Children's Bureau
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- childhood adversity, child abuse, physical abuse, orbitofrontal cortex, brain structure, social behavior, social difficulties, individual differences, behavioral risk, pediatric neuroimaging
- MeSH terms
- Adaptation, Psychological, Adolescent, Brain Mapping, Child, Child Abuse, Child Behavior Disorders, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Neuropsychological Tests, Stress, Psychological, Diffusion Tensor Imaging
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