Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse
Open accessAbstract
UNLABELLED: Oxytocin (OXT) has drawn increasing attention as a developmentally relevant neuropeptide given its role in the brain regulation of social behavior. It has been suggested that OXT plays an important role in the infant brain during caregiver attachment in nurturing familial contexts, but there is incomplete experimental evidence. Mouse models of OXT system genes have been particularly informative for the role of the OXT system in social behavior, however, the developing brain areas that could respond to ligand activation of the OXT receptor (OXTR) have yet to be identified in this species. Here we report new data revealing dynamic ligand-binding distribution of OXTR in the developing mouse brain. Using male and female C57BL/6J mice at postnatal days (P) 0, 7, 14, 21, 35, and 60 we quantified OXTR ligand binding in several brain areas which changed across development. Further, we describe OXTR ligand binding in select tissues of the near-term whole embryo at E18.5. Together, these data aid in the interpretation of findings in mouse models of the OXT system and generate new testable hypotheses for developmental roles for OXT in mammalian systems. We discuss our findings in the context of developmental disorders (including autism), attachment biology, and infant physiological regulation. SUMMARY: Quantitative mapping of selective OXTR ligand binding during postnatal development in the mouse reveals an unexpected, transient expression in layers II/III throughout the mouse neocortex. OXTR are also identified in several tissues in the whole late embryo, including the adrenal glands, brown adipose tissue, and the oronasal cavity.
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The study by Hammock and Levitt examined only one embryonic time point.
“However, this was the only embryonic time point that was examined.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [105]
A study by Hammock and Levitt found Oxtr binding in the brains of E18.5 C57BL/6J mice.
“In mice, a study by Hammock and Levitt (105), which focused primarily on Oxtr binding during postnatal development, found Oxtr binding in the brains of E18.5 C57BL/6J mice.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [105]
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- Authors
- Hammock, E. A. D.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Hammock, Elizabeth A. D.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 195-195
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC3858721
- OpenAlex
- W2046016307
- Cited by
- 115
- References
- 63
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 3
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (R01MH080759)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin receptor, postnatal brain development, embryonic development, C57BL/6J mice, social behavior, attachment, autism spectrum disorder, adrenal gland, brown adipose tissue
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