Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China
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Background: From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical features are needed. Methods: We reviewed 69 patients who were hospitalized in Union hospital in Wuhan between 16 January and 29 January 2020. All patients were confirmed to be infected with SARS-CoV-2, and the final date of follow-up was 4 February 2020. Results: The median age of 69 enrolled patients was 42.0 years (interquartile range 35.0–62.0), and 32 patients (46%) were men. The most common symptoms were fever (60 [87%]), cough (38 [55%]), and fatigue (29 [42%]). Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). As of 4 February 2020, 18 (26.9%) of 67 patients had been discharged, and 5 patients had died, with a mortality rate of 7.5%. According to the lowest SpO2 during admission, cases were divided into the SpO2 ≥ 90% group (n = 55) and the SpO2 < 90% group (n = 14). All 5 deaths occurred in the SpO2 < 90% group. Compared with SpO2 ≥ 90% group, patients of the SpO2 < 90% group were older and showed more comorbidities and higher plasma levels of interleukin (IL) 6, IL10, lactate dehydrogenase, and C reactive protein. Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate. Conclusions: COVID-19 appears to show frequent fever, dry cough, and increase of inflammatory cytokines, and induced a mortality rate of 7.5%. Older patients or those with underlying comorbidities are at higher risk of death.
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Patients infected with SARS-CoV-2 present elevated levels of IL-6, IL-10, IL-1β, INF-γ, CCL2, TNF-α, CXCL10, CCL7, IL-1 receptor antagonist and IL-2 receptor, supposedly associated with disease severity.
“Patients infected with SARS-CoV-2 present elevated levels of IL-6, IL-10, IL-1β, INF-γ, CCL2, TNF-α, CXCL10, CCL7, IL-1 receptor antagonist and IL-2 receptor, supposedly associated with disease severity [9, 98–105].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [105]
Wang et al. provide a detailed description of major signs and symptoms of overt disease but fail to give an account of minor symptoms that may be present at earlier stages of the infection.
“The authors provide a detailed description of major signs and symptoms of overt disease [2, 3], but fail to give an account of minor symptoms that may be present at earlier stages of the infection.”
From Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study (2020) · cites this paper as [1]
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- Authors
- Wang, Z., Yang, B., Li, Q., Wen, L., & Zhang, R.
- Affiliations
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Zhang, Ruiguang
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-16
- Volume
- 71
- Issue
- 15
- Pages
- 769-777
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC7184452
- OpenAlex
- W3012492786
- Cited by
- 1,063
- References
- 28
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 32 · 2023: 92 · 2022: 120 · 2021: 288 · 2020: 516 · 2015: 1
- FWCI
- 33.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- COVID-19 pandemic, SARS-CoV-2, clinical features, mortality, oxygen saturation, comorbidities, inflammatory cytokines, interleukin-6, IL-10, C-reactive protein, lactate dehydrogenase, arbidol, antiviral therapy, hospitalized patients
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Aged, C-Reactive Protein, China, Cough, Female, Fever, Hospitalization, Humans, Male, Middle Aged, Patient Discharge, Pneumonia, Viral, Interleukin-6, Interleukin-10, Coronavirus Infections, Pandemics
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