Cited by 436Inflammatory Bowel DiseaseGut microbiota and healthMicroscopic Colitis

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Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

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Paramsothy, Sudarshan, Paramsothy, Ramesh, Rubin, David T, Kamm, Michael A., Kaakoush, Nadeem O., Mitchell, Hazel M, Castaño-Rodríguez, Natalia·2017·Journal of Crohn s and Colitis

DOI 10.1093/ecco-jcc/jjx063

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Abstract

BACKGROUND: Faecal microbiota transplantation [FMT] has been investigated as a potential treatment for inflammatory bowel disease [IBD]. We thus performed a systematic review and meta-analysis assessing the effectiveness and safety of FMT in IBD. METHODS: A systematic review was conducted until January 2017. Studies were excluded if patients had co-infection or data were pooled across disease subtypes (ulcerative colitis [UC], Crohn's disease [CD], pouchitis). Clinical remission was established as the primary outcome. Pooled effect sizes and 95% confidence intervals were obtained using the random effects model. RESULTS: In all, 53 studies were included [41 in UC, 11 in CD, 4 in pouchitis]. Overall, 36% [201/555] of UC, 50.5% [42/83] of CD, and 21.5% [5/23] of pouchitis patients achieved clinical remission. Among cohort studies, the pooled proportion achieving clinical remission was 33% (95% confidence interval [CI] = 23%-43%] for UC and 52% [95% CI = 31%-72%] for CD, both with moderate risk of heterogeneity. For four RCTs in UC, significant benefit in clinical remission (pooled odds ratios [[P-OR] = 2.89, 95% CI = 1.36-6.13, p = 0.006) with moderate heterogeneity [Cochran's Q, p = 0.188; I2 = 37%] was noted. Sub-analyses suggest remission in UC improved with increased number of FMT infusions and lower gastrointestinal tract administration. Most adverse events were transient gastrointestinal complaints. Microbiota analysis was performed in 24 studies, with many identifying increased diversity and a shift in recipient microbiota profile towards the donor post-FMT. CONCLUSIONS: FMT appears effective in UC remission induction, but long-term durability and safety remain unclear. Additional well-designed controlled studies of FMT in IBD are needed, especially in CD and pouchitis.

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Authors: Paramsothy, S., Paramsothy, R., Rubin, D. T., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., & Castaño-Rodríguez, N.
Affiliations: UNSW Sydney (AU)
Liverpool Hospital (AU)
University of Chicago (US)
The University of Melbourne (AU)
ORCID: Paramsothy, Sudarshan
Rubin, David T
Kamm, Michael A.
Kaakoush, Nadeem O.
Mitchell, Hazel M
Venue: Journal of Crohn s and Colitis
Publisher: Oxford University Press (OUP)
Published: 2017-05-09
Volume: 11
Issue: 10
Pages: 1180-1199
ISSN: 1873-9946 (ISSN-L)
1876-4479
DOI: 10.1093/ecco-jcc/jjx063
OpenAlex: W2586374101
Cited by: 436
References: 71
Citations by year: 2026: 21 · 2025: 36 · 2024: 41 · 2023: 39 · 2022: 56 · 2021: 56 · 2020: 77 · 2019: 62 · 2018: 40 · 2017: 7
FWCI: 6.56
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Crohn s and Colitis (publishedVersion)
PubMed (publishedVersion)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Funders: Cancer Institute NSW
Medical Research Council
National Health and Medical Research Council
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords: fecal microbiota transplantation, inflammatory bowel disease
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Colitis, Ulcerative, Crohn Disease, Humans, Inflammatory Bowel Diseases, Treatment Outcome

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Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

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