Microbiota, microbial metabolites, and barrier function in a patient with anorexia nervosa after fecal microbiota transplantation
Open accessAbstract
The change in the gut microbiome and microbial metabolites in a patient suffering from severe and enduring anorexia nervosa (AN) and diagnosed with small intestinal bacterial overgrowth syndrome (SIBO) was investigated. Microbial gut dysbiosis is associated with both AN and SIBO, and therefore gut microbiome changes by serial fecal microbiota transplantation (FMT) is a possible therapeutic modality. This study assessed the effects of FMT on gut barrier function, microbiota composition, and the levels of bacterial metabolic products. The patient treatment with FMT led to the improvement of gut barrier function, which was altered prior to FMT. Very low bacterial alpha diversity, a lack of beneficial bacteria, together with a great abundance of fungal species were observed in the patient stool sample before FMT. After FMT, both bacterial species richness and gut microbiome evenness increased in the patient, while the fungal alpha diversity decreased. The total short-chain fatty acids (SCFAs) levels (molecules presenting an important source of energy for epithelial gut cells) gradually increased after FMT. Contrarily, one of the most abundant intestinal neurotransmitters, serotonin, tended to decrease throughout the observation period. Overall, gut microbial dysbiosis improvement after FMT was considered. However, there were no signs of patient clinical improvement. The need for an in-depth analysis of the donor´s stool and correct selection pre-FMT is evident.
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Microbial metabolites have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.
“Further, they have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.73,74”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [74]
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- Authors
- Prochazkova, P., Roubalova, R., Dvorak, J., Tlaskalova-Hogenova, H., Cermakova, M., Tomasova, P., Sediva, B., Kuzma, M., Bulant, J., Bilej, M., Hrabak, P., Meisnerova, E., Lambertova, A., & Papezova, H.
- Affiliations
- Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, 142 20 Prague 4, Czech Republic
- Czech Academy of Sciences (CZ)
- Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, 142 20 Prague 4, Czech Republic
- Charles University (CZ)
- Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, 121 08 Prague 2, Czech Republic
- Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, 121 08 Prague 2, Czech Republic
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2019-09-10
- Volume
- 7
- Issue
- 9
- Pages
- 338
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC6780752
- OpenAlex
- W2973142894
- Cited by
- 93
- References
- 52
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 17 · 2022: 23 · 2021: 18 · 2020: 4 · 2019: 1
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Digital Library (University of West Bohemia) (submittedVersion, cc-by)
- Funders
- MINISTRY OF HEALTH OF THE CZECH REPUBLIC (17-28905A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- anorexia nervosa, fecal microbiota transplantation, small intestinal bacterial overgrowth, gut dysbiosis, intestinal barrier, short-chain fatty acids, serotonin, microbial metabolites, fungal diversity, alpha diversity, donor selection
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