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Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Abstract
AIMS: To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation. METHODS AND RESULTS: We performed a 20 week standardized exercise training programme in 652 sedentary healthy white and black men and women. C-reactive protein was measured with a high sensitivity assay. The study sample was stratified according to baseline C-reactive protein levels using a recommended classification (low <1.0 mg/L, n=265; moderate 1.0-3.0 mg/L, n=225; high >3.0 mg/L, n=162). The median C-reactive protein reduction was 1.34 mg/L in the high baseline C-reactive protein group. C-reactive protein levels did not change in the low or moderate baseline C-reactive protein groups. The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P<0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P<0.001). The C-reactive protein reduction in the high baseline C-reactive protein group was consistent across all population groups (P<0.001 for difference among baseline C-reactive protein groups). CONCLUSION: Plasma C-reactive protein levels are reduced in response to exercise training in sedentary healthy adults with high initial C-reactive protein levels. This finding may partly explain the effectiveness of regular physical activity in the prevention and treatment of cardiovascular and metabolic diseases.
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“In another study, low plasma vitamin C concentrations were related to central fat distribution, independent of BMI (758) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [758]
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Metadata
- Authors
- Lakka, T. A., Lakka, H.-M., Rankinen, T., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C.
- Affiliations
- Pennington Biomedical Research Center (US)
- Louisiana State University (US)
- Washington University in St. Louis (US)
- Indiana University Bloomington (US)
- Texas A&M University (US)
- Corresponding author
- Lakka, Timo A.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-06-29
- Volume
- 26
- Issue
- 19
- Pages
- 2018-2025
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2144871493
- Cited by
- 206
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 10 · 2020: 3 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Centers for Disease Control and Prevention
- National Heart, Lung, and Blood Institute (R01HL047327, HL 47321, HL 45670, HL47323, R01HL047317, HL 47327, R01HL047323, HL47317, R01HL045670, R01HL047321)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- C-reactive protein, exercise training, inflammation, sedentary adults, high-sensitivity C-reactive protein, cardiovascular disease prevention, metabolic disorders, physical activity, HERITAGE Family Study
- MeSH terms
- Adult, Aged, Blood, C-Reactive Protein, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Exercise, Risk Reduction Behavior, Black People, White People
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