Cited by 206Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesPhysical Activity and Health

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Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study

Lakka, Timo A., Lakka, Hanna-Maaria, Rankinen, Tuomo, Leon, Arthur S., Rao, D.C., Skinner, James S., Wilmore, Jack H., Bouchard, Claude·2005·European Heart Journal

DOI 10.1093/eurheartj/ehi394

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Abstract

AIMS: To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation. METHODS AND RESULTS: We performed a 20 week standardized exercise training programme in 652 sedentary healthy white and black men and women. C-reactive protein was measured with a high sensitivity assay. The study sample was stratified according to baseline C-reactive protein levels using a recommended classification (low <1.0 mg/L, n=265; moderate 1.0-3.0 mg/L, n=225; high >3.0 mg/L, n=162). The median C-reactive protein reduction was 1.34 mg/L in the high baseline C-reactive protein group. C-reactive protein levels did not change in the low or moderate baseline C-reactive protein groups. The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P<0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P<0.001). The C-reactive protein reduction in the high baseline C-reactive protein group was consistent across all population groups (P<0.001 for difference among baseline C-reactive protein groups). CONCLUSION: Plasma C-reactive protein levels are reduced in response to exercise training in sedentary healthy adults with high initial C-reactive protein levels. This finding may partly explain the effectiveness of regular physical activity in the prevention and treatment of cardiovascular and metabolic diseases.

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Authors: Lakka, T. A., Lakka, H.-M., Rankinen, T., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C.
Affiliations: Pennington Biomedical Research Center (US)
Louisiana State University (US)
Washington University in St. Louis (US)
Indiana University Bloomington (US)
Texas A&M University (US)
Corresponding author: Lakka, Timo A.
ORCID: Lakka, Timo A.
Rao, D.C.
Skinner, James S.
Bouchard, Claude
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2005-06-29
Volume: 26
Issue: 19
Pages: 2018-2025
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehi394
OpenAlex: W2144871493
Cited by: 206
References: 49
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 10 · 2020: 3 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 6 · 2013: 9 · 2012: 10
FWCI: 17.33
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Centers for Disease Control and Prevention
National Heart, Lung, and Blood Institute (R01HL047327, HL 47321, HL 45670, HL47323, R01HL047317, HL 47327, R01HL047323, HL47317, R01HL045670, R01HL047321)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: C-reactive protein, exercise training, inflammation, sedentary adults, high-sensitivity C-reactive protein, cardiovascular disease prevention, metabolic disorders, physical activity, HERITAGE Family Study
MeSH terms: Adult, Aged, Blood, C-Reactive Protein, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Exercise, Risk Reduction Behavior, Black People, White People

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Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study

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