Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease
Open accessAbstract
Obesity is becoming the new pediatric epidemic. Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and has become the most common cause of pediatric liver disease. The gut microbiome is the major metabolic organ and determines how calories are processed, serving as a caloric gate and contributing towards the pathogenesis of NAFLD. The goal of this study is to examine gut microbial profiles in children with NAFLD using phylogenetic, metabolomic, metagenomic and proteomic approaches. Fecal samples were obtained from obese children with or without NAFLD and healthy lean children. Stool specimens were subjected to 16S rRNA gene microarray, shotgun sequencing, mass spectroscopy for proteomics and NMR spectroscopy for metabolite analysis. Children with NAFLD had more abundant Gammaproteobacteria and Prevotella and significantly higher levels of ethanol, with differential effects on short chain fatty acids. This group also had increased genomic and protein abundance for energy production with a reduction in carbohydrate and amino acid metabolism and urea cycle and urea transport systems. The metaproteome and metagenome showed similar findings. The gut microbiome in pediatric NAFLD is distinct from lean healthy children with more alcohol production and pathways allocated to energy metabolism over carbohydrate and amino acid metabolism, which would contribute to development of disease.
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Prevotella has been noted to be associated with several disease states.
“Prevotella has been noted to be associated with several disease states.”
From The athletic gut microbiota (2020) · cites this paper as [216]
Prevotella has been shown to be higher in patients with depression, insulin resistance, non-alcoholic fatty liver disease, hypertension, and colon cancer.
“Prevotella has been shown to be higher in patients with depression [214], insulin resistance [215], non-alcoholic fatty liver disease [216, 217], hypertension [217], and colon cancer [218].”
From The athletic gut microbiota (2020) · cites this paper as [216]
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- Authors
- Michail, S., Lin, M., Frey, M. R., Fanter, R., Paliy, O., Hilbush, B., & Reo, N. V.
- Affiliations
- University of Southern California (US)
- Children's Hospital Los Angeles (US)
- Wright State University (US)
- Corresponding author
- Michail, Sonia
- Venue
- FEMS Microbiology Ecology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-05
- Volume
- 91
- Issue
- 2
- Pages
- 1-9
- ISSN
- 0168-6496 (ISSN-L)
- 1574-6941
- PMC
- PMC4358749
- OpenAlex
- W2103563407
- Cited by
- 336
- References
- 56
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 33 · 2023: 31 · 2022: 35 · 2021: 44 · 2020: 52 · 2019: 30 · 2018: 32 · 2017: 17 · 2016: 21 · 2015: 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FEMS Microbiology Ecology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK095004)
- National Center for Complementary and Alternative Medicine
- National Center for Complementary and Integrative Health (R21AT003423, R21AT003400, AT003423)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD065575, R01HD081197, R03HD065575)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- non-alcoholic fatty liver disease, childhood obesity, gut microbiota, energy metabolism, short-chain fatty acids, ethanol production, Gammaproteobacteria, Prevotella, metaproteomics, metagenomics, urea cycle, amino acid metabolism, carbohydrate metabolism
- MeSH terms
- Adolescent, Ethanol, Child, Energy Metabolism, Feces, Humans, Intestines, Male, Obesity, Phylogeny, RNA, Ribosomal, 16S, Prevotella, Gammaproteobacteria, Metagenome, Microbiota, Non-alcoholic Fatty Liver Disease
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