The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans
Abstract
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86–94 years). Immune system measurements consisted of determinations of T-cell subsets, plasma interleukin 6 and cytomegalovirus and Epstein–Barr virus serology. Interleukin 2 responsiveness to concanavalin A, using data from the previous OCTO (octogenarians) immune study, hereafter OCTO immune, was also examined. Cognitive status was rated using a battery of neuropsychological tests. Logistic regression indicated that the IRP and cognitive impairment together predicted 58% of observed deaths. IRP was associated with late differentiated CD8+CD28−CD27− cells (p <.001), decreased interleukin 2 responsiveness (p <.05) and persistent viral infection (p <.01). Cognitive impairment was associated with increased plasma interleukin 6 (p <.001). IRP individuals with cognitive impairment were all deceased at the follow-up, indicating an allostatic overload.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Letter: Hypoglycaemia in propranolol-treated dialysis patients.
Jensen, H. A., Bjaeldager, P., & Broch‐Møller, B. (1976) · PubMed · Cited by 649
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.
Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591
Cited by
Sorted by citations
Items 101–200 of 414
CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells
Pangrazzi, L., Reidla, J., Arana, J. A. C., Naismith, E., Miggitsch, C., Meryk, A., Keller, M., Krause, A. A. N., Melzer, F. L., Trieb, K., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201948362 · Cited by 65
Correa, B. L., Ornaghi, A. P., Müller, G. C., Engroff, P., Lopes, R. P., Filho, I. G. D. S., Bosch, J. A., Bonorino, C., & Bauer, M. E. (2014) · NeuroImmunoModulation · doi:10.1159/000356827 · Cited by 69
Effects of Aging on Immune Function
Stowe, R. P., & Goodwin, J. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-6999-6_4 · Cited by 68
Trzonkowski, P., Dębska-Ślizień, A. M., Jankowska, M., Wardowska, A., Carvalho‐Gaspar, M., Hak, Ł., Moszkowska, G., Bzoma, B., Mills, N., Wood, K. J., et al. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.006 · Cited by 68
Nuclear factor‐κB‐dependent reversal of aging‐induced alterations in T cell cytokines
Huang, M., Liao, J., Bonasera, S. J., Longo, D. L., & Goetzl, E. J. (2008) · The FASEB Journal · doi:10.1096/fj.07-103721 · Cited by 68
PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit
Aiello, A. E., Dowd, J. B., Jayabalasingham, B., Feinstein, L., Uddin, M., Simanek, A. M., Cheng, C. K., Galea, S., Wildman, D. E., Koenen, K., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.024 · Cited by 66
Self-citationCaruso, C. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s72 · Cited by 68
Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 66
Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans
Bayard, C., Lepetitcorps, H., Roux, A., Larsen, M., Fastenackels, S., Salle, V., Vieillard, V., Marchant, A., Stern, M., Boddaert, J., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546179 · Cited by 65
Trzonkowski, P., Myśliwska, J. M., Pawelec, G., & Myśliwski, A. (2008) · Biogerontology · doi:10.1007/s10522-008-9155-5 · Cited by 64
Self-citationArens, R., Loewendorf, A. I., Redeker, A., Sierro, S. R., Boon, L., Klenerman, P., Benedict, C. A., & Schoenberger, S. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003231 · Cited by 57
Arranz, L., Caamaño, J., Lord, J. M., & de la Fuente, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq101 · Cited by 60
Normal Values of T, B and NK Lymphocyte Subpopulations in Peripheral Blood of Healthy Cuban Adults
Kokuina, E., Breff-Fonseca, M. C., Valverde, C. A. V., & Díaz, I. M. (2019) · MEDICC Review · doi:10.37757/mr2019.v21.n2-3.5 · Cited by 59
Herpesvirus reactivation and socioeconomic position: a community-based study
Stowe, R. P., Peek, M. K., Pérez, N. A., Yetman, D. L., Cutchin, M. P., & Goodwin, J. S. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2008.078808 · Cited by 59
Ng, T. P., Camous, X., Nyunt, M. S. Z., Vasudev, A., Tan, C. T. Y., Feng, L., Fulop, T., Yap, K. B., & Larbi, A. (2015) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2015.5 · Cited by 58
Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging
Garrido, A., Cruces, J., Ceprián, N., Vara, E., & la Fuente, M. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030769 · Cited by 59
Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort
Dowd, J. B., Bosch, J. A., Steptoe, A., Jayabalasingham, B., Lin, J., Yolken, R. H., & Aiello, A. E. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix255 · Cited by 56
Bolton, C., & Smith, P. A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.005 · Cited by 59
How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19
Müller, L., & Benedetto, S. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212539 · Cited by 58
Elmezayen, R., Gazzar, M. E., Myer, R. G., & High, K. P. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00502.x · Cited by 57
Lee, S. A., Sinclair, E., Jain, V., Huang, Y., Epling, L., Natta, M. L. V., Meinert, C. L., Martin, J. N., McCune, J. M., Deeks, S. G., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu109 · Cited by 54
Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management
Tannou, T., Koeberle, S., Manckoundia, P., & Aubry, R. (2019) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2019.01.012 · Cited by 54
Immunosenescence, suppression and tumour progression
Pawelec, G., Koch, S. D., Griesemann, H., Rehbein, A., Hähnel, K., & Gouttefangeas, C. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0109-3 · Cited by 54
Self-citationCampos, C., López, N., Pera, A., Gordillo, J. J., Hassouneh, F., Tarazona, R., & Solana, R. (2015) · Biogerontology · doi:10.1007/s10522-015-9581-0 · Cited by 54
An immunologist’s guide to immunosenescence and its treatment
Caruso, C., Ligotti, M. E., Accardi, G., Aiello, A., & Candore, G. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2106217 · Cited by 53
Poschke, I. C., de Boniface, J., Mao, Y., & Kiessling, R. W. (2011) · International Journal of Cancer · doi:10.1002/ijc.27410 · Cited by 53
Intracellular signalling pathways: targets to reverse immunosenescence
Fülöp, T., Witkowski, J. M., Page, A. Y. L., Fortin, C. F., Pawelec, G., & Larbi, A. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12836 · Cited by 54
Self-citationDerhovanessian, E., & Pawelec, G. (2012) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2011.00283.x · Cited by 51
Self-citationActivation-induced and damage-induced cell death in aging human T cells
Sikora, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.011 · Cited by 50
The impact of sex and age on T cell immunity and ischemic stroke outcomes
Ahnstedt, H. W., & McCullough, L. D. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103960 · Cited by 52
Lang, A. M., Brien, J. D., & Nikolich‐Žugich, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801117 · Cited by 50
Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice
Arranz, L., Lord, J. M., & la Fuente, M. D. (2010) · AGE · doi:10.1007/s11357-010-9151-y · Cited by 50
Is There a Positive Side to T Cell Exhaustion?
Pawelec, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00111 · Cited by 50
Self-citationPeters, T., Weiss, J. M., Sindrilaru, A., Wang, H., Oreshkova, T., Wlaschek, M., Maity, P., Reimann, J., & Scharffetter‐Kochanek, K. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.07.003 · Cited by 51
Chen, S., Pawelec, G., Trompet, S., Goldeck, D., Mortensen, L. H., Slagboom, P. E., Christensen, K., Gussekloo, J., Kearney, P. M., Buckley, B. M., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa480 · Cited by 49
Self-citationInfection, Rejection, and the Connection
Higdon, L. E., Tan, J. C., & Maltzman, J. S. (2022) · Transplantation · doi:10.1097/tp.0000000000004297 · Cited by 53
Peralbo, E., DelaRosa, O., Gayoso, I., Pita, M. L., Tarazona, R., & Solana, R. (2006) · Biogerontology · doi:10.1007/s10522-006-9063-5 · Cited by 47
Alam, I., Goldeck, D., Larbi, A., & Pawelec, G. (2012) · AGE · doi:10.1007/s11357-012-9455-1 · Cited by 47
Self-citationMartorana, A., Balistreri, C. R., Bulati, M., Buffa, S., Azzarello, D. M., Camarda, C., Monastero, R., Caruso, C., & Colonna‐Romano, G. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.003 · Cited by 47
Vallejo, A. N., Hamel, D. L., Mueller, R. G., Ives, D. G., Michel, J. J., Boudreau, R. M., & Newman, A. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026558 · Cited by 45
Does the human immune system ever really become “senescent”?
Pawelec, G. (2017) · F1000Research · doi:10.12688/f1000research.11297.1 · Cited by 45
Self-citationT-Cell Senescence in Human Metabolic Diseases
Nga, H. T., Nguyen, T. L., & Yi, H. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0140 · Cited by 47
Lang, A. M., Brien, J. D., Messaoudi, I., & Nikolich‐Žugich, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4848 · Cited by 45
Emu, B., Moretto, W. J., Hoh, R., Krone, M., Martin, J. N., Nixon, D. F., Deeks, S. G., & McCune, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085613 · Cited by 45
Immune senescence in aged nonhuman primates☆
Haberthur, K., Engelmann, F., Barron, A., & Messaoudi, I. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.06.001 · Cited by 46
Vasto, S., Malavolta, M., & Pawelec, G. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-2 · Cited by 45
Self-citationPfister, G., & Savino, W. (2008) · NeuroImmunoModulation · doi:10.1159/000156477 · Cited by 44
Immunologic resilience and COVID-19 survival advantage
Lee, G. C., Restrepo, M. I., Harper, N., Manoharan, M. S., Smith, A. M., Meunier, J. A., Sanchez-Reilly, S. E., Ehsan, A., Branum, A. P., Winter, C., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.08.021 · Cited by 44
Terminally Differentiated CD4+ T Cells Promote Myocardial Inflammaging
Delgobo, M., Heinrichs, M., Hapke, N., Ashour, D., Appel, M., Srivastava, M., Heckel, T., Spyridopoulos, I., Hofmann, U., Frantz, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.584538 · Cited by 43
Arnold, C. R., Pritz, T., Brunner, S., Knabb, C., Salvenmoser, W., Holzwarth, B., Thedieck, K., & Grubeck-Loebenstein, B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.018 · Cited by 42
Pablo-Bernal, R. S. D., Cañizares, J., Rosado‐Sánchez, I., Galvá, M. I., Álvarez‐Ríos, A. I., Carrillo‐Vico, A., Ferrando‐Martínez, S., Muñoz‐Fernández, M. Á., Benhnia, M. R., Pacheco, Y. M., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv121 · Cited by 42
Regulatory function of cytomegalovirus-specific CD4+CD27−CD28− T cells
Tovar-Salazar, A., Patterson‐Bartlett, J., Jesser, R. D., & Weinberg, A. (2009) · Virology · doi:10.1016/j.virol.2009.11.038 · Cited by 42
Tan, J., Ren, J., Fan, L., Wei, Y., Hu, S., Zhu, S., Yang, Y., & Cai, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.884298 · Cited by 42
Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity
Lindau, P., Mukherjee, R., Gutschow, M. V., Vignali, M., Warren, E. H., Riddell, S. R., Makar, K. W., Turtle, C. J., & Robins, H. S. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800217 · Cited by 42
Neuroendocrine and viral correlates of premature immunosenescence
Bauer, M. E., Wieck, A., Petersen, L. E., & Baptista, T. S. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12786 · Cited by 43
Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging
Michel, J. J., Griffin, P. C., & Vallejo, A. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00530 · Cited by 44
Immunosénescence et infections, mythe ou réalité ?
Crétel, E., Veen, I. D. G.-V., Pierrès, A., Bongrand, P., & Gavazzi, G. (2010) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2009.12.008 · Cited by 38
The human immunosenescence phenotype: does it exist?
Pawelec, G. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00810-3 · Cited by 40
Self-citationDuchemann, B., Naigeon, M., Auclin, É., Ferrara, R., Cassard, L., Jouniaux, J.-M., Boselli, L., Grivel, J., Desnoyer, A., Danlos, F., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004012 · Cited by 42
The interplay between immune maturation, age, chronic viral infection and environment
Oxford, K. L., Pena-Ponce, M. G. D., Jensen, K., Eberhardt, M. K., Spinner, A., Rompay, K. K. A. V., Rigdon, J., Mollan, K. R., Krishnan, V., Hudgens, M. G., et al. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0030-3 · Cited by 37
Immunological hurdles of ageing: Indispensable research of the human model
Vallejo, A. N. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.005 · Cited by 36
Vida, C., Kobayashi, H., Garrido, A., de Toda, I. M., Carro, E., Molina, J. A., & la Fuente, M. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030771 · Cited by 36
Villar, S. S., Wu, K., Hunt, P. W., Lok, J. J., Ron, R., Sainz, T., Moreno, S., Deeks, S. G., & Bosch, R. J. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104072 · Cited by 38
Thorstensson, H., & Johansson, B. E. A. (2009) · Community Dentistry And Oral Epidemiology · doi:10.1111/j.1600-0528.2009.00467.x · Cited by 35
Self-citationMorrison, F. G., Logue, M. W., Guetta, R. E., Maniates, H., Stone, A., Schichman, S. A., McGlinchey, R. E., Milberg, W., Miller, M. W., & Wolf, E. J. (2019) · Aging · doi:10.18632/aging.101992 · Cited by 39
Angel, C. J. L., Pham, E. A., Du, H., Vallania, F., Fram, B. J., Pérez, K., Nguyen, T., Rosenberg‐Hasson, Y., Ahmed, A., Dekker, C. L., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022928118 · Cited by 35
Belisle, S. E., Hamer, D. H., Leka, L. S., Dallal, G. E., Delgado‐Lista, J., Fine, B. C., Jacques, P. F., Ordovás, J. M., & Meydani, S. N. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29207 · Cited by 34
B7-Mediated Costimulation of CD4 T Cells Constrains Cytomegalovirus Persistence
Arens, R., Loewendorf, A. I., Her, M. J., Schneider, K., SHELLAM, G. R., Janssen, E. M., Ware, C. F., Schoenberger, S. P., & Benedict, C. A. (2010) · Journal of Virology · doi:10.1128/jvi.01839-10 · Cited by 34
Jais, M., Younes, N., Chapman, S., Cu‐Uvin, S., & Ghosh, M. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.03.041 · Cited by 33
Thymic Function Impacts the Peripheral CD4/CD8 Ratio of HIV-Infected Subjects
Rosado‐Sánchez, I., Herrero-Fernández, I., Genebat, M., Ruíz-Mateos, E., Leal, M., & Pacheco, Y. M. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw711 · Cited by 33
Almajwal, A. M., Alam, I., Abulmeaty, M. M. A., Razak, S., Pawelec, G., & Alam, W. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1389 · Cited by 33
Self-citationVaccination in the Elderly: What Can Be Recommended?
Lang, P. O., & Aspinall, R. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0193-1 · Cited by 33
Bernal, E., Serrano, J. J., Muñoz, Á., Marín, I., Masiá, M., Gutiérrez, F., & Cano, A. (2016) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2015.0385 · Cited by 33
Frailty in People Living with HIV
Falutz, J. (2020) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00494-2 · Cited by 32
Stebbins, R. C., Noppert, G. A., Yang, Y. C., Dowd, J. B., Simanek, A. M., & Aiello, A. E. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa238 · Cited by 31
Saracino, A., Bruno, G., Scudeller, L., Volpe, A. R., Caricato, P., Ladisa, N., Monno, L., & Angarano, G. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0080 · Cited by 32
Elite controllers long-term non progressors present improved survival and slower disease progression
Capa, L., Ayala-Suárez, R., Tarazona, E. D. L. T., González‐García, J., del Romero, J., Alcamı́, J., & Díez‐Fuertes, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-19970-3 · Cited by 32
Poloni, C., Szyf, M., Cheishvili, D., & Tsoukas, C. M. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab365 · Cited by 32
Goldeck, D., Pawelec, G., Norman, K., Steinhagen-Thiessen, E., Oettinger, L., Haehnel, K., & Demuth, I. (2016) · Biogerontology · doi:10.1007/s10522-015-9577-9 · Cited by 30
Self-citationTRIB2 safeguards naive T cell homeostasis during aging
Cao, W., Sturmlechner, I., Zhang, H., Jin, J., Hu, B., Jadhav, R. R., Fang, F., Weyand, C. M., & Goronzy, J. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112195 · Cited by 33
Licastro, F., Carbone, I., Raschi, E., & Porcellini, E. (2014) · Immunity & Ageing · doi:10.1186/s12979-014-0022-8 · Cited by 30
Cytomegalovirus driven immunosenescence—An immune phenotype with or without clinical impact?
Söderberg‐Nauclér, C., Fornara, O., & Rahbar, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.005 · Cited by 30
Ghosh, M., Daniels, J., Pyra, M. N., Juzumaite, M., Jais, M., Murphy, K., Taylor, T., Kassaye, S., Benning, L., Cohen, M. H., et al. (2018) · Europe PMC (PubMed Central) · doi:10.1371/journal.pone.0198412 · Cited by 32
Assessments of frailty in bladder cancer
Grimberg, D. C., Shah, A., Molinger, J., Whittle, J., Gupta, R. T., Wischmeyer, P. E., McDonald, S. R., & Inman, B. A. (2020) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2020.04.036 · Cited by 28
Sharma, R., & Padwad, Y. S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101141 · Cited by 27
Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant
Higdon, L. E., Gustafson, C. E., Ji, X., Sahoo, M. K., Pinsky, B. A., Margulies, K. B., Maecker, H. T., Goronzy, J. J., & Maltzman, J. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661551 · Cited by 30
Dinh, H. C., Bautmans, I., Beyer, I., Mets, T. F., Onyema, O. O., Forti, L. N., Renmans, W., Meeren, S. V., Jochmans, K., Vermeiren, S., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly135 · Cited by 28
Mazzatti, D. J., White, A., Forsey, R. J., Powell, J. R., & Pawelec, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00269.x · Cited by 28
Self-citationMazzatti, D. J., Pawelec, G., Longdin, R., Powell, J. R., & Forsey, R. J. (2007) · Proteome Science · doi:10.1186/1477-5956-5-7 · Cited by 28
Self-citationCantisán, S., Torre-Cisneros, J., Lara, R., Rodríguez-Benot, A., Santos, F., Gutiérrez-Aroca, J., Gayoso, I., González-Padilla, M., Casal, M., Rivero, A., et al. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00214-09 · Cited by 27
Cantisán, S., Torre‐Cisneros, J., Lara, R., Zárraga, S., Montejo, M., & Solana, R. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls130 · Cited by 27
CD28−CD8+ T cells do not contain unique clonotypes and are therefore dispensable
Weinberger, B., Welzl, K., Herndler‐Brandstetter, D., Parson, W., & Grubeck‐Loebenstein, B. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.08.008 · Cited by 26
Zheng, H., Zhang, M., Pang, W., & Zheng, Y. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.04.004 · Cited by 27
Reed, R. G., Al‐Attar, A., Presnell, S. R., Lutz, C. T., & Segerstrom, S. C. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.03.006 · Cited by 27
Hasselmo, K., Mehl, M. R., Tackman, A. M., Carey, A. L., Wertheimer, A. M., Stowe, R. P., & Sbarra, D. A. (2018) · Annals of Behavioral Medicine · doi:10.1093/abm/kax034 · Cited by 28
Castilho, J. L., Turner, M. M., Shepherd, B. E., Koethe, J. R., Furukawa, S. S., Bofill, C., Raffanti, S. P., & Sterling, T. R. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0064 · Cited by 26
Maté, I., Cruces, J., Giménez‐Llort, L., & la Fuente, M. D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140861 · Cited by 28
Pozzo, E. D., Giacomelli, C., Cavallini, C., & Martini, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200924 · Cited by 25
Reed, R. G., Presnell, S. R., Al‐Attar, A., Lutz, C. T., & Segerstrom, S. C. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.018 · Cited by 26
Immunosenescence and Vaccination
Pawelec, G. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-16 · Cited by 25
Self-citation
Metadata
- Authors
- Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B.
- Affiliations
- Jönköping University (SE)
- Corresponding author
- Wikby, Anders
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-01
- Volume
- 60
- Issue
- 5
- Pages
- 556-565
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2153840275
- Cited by
- 407
- References
- 57
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 14 · 2021: 22 · 2020: 20 · 2019: 30 · 2018: 22 · 2017: 30 · 2016: 29 · 2015: 18 · 2014: 27 · 2013: 18 · 2012: 21
- FWCI
- 23.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- allostatic load, cognitive impairment, survival, octogenarians, nonagenarians, interleukin-2 responsiveness, interleukin-6, cytomegalovirus serology, Epstein-Barr virus serology, viral persistence, T cell subsets, mortality prediction, oldest old
- MeSH terms
- Aged, Aged, 80 and over, Aging, Analysis of Variance, Cognition Disorders, Female, Health Status Indicators, Humans, Interleukin-2, Life Expectancy, Longevity, Longitudinal Studies, Male, Phenotype, Probability, Sweden, Cohort Studies, Geriatric Assessment, Antigens, CD, Interleukin-6, Survival Rate, CD4-CD8 Ratio, Immunocompromised Host, Risk Assessment, Statistics, Nonparametric
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review