No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study

Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474 · see citing works

Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly

Hadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B. E. A., Pawelec, G., Straten, P. T., & Wikby, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2645 · Cited by 471 · see citing works

Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study

Wikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414 · see citing works

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works

Human immunosenescence: is it infectious?

Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405 · see citing works

Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors

Ferguson, F. G., Wikby, A., Maxson, P., Olsson, J., & Johansson, B. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.b378 · Cited by 378 · see citing works

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence

Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 1× · see citing works

Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study

Wikby, A., Maxson, P., Olsson, J., Johansson, B. E. A., & Ferguson, F. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00151-6 · Cited by 377 · see citing works

Aging and Innate Immunity

Solana, R., Pawelec, G., & Tarazona, R. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.003 · Cited by 313 · see citing works

Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60

Wayne, S. J., Rhyne, R. L., Garry, P. J., & Goodwin, J. S. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.2.m45 · Cited by 303 · cited 1× · see citing works

The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning

Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284 · see citing works

Chronic herpesvirus reactivation occurs in aging

Stowe, R., KOZLOVA, E., Yetman, D. L., Walling, D. M., Goodwin, J. S., & Glaser, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.005 · Cited by 279 · see citing works

Large Numbers of Dysfunctional CD8+ T Lymphocytes Bearing Receptors for a Single Dominant CMV Epitope in the Very Old

Ouyang, Q., Wagner, W. M., Wikby, A., Walter, S., Aubert, G., Dodi, A. I., Travers, P. J., & Pawelec, G. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1024580531705 · Cited by 239 · see citing works

Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

DelaRosa, O., Pawelec, G., Peralbo, E., Wikby, A., Mariani, E., Mocchegiani, E., Tarazona, R., & Solana, R. (2006) · Biogerontology · doi:10.1007/s10522-006-9062-6 · Cited by 150 · see citing works

Absolute Peripheral Blood Lymphocyte Count and Subsequent Mortality of Elderly Men

Bender, B. S., Nagel, J. E., Adler, W. H., & Andres, R. (1986) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1986.tb04906.x · Cited by 110 · see citing works

Human Immunosenescence

Pawelec, G., Koch, S. D., Franceschi, C., & Wikby, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.009 · Cited by 94 · see citing works

Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols

Nilsson, B.-O., Ernerudh, J., Johansson, B. E. A., Evrin, P., Löfgren, S., Ferguson, F. G., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00024-1 · Cited by 87 · see citing works

Living longer — but better?

Jeune, B. (2002) · Aging Clinical and Experimental Research · doi:10.1007/bf03324421 · Cited by 76 · see citing works

From Hayflick to Walford: the role of T cell replicative senescence in human aging

Effros, R. B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.03.004 · Cited by 61 · see citing works

The OCTO and NONA immune longitudinal studies: a review of 11 years studies of Swedish very old humans

Wikby, A., Johansson, B. E. A., & Ferguson, F. G. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13001-x · Cited by 18 · see citing works

HIV Infection, Inflammation, Immunosenescence, and Aging

Deeks, S. G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042909-093756 · Cited by 1,349 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

Age and immunity: What is “immunosenescence”?

Pawelec, G. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.024 · Cited by 606 · see citing works

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603 · see citing works

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell · doi:10.1111/acel.13028 · Cited by 477 · see citing works

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works

Human T Cell Aging and the Impact of Persistent Viral Infections

Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works

Cytomegalovirus and human immunosenescence

Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339 · see citing works

Aging, melatonin, and the pro- and anti-inflammatory networks

Hardeland, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051223 · Cited by 337 · see citing works

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.029 · Cited by 333 · see citing works

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

Hardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 285 · see citing works

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

Naylor, R. M., Baker, D. J., & van Deursen, J. M. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.193 · Cited by 280 · see citing works

Human T cell immunosenescence and inflammation in aging

Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0716-335r · Cited by 270 · see citing works

The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20–100 years of age

Wikby, A., Månsson, I. A., Johansson, B. E. A., Strindhall, J., & Nilsson, S. E. (2008) · Biogerontology · doi:10.1007/s10522-008-9138-6 · Cited by 259 · see citing works

Hallmarks of human “immunosenescence”: adaptation or dysregulation?

Pawelec, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-15 · Cited by 257 · see citing works

Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals

Chidrawar, S. M., Khan, N., Wei, W., McLarnon, A., Smith, N., Nayak, L., & Moss, P. A. H. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03785.x · Cited by 244 · see citing works

Cytomegalovirus Infection: A Driving Force in Human T Cell Immunosenescence

KOCH, S., LARBI, A., ÖZCELIK, D., SOLANA, R., GOUTTEFANGEAS, C., ATTIG, S., WIKBY, A., STRINDHALL, J., FRANCESCHI, C., & PAWELEC, G. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.043 · Cited by 242 · see citing works

CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV‐positive patients

Lu, W., Mehraj, V., Vyboh, K., Cao, W., Li, T., & Routy, J. (2015) · Journal of the International AIDS Society · doi:10.7448/ias.18.1.20052 · Cited by 228 · see citing works

Biomarkers of human immunosenescence: impact of cytomegalovirus infection

Derhovanessian, E., Larbi, A., & Pawelec, G. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.012 · Cited by 220 · see citing works

Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219531 · Cited by 208 · see citing works

Slower immune system aging in women versus men in the Japanese population

Hirokawa, K., Utsuyama, M., Hayashi, Y., Kitagawa, M., Makinodan, T., & Fulop, T. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-19 · Cited by 186 · see citing works

A Natural Product Telomerase Activator As Part of a Health Maintenance Program

Harley, C. B., Liu, W., Blasco, M. A., Vera, E., Andrews, W. H., Briggs, L., & Raffaele, J. M. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1085 · Cited by 196 · see citing works

Immunosenescence and Immunogenetics of Human Longevity

Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 188 · see citing works

Melatonin and brain inflammaging

Hardeland, R., Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.02.001 · Cited by 186 · see citing works

Senescence of the Human Immune System

Pawelec, G., Larbi, A., & Derhovanessian, E. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.09.005 · Cited by 180 · see citing works

Immunosenenescence: role of cytomegalovirus

Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163 · see citing works

Cytomegalovirus and HIV: A Dangerous Pas de Deux

Gianella, S., & Letendre, S. L. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw217 · Cited by 146 · see citing works

Neutrophils in aging and aging‐related pathologies

Avondt, K. V., Strecker, J., Tulotta, C., Minnerup, J., Schulz, C., & Soehnlein, O. (2022) · Immunological Reviews · doi:10.1111/imr.13153 · Cited by 146 · see citing works

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Cicin-Sain, L., Brien, J. D., Uhrlaub, J. L., Drabig, A., Marandu, T. F., & Nikolich-Zugich, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002849 · Cited by 126 · see citing works

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

Cardinali, D. P., & Hardeland, R. (2016) · Neuroendocrinology · doi:10.1159/000446543 · Cited by 131 · see citing works

Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

Martin-Ruiz, C. M., Jagger, C., Kingston, A., Collerton, J. C., Catt, M., Davies, K., Dunn, M., Hilkens, C. M. U., Keavney, B. D., Pearce, S. H. S., et al. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.08.001 · Cited by 125 · see citing works

The role of melatonin, a multitasking molecule, in retarding the processes of ageing

Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 123 · see citing works

Tracing thymic output in older individuals

Mitchell, W. A., Lang, P.-O., & Aspinall, R. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04209.x · Cited by 114 · see citing works

From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”

Bulati, M., Caruso, C., & Colonna‐Romano, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.001 · Cited by 113 · see citing works

Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing

Wang, Y., Yu, X.-H., Luo, S., & Han, H. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0042-z · Cited by 111 · see citing works

Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection

Freeman, M. L., Lederman, M. M., & Gianella, S. (2016) · Current HIV/AIDS Reports · doi:10.1007/s11904-016-0297-9 · Cited by 112 · see citing works

Exceptional Human Longevity

Pignolo, R. J. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.10.005 · Cited by 108 · see citing works

Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans

Ferrando‐Martínez, S., Romero-Sánchez, M. C., Solana, R., Delgado, J., de la Rosa, R., Muñoz‐Fernández, M. Á., Ruíz-Mateos, E., & Leal, M. (2011) · AGE · doi:10.1007/s11357-011-9341-2 · Cited by 107 · see citing works

Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients

Meijers, R. W. J., Litjens, N. H. R., de Wit, E. A., Langerak, A. W., van der Spek, A., Baan, C. C., Weimar, W., & Betjes, M. G. H. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-19 · Cited by 106 · see citing works

HSC Aging and Senescent Immune Remodeling

Denkinger, M. D., Leins, H., Schirmbeck, R., Florian, M. C., & Geiger, H. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.008 · Cited by 105 · see citing works

Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging

Lee, S. A., Sinclair, E., Hatano, H., Hsue, P. Y., Epling, L., Hecht, F. M., Bangsberg, D. R., Martin, J. N., McCune, J. M., Deeks, S. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089444 · Cited by 102 · see citing works

Immunosenescence and Vaccination in Nursing Home Residents

Fülöp, T., Pawelec, G., Castle, S. C., & Loeb, M. B. (2009) · Clinical Infectious Diseases · doi:10.1086/596475 · Cited by 102 · see citing works

Aging, immune senescence, and immunotherapy: a comprehensive review

Elias, R., Hartshorn, K., Rahma, O., Lin, N., & Snyder-Cappione, J. E. (2018) · Seminars in Oncology · doi:10.1053/j.seminoncol.2018.08.006 · Cited by 96 · see citing works

Immunity and ageing in man: Annual review 2006/2007

Pawelec, G., & Larbi, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.09.009 · Cited by 94 · see citing works

The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process

Andrade, B., Jara‐Gutiérrez, C., Paz-Araos, M., Vázquez, M. C., Díaz, P., & Murgas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315182 · Cited by 92 · see citing works

Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise

Turner, J. E., Aldred, S., Witard, O. C., Drayson, M. T., Moss, P. M., & Bosch, J. A. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.07.239 · Cited by 90 · see citing works

Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair

Elyahu, Y., & Monsonego, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101231 · Cited by 91 · see citing works

Residual immune dysfunction under antiretroviral therapy

Cai, C. W., & Sereti, I. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101471 · Cited by 80 · see citing works

Multiparametric Bioinformatics Distinguish the CD4/CD8 Ratio as a Suitable Laboratory Predictor of Combined T Cell Pathogenesis in HIV Infection

Buggert, M., Frederiksen, J., Noyan, K., Svärd, J., Barqasho, B., Sönnerborg, A. B., Lund, O., Nowak, P., & Karlsson, A. C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302596 · Cited by 76 · see citing works

Epigenomic drivers of immune dysfunction in aging

Keenan, C. R., & Allan, R. S. (2018) · Aging Cell · doi:10.1111/acel.12878 · Cited by 76 · see citing works

Impact of aging on viral infections

Leng, J., & Goldstein, D. R. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.08.009 · Cited by 76 · see citing works

Reversing T cell immunosenescence: why, who, and how

Lang, P. O., Govind, S., & Aspinall, R. (2012) · AGE · doi:10.1007/s11357-012-9393-y · Cited by 76 · see citing works

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks

Sorrenti, V., Benedetti, F., Buriani, A., Fortinguerra, S., Caudullo, G., Davinelli, S., Zella, D., & Scapagnini, G. (2022) · Pharmaceuticals · doi:10.3390/ph15080912 · Cited by 78 · see citing works

Immunosenescence, inflammation and Alzheimer’s disease

Martorana, A., Bulati, M., Buffa, S., Pellicanò, M., Caruso, C., Candore, G., & Colonna‐Romano, G. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-8 · Cited by 75 · see citing works

Cytomegalovirus Exposure and Cardiovascular Disease in Kidney Transplant Recipients

Courivaud, C., Bamoulid, J., Chalopin, J., Gaiffe, É., Tiberghien, P., Saas, P., & Ducloux, D. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit064 · Cited by 74 · see citing works

Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice

Finamore, A., Roselli, M., Donini, L. M., Brasili, E., Rami, R., Carnevali, P., Mistura, L., Pinto, A., Giusti, A. M., & Mengheri, E. (2019) · Nutrition · doi:10.1016/j.nut.2019.02.005 · Cited by 74 · see citing works

COVID-19 — Toward a comprehensive understanding of the disease

Kowalik, M. M., Trzonkowski, P., Łasińska-Kowara, M., Mital, A., Smiatacz, T., & Jaguszewski, M. J. (2020) · Cardiology Journal · doi:10.5603/cj.a2020.0065 · Cited by 69 · see citing works

Frequent participation in high volume exercise throughout life is associated with a more differentiated adaptive immune response

Moro-García, M. A., Fernández-García, B., Echeverría, A., Rodríguez-Alonso, M., Suárez-García, F. M., Solano-Jaurrieta, J. J., López-Larrea, C., & Alonso-Arias, R. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.12.014 · Cited by 64 · see citing works

From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly

Trzonkowski, P., Myśliwska, J. M., Pawelec, G., & Myśliwski, A. (2008) · Biogerontology · doi:10.1007/s10522-008-9155-5 · Cited by 64 · see citing works

Vaccine effectiveness in older individuals: What has been learned from the influenza-vaccine experience

Lang, P. O., Govind, S., Mitchell, W. A., Siegrist, C., & Aspinall, R. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.005 · Cited by 63 · see citing works

Thymopoiesis in elderly human is associated with systemic inflammatory status

Ferrando‐Martínez, S., Franco, J. M., Hernández, A., Ordóñez, A., Gutiérrez, E. A., Abad, A., & Leal, M. (2009) · AGE · doi:10.1007/s11357-008-9084-x · Cited by 60 · see citing works

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19

Tan, D. X., & Hardeland, R. (2020) · Molecules · doi:10.3390/molecules25194410 · Cited by 60 · see citing works

Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly

Verschoor, C. P., Loukov, D., Naidoo, A., Puchta, A., Johnstone, J., Millar, J., Lelic, A., Novakowski, K. E., Dorrington, M. G., Loeb, M. B., et al. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.01.015 · Cited by 62 · see citing works

Molecular Mechanisms of Immunosenescene and Inflammaging: Relevance to the Immunopathogenesis and Treatment of Multiple Sclerosis

Perdaens, O., & Pesch, V. V. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.811518 · Cited by 59 · see citing works

Cellular aging and senescence characteristics of human T-lymphocytes

Onyema, O. O., Njemini, R., Bautmans, I., Renmans, W., Waele, M. D., & Mets, T. F. (2011) · Biogerontology · doi:10.1007/s10522-011-9366-z · Cited by 57 · see citing works

The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE)

Bolton, C., & Smith, P. A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.005 · Cited by 57 · see citing works

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

Muller, G. C., Gottlieb, M. G. V., Luz Correa, B., Filho, I. G., Moresco, R. N., & Bauer, M. E. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.05.006 · Cited by 55 · see citing works

Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms

Ventura, M. T., Scichilone, N., Paganelli, R., Minciullo, P. L., Patella, V., Bonini, M., Passalacqua, G., Lombardi, C., Simioni, L., Ridolo, E., et al. (2017) · Clinical and Molecular Allergy · doi:10.1186/s12948-017-0059-2 · Cited by 56 · see citing works

The emerging role of cytomegalovirus in driving immune senescence: a novel therapeutic opportunity for improving health in the elderly

Moss, P. A. H. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.07.001 · Cited by 52 · see citing works

Parameters of the Immune System and Vitamin D Levels in Old Individuals

Alves, A. S., Ishimura, M. E., Duarte, Y. A. D. O., & Bueno, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01122 · Cited by 49 · see citing works

Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity

Peters, T., Weiss, J. M., Sindrilaru, A., Wang, H., Oreshkova, T., Wlaschek, M., Maity, P., Reimann, J., & Scharffetter‐­Kochanek, K. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.07.003 · Cited by 49 · see citing works

Can the Immune System Still Be Efficient in the Elderly? An Immunological and Immunoendocrine Therapeutic Perspective

Pfister, G., & Savino, W. (2008) · NeuroImmunoModulation · doi:10.1159/000156477 · Cited by 44 · see citing works

Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II

Wistuba‐Hamprecht, K., Haehnel, K., Janssen, N., Demuth, I., & Pawelec, G. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0052-x · Cited by 42 · see citing works

Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3

Chen, J., Li, J., Lim, F. C., Wu, Q., Douek, D. C., Scott, D. K., Ravussin, É., Hsu, H., Jazwinski, S. M., & Mountz, J. D. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.11.003 · Cited by 42 · see citing works

CD4:8 Ratio >5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study

Adriaensen, W. J., Derhovanessian, E., Vaes, B., Pottelbergh, G. V., Degryse, J., Pawelec, G., Hamprecht, K., Theeten, H., & Matheï, C. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu018 · Cited by 41 · see citing works

Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1–Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy

Gras, L. A., May, M., Ryder, L. P., Trickey, A., Helleberg, M., Obel, N., Thiébaut, R., Guest, J. L., Gill, M. J., Crane, H. M., et al. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001913 · Cited by 41 · see citing works

Cytomegalovirus, aging, and HIV: a perfect storm.

Barrett, L., Fowke, K. R., & Grant (2012) · PubMed · Cited by 40 · see citing works

Age-associated changes in innate and adaptive immunity: role of the gut microbiota

Gao, H., Nepovimová, E., Adam, V., Heger, Z., Valko, M., Wu, Q., & Kuča, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1421062 · Cited by 37 · see citing works

Immune parameters identify Italian centenarians with a longer five-year survival independent of their health and functional status

Bucci, L., Ostan, R., Giampieri, E., Cevenini, E., Pini, E., Scurti, M., Vescovini, R., Sansoni, P., Caruso, C., Mari, D., et al. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.023 · Cited by 36 · see citing works

Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

Rezzani, R., Franco, C., Hardeland, R., & Rodella, L. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228806 · Cited by 37 · see citing works

‘From immunosenescence to immune modulation’: a re-appraisal of the role of cytomegalovirus as major regulator of human immune function

Moss, P. A. H. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00612-x · Cited by 35 · see citing works

Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults

Leng, S. X., Li, H., Xue, Q., Tian, J., Yang, X., Ferrucci, L., Fedarko, N. S., Fried, L. P., & Semba, R. D. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.04.002 · Cited by 34 · see citing works

Immune ageing and susceptibility to Streptococcus pneumoniae

Gonçalves, M. T., Mitchell, T. J., & Lord, J. M. (2015) · Biogerontology · doi:10.1007/s10522-015-9614-8 · Cited by 33 · see citing works

Vaccination in the Elderly: What Can Be Recommended?

Lang, P. O., & Aspinall, R. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0193-1 · Cited by 33 · see citing works

Immune risk phenotype is associated with nosocomial lung infections in elderly in-patients

Plonquet, A., Bastuji‐Garin, S., Tahmasebi, F., Brisacier, C., Dudal, K. L., Farcet, J., & Paillaud, É. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-8 · Cited by 33 · see citing works

Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows

Denholm, S. J., McNeilly, T. N., Banos, G., Coffey, M. P., Russell, G. C., Bagnall, A., Mitchell, M. C., & Wall, E. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11679 · Cited by 34 · see citing works

Frailty in People Living with HIV

Falutz, J. (2020) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00494-2 · Cited by 32 · see citing works

Are the Healthy Vulnerable? Cytomegalovirus Seropositivity in Healthy Adults Is Associated With Accelerated Epigenetic Age and Immune Dysregulation

Poloni, C., Moshe Szyf, A., Cheishvili, D., & Tsoukas, C. M. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab365 · Cited by 31 · see citing works

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction

Bawamia, B., Spray, L., Wangsaputra, V. K., Bennaceur, K., Vahabi, S., Stellos, K., Kharatikoopaei, E., Ogundimu, E. O., Gale, C. P., Keavney, B. D., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00794-6 · Cited by 30 · see citing works

Influenza vaccine effectiveness in aged individuals: The role played by cell-mediated immunity

Lang, P.-O., Govind, S., Mitchell, W. A., Kenny, N., Lapenna, A., Pitts, D. G., & Aspinall, R. (2010) · European Geriatric Medicine · doi:10.1016/j.eurger.2010.07.002 · Cited by 28 · see citing works

Reduced thymus activity and infection prematurely age the immune system

Gress, R. E., & Deeks, S. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40855 · Cited by 28 · see citing works

Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species

Mao, G., Li, H., Ding, X., Meng, X., Wang, G., & Leng, S. X. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.12.005 · Cited by 27 · see citing works

Immunosenescence in the nursing home elderly

Johnstone, J., Millar, J., Lelic, A., Verschoor, C. P., Walter, S. D., Devereaux, P. J., Bramson, J. L., & Loeb, M. B. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-50 · Cited by 27 · see citing works

Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study

Formiga, F., Ferrer, A., Padrós, G., Montero, A., Gimenez‐Argente, C., & Corbella, X. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s101447 · Cited by 26 · see citing works

Immunological and non-immunological mechanisms of allergic diseases in the elderly: biological and clinical characteristics

Lorenzo, G. D., Bona, D. D., Belluzzo, F., & Macchia, L. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0105-4 · Cited by 24 · see citing works

Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium

Pawelec, G. (2017) · Biogerontology · doi:10.1007/s10522-017-9739-z · Cited by 24 · see citing works

Cytomegalovirus and immune senescence: Culprit or innocent bystander?

Karrer, U. W., Mekker, A., Wanke, K., Tchang, V. S., & Haeberli, L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.003 · Cited by 24 · see citing works

Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes

Nuszkiewicz, J., Kukulska-Pawluczuk, B., Piec, K., Jarek, D. J., Motolko, K., Szewczyk‐Golec, K., & Woźniak, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144258 · Cited by 23 · see citing works

Cytomegalovirus and paediatric HIV infection

Slyker, J. A. (2016) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30873-6 · Cited by 23 · see citing works

Impact of Age on Markers of HIV-1 Disease

Pirrone, V., Libon, D. J., Sell, C., Lerner, C. A., Nonnemacher, M. R., & Wigdahl, B. L. (2012) · Future Virology · doi:10.2217/fvl.12.127 · Cited by 23 · see citing works

Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study

Wikby, A., Ferguson, F. G., Strindhall, J., Forsey, R. J., Fülöp, T., Hadrup, S. R., Straten, P. T., Pawelec, G., & Johansson, B. E. A. (2008) · Springer eBooks · doi:10.1007/978-0-387-76842-7_1 · Cited by 4 · see citing works

The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies

Wikby, A., Strindhall, J., & Johansson, B. E. A. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_1 · Cited by 8 · see citing works

The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study

Strindhall, J., Skog, M., Ernerudh, J., Bengnér, M., Löfgren, S., Matussek, A., Nilsson, B. O., & Wikby, A. (2012) · AGE · doi:10.1007/s11357-012-9400-3 · Cited by 186 · see citing works

The Immune System in the Oldest-Old Clinical and Immunological Studies in the NONA Immune Cohort

Nilsson, B. (2010)

The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning

Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284 · see citing works