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Human Immunosenescence

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Deep sequencing and flow cytometric characterization of expanded effector memory CD8 + CD57 + T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia

Giudice, V., Feng, X., Lin, Z., Hu, W., Zhang, F., Qiao, W., Ibanez, M. D. P. F., Rios, O., & Young, N. S. (2018) · Haematologica · doi:10.3324/haematol.2017.176701 · Cited by 92

Psychologically adverse work conditions are associated with CD8+ T cell differentiation indicative of immunesenescence

Bosch, J. A., Fischer, J. E., & Fischer, J. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.002 · Cited by 96

Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease

Wolf, E. J., & Morrison, F. G. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0823-5 · Cited by 99

Environmental Enrichment Improves Age-Related Immune System Impairment: Long-Term Exposure Since Adulthood Increases Life Span in Mice

Arranz, L., Castro, N. M. D., Baeza, I., Maté, I., Viveros, M., & la Fuente, M. D. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0989 · Cited by 96

Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

Stowe, R. P., Peek, M. K., Cutchin, M. P., & Goodwin, J. S. (2012) · Journal of Medical Virology · doi:10.1002/jmv.23397 · Cited by 88

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

Turner, J. E., Campbell, J. P., Edwards, K. M., Howarth, L. J., Pawelec, G., Aldred, S., Moss, P., Drayson, M. T., Burns, V. E., & Bosch, J. A. (2014) · AGE · doi:10.1007/s11357-013-9557-4 · Cited by 87

Dynamics of T cell memory in human cytomegalovirus infection

Waller, E. C. P., Day, E., Sissons, J. G. P., & Wills, M. R. (2008) · Medical Microbiology and Immunology · doi:10.1007/s00430-008-0082-5 · Cited by 84

Upregulation of miR‐24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death

Brunner, S. M., Herndler‐Brandstetter, D., Arnold, C. R., Wiegers, G. J., Villunger, A., Hackl, M., Grillari, J., Moreno‐Villanueva, M., Bürkle, A., & Grubeck‐Loebenstein, B. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00819.x · Cited by 83

Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA

Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Wallace, D., Sims, S., Rivino, L., Larbi, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203267 · Cited by 82

T cell senescence and cardiovascular diseases

Yu, H. T., Park, S., Shin, E., & Lee, W. (2015) · Clinical and Experimental Medicine · doi:10.1007/s10238-015-0376-z · Cited by 84

Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage

Rajasuriar, R., Wright, E., & Lewin, S. R. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000118 · Cited by 82

Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature

Grebenciucova, E., Reder, A. T., & Bernard, J. T. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.07.015 · Cited by 82

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Müller, L., & Benedetto, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020753 · Cited by 84

Reference Values for CD4+ and CD8+ T Lymphocytes with Naïve or Memory Phenotype and Their Association with Mortality in the Elderly

Provinciali, M., Moresi, R., Donnini, A., & Lisa, R. (2009) · Gerontology · doi:10.1159/000199451 · Cited by 77

Reversing T cell immunosenescence: why, who, and how

Lang, P. O., Govind, S., & Aspinall, R. (2012) · AGE · doi:10.1007/s11357-012-9393-y · Cited by 79

Nonhuman Primates in Translational Research

Tarantal, A. F., Noctor, S. C., & Hartigan-O’Connor, D. J. (2022) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-021419-083813 · Cited by 81

Immunosenescence, inflammation and Alzheimer’s disease

Martorana, A., Bulati, M., Buffa, S., Pellicanò, M., Caruso, C., Candore, G., & Colonna‐Romano, G. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-8 · Cited by 77

Why do some people lose teeth across their lifespan whereas others retain a functional dentition into very old age?

Thorstensson, H., & Johansson, B. E. A. (2009) · Gerodontology · doi:10.1111/j.1741-2358.2009.00297.x · Cited by 72

Cytomegalovirus Infection and Memory T Cell Inflation

Kim, J., Kim, A.-R., & Shin, E. (2015) · Immune Network · doi:10.4110/in.2015.15.4.186 · Cited by 72

Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis

Grebenciucova, E., & Berger, J. R. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0771-9 · Cited by 75

Immunosupportive therapies in aging

Fülöp, T., Larbi, A., Hirokawa, K., Mocchegiani, E., Lesourd, B., Castle, S., Wikby, A., Franceschi, C., & Pawelec, G. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.33 · Cited by 71

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian

Humans, N. (2015)

No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., & Wikby, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.001 · Cited by 209

Inflammatory and immunological markers and risk for mortality and cognitive impairment in a longitudinal study of older adults from the longevous project

Caldeira, M. H. R., Almada-Filho, C. M., Brunialti, M. K. C., Salomão, R., & Cendoroglo, M. S. (2024) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2024.100116 · Cited by 1

The Immune Risk Phenotype and IL-6 among Nonagenarians and Associations with Morbidity and Mortality : Findings from the Swedish NONA Immune Longitudinal Study

Nilsson, B., Strindhall, J., Löfgren, S., Forsey, R. J., Thompson, J., Johansson, B. E. A., Ernerudh, J., & Wikby, A. (2010)

Peripheral immune signatures predict cognitive decline in older adults: a population-based cohort study

Luan, H., Shan, A., Han, X., Wang, X., Li, S., Wen, B., Sun, Y., Li, C., Sun, Q., & Wei, C. (2026) · Age and Ageing · doi:10.1093/ageing/afag289