Role of brain iron accumulation in cognitive dysfunction: evidence from animal models and human studies

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

Epigenetic modifications and human disease

Portela, A., & Esteller, M. (2010) · Nature Biotechnology · doi:10.1038/nbt.1685 · Cited by 2,843 · see citing works

Memory systems of the brain: A brief history and current perspective

Squire, L. R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.06.005 · Cited by 2,269 · see citing works

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120 · see citing works

Iron, brain ageing and neurodegenerative disorders

Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801 · see citing works

Learning and Memory Functions of the Basal Ganglia

Packard, M. G., & Knowlton, B. J. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142937 · Cited by 1,717 · see citing works

Apoptosis in neurodegenerative disorders

Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605 · see citing works

The effect of age on the non-haemin iron in the human brain

Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427 · see citing works

Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains

Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383 · see citing works

Life and Death of Neurons in the Aging Brain

Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344 · see citing works

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149 · see citing works

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

Huang, X., Atwood, C., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J. T., Moir, R. D., et al. (1999) · Biochemistry · doi:10.1021/bi990438f · Cited by 1,107 · see citing works

Iron metabolism and toxicity

Papanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

DEXTER, D. T., CARAYON, A., JAVOY-AGID, F., AGID, Y., WELLS, F. R., DANIEL, S. E., LEES, A. J., JENNER, P., & MARSDEN, C. D. (1991) · Brain · doi:10.1093/brain/114.4.1953 · Cited by 1,043 · see citing works

Recognition memory and the medial temporal lobe: a new perspective

Squire, L. R., Wixted, J. T., & Clark, R. E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2154 · Cited by 1,013 · see citing works

Increased nigral iron content in postmortem parkinsonian brain

Dexter, D. T., Wells, F. R., Agid, F., Agid, Y., Lees, A. J., Jenner, P., & Marsden, C. D. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91361-4 · Cited by 963 · see citing works

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951 · see citing works

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works

Intramuscular desferrioxamine in patients with Alzheimer's disease

MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764 · see citing works

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

Duce, J. A., Tsatsanis, A., Cater, M. A., James, S., Robb, E. L., Wikhe, K., Leong, S. L., Perez, K. A., Johanssen, T., Greenough, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.08.014 · Cited by 682 · see citing works

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway

Bach, M. E., Barad, M., Son, H., Zhuo, M., Lü, Y.-F., Shih, R., Mansuy, I. M., Hawkins, R. D., & Kandel, E. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5280 · Cited by 561 · see citing works

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

Rogers, J. T., Randall, J. D., Cahill, C. M., Eder, P. S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S. S., Utsuki, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207435200 · Cited by 551 · see citing works

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress.

Deibel, M. A., Ehmann, W. D., & Markesbery, W. R. (1996) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)00203-1 · Cited by 540 · see citing works

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

Hirsch, E. C., Brandel, J. ‐., Galle, P., Javoy‐Agid, F., & Agid, Y. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08170.x · Cited by 537 · see citing works

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

Sofic, E., Paulus, W., Jellinger, K. A., Riederer, P. F., & Youdim, M. B. H. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02017.x · Cited by 523 · see citing works

MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

Bilgic, B., Pfefferbaum, A., Rohlfing, T., Sullivan, E. V., & Adalsteinsson, E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.077 · Cited by 499 · see citing works

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

Zündorf, G., & Reiser, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3359 · Cited by 482 · see citing works

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

Good, P. F., Perl, D. P., Bierer, L. M., & Schmeidler, J. (1992) · Annals of Neurology · doi:10.1002/ana.410310310 · Cited by 476 · see citing works

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

Connor, J. R., Menzies, S. L., Martin, S. M. S., & Mufson, E. J. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310111 · Cited by 468 · see citing works

Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro

Hashimoto, M., Hsu, L. J., Xia, Y., Takeda, A., Sisk, A., Sundsmo, M., & Masliah, E. (1999) · NeuroReport · doi:10.1097/00001756-199903170-00011 · Cited by 429 · see citing works

Selective iron chelation in Friedreich ataxia: biologic and clinical implications

Boddaert, N., Le Quan Sang, K. H., Rötig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J.-C., Munnich, A., & Cabantchik, Z. I. (2007) · Blood · doi:10.1182/blood-2006-12-065433 · Cited by 409 · see citing works

Memory Consolidation for Contextual and Auditory Fear Conditioning Is Dependent on Protein Synthesis, PKA, and MAP KinasePreprint

Schafe, G. E., Nadel, N. V., Sullivan, G. M., Harris, A. Z., & LeDoux, J. E. (1999) · Learning & Memory · doi:10.1101/lm.6.2.97 · Cited by 407 · see citing works

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1239 · Cited by 400 · see citing works

Promising Strategies for the Prevention of Dementia

Middleton, L. E., & Yaffe, K. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.201 · Cited by 396 · see citing works

Astroglia in dementia and Alzheimer's disease

Rodriguez, J. J., Olabarria, M., Chvátal, A., & Verkhratsky, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.172 · Cited by 396 · see citing works

Brain iron pathways and their relevance to Parkinson's disease

Berg, D., Gerlach, M., Youdim, M. B. H., Double, K. L., Zecca, L., Riederer, P., & Becker, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00608.x · Cited by 362 · see citing works

Neuroprotective effect of cannabidiol, a non‐psychoactive component from<i>Cannabis sativa</i>, on β‐amyloid‐induced toxicity in PC12 cells

Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., & Izzo, A. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2003.02327.x · Cited by 361 · see citing works

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works

The relevance of iron in the pathogenesis of Parkinson’s disease

Sian‐Hülsmann, J., Mandel, S. A., Youdim, M. B. H., & Riederer, P. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07132.x · Cited by 349 · see citing works

Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

Bartzokis, G., Tishler, T. A., Lu, P. H., Villablanca, P. J., Altshuler, L. L., Carter, M., Huang, D., Edwards, N. J., & Mintz, J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.005 · Cited by 343 · see citing works

Copper(II)-induced self-oligomerization of α-synuclein

Paik, S. R., Shin, H.-J., Lee, J., Chang, C., & Kim, J. (1999) · Biochemical Journal · doi:10.1042/bj3400821 · Cited by 332 · see citing works

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

Schipper, H. M., Song, W., Zukor, H., Hascalovici, J. R., & Zeligman, D. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06160.x · Cited by 298 · see citing works

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid

Barnham, K. J., Hæffner, F., Ciccotosto, G. D., Curtain, C. C., Tew, D. J., Mavros, C., Beyreuther, K. T., Carrington, D., Masters, C. L., Cherny, R. A., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-1890fje · Cited by 262 · see citing works

Early Iron Deficiency Has Brain and Behavior Effects Consistent with Dopaminergic Dysfunction1–3

Lozoff, B. (2011) · Journal of Nutrition · doi:10.3945/jn.110.131169 · Cited by 260 · see citing works

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Hardingham, G. E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371147 · Cited by 260 · see citing works

Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease

Iyo, M., Namba, H., Fukushi, K., Shinotoh, H., Nagatsuka, S., Suhara, T., Sudo, Y., Suzuki, K., & Irie, T. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09124-6 · Cited by 259 · see citing works

Early‐onset L‐dopa‐responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations

Paisán‐Ruiz, C., Guevara, R., Federoff, M., Hanagasi, H. A., Sina, F., Elahi, E., Schneider, S. A., Schwingenschuh, P., Bajaj, N. P. S., Emre, M., et al. (2010) · Movement Disorders · doi:10.1002/mds.23221 · Cited by 256 · see citing works

Beyond transcription factors: The role of chromatin modifying enzymes in regulating transcription required for memoryPreprint

Barrett, R. M., & Wood, M. A. (2008) · Learning & Memory · doi:10.1101/lm.917508 · Cited by 239 · see citing works

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

Corneveaux, J. J., Myers, A. J., Allen, A. N., Pruzin, J. J., Ramirez, M., Engel, A., Nalls, M. A., Chen, K., Lee, W., Chewning, K., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq221 · Cited by 237 · see citing works

The Role of Iron in Learning and Memory

Fretham, S. J. B., Carlson, E. S., & Georgieff, M. K. (2011) · Advances in Nutrition · doi:10.3945/an.110.000190 · Cited by 235 · see citing works

Developmental changes in transferrin and iron uptake by the brain in the rat

Taylor, E. M., & Morgan, E. H. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90103-6 · Cited by 221 · see citing works

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

Guo, C., Wang, T., Zheng, W. H., Shan, Z., Teng, W., & Wang, Z. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.009 · Cited by 200 · see citing works

MRI estimates of brain iron concentration in normal aging: Comparison of field-dependent (FDRI) and phase (SWI) methods

Pfefferbaum, A., Elfar Adalsteinsson, A., Torsten Rohlfing, B., & Sullivan, E. V. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.006 · Cited by 165 · see citing works

The Role of Iron in Beta Amyloid Toxicity

Schubert, D. A., & Chevion, M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2678 · Cited by 159 · see citing works

Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis

Brass, S. D., Benedict, R. H. B., Weinstock‐Guttman, B., Munschauer, F., & Bakshi, R. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1301oa · Cited by 158 · see citing works

Quantitative MR Phase-corrected Imaging to Investigate Increased Brain Iron Deposition of Patients with Alzheimer Disease

Zhu, W., Zhong, W., Wang, W., Zhan, C., Wang, C., Jianpin, Q., Wang, J., & Lei, T. (2009) · Radiology · doi:10.1148/radiol.2532082324 · Cited by 151 · see citing works

Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells

Gaasch, J. A., Lockman, P. R., Geldenhuys, W. J., Allen, D. D., & der Schyf, C. J. V. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9488-5 · Cited by 149 · see citing works

Caspase-Dependent and -Independent Neuronal Death: Two Distinct Pathways to Neuronal Injury

Stefanis, L. (2005) · The Neuroscientist · doi:10.1177/1073858404271087 · Cited by 142 · see citing works

Protein kinase A as a therapeutic target for memory disorders: rationale and challenges

Arnsten, A. F. T., Ramos, B. P., Birnbaum, S. G., & Taylor, J. R. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.01.006 · Cited by 141 · see citing works

Neurodegeneration with brain iron accumulation–clinical syndromes and neuroimaging

Schipper, H. M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.016 · Cited by 141 · see citing works

Iron: A Pathological Mediator of Alzheimer Disease?

Bishop, G. M., Robinson, S. R., Liu, Q., Perry, G. L., Atwood, C., & Smith, M. A. (2002) · Developmental Neuroscience · doi:10.1159/000065696 · Cited by 138 · see citing works

Brain iron deposits are associated with general cognitive ability and cognitive aging

Penke, L., Hernández, M. C. V., Maniega, S. M., Gow, A. J., Murray, C. L., Starr, J. M., Bastin, M. E., Deary, I. J., & Wardlaw, J. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.032 · Cited by 134 · see citing works

A histochemical study of iron‐positive cells in the developing rat brain

Connor, J. R., Pavlick, G., Karli, D. C., Menzies, S. L., & Palmer, C. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903550112 · Cited by 134 · see citing works

Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease

Ding, B., Chen, K., Ling, H., Sun, F., Li, X., Wan, T., Chai, W., Zhang, H., Zhan, Y., & Guan, Y. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21730 · Cited by 129 · see citing works

Iron-Fortified vs Low-Iron Infant Formula

Lozoff, B. (2011) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2011.197 · Cited by 127 · see citing works

Drugs acting upon the cyclic adenosine monophosphate/ protein kinase A signalling pathway modulate memory consolidation when given late after training into rat hippocampus but not amygdala

Bevilaqua, L. R., Ardenghi, P. G., der, N. S., Bromberg, E., Schmitz, P. K., Schaeffer, E. L., Quevedo, J., Bianchin, M. M., Walz, R., Medina, J. H., et al. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199708000-00006 · Cited by 127 · see citing works

Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease

Bohnen, N. I., Kaufer, D., Hendrickson, R., Ivanco, L. S., Lopresti, B. J., Davis, J. G., Constantine, G. M., Mathis, C. A., Moore, R. Y., & DeKosky, S. T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.031 · Cited by 117 · see citing works

Recognition memory impairment and brain oxidative stress induced by postnatal iron administration

de Lima, M. N. M., Polydoro, M., Laranja, D. C., Bonatto, F., Bromberg, E., Moreira, J. C. F., Dal‐Pizzol, F., & Schröder, N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04083.x · Cited by 116 · see citing works

Neonatal Iron Exposure Induces Neurobehavioural Dysfunctions in Adult Mice

Fredriksson, A., Schröder, N., Eriksson, P., Izquierdo, I., & Archer, T. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8711 · Cited by 108 · see citing works

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

Bartzokis, G., Lu, P. H., Tingus, K., Peters, D. G., Amar, C. P., Tishler, T. A., Finn, J. P., Villablanca, P. J., Altshuler, L. L., Mintz, J., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.22 · Cited by 104 · see citing works

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

Zhang, S., Wang, J., Song, N., Xie, J., & Jiang, H. F. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.025 · Cited by 104 · see citing works

Reversal of age-related deficits in object recognition memory in rats with l-deprenyl

de Lima, M. N. M., Laranja, D. C., Caldana, F., Bromberg, E., Roesler, R., & Schröder, N. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.03.004 · Cited by 103 · see citing works

An autoradiographic study of the uptake and distribution of iron by the brain of the young rat

Dwork, A. J., Lawler, G., ZYBERT, P. A., Durkin, M. M., Osman, M., Willson, N. J., & Barkai, A. I. (1990) · Brain Research · doi:10.1016/0006-8993(90)90950-g · Cited by 99 · see citing works

Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances

Hu, N., Ondrejčák, T., & Rowan, M. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.013 · Cited by 99 · see citing works

Age-dependent and gender-specific changes in mouse tissue iron by strain

Hahn, P., Song, Y., Ying, G.-S., He, X., Beard, J., & Dunaief, J. L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.06.006 · Cited by 98 · see citing works

The Role of Hippocampal Iron Concentration and Hippocampal Volume in Age-Related Differences in Memory

Rodrigue, K. M., Daugherty, A. M., Haacke, E. M., & Raz, N. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs139 · Cited by 98 · see citing works

Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture

Cassol-Jr, O. J., Comim, C. M., Silva, B. R., Hermani, F. V., Constantino, L. S., Felisberto, F., Petronilho, F., Hallak, J. E. C., De Martinis, B. S., Zuardi, A. W., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.023 · Cited by 94 · see citing works

Biological Significance of Iron-Related Magnetic Resonance Imaging Changes in the Brain

Pujol, J., Junqué, C., Vendrell, P., Grau, J. M., Martí-Vilalta, J. L., Olivé, C., & Gili, J. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530310053012 · Cited by 88 · see citing works

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

Fagherazzi, E. V., Garcia, V. A., Maurmann, N., Bervanger, T., Halmenschlager, L. H., Busato, S. B., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Schröder, N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2449-3 · Cited by 87 · see citing works

Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss.

House, M. J., Pierre, T. G. S., Foster, J. K., Martins, R. N., & Clarnette, R. (2006) · PubMed Central · Cited by 87 · see citing works

Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period

Fredriksson, A., Schröder, N., Eriksson, P., Izquierdo, I., & Archer, T. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00160-1 · Cited by 86 · see citing works

Deferoxamine improves spatial memory performance following experimental brain injury in rats

Long, D. A., Ghosh, K., Moore, A. N., Dixon, C. E., & Dash, P. K. (1996) · Brain Research · doi:10.1016/0006-8993(95)01500-0 · Cited by 86 · see citing works

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

Kupershmidt, L., Amit, T., Bar‐Am, O., Youdim, M. B. H., & Weinreb, O. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4279 · Cited by 85 · see citing works

Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats

Quevedo, J., Vianna, M. R. M. R., Martins, M. R., Barichello, T., Medina, J. H., Roesler, R., & Izquierdo, I. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.03.001 · Cited by 84 · see citing works

Impairment of emotional behavior and spatial learning in adult Wistar rats by ferrous sulfate

Maâroufi, K., Ammari, M., Jeljeli, M., Roy, V., Sakly, M., & Abdelmelek, H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.10.019 · Cited by 82 · see citing works

Metals in alzheimer's disease: a systemic perspective

Squitti, R. (2011) · Frontiers in bioscience · doi:10.2741/3938 · Cited by 79 · see citing works

Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

Fine, J. M., Baillargeon, A. M., Renner, D. B., Hoerster, N., Tokarev, J. V., Colton, S., Pelleg, A. R., Andrews, A. W., Sparley, K., Krogh, K., et al. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3101-0 · Cited by 77 · see citing works

Memory deficits in adult rats following postnatal iron administration

Schröder, N. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00236-4 · Cited by 76 · see citing works

Protein degradation and memory formation

Fioravante, D., & Byrne, J. H. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.11.002 · Cited by 75 · see citing works

HFE mutations and Alzheimer's disease

Connor, J. R., & Lee, S. Y. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-102-311 · Cited by 74 · see citing works

Relevance of Iron Deposition in Deep Gray Matter Brain Structures to Cognitive and Motor Performance in Healthy Elderly Men and Women: Exploratory Findings

Sullivan, E. V., Elfar Adalsteinsson, A., Torsten Rohlfing, B., & Pfefferbaum, A. (2009) · Brain Imaging and Behavior · doi:10.1007/s11682-008-9059-7 · Cited by 73 · see citing works

The Cholinergic System in Aging

Bigl, V., Arendt, T., Fischer, S., Fischer, S., Werner, M., & Arendt, A. (2009) · Gerontology · doi:10.1159/000212872 · Cited by 71 · see citing works

Iron and Neurodegeneration: From Cellular Homeostasis to Disease

Batista-Nascimento, L. S., Pimentel, C., Menezes, R., & Rodrigues‐Pousada, C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/128647 · Cited by 70 · see citing works

Prevalent Iron Metabolism Gene Variants Associated with Increased Brain Ferritin Iron in Healthy Older Men

Bartzokis, G., Lu, P. H., Tishler, T. A., Peters, D. G., Kosenko, A., Barrall, K. A., Finn, J. P., Villablanca, P. J., Laub, G. A., Altshuler, L. L., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1368 · Cited by 69 · see citing works

The PICALM Protein Plays a Key Role in Iron Homeostasis and Cell Proliferation

Scotland, P., Heath, J. L., Conway, A. E., Porter, N. B., Armstrong, M. B., Walker, J. A., Klebig, M. L., Lavau, C., & Wechsler, D. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044252 · Cited by 67 · see citing works

Neonatal iron exposure induces oxidative stress in adult Wistar rat

Dal‐Pizzol, F., Klamt, F., da Frota, M. L. C., Andrades, M. É., Caregnato, F. F., Vianna, M. R. M. R., Schröder, N., Quevedo, J., Izquierdo, I., Archer, T., et al. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00218-8 · Cited by 64 · see citing works

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

Lehmann, D. J., Schuur, M., Warden, D. R., Hammond, N., Belbin, O., Kölsch, H., Lehmann, M. G., Wilcock, G. K., Brown, K. S., Kehoe, P. G., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.018 · Cited by 63 · see citing works

Relative importance of female‐specific and non‐female‐specific effects on variation in iron stores between women

Whitfield, J. B., Treloar, S. A., Zhu, G., Powell, L. W., & Martin, N. G. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04224.x · Cited by 63 · see citing works

Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats

de Lima, M. N., Presti-Torres, J., Garcia, V. A., Guimarães, M. R., Scalco, F. S., Roesler, R., & Schröder, N. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.025 · Cited by 58 · see citing works

Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate

da Silva, P. F., Garcia, V. A., Dornelles, A. D. S., da Silva, V. K., Maurmann, N., Portal, B. C. D., Ferreira, R. D. P., Piazza, F. C., Roesler, R., & Schröder, N. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.038 · Cited by 56 · see citing works

Reversion of age-related recognition memory impairment by iron chelation in rats

de Lima, M. N. M., Dias, C. P., Torres, J. P., Dornelles, A. D. S., Garcia, V. A., Scalco, F. S., Guimarães, M. R., Petry, R. C., Bromberg, E., Constantino, L. D. S., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.006 · Cited by 55 · see citing works

Iron as the malignant spirit in successful ageing.

Polla, A. S., Polla, L. L., & Polla, B. S. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00048-x · Cited by 52 · see citing works

Time sequence of oxidative stress in the brain from transgenic mouse models of Alzheimer's disease related to the amyloid-β cascade

Belkacemi, A., & Ramassamy, C. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.020 · Cited by 49 · see citing works

Selegiline protects against recognition memory impairment induced by neonatal iron treatment

DELIMA, M., Laranja, D. C., Caldana, F., Grazziotin, M. M., GARCIA, V., Dal‐Pizzol, F., Bromberg, E., & Schröder, N. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.017 · Cited by 45 · see citing works

Intellectual and adaptive behaviour functioning in pantothenate kinase‐associated neurodegeneration

Freeman, K., Gregory, A., Turner, A., et al. (2007) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2006.00889.x · Cited by 45 · see citing works

Desferoxamine reverses neonatal iron-induced recognition memory impairment in rats

de Lima, M. N. M., Presti-Torres, J., Caldana, F., Grazziotin, M. M., Scalco, F. S., Guimarães, M. R., Bromberg, E., Franke, S. I. R., Henriques, J. A. P., & Schröder, N. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.002 · Cited by 43 · see citing works

Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders

Zabel, C., Nguyen, H. P., Hin, S. C., Hartl, D., Mao, L., & Klose, J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.08.008 · Cited by 43 · see citing works

Iron Leads to Memory Impairment that is Associated with a Decrease in Acetylcholinesterase Pathways

Perez, V. P., de Lima, M. M., da Silva, R. S., Dornelles, A. D. S., Vedana, G., Bogo, M. R., Bonan, C. D., & Schröder, N. (2010) · Current Neurovascular Research · doi:10.2174/156720210790820172 · Cited by 42 · see citing works

The Effect of Metals on Spatial Memory in a Transgenic Mouse Model of Alzheimer's Disease

Railey, A. M., Groeber, C. M., & Flinn, J. M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101452 · Cited by 38 · see citing works

The path to epigenetic treatment of memory disorders

Mikaelsson, M. A., & Miller, C. A. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.003 · Cited by 38 · see citing works

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice

Kupershmidt, L., Amit, T., Bar‐Am, O., Youdim, M. B. H., & Weinreb, O. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.03.001 · Cited by 38 · see citing works

Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry

Manaye, K. F., Wang, P. C., O’Neil, J. N., Huang, S., Xu, T., Lei, D.-L., Tizabi, Y., Ottinger, M. A., Ingram, D. K., & Mouton, P. R. (2007) · AGE · doi:10.1007/s11357-007-9035-y · Cited by 35 · see citing works

Reversal of age-associated memory impairment by rosuvastatin in rats

Rech, R. L., de Lima, M. N. M., Dornelles, A., Garcia, V. A., Alcalde, L. A., Vedana, G., & Schröder, N. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.001 · Cited by 35 · see citing works

Evaluation of Brain Iron Content Based on Magnetic Resonance Imaging (MRI): Comparison among Phase Value, R2* and Magnitude Signal Intensity

Yan, S., Sun, J., Yan, Y., Wang, H., & Lou, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031748 · Cited by 35 · see citing works

Considerations for measuring iron in post-mortem tissue of Parkinson’s disease patients

Hare, D. J., Gerlach, M., & Riederer, P. F. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0898-4 · Cited by 35 · see citing works

Neonatal Iron Treatment Increases Apoptotic Markers in Hippocampal and Cortical Areas of Adult Rats

Miwa, C., de Lima, M. N. M., Scalco, F. S., Vedana, G., Mattos, R., Fernandez, L. L., Hilbig, A., Schröder, N., & Vianna, M. R. M. R. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9181-3 · Cited by 33 · see citing works

Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis

Lovell, M. A., & Markesbery, W. R. (2006) · Current Alzheimer Research · doi:10.2174/156720506778249506 · Cited by 33 · see citing works

Increased iron and oxidative stress are separately related to cognitive decline in elderly

Umur, E. E., Öktenli, Ç., Çelik, S., Tangı, F., Sayan, Ö., Sanısoğlu, Y., İpçioğlu, O. M., Terekeci, H., Top, C., Nalbant, S., et al. (2011) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2011.00694.x · Cited by 28 · see citing works

A Cross-Sectional Community Study of Serum Iron Measures and Cognitive Status in Older Adults

Milward, E. A., Bruce, D. G., Knuiman, M. W., Divitini, M., Cole, M., Inderjeeth, C. A., Clarnette, R., Maier, G., Jablensky, A. V., & Olynyk, J. K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1402 · Cited by 25 · see citing works

Pilocarpine prevents age-related spatial learning impairments in rats

De-Mello, N., SOUZAJUNIOR, I., & Carobrez, A. P. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.09.006 · Cited by 25 · see citing works

Antioxidant Effects of SelegilIne in Oxidative Stress Induced by Iron Neonatal Treatment in Rats

Budni, P., de Lima, M. N. M., Polydoro, M., Moreira, J. C. F., Schröder, N., & Dal‐Pizzol, F. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9249-x · Cited by 23 · see citing works

Early Post-Natal Iron Administration Induces Astroglial Response in the Brain of Adult and Aged Rats

Fernandez, L. L., de Lima, M. N. M., Scalco, F. S., Vedana, G., Miwa, C., Hilbig, A., Vianna, M. R. M. R., & Schröder, N. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9235-6 · Cited by 23 · see citing works

Effects of Increased Iron Intake During the Neonatal Period on the Brain of Adult AβPP/PS1 Transgenic Mice

Fernandez, L. L., Carmona, M., Portero‐Otín, M., Naudí, A., Pamplona, R., Schröder, N., & Ferrer, I. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1304 · Cited by 20 · see citing works

Alzheimer-associated mutant ubiquitin impairs spatial reference memory

van Tijn, P., Hobo, B., Verhage, M. C., Oitzl, M. S., van Leeuwen, F. W., & Fischer, D. F. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.001 · Cited by 15 · see citing works

Regulation of iron-related molecules in the rat hippocampus: sex- and age-associated differences.

Thulluri, S., Wu, M., Blough, E. R., Manne, N. D. P. K., Litchfield, A. B., & Wang, B. (2012) · PubMed · Cited by 12 · see citing works

The role of iron in brain ageing and neurodegenerative disorders

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer’s Disease Detected in vivo with Magnetic Resonance Imaging

Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., & Bartzokis, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130209 · Cited by 270 · see citing works

Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection

da Silva, V. K., de Freitas, B. S., da Silva Dornelles, A., Nery, L. R., Falavigna, L., Ferreira, R. D. P., Bogo, M. R., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A. S., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8514-7 · Cited by 91 · see citing works

Iron-dependent trafficking of 5-lipoxygenase and impact on human macrophage activation

Dufrusine, B., Di Francesco, A., Oddi, S., Scipioni, L., Angelucci, C. B., D'Addario, C., Serafini, M., Häfner, A.-K., Steinhilber, D., Maccarrone, M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01347 · Cited by 63 · see citing works

Neurocognitive Function Is Associated With Serum Iron Status in Early Adolescents

Ji, X., Cui, N., & Liu, J. (2017) · Biological Research For Nursing · doi:10.1177/1099800417690828 · Cited by 33 · see citing works

Maresin1 improves hippocampal neuroinflammation and cognitive function in septic rats by activating the SLC7A11/GPX4 ferroptosis signaling pathway

Wu, H., Li, N., Peng, S., Fu, H., Hu, Z., & Su, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111792 · Cited by 32 · see citing works

The Basal Ganglia and Motor Control

Groenewegen, H. J. (2003) · Neural Plasticity · doi:10.1155/np.2003.107 · Cited by 459 · see citing works

Basal Ganglia

Galván, A., & Smith, Y. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374105-9.00015-0 · Cited by 2 · see citing works

Seven problems on the basal ganglia

Nambu, A. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.11.001 · Cited by 252 · see citing works

The basal ganglia and the initiation of movement.

Graybiel, A. M. (1990) · PubMed · Cited by 46 · see citing works

The Basal Ganglia

Chesselet, M., Cooper, G. M., & Rodnitzky, R. L. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-371-2_18