Vascular endothelial growth factor and endometriotic angiogenesis

McLaren, J.

doi:10.1093/humupd/6.1.45

Cited by 269Endometriosis Research and TreatmentAngiogenesis and VEGF in CancerEctopic Pregnancy Diagnosis and Management

Vascular endothelial growth factor and endometriotic angiogenesis

McLaren, J.·2000·Human Reproduction Update

DOI 10.1093/humupd/6.1.45

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Abstract

Peritoneal endometriosis is a significant debilitating gynaecological problem of widespread prevalence. It is now generally accepted that the pathogenesis of peritoneal endometriosis involves the implantation of exfoliated endometrium. Essential for its survival is the generation and maintenance of an extensive blood supply both within and surrounding the ectopic tissue. The vascular endothelial growth factor (VEGF) family of angiogenic molecules is involved in both physiological angiogenesis, and a number of pathological conditions that are characterized by excessive angiogenesis. Increasing evidence suggests that the VEGF family may also be involved with both the aetiology and maintenance of peritoneal endometriosis. Sources of this factor include the eutopic endometrium, ectopic endometriotic tissue and peritoneal fluid macrophages. Important to its aetiology is the correct peritoneal environment in which the exfoliated endometrium is seeded and implants. Established ectopic tissue is then dependent on the peritoneal environment for its survival, an environment that supports angiogenesis. Our increasing knowledge of the involvement of the VEGF family in endometriotic angiogenesis raises the possibility of novel approaches to its medical management, with particular focus on the anti-angiogenic control of the action of VEGF.

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Endometrial cells require an adequate blood supply to survive in their ectopic sites, and angiogenesis plays an important role in the pathogenesis of endometriosis.
“Endometrial cells require an adequate blood supply to survive in their ectopic sites, and angiogenesis plays an important role in the pathogenesis of endometriosis [25].”
From Cesarean scar endometriosis: presentation of 198 cases and literature review (2019) · cites this paper as [25]

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Authors: McLaren, J.
Affiliations: University of Leicester (GB)
Corresponding author: McLaren, J.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2000-01-01
Volume: 6
Issue: 1
Pages: 45-55
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/6.1.45
OpenAlex: W2166572585
Cited by: 269
References: 122
Citations by year: 2026: 11 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 5 · 2019: 10 · 2018: 5 · 2017: 11 · 2016: 9 · 2015: 9 · 2014: 18 · 2013: 14 · 2012: 16
FWCI: 8.57
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords: vascular endothelial growth factor, peritoneal endometriosis, angiogenesis, endometriosis pathogenesis, anti-angiogenic therapy, peritoneal macrophages
MeSH terms: Animals, Ascitic Fluid, Endometriosis, Endometrium, Female, Humans, Lymphokines, Neovascularization, Pathologic, Cell Adhesion Molecules, Endothelial Growth Factors, Receptors, Growth Factor, Neovascularization, Physiologic, Angiogenesis Inhibitors, Receptor Protein-Tyrosine Kinases, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

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Vascular endothelial growth factor and endometriotic angiogenesis

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