Orally Administered Leucine Stimulates Protein Synthesis in Skeletal Muscle of Postabsorptive Rats in Association with Increased eIF4F Formation

Novel metabolic and physiological functions of branched chain amino acids: a review

Zhang, S., Zeng, X., Ren, M., Mao, X., & Qiao, S. (2017) · Journal of Animal Science and Biotechnology · doi:10.1186/s40104-016-0139-z · Cited by 639

Effects of leucine and its metabolite β‐hydroxy‐β‐methylbutyrate on human skeletal muscle protein metabolism

Wilkinson, D. J., Hossain, T., Hill, D. S., Phillips, B. E., Crossland, H., Williams, J., Loughna, P., Churchward‐Venne, T. A., Breen, L., Phillips, S. M., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.253203 · Cited by 484

The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly1

Volpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464

Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle

Dreyer, H. C., Drummond, M. J., Pennings, B., Fujita, S., Glynn, E. L., Chinkes, D. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2007 · Cited by 447

Signaling Pathways Involved in Translational Control of Protein Synthesis in Skeletal Muscle by Leucine

Anthony, J. C., Anthony, T. G., Kimball, S. R., & Jefferson, L. S. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.3.856s · Cited by 434

Essential amino acids and muscle protein recovery from resistance exercise

Børsheim, E., Tipton, K. D., Wolf, S. E., & Wolfe, R. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00466.2001 · Cited by 422

Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia

Rieu, I., Balage, M., Sornet, C., Giraudet, C., Pujos, E., Grizard, J., Mosoni, L., & Dardevet, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110742 · Cited by 410

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

Atherton, P. J., Etheridge, T., Watt, P. W., Wilkinson, D., Selby, A., Rankin, D., Smith, K., & Rennie, M. J. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29819 · Cited by 404

Oral leucine administration stimulates protein synthesis in rat skeletal muscle

Crozier, S. J., Kimball, S. R., Emmert, S. W., Anthony, J. C., & Jefferson, L. S. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.376 · Cited by 371

Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle after Exercise

Norton, L. E., & Layman, D. K. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.2.533s · Cited by 333

Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells

Atherton, P. J., Smith, K., Etheridge, T., Rankin, D., & Rennie, M. J. (2010) · Amino Acids · doi:10.1007/s00726-009-0377-x · Cited by 323

Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling

Drummond, M. J., Dreyer, H. C., Fry, C. S., Glynn, E. L., & Rasmussen, B. B. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91397.2008 · Cited by 322

Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men

Churchward‐Venne, T. A., Burd, N. A., Mitchell, C. J., West, D. W. D., Philp, A., Marcotte, G. R., Baker, S. K., Baar, K., & Phillips, S. M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.228833 · Cited by 314

Regulation of Muscle Protein by Amino Acids

Wolfe, R. R. (2002) · The Journal of Nutrition · doi:10.1093/jn/131.10.3219s · Cited by 288

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

Drummond, M. J., & Rasmussen, B. B. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3282fa17fb · Cited by 274

Late evening snack: exploiting a period of anabolic opportunity in cirrhosis

Tsien, C. D., McCullough, A. J., & Dasarathy, S. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06951.x · Cited by 252

Aging does not impair the anabolic response to a protein-rich meal

Symons, T. B., Schutzler, S. E., Cocke, T. L., Chinkes, D. L., Wolfe, R. R., & Paddon-Jones, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.451 · Cited by 240

Signaling pathways initiated by β-hydroxy-β-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli

Eley, H. L., Russell, S. T., Baxter, J. H., Mukerji, P., & Tisdale, M. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2007 · Cited by 204

Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women

Glynn, E. L., Fry, C. S., Drummond, M. J., Timmerman, K. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2010) · The Journal of Nutrition · doi:10.3945/jn.110.127647 · Cited by 194

Cardiac atrophy in women following bed rest

Dorfman, T. A., Levine, B. D., Tillery, T., Peshock, R. M., Hastings, J. L., Schneider, S. M., Macias, B. R., Biolo, G., & Hargens, A. R. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01162.2006 · Cited by 189

Effect of Branched-Chain Amino Acids on Muscle Atrophy in Cancer Cachexia

Eley, H. L., Russell, S. T., & Tisdale, M. J. (2007) · Biochemical Journal · doi:10.1042/bj20070651 · Cited by 184

The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats

Norton, L. E., Layman, D. K., Bunpo, P., Anthony, T. G., Brana, D. V., & Garlick, P. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.103853 · Cited by 178

Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults

Kim, I.-Y., Schutzler, S., Schrader, A., Spencer, H., Kortebein, P., Deutz, N. E. P., Wolfe, R. R., & Ferrando, A. A. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00382.2014 · Cited by 171

Leucine partially protects muscle mass and function during bed rest in middle-aged adults

English, K. L., Mettler, J. A., Ellison, J. B., Mamerow, M. M., Arentson-Lantz, E., Pattarini, J. M., Ploutz-Snyder, R., Sheffield-Moore, M., & Paddon-Jones, D. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112359 · Cited by 162

Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans

Jackman, S. R., Witard, O. C., Philp, A., Wallis, G. A., Baar, K., & Tipton, K. D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00390 · Cited by 145

Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin

Boirie, Y., Short, K. R., Ahlman, B., Charlton, M., & Nair, K. S. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2652 · Cited by 137

Leucine as a pharmaconutrient in health and disease

van Loon, L. J. C. (2012) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834d617a · Cited by 119

Regulation of skeletal muscle protein metabolism in catabolic states

Wolfe, R. R. (2005) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200501000-00009 · Cited by 108

Role of Leucine in Protein Metabolism During Exercise and Recovery

Layman, D. K. (2002) · Canadian Journal of Applied Physiology · doi:10.1139/h02-038 · Cited by 104

Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B

Kobayashi, H., Børsheim, E., Anthony, T. G., Traber, D. L., Badalamenti, J., Kimball, S. R., Jefferson, L. S., & Wolfe, R. R. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00094.2002 · Cited by 103

Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by β-hydroxy-β-methylbutyrate

Eley, H. L., Russell, S. T., & Tisdale, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90530.2008 · Cited by 100

Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion

Farnfield, M. M., Breen, L., Carey, K. A., Garnham, A., & Cameron-Smith, D. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-132 · Cited by 89

Branched-Chain Amino Acids Reduce Hindlimb Suspension-Induced Muscle Atrophy and Protein Levels of Atrogin-1 and MuRF1 in Rats

Maki, T., Yamamoto, D., Nakanishi, S., Iida, K., Iguchi, G., Takahashi, Y., Kaji, H., Chihara, K., & Okimura, Y. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.07.005 · Cited by 85

Nutritional strategies to counteract muscle atrophy caused by disuse and to improve recovery

Magne, H., Savary-Auzeloux, I., Rémond, D., & Dardevet, D. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000115 · Cited by 78

Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet: A pilot study

Jourdan, M., Nair, K. S., Carter, R. E., Schimke, J., Ford, G. C., Marc, J., Aussel, C., & Cynober, L. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.019 · Cited by 73

Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats

Wilson, G. J., Layman, D. K., Moulton, C. J., Norton, L. E., Anthony, T. G., Proud, C. G., Rupassara, S. I., & Garlick, P. J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00242.2011 · Cited by 71

β-hydroxy-β-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans

Vukovich, M. D., Slater, G., Macchi, M. B., Turner, M. J., Fallon, K., Boston, T., & Rathmacher, J. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00182-6 · Cited by 66

A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states

Ely, I. A., Phillips, B. E., Smith, K., Wilkinson, D. J., Piasecki, M., Breen, L., Larsen, M. S., & Atherton, P. J. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.08.010 · Cited by 64

Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids: Nutrition Reviews©, Vol. ••, No. ••

Pasiakos, S. M., & McClung, J. P. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00420.x · Cited by 53

Addition of Carbohydrate or Alanine to an Essential Amino Acid Mixture Does Not Enhance Human Skeletal Muscle Protein Anabolism

Glynn, E. L., Fry, C. S., Timmerman, K. L., Drummond, M. J., Volpi, E., & Rasmussen, B. B. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.168203 · Cited by 52

The 2017 Sir David P Cuthbertson lecture. Amino acids and muscle protein metabolism in critical care

Wolfe, R. R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.12.010 · Cited by 50

Muscle Performance, Size, and Safety Responses After Eight Weeks of Resistance Training and Protein Supplementation: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Herda, A. A., Herda, T. J., Costa, P. B., Ryan, E. D., Stout, J. R., & Cramer, J. T. (2013) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828c289f · Cited by 39

Skeletal Muscle Atrophy Is Attenuated in Tumor-Bearing Mice under Chemotherapy by Treatment with Fish Oil and Selenium

Wang, H., Li, T.-L., Hsia, S., Su, I.-L., Chan, Y.-L., & Wu, C.-J. (2015) · Oncotarget · doi:10.18632/oncotarget.3483 · Cited by 39

Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men

JAKUBOWSKI, J. S., WONG, E. P. T., NUNES, E. A., NOGUCHI, K. S., VANDEWEERD, J. K., MURPHY, K. T., MORTON, R. W., MCGLORY, C., & PHILLIPS, S. M. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001752 · Cited by 34

Nutrient Timing: The Means to Improved Exercise Performance, Recovery, and Training Adaptation

Ivy, J. L., & Ferguson-Stegall, L. M. (2014) · American Journal of Lifestyle Medicine · doi:10.1177/1559827613502444 · Cited by 22

The effect of 8-weeks of combined resistance training and chocolate milk consumption on maximal strength, muscle thickness, peak power and lean mass, untrained, university-aged males

Yapici, H., Gülü, M., Yagin, F. H., Ugurlu, D., Comertpay, E., Eroglu, O., Kocoğlu, M., Aldhahi, M. I., Karayigit, R., & Badri AL-Mhanna, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1148494 · Cited by 13