What Is the Evidence That Tumors Are Angiogenesis Dependent?

Induction of angiogenesis during the transition from hyperplasia to neoplasia

Folkman, J., Watson, K., Ingber, D., & Hanahan, D. (1989) · Nature · doi:10.1038/339058a0 · Cited by 1,879

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

Sandler, A., Gray, R., Perry, M. C., Brahmer, J., Schiller, J. H., Dowlati, A., Lilenbaum, R., & Johnson, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061884 · Cited by 5,761

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486

Vascular-specific growth factors and blood vessel formation

Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272

The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

Boehm, T., Folkman, J., Browder, T., & O'Reilly, M. S. (1997) · Nature · doi:10.1038/37126 · Cited by 1,683

Tumor targeting via EPR: Strategies to enhance patient responses

Golombek, S. K., May, J.-N., Theek, B., Appold, L., Drude, N., Kiessling, F., & Lammers, T. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.007 · Cited by 1,262

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

Coussens, L. M., Raymond, W. W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G. H., & Hanahan, D. (1999) · Genes & Development · doi:10.1101/gad.13.11.1382 · Cited by 946

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

Robinson, C. J., & Stringer, S. E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.5.853 · Cited by 944

Mechanisms of normal and tumor-derived angiogenesis

Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

Gerber, H.-P., Condorelli, F., Park, J., & Ferrara, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23659 · Cited by 794

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Fang, J., Islam, W., & Maeda, H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.005 · Cited by 757

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Emami Nejad, A., Najafgholian, S., Rostami, A., Sistani, A., Shojaeifar, S., Esparvarinha, M., Nedaeinia, R., Haghjooy Javanmard, S., Taherian, M., Ahmadlou, M., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-020-01719-5 · Cited by 693

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell · doi:10.1016/j.cell.2004.08.025 · Cited by 588

Obesity, adipocytokines, and insulin resistance in breast cancer

Rose, D. P., Komninou, D., & Stephenson, G. D. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00142.x · Cited by 460

Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin

Lechner, M., Lirk, P., & Rieder, J. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.004 · Cited by 410

Role of integrated cancer nanomedicine in overcoming drug resistance

Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.012 · Cited by 343

Untitled work

(2000) · PubMed · Cited by 304

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

McAllister, S. D., Murase, R., Christian, R. T., Lau, D., Zielinski, A. J., Allison, J., Almanza, C., Pakdel, A., Lee, J., Limbad, C., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1177-4 · Cited by 229

Angiopoietin‐2 expression in breast cancer correlates with lymph node invasion and short survival

Sfiligoi, C., de Luca, A., Cascone, I., Sorbello, V., Fuso, L., Ponzone, R., Biglia, N., Audero, E., Arisio, R., Bussolino, F., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.10851 · Cited by 203

Absence of Smooth Muscle Actin-Positive Pericyte Coverage of Tumor Vessels Correlates with Hematogenous Metastasis and Prognosis of Colorectal Cancer Patients

Yonenaga, Y., Mori, A., Onodera, H., Yasuda, S., Oe, H., Fujimoto, A., Tachibana, T., & Imamura, M. (2005) · Oncology · doi:10.1159/000087840 · Cited by 203

Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

Huang, D., Sun, L., Huang, L., & Chen, Y. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11020124 · Cited by 176

Vascular endothelial growth factor and social support in patients with ovarian carcinoma

Lutgendorf, S. K., Johnsen, E. L., Cooper, B., Anderson, B., Sorosky, J. I., Buller, R. E., & Sood, A. K. (2002) · Cancer · doi:10.1002/cncr.10739 · Cited by 160

The Regulation and Localization of Angiopoietin-1, -2, and Their Receptor Tie2 in Normal and Pathologic Human Placentae

Zhang, E. G., Smith, S. K., Baker, P. N., & Charnock-Jones, D. S. (2001) · Molecular Medicine · doi:10.1007/bf03401869 · Cited by 125

Mevalonate Promotes the Growth of Tumors Derived from Human Cancer Cells in Vivo and Stimulates Proliferation in Vitro with Enhanced Cyclin-dependent Kinase-2 Activity

Duncan, R. E., El-Sohemy, A., & Archer, M. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400732200 · Cited by 113

Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells

Kunz, M., Moeller, S., Koczan, D., Lorenz, P., Wenger, R. H., Glocker, M. O., Thiesen, H.-J., Gross, G., & Ibrahim, S. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301373200 · Cited by 104

Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer

Takenaka, K., Ishikawa, S., Kawano, Y., Yanagihara, K., Miyahara, R., Otake, Y., Morioka, Y., Takahashi, C., Noda, M., Wada, H., et al. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.02.028 · Cited by 104

The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog

Mooberry, S. L., Leal, R. M., Tinley, T. L., Luesch, H., Moore, R. E., & Corbett, T. H. (2003) · International Journal of Cancer · doi:10.1002/ijc.10982 · Cited by 87

Well‐Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Chen, C., Law, W., Aalinkeel, R., Nair, B., Kopwitthaya, A., Mahajan, S. D., Reynolds, J. L., Zou, J., Schwartz, S. A., Prasad, P. N., et al. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200094 · Cited by 82

Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs

Huang, W., Chen, L., Kang, L., Jin, M., Sun, P., Xin, X., Gao, Z., & Bae, Y. H. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.004 · Cited by 77

Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Torok, S., Rezeli, M., Kelemen, O., Vegvari, A., Watanabe, K., Sugihara, Y., Tisza, A., Marton, T., Kovacs, I., Tovari, J., et al. (2017) · Theranostics · doi:10.7150/thno.16767 · Cited by 70

Micro RNA ‐1258 suppresses tumour progression via GRB 2/Ras/Erk pathway in non‐small‐cell lung cancer

Jiang, W., Wei, K., Pan, C., Li, H., Cao, J., Han, X., Tang, Y., Zhu, S., Yuan, W., He, Y., et al. (2018) · Cell Proliferation · doi:10.1111/cpr.12502 · Cited by 67

Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors

Iyer, A. K., Duan, Z., & Amiji, M. M. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500024p · Cited by 55

Angiogenesis Inhibitors for Colorectal Cancer. A Review of the Clinical Data

Hansen, T. F., Qvortrup, C., & Pfeiffer, P. (2021) · Cancers · doi:10.3390/cancers13051031 · Cited by 43

Psychosocial Influences in Oncology: An Expanded Model of Biobehavioral Mechanisms

LUTGENDORF, S. K., COSTANZO, E. S., & SIEGEL, S. D. (2007) · Psychoneuroimmunology · doi:10.1016/b978-012088576-3/50048-4 · Cited by 28

Non‐angiogenic tumours unveil a new chapter in cancer biology

Pezzella, F., & Gatter, K. (2015) · The Journal of Pathology · doi:10.1002/path.4474 · Cited by 18

Development of Dendritic Cell-Based Immunotherapy Targeting Tumor Blood Vessels in a Mouse Model of Lung Metastasis

Nomura, T., Yamakawa, M., Shimaoka, T., Hirai, T., Koizumi, N., Maruyama, K., & Utoguchi, N. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00737 · Cited by 6