Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort
Open accessAbstract
Background: Diabetes has been proposed to be a risk factor for and a consequence of pancreatic cancer (PC). The relationship between recent-onset diabetes and PC is not well understood, and data in minorities are sparse. We examined the relationships between recent-onset diabetes and PC incidence in African Americans and Latinos in the Multiethnic Cohort. Methods: A total of 48 995 African Americans and Latinos without prior diabetes and cancer at baseline (1993-1996) were included in the study. Questionnaires, Medicare data, and California hospital discharge files were used to identify new diabetes diagnoses. Cox regressions were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for cancer associated with diabetes and with diabetes duration. Results: A total of 15 833 (32.3%) participants developed diabetes between baseline and 2013. A total of 408 incident PC cases were identified during follow-up. Diabetes was associated with PC (HRage75 = 2.39, 95% CI = 1.91 to 2.98). Individuals with recent-onset diabetes (within three or fewer years of PC diagnosis) had a greater risk compared with those with long-term diabetes across all ages. The HRage75 for recent-onset diabetes was 4.08 (95% CI = 2.76 to 6.03) in Latinos and 3.38 (95% CI = 2.30 to 4.98) in African Americans. Conclusions: Diabetes was associated with a more than twofold higher risk of PC in African Americans and Latinos, but recent-onset diabetes was associated with a 2.3-fold greater increase in risk of PC than long-standing diabetes. Our findings support the hypothesis that recent-onset diabetes is a manifestation of PC and that long-standing diabetes is a risk factor for this malignancy.
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Several studies show that the probability PDAC development can be further increased by including additional factors such as weight change, ethnicity, and lifestyle factors that are commonly contained in electronic medical records.
“Of note, several studies show that the probability PDAC development can be further increased by including additional factors such as weight change, ethnicity, and lifestyle factors that are commonly contained in electronic medical records.171–178”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [172]
Cites
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811 · see citing works
Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012
Menke, A., Casagrande, S., Geiss, L., & Cowie, C. C. (2015) · JAMA · doi:10.1001/jama.2015.10029 · Cited by 2,362 · see citing works
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602619 · Cited by 1,105 · see citing works
A Multiethnic Cohort in Hawaii and Los Angeles: Baseline Characteristics
Kolonel, L. N., Henderson, B. E., Hankin, J. H., Nomura, A. M. Y., Wilkens, L. R., Pike, M. C., Stram, D. O., Monroe, K. R., Earle, M. E., & Nagamine, F. S. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010213 · Cited by 1,024 · see citing works
Self-citationDiabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies
Ben, Q., Xu, M., Ning, X., Liu, J., Hong, S., Huang, W., Zhang, H., & Li, Z. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.03.003 · Cited by 685 · see citing works
Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus
Pannala, R., Leirness, J. B., Bamlet, W. R., Basu, A., Petersen, G. M., & Chari, S. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.039 · Cited by 621 · see citing works
Self-citationType 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer
Hart, P. A., Bellin, M. D., Andersen, D. K., Bradley, D., Cruz-Monserrate, Z., Forsmark, C. E., Goodarzi, M. O., Habtezion, A., Korc, M., Kudva, Y. C., et al. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30106-6 · Cited by 551 · see citing works
Self-citationChari, S. T., Leibson, C. L., Rabe, K. G., Timmons, L. J., Ransom, J. E., de Andrade, M., & Petersen, G. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.040 · Cited by 519 · see citing works
Self-citationNew insights into pancreatic cancer-induced paraneoplastic diabetes
Sah, R. P., Nagpal, S. J. S., Mukhopadhyay, D., & Chari, S. T. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.49 · Cited by 336 · see citing works
Self-citationEarly Detection of Sporadic Pancreatic Cancer: Summative Review
Chari, S. T., Kelly, K., Hollingsworth, M. A., Thayer, S. P., Ahlquist, D. A., Andersen, D. K., Batra, S. K., Brentnall, T. A., Canto, M., Cleeter, D. F., et al. (2015) · Pancreas · doi:10.1097/mpa.0000000000000368 · Cited by 295 · see citing works
Self-citationRacial Disparity in Gastrointestinal Cancer Risk
Ashktorab, H., Kupfer, S. S., Brim, H., & Carethers, J. M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.08.018 · Cited by 254 · see citing works
Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer
Permert, J., Ihse, I., Jorfeldt, L., von Schenck, H., Arnquist, H. J., & Larsson, D. G. J. (1993) · British journal of surgery · doi:10.1002/bjs.1800800841 · Cited by 241 · see citing works
Diabetes and risk of pancreatic cancer: a pooled analysis of three large case–control studies
Li, D., Tang, H., Hassan, M. M., Holly, E. A., Bracci, P. M., & Silverman, D. T. (2010) · Cancer Causes & Control · doi:10.1007/s10552-010-9686-3 · Cited by 214 · see citing works
Aggarwal, G., Ramachandran, V., Javeed, N., Arumugam, T., Dutta, S. K., Klee, G. G., Klee, E. W., Smyrk, T. C., Bamlet, W. R., Han, J., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.044 · Cited by 170 · see citing works
Self-citationPrevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers
Aggarwal, G., Kamada, P., & Chari, S. T. (2013) · Pancreas · doi:10.1097/mpa.0b013e3182592c96 · Cited by 167 · see citing works
Self-citationPancreatic Steatosis and Its Relationship to β-Cell Dysfunction in Humans
Szczepaniak, L. S., Victor, R. G., Mathur, R., Nelson, M. D., Szczepaniak, E. W., Tyer, N. M., Chen, Y. I., Unger, R. H., Bergman, R. N., & Lingvay, I. (2012) · Diabetes Care · doi:10.2337/dc12-0701 · Cited by 139 · see citing works
Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer
Eibl, G., Cruz‐Monserrate, Z., Korc, M., Petrov, M. S., Goodarzi, M. O., Fisher, W. E., Habtezion, A., Lugea, A., Pandol, S. J., Hart, P. A., et al. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2017.07.005 · Cited by 138 · see citing works
Self-citationNew-Onset Diabetes and Pancreatic Cancer
Gupta, S. N., Vittinghoff, E., Bertenthal, D., Corley, D. A., Shen, H., Walter, L. C., & McQuaid, K. R. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.06.024 · Cited by 137 · see citing works
Time-Dependent Risk of Cancer After a Diabetes Diagnosis in a Cohort of 2.3 Million Adults
Dankner, R. S., Boffetta, P., Balicer, R. D., Keinan‐Boker, L., Sadeh, M., Berlin, A., Olmer, L., Goldfracht, M., & Freedman, L. S. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv290 · Cited by 133 · see citing works
Pancreatitis-Diabetes-Pancreatic Cancer
Andersen, D. K., Andrén‐Sandberg, Å., Duell, E. J., Goggins, M., Korc, M., Petersen, G. M., Smith, J. P., & Whitcomb, D. C. (2013) · Pancreas · doi:10.1097/mpa.0b013e3182a9ad9d · Cited by 132 · see citing works
Song, S., Wang, B., Zhang, X., Hao, L., Hu, X., Li, Z., & Sun, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134321 · Cited by 116 · see citing works
Ben, Q., Cai, Q.-C., Li, Z., Yuan, Y., Ning, X., Deng, S., & Wang, K. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.07.010 · Cited by 105 · see citing works
New-onset diabetes in pancreatic cancer: A study in the primary care setting
Aggarwal, G., Rabe, K. G., Petersen, G. M., & Chari, S. T. (2012) · Pancreatology · doi:10.1016/j.pan.2012.02.003 · Cited by 90 · see citing works
Self-citationNoy, A., & Bilezikian, J. P. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962312 · Cited by 87 · see citing works
Diabetes Mellitus in Association with Primary Carcinoma of the Pancreas
Green, R. C., Baggenstoss, A. H., & Sprague, R. G. (1958) · Diabetes · doi:10.2337/diab.7.4.308 · Cited by 81 · see citing works
The relationship of diabetes with race, sex, and obesity
Bonham, G. S., & Brock, D. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/41.4.776 · Cited by 68 · see citing works
Diabetes mellitus as a risk factor for gastrointestinal canceramong American veterans
Jamal, M. M., Yoon, E. J., Vega, K. J., Hashemzadeh, M., & Chang, K. J. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5274 · Cited by 63 · see citing works
Risch, H. A., Yu, H., Lu, L., & Kidd, M. S. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv026 · Cited by 62 · see citing works
Pancreatic cancer and diabetes: A two-way relationship in the perspective of diabetologist
Salvatore, T., Marfella, R., Rizzo, M. R., & Sasso, F. C. (2015) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.06.063 · Cited by 50 · see citing works
The bidirectional interation between pancreatic cancer and diabetes
Li, J., Cao, G., Ma, Q., Liu, H., Li, W., & Han, L. (2012) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-10-171 · Cited by 49 · see citing works
Tan, J., You, Y., Guo, F., Xu, J., Dai, H., & Bie, P. (2017) · Oncology Letters · doi:10.3892/ol.2017.5586 · Cited by 48 · see citing works
Are Racial Differences in the Prevalence of Diabetes in Adults Explained by Differences in Obesity?
OʼBrien, T. R. (1989) · JAMA · doi:10.1001/jama.1989.03430110075031 · Cited by 42 · see citing works
Diabetes Mellitus and Pancreatic Cancer
Hart, P. A., & Chari, S. T. (2013) · Pancreas · doi:10.1097/mpa.0b013e3182a7c963 · Cited by 30 · see citing works
Self-citationAndersen, D. K. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32835eddd3 · Cited by 29 · see citing works
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cancer health disparities in racial/ethnic minorities in the United States
Zavala, V. A., Bracci, P. M., Carethers, J. M., Carvajal‐Carmona, L. G., Halmai, N. B., Cruz-Correa, M. R., Davis, M. B., de Smith, A. J., Dutil, J., Figueiredo, J. C., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01038-6 · Cited by 922 · see citing works
Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E. K., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319352 · Cited by 659 · see citing works
Pancreatic cancer: A review of epidemiology, trend, and risk factors
Hu, J.-X., Zhao, C., Chen, W.-B., Liu, Q., Li, Q.-W., Lin, Y., & Gao, F. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i27.4298 · Cited by 602 · see citing works
Stoffel, E. M., Brand, R. E., & Goggins, M. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.012 · Cited by 540 · see citing works
Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications
Lega, I. C., & Lipscombe, L. L. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz014 · Cited by 374 · see citing works
Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms
Renzi, C., Kaushal, A., Emery, J. D., Hamilton, W. T., Neal, R. D., Rachet, B., Rubin, G. P., Singh, H., Walter, F. M., de Wit, N. J., et al. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0249-6 · Cited by 184 · see citing works
Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158 · see citing works
Self-citationDiabetes and cancer: Epidemiological and biological links
Wang, M., Yang, Y., & Liao, Z. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i6.227 · Cited by 158 · see citing works
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
Pothuraju, R., Rachagani, S., Junker, W. M., Chaudhary, S., Saraswathi, V., Kaur, S., & Batra, S. K. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0963-4 · Cited by 114 · see citing works
An overview of cancer health disparities: new approaches and insights and why they matter
Minas, T. Z., Bailey‐Whyte, M., Ajao, A., & Ambs, S. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa121 · Cited by 117 · see citing works
Diabetes and pancreatic cancer: Exploring the two-way traffic
Roy, A., Sahoo, J., Kamalanathan, S., Naik, D., Mohan, P., & Kalayarasan, R. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.4939 · Cited by 104 · see citing works
Partyka, O., Pajewska, M., Kwaśniewska, D., Czerw, A. I., Deptała, A., Budzik, M. P., Cipora, E., Gąska, I., Gazdowicz, L., Mielnik, A., et al. (2023) · Cancers · doi:10.3390/cancers15143634 · Cited by 103 · see citing works
Huang, B. Z., Pandol, S. J., Jeon, C. Y., Chari, S. T., Sugar, C. A., Chao, C. R., Zhang, Z.-F., Wu, B. U., & Setiawan, V. W. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.11.043 · Cited by 87 · see citing works
Self-citationThe intricate relationship between diabetes, obesity and pancreatic cancer
Paternoster, S., & Falasca, M. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188326 · Cited by 79 · see citing works
Molina‐Montes, E., Coscia, C., Gómez-Rubio, P., Fernández, A. M., Boenink, R., Rava, M., Márquez, M., Molero, X., Löhr, M. J., Sharp, L., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319990 · Cited by 75 · see citing works
Diabetes and Pancreatic Cancer—A Dangerous Liaison Relying on Carbonyl Stress
Menini, S., Iacobini, C., Vitale, M., Pesce, C. M., & Pugliese, G. (2021) · Cancers · doi:10.3390/cancers13020313 · Cited by 75 · see citing works
Environmental Risk Factors of Pancreatic Cancer
Tsai, H., & Chang, J. S.-M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091427 · Cited by 51 · see citing works
Epidemiology of pancreatic cancer: New version, new vision
Luo, W., Wang, J., Chen, H., Ye, L., Qiu, J., Liu, Y., Wang, R., Weng, G., Liu, T., Su, D., et al. (2023) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2023.05.03 · Cited by 51 · see citing works
Associations between Diabetes Mellitus and Selected Cancers
Pliszka, M., & Szablewski, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137476 · Cited by 52 · see citing works
Diabetes and Pancreatic Cancer: Both Cause and Effect
Risch, H. A. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy093 · Cited by 45 · see citing works
The relationship between pancreatic cancer and type 2 diabetes: cause and consequence
Li, Y., Bian, X., Wei, S., He, M., & Yang, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s211972 · Cited by 47 · see citing works
Deng, J., Guo, Y., Du, J., Gu, J., Kong, L., Tao, B., Li, J., & Fu, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844028 · Cited by 31 · see citing works
Barzi, A., Zhou, K., Wang, S., Dodge, J. L., El-Khoueiry, A. B., & Setiawan, V. W. (2021) · Cancers · doi:10.3390/cancers13143476 · Cited by 30 · see citing works
Self-citationValidation of the Enriching New-Onset Diabetes for Pancreatic Cancer Model
Boursi, B., Patalon, T., Webb, M., Margalit, O., Beller, T., Yang, Y.-X., & Chodick, G. (2022) · Pancreas · doi:10.1097/mpa.0000000000002000 · Cited by 29 · see citing works
Hidayat, K., Zhou, Y., Du, H., Qin, L., Shi, B., & Li, Z. (2022) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5550 · Cited by 29 · see citing works
The current surgical treatment of pancreatic cancer in China: a national wide cross-sectional study
Wu, W., Jin, G., Wang, C., Miao, Y., Wang, H., Lou, W., Yu, X., Sun, B., Li, H., Qin, R., et al. (2019) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000012 · Cited by 26 · see citing works
Association of Glycated Hemoglobin Levels With Risk of Pancreatic Cancer
Wu, B. U., Butler, R. K., Lustigova, E., Lawrence, J. M., & Chen, W. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.4945 · Cited by 26 · see citing works
Perera, C. J., Falasca, M., Chari, S. T., Greenfield, J. R., Xu, Z., Pirola, R. C., Wilson, J. S., & Apte, M. V. (2021) · Cancers · doi:10.3390/cancers13205224 · Cited by 24 · see citing works
Self-citationScreening for pancreatic cancer has the potential to save lives, but is it practical?
Mazer, B. L., Lee, J. W., Roberts, N. J., Chu, L. C. H., Lennon, A. M., Klein, A. P., Eshleman, J. R., Fishman, E. K., Canto, M. I., Goggins, M., et al. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2217354 · Cited by 23 · see citing works
The role of biomarkers in the early detection of pancreatic cancer
Goggins, M. (2024) · Familial Cancer · doi:10.1007/s10689-024-00381-4 · Cited by 26 · see citing works
Ruze, R., Chen, Y., Xu, R., Song, J., Yin, X., Wang, C., & Xu, Q. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188844 · Cited by 19 · see citing works
Hu, Y., Yeh, C., Liu, C.-J., Chen, T., Huang, N., & Chou, Y. (2023) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-003262 · Cited by 21 · see citing works
Prediction of Pancreatic Cancer in Diabetes Patients with Worsening Glycemic Control
Jeon, C. Y., Kim, S., Lin, Y., Risch, H. A., Goodarzi, M. O., Nuckols, T. K., Freedland, S. J., Pandol, S. J., & Pisegna, J. R. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0712 · Cited by 19 · see citing works
Self-citationPancreatic Cancer Exposome Profile to Aid Early Detection and Inform Prevention Strategies
Monroy‐Iglesias, M. J., Dolly, S. O., Sarker, D., Thillai, K., Hemelrijck, M. V., & Santaolalla, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081665 · Cited by 14 · see citing works
Diabetes-Related Complications and Pancreatic Cancer Incidence in the Multiethnic Cohort
Farias, A. J., Wu, A. H., Porcel, J., Marchand, L. L., Wilkens, L. R., Monroe, K. R., Maskarinec, G., Pandol, S. J., & Setiawan, V. W. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa035 · Cited by 13 · see citing works
Self-citationImaging of the Pancreas in New-Onset Diabetes: A Prospective Pilot Study
Wu, B. U., Lustigova, E., Chen, Q., Dong, E. Y., Maitra, A., Chari, S. T., Feng, Z., Rinaudo, J. A., Matrisian, L. M., & Parker, R. (2022) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000478 · Cited by 12 · see citing works
Self-citationWhite, M. J., Sheka, A. C., LaRocca, C. J., Irey, R., Ma, S., Wirth, K. M., Benner, A., Denbo, J. W., Jensen, E. H., Ankeny, J. S., et al. (2022) · Journal of Public Health · doi:10.1093/pubmed/fdac118 · Cited by 11 · see citing works
Yamaguchi, A., Tazuma, S., Tamaru, Y., Kusunoki, R., Kuwai, T., Kouno, H., Toyota, N., Sudo, T., Kuraoka, K., & Kohno, H. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02564-8 · Cited by 12 · see citing works
Diabetes and Other Comorbidities: Microvascular and Macrovascular Diseases Diabetes and Cancer
Nithya, V., Sangavi, P., Srinithi, R., Nachammai, K. T., Kumar, S. G., Prabu, D., & Langeswaran, K. (2023) · Springer eBooks · doi:10.1007/978-981-19-0027-3_2 · Cited by 11 · see citing works
Screening Strategy of Pancreatic Cancer in Patients with Diabetes Mellitus
Mizuno, S., Nakai, Y., Ishigaki, K., Saito, K., Oyama, H., Hamada, T., Suzuki, Y., Inokuma, A., Kanai, S., Noguchi, K., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10080572 · Cited by 10 · see citing works
Brewer, M. J., Doucette, J. T., Bar-Mashiah, A., Glickman, J. W., Kessel, E., Aronson, A., & Lucas, A. L. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.07.046 · Cited by 10 · see citing works
A review of the last decade: pancreatic cancer and type 2 diabetes
Wu, J., Tang, L., Zheng, F., Chen, X., & Li, L. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2252204 · Cited by 9 · see citing works
Syndecan-1 and KRAS Gene Expression Signature Associates With Patient Survival in Pancreatic Cancer
Wu, Y., Huang, H., Fervers, B., & Lu, L. (2020) · Pancreas · doi:10.1097/mpa.0000000000001654 · Cited by 9 · see citing works
Hsieh, M., Zhang, L., Velasco‐Gonzalez, C., Yi, Y., Pareti, L. A., Trapido, E. J., Chen, V. W., & Wu, X. (2021) · Cancer Causes & Control · doi:10.1007/s10552-021-01497-z · Cited by 8 · see citing works
Munigala, S., Bowe, B. C., Subramaniam, D. S., Xian, H., Gowda, A. N., Sheth, S. G., Chhabra, R., Burroughs, T. E., & Agarwal, B. (2025) · Cancer Medicine · doi:10.1002/cam4.70878 · Cited by 7 · see citing works
Current paradigm and futuristic vision on new-onset diabetes and pancreatic cancer research
Moreland, R., Arredondo, A., Dhasmana, A., Dhasmana, S., Shabir, S., Siddiqua, A., Banerjee, B., Yallapu, M. M., Behrman, S. W., Chauhan, S. C., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1543112 · Cited by 6 · see citing works
Pathway-Specific Genomic Alterations in Pancreatic Cancer Across Populations at Risk
Monge, C., Waldrup, B., Carranza, F., Manjarrez, S., & Velazquez-Villarreal, E. I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167695 · Cited by 6 · see citing works
Sánchez, P., Espinosa, M., Maldonado, V., Barquera, R., Gabiño‐López, N. B., Torres, J., Cravioto-Villanueva, A., & Meléndez-Zajgla, J. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05592-3 · Cited by 6 · see citing works
Sherchan, A., Jin, F., Sherchan, B., Mandal, S. K., Regmi, B. U., Ghising, R., Upadhaya, S. R., Gautam, B., Pathak, D., & Li, M. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1551926 · Cited by 5 · see citing works
Ma, M., Li, W., Xu, L., Ping, F., Zhang, H., & Li, Y. (2022) · Journal of Diabetes · doi:10.1111/1753-0407.13259 · Cited by 4 · see citing works
The association between diabetes and cancer in Mexico
Hernández-Garduño, E. (2020) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_878_19 · Cited by 5 · see citing works
Kaleru, T., Vankeshwaram, V., Maheshwary, A., Mohite, D., & Khan, S. (2020) · Cureus · doi:10.7759/cureus.8884 · Cited by 5 · see citing works
Bhat, A. A., Ahmed, M. F., Elboughdiri, N., Thakur, P., Natarajan, V., El-kott, A. F., Rajab, B. S., Alghamdi, S., Singh, J., Wani, A. K., et al. (2026) · Drug Development Research · doi:10.1002/ddr.70262 · Cited by 4 · see citing works
Current Approaches of Pancreatic Cancer Surveillance in High-Risk Individuals
Heller, M., Mann, D. A., & Katona, B. W. (2025) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-025-01184-1 · Cited by 4 · see citing works
Pancreatic Cancer Presenting as a Pancreatic Duct Disruption
Liu, A., Zeh, H. J., & Boone, B. A. (2019) · Case Reports in Surgery · doi:10.1155/2019/6381249 · Cited by 4 · see citing works
Diabetes and Pancreatic Cancer: A Bidirectional Relationship Perspective
Gupta, M. K., Sarojamma, V., & Vadde, R. (2019) · Springer eBooks · doi:10.1007/978-981-32-9393-9_3 · Cited by 4 · see citing works
Liu, P., Zhou, Z., Wang, G.-Y., Xu, S., Wang, W., Chen, X., Tan, X., Liu, Z.-H., Zhao, Z.-M., Gao, Y., et al. (2025) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2025.04.008 · Cited by 3 · see citing works
Afghani, E., Lau, B. M., Becker, L. K., Goggins, M., & Klein, A. P. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-099488 · Cited by 4 · see citing works
Ghosh, R., Sui, P., Fritze, D. M., Fernandez, S., Torres, A., Woodworth, J., Cigarroa, F. G., Halff, G. A., & Kumar, A. P. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.06.015 · Cited by 3 · see citing works
Verhoeff, K. K., & Shapiro, A. M. J. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101414 · Cited by 3 · see citing works
Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps
Hill, J. L. E., Hill, T. G., Parslow, D., & Hill, D. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110245 · Cited by 4 · see citing works
Rodríguez-Olivares, J. L., Kimball, T. N., Jeter, J., de la Mora‐Molina, H., Núñez, I., Weitzel, J. N., & Chávarri-Guerra, Y. (2024) · Pancreatology · doi:10.1016/j.pan.2024.09.018 · Cited by 3 · see citing works
Epidemiologia e fatores de risco relacionado a neoplasias pancreáticas: uma revisão da literatura
Mello, D. M. D. S., Neves, V. H. D., Vieira, M. A., Andrade, E. K. B., Martins, T. B. D., & Gomes, I. C. P. (2021) · Revista Eletrônica Acervo Científico · doi:10.25248/reac.e7381.2021 · Cited by 3 · see citing works
Pathway-specific genomic alterations in pancreatic cancer across diverse cohortsPreprint
Monge, C., Waldrup, B., Carranza, F. G., & Velazquez-Villarreal, E. I. (2025) · medRxiv · doi:10.1101/2025.02.27.25323058 · Cited by 3 · see citing works
Tao, L. V., Karasinska, J. M., Souza, V. G. P., Loree, J. M., Johnson, J. D., Renouf, D. J., & Schaeffer, D. F. (2026) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2025.1645459 · Cited by 3 · see citing works
Lin, Y., Sasado, H., Sasahira, N., Ueno, M., Ishii, H., Egawa, N., ADACHI, Y., Ozaka, M., Kobayashi, S., Koyanagi, Y. N., et al. (2026) · Cancer Science · doi:10.1111/cas.70344 · Cited by 2 · see citing works
The Link Between Diabetes and Cancer: Converging Mechanistic and Epidemiologic Evidence
Lipscombe, L. L., Ali, S., & Lega, I. C. (2026) · Diabetes · doi:10.2337/dbi26-0003 · Cited by 3 · see citing works
Lee, P. N., & Coombs, K. J. (2020) · World Journal of Meta-Analysis · doi:10.13105/wjma.v8.i2.119 · Cited by 2 · see citing works
Hu, Y., Yeh, C., Liu, C., Chen, T., Huang, N., & Chou, Y. (2024) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-23-1600 · Cited by 2 · see citing works
The Diabetes-Pancreatic Cancer Risk Relationship over Time: A Systematic Review and Meta-Analysis
Fuentes, A., Montserrat-Capdevila, J., Florensa, D., Godoy, S., Serrano, J., & Godoy, P. (2025) · Diabetology · doi:10.3390/diabetology6110131 · Cited by 2 · see citing works
Diabetes Mellitus and Early Detection of Pancreatic Cancer
Fu, Y.-B., Yang, G., Qiu, J., & Zhang, T. (2022) · Cancer Screening and Prevention · doi:10.14218/csp.2022.00013 · Cited by 2 · see citing works
New‐onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible?
Andersen, D. K., Chari, S. T., Costello, E., Crnogorac‐Jurcevic, T., Hart, P. A., Maitra, A., & Pandol, S. J. (2021) · doi:10.1002/9781119570097.ch51 · Cited by 2 · see citing works
Self-citationCarrara, S., Archibugi, L., Terrin, M., Secchettin, E., Luca, R. D., & Paiella, S. (2026) · Digestive and Liver Disease · doi:10.1016/j.dld.2026.04.007 · Cited by 1 · see citing works
Apurva, Chaudhary, P., & Bahuguna, S. (2026) · Current Cancer Therapy Reviews · doi:10.2174/0115733947414188251210123952 · Cited by 1 · see citing works
Worthington, C., Raitses‐Gurevich, M., Innamorati, G., Hart, P. A., Wilkie, T. M., Tau, N., Brin, D., Yablecovitch, D., Laish, I., Keith, D., et al. (2026) · International Journal of Cancer · doi:10.1002/ijc.70592 · Cited by 1 · see citing works
Marzan, A. A., Shahi, S., Arman, M. S., Hasan, M. Z., & Ghosh, A. (2023) · Advances in Biomarker Sciences and Technology · doi:10.1016/j.abst.2023.10.001 · Cited by 1 · see citing works
Zeighami, S., Seifi, A., Sharifi, M. H., Gheibi, Z., Rezvani, A., Heiran, A., Sahraian, S., Salimi, H., & Mirahmadizadeh, A. (2025) · Research Square · doi:10.21203/rs.3.rs-7414347/v1 · Cited by 1 · see citing works
Mirahmadizadeh, A., Sharifi, M. H., Aryaie, M., Gheibi, Z., Rezvani, A., Zeighami, S., Heiran, A., & Seifi, A. (2021) · Research Square · doi:10.21203/rs.3.rs-963608/v1
Hamd, Z. Y., Gareeballah, A., Abdelsalam, A. E. A. A. E., Alshebl, S. S. A. S. S., Aldawas, G. A. A. G. A., Alqahtani, R. M. A. R. M., Almuhatib, R. A. A. R. A., Madani, R. F. M. R. F., & Alhomida, B. A. (2023) · International Journal of Biomedicine · doi:10.21103/article13(1)_oa11
The Potential Clue for Early Diagnosis of Pancreatic Cancer—New-Onset Diabetes
周, 积. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.133540
Diabetes mellitus and pancreatic cancer: a literature review
As, A., Pashkova, E. Y., Antsiferova, D. M., & Rumer, V. B. (2023) · Endocrinology News Opinions Training · doi:10.33029/2304-9529-2023-12-4-55-62
The Impact of Sugar Control on Pancreatic Cancer Progression for the Elderly
Chirayath, A., Obawole, C., Ulucan, O., & Bayar, Y. (2024) · Proceedings of London International Conferences · doi:10.31039/plic.2024.11.245
Afghani, E., Lau, B. M., Becker, L. K., Goggins, M., & Klein, A. P. (2024) · medRxiv · doi:10.1101/2024.12.13.24319002
Chirayath, A., Obawole, C., Ulucan, O., & Bayar, Y. (2025) · London journal of interdisciplinary sciences. · doi:10.31039/ljis.2025.4.306
Yamaguchi, A., Tazuma, S., Tamaru, Y., Kusunoki, R., Kuwai, T., Kouno, H., Toyota, N., Sudo, T., Kuraoka, K., & Kohno, H. (2023) · Figshare · doi:10.6084/m9.figshare.22601990
Yamaguchi, A., Tazuma, S., Tamaru, Y., Kusunoki, R., Kuwai, T., Kouno, H., Toyota, N., Sudo, T., Kuraoka, K., & Kohno, H. (2023) · Figshare · doi:10.6084/m9.figshare.22601987
Yamaguchi, A., Tazuma, S., Tamaru, Y., Kusunoki, R., Kuwai, T., Kouno, H., Toyota, N., Sudo, T., Kuraoka, K., & Kohno, H. (2023) · Figshare · doi:10.6084/m9.figshare.22601984
Yamaguchi, A., Tazuma, S., Tamaru, Y., Kusunoki, R., Kuwai, T., Kouno, H., Toyota, N., Sudo, T., Kuraoka, K., & Kohno, H. (2023) · Figshare · doi:10.6084/m9.figshare.22601993
Yamaguchi, A., Tazuma, S., Tamaru, Y., Kusunoki, R., Kuwai, T., Kouno, H., Toyota, N., Sudo, T., Kuraoka, K., & Kohno, H. (2023) · Figshare · doi:10.6084/m9.figshare.22601996
Wu, B., Li, R. J., Wang, M., Wang, X., Chen, Q., Luo, D., & Liu, J. (2026) · Discover Oncology · doi:10.1007/s12672-026-05362-w
Dong, Z., Zhou, T., Ma, S., Chen, X., & Lai, Y. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1945735
- Authors
- Setiawan, V. W., Stram, D. O., Porcel, J., Chari, S. T., Maskarinec, G., Le Marchand, L., Wilkens, L. R., Haiman, C. A., Pandol, S. J., & Monroe, K. R.
- Affiliations
- University of Southern California (US)
- Mayo Clinic (US)
- University of Hawaii Cancer Center (US)
- Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Setiawan, Veronica Wendy
- ORCID
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-06-18
- Volume
- 111
- Issue
- 1
- Pages
- 27-33
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- PMC
- PMC6335114
- OpenAlex
- W2808803965
- Cited by
- 91
- References
- 35
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 6 · 2023: 16 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 10 · 2018: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (RO1CA209798, UO1CA164973)
- American Cancer Society (RSG-16-250-01-CPHPS)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- pancreatic cancer, recent-onset diabetes, diabetes duration, African Americans, Hispanic Americans, cancer risk factors, multi-ethnic cohort
- MeSH terms
- Adult, Aged, Asian, Black or African American, California, Diabetes Mellitus, Female, Follow-Up Studies, Hispanic or Latino, Humans, Male, Middle Aged, Pancreatic Neoplasms, Prognosis, Prospective Studies, Risk Factors, Incidence, White People
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