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Limited Evidence for Selection at the FADS Locus in Native American Populations
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Abstract
The FADS locus contains the genes FADS1 and FADS2 that encode enzymes involved in the synthesis of long-chain polyunsaturated fatty acids. This locus appears to have been a repeated target of selection in human evolution, likely because dietary input of long-chain polyunsaturated fatty acids varied over time depending on environment and subsistence strategy. Several recent studies have identified selection at the FADS locus in Native American populations, interpreted as evidence for adaptation during or subsequent to the passage through Beringia. Here, we show that these signals are confounded by independent selection—postdating the split from Native Americans—in the European and, possibly, the East Asian populations used in the population branch statistic test. This is supported by direct evidence from ancient DNA that one of the putatively selected haplotypes was already common in Northern Eurasia at the time of the separation of Native American ancestors. An explanation for the present-day distribution of the haplotype that is more consistent with the data is that Native Americans retain the ancestral state of Paleolithic Eurasians. Another haplotype at the locus may reflect a secondary selection signal, although its functional impact is unknown.
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The adaptations include the ancestral allele for FADS1, already common in the north Eurasian population, which became fixed not only in arctic and non-arctic First Peoples but also in related East Asian groups.
“The adaptations include the ancestral allele for FADS1, already common in the north Eurasian population, which became fixed not only in arctic and non-arctic First Peoples but also in related East Asian groups [59].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [59]
Modern human genetics reflect adaptation to a diet high in polyunsaturated fatty acids (PUFAs).
“while their genetics reflect adaptation to a diet high in polyunsaturated fatty acids (PUFAs) [59].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [59]
The Yana River occupants carried a genetic adaptation to a northern diet (ancestral allele for expression of the FADS1 gene, advantageous for a diet rich in PUFAs).
“They carried a genetic adaptation to a northern diet (ancestral allele for expression of the FADS1 gene, advantageous for a diet rich in PUFAs) which presumably reflects a shift from a low-latitude diet containing a relatively high proportion of plant foods [59].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [59]
This genetic adaptation presumably reflects a shift from a low-latitude diet containing a relatively high proportion of plant foods.
“They carried a genetic adaptation to a northern diet (ancestral allele for expression of the FADS1 gene, advantageous for a diet rich in PUFAs) which presumably reflects a shift from a low-latitude diet containing a relatively high proportion of plant foods [59].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [59]
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Beringia and the peopling of the Western Hemisphere
Hoffecker, J. F., Elias, S. A., Scott, G. R., O'Rourke, D. H., Hlusko, L. J., Potapova, O., Pitulko, V., Pavlova, E., Bourgeon, L., & Vachula, R. S. (2023) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2022.2246 · Cited by 17
Metadata
- Authors
- Mathieson, I.
- Affiliations
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-07
- Volume
- 37
- Issue
- 7
- Pages
- 2029-2033
- ISSN
- 0737-4038
- 1537-1719
- PMC
- PMC7306688
- Cited by
- 34
- References
- 13
- Language
- en
- Funders
- Alfred P. Sloan Foundation (FG-2018-10647)
- Charles E. Kaufman Foundation (KA2018-98559)
- NIGMS (R35GM133708)
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