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Cited by 341

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Schizophrenia: A Subcortical Neurotransmitter Imbalance Syndrome?

Open access
Carlsson, M., Carlsson, A.·1990·Schizophrenia Bulletin
DOI 10.1093/schbul/16.3.425
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Abstract

Recent animal experiments suggest that glutamate plays a fundamental role in the control of psychomotor activity. This is illustrated by the finding that even in the virtually complete absence of dopamine, a marked behavioral activation is produced in mice following suppression of glutamatergic neurotransmission. This article discusses the possibility that a deficient activity within the cortico-striatal glutamatergic pathway is an important pathophysiological component in some cases of schizophrenia and that glutamatergic agonists may prove beneficial in this disorder. In a broader perspective, schizophrenia may be looked upon as a syndrome induced by a neurotransmitter imbalance in a feedback-regulated system, where dopamine and glutamate play a crucial role in controlling arousal and the processing of signals from the outer world to the cerebral cortex via the thalamus.

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Metadata

Authors
Carlsson, M., & Carlsson, A.
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
1990-01-01
Volume
16
Issue
3
Pages
425-432
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/16.3.425
OpenAlex
W2158648681
Cited by
341
References
1
FWCI
6.06
Type
journal article
Language
en
Open access
bronze

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