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Cited by 439

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Sleep and Mortality: A Population-Based 22-Year Follow-Up Study

Open access
Hublin, Christer, Partinen, Markku, Koskenvuo, Markku, Kaprio, Jaakko·2007·Sleep
DOI 10.1093/sleep/30.10.1245
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Abstract

STUDY OBJECTIVES: Long and short sleep have been associated with increased mortality. We assessed mortality and 3 aspects of sleep behavior in a large cohort with 22-year follow-up. DESIGN/SETTING: Prospective, population-based cohort study. PARTICIPANTS: 21,268 twins aged > or =18 years responding to questionnaires administered to the Finnish Twin Cohort in 1975 (response rate 89%), and 1981 (84%). INTERVENTIONS: N/A. MEASUREMENTS: Subjects were categorized as short (<7 h), average, or long (>8 h) sleepers; sleeping well, fairly well, or fairly poorly/poorly; no, infrequent, or frequent users of hypnotics and/or tranquilizers. Cox proportional hazard models were used to obtain hazard ratios (HR) for mortality during 1982-2003 by sleep variable categories and their combinations. Adjustments were done for 10 sociodemographic and lifestyle covariates known to affect risk of death. RESULTS: Significantly increased risk of mortality was observed both for short sleep in men (+26%) and in women (+21%), and for long sleep (+24% and +17%), respectively, and also frequent use of hypnotics/tranquilizers (+31% in men and +39% in women). Snoring as a covariate did not change the results. The effect of sleep on mortality varied between age groups, with strongest effects in young men. Between 1975 and 1981, sleep length and sleep quality changed in one-third of subjects. In men there was a significant increase for stable short (1.34) and stable long (1.29) sleep for natural deaths, and for external causes in stable short sleepers (1.62). CONCLUSIONS: Our results show complicated associations between sleep and mortality, with increased risk in short and long sleep.

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Metadata

Authors
Hublin, C., Partinen, M., Koskenvuo, M., & Kaprio, J.
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2007-10
Volume
30
Issue
10
Pages
1245-1253
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/30.10.1245
OpenAlex
W1521588690
Cited by
439
References
6
FWCI
25.86
Type
journal article
Language
en
Open access
bronze

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