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Sustaining Executive Functions During Sleep Deprivation: A Comparison of Caffeine, Dextroamphetamine, and Modafinil

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Killgore, William D. S., Kahn-Greene, Ellen T., Grugle, Nancy L., Killgore, Desiree B., Balkin, Thomas J.·2009·Sleep

DOI 10.1093/sleep/32.2.205PMC PMC2635585

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Abstract

OBJECTIVES: Stimulant medications appear effective at restoring simple alertness and psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making. DESIGN: After 44 hours awake, participants received a double-blind dose of one of 3 stimulant medications or placebo. After 45-50 hours awake, participants were tested on computerized versions of the 5-Ring Tower of Hanoi (TOH), the Tower of London (TOL), and the Wisconsin Card Sorting Test (WCST). SETTING: In-residence sleep-laboratory facility at the Walter Reed Army Institute of Research. PARTICIPANTS: Fifty-four healthy adults (29 men, 25 women), ranging in age from 18 to 36 years. INTERVENTIONS: Participants were randomly assigned to 1 of 3 stimulant medication groups, including caffeine, 600 mg (n=12), modafinil, 400 mg (n=12), dextroamphetamine, 20 mg (n=16), or placebo (n=14). MEASUREMENTS AND RESULTS: At the doses tested, modafinil and dextroamphetamine groups completed the TOL task in significantly fewer moves than the placebo group, and the modafinil group demonstrated greater deliberation before making moves. In contrast, subjects receiving caffeine completed the TOH in fewer moves than all 3 of the other groups, although speed of completion was not influenced by the stimulants. Finally, the modafinil group outperformed all other groups on indices of perseverative responding and perseverative errors from the WCST. CONCLUSIONS: Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.

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The Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks: A Latent Variable Analysis
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000) · Cognitive Psychology · doi:10.1006/cogp.1999.0734 · Cited by 15,798
Untitled work
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741
Storage and Executive Processes in the Frontal Lobes
Smith, E. E., & Jonides, J. (1999) · Science · doi:10.1126/science.283.5408.1657 · Cited by 2,834
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154
Principles of Frontal Lobe Function
Stuss, D. T. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195134971.001.0001 · Cited by 1,731
Neurocognitive Consequences of Sleep Deprivation
Durmer, J. S., & Dinges, D. F. (2005) · Seminars in Neurology · doi:10.1055/s-2005-867080 · Cited by 1,473
The impact of sleep deprivation on decision making: A review.
Harrison, Y., & Horne, J. A. (2000) · Journal of Experimental Psychology: Applied · doi:10.1037/1076-898x.6.3.236 · Cited by 1,238

Show all 75 references

Research works printed but not linked: 1

Barcelo F, Santome-Calleja A. [A critical review of the specificity of the Wisconsin card sorting test for the assessment of prefrontal function]. Rev Neurol 2000;30:855-64.

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Authors: Killgore, W. D. S., Kahn-Greene, E. T., Grugle, N. L., Killgore, D. B., & Balkin, T. J.
Affiliations: Walter Reed Army Institute of Research (US)
Corresponding author: Killgore, William D. S.
ORCID: Killgore, William D. S.
Balkin, Thomas J.
Venue: Sleep
Publisher: Oxford University Press (OUP)
Published: 2009-02
Volume: 32
Issue: 2
Pages: 205-216
ISSN: 0161-8105 (ISSN-L)
1550-9109
DOI: 10.1093/sleep/32.2.205
PMC: PMC2635585
OpenAlex: W2250865
Cited by: 132
References: 75
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 11 · 2012: 16
FWCI: 15.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: SLEEP (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: sleep deprivation, executive function, caffeine, d-amphetamine, modafinil, stimulant medication, cognitive performance, Tower of Hanoi, Tower of London, Wisconsin Card Sorting Test, perseverative responding, planning, decision-making
MeSH terms: Modafinil, Adolescent, Adult, Central Nervous System Stimulants, Arousal, Attention, Benzhydryl Compounds, Caffeine, Cognition Disorders, Decision Making, Dextroamphetamine, Discrimination Learning, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Neuropsychological Tests, Pattern Recognition, Visual, Problem Solving, Psychomotor Performance, Sleep Deprivation, Young Adult

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Sustaining Executive Functions During Sleep Deprivation: A Comparison of Caffeine, Dextroamphetamine, and Modafinil

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