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Cited by 107Sleep and Wakefulness ResearchMemory and Neural MechanismsSleep and related disorders

Slow Wave Sleep and REM Sleep Awakenings Do Not Affect Sleep Dependent Memory Consolidation

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Genzel, Lisa, Dresler, Martin, Wehrle, Renate, Grözinger, Michael, Steiger, Axel·2009·Sleep
DOI 10.1093/sleep/32.3.302PMC PMC2647784
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Abstract

STUDY OBJECTIVES: The effects of REM sleep and slow wave sleep (SWS) deprivation on sleep-dependent motor and declarative memory consolidation. DESIGN: Randomized, within-subject, cross-over study. SETTING: Weekly (women: monthly) sleep laboratory visits, with retest 60 hours later. PARTICIPANTS: Twelve healthy subjects (6 men) aged between 20 and 30 years. INTERVENTIONS: REM sleep deprivation, SWS deprivation, or undisturbed sleep. MEASUREMENTS AND RESULTS: We deprived subjects once each of REM sleep and SWS, and once let them sleep undisturbed through the night. After each night, we tested declarative and procedural memory consolidation. We tested memory performance by a verbal paired associate task and a sequential finger-tapping task at 21:00 on the study night and again 60 hours later. Although REM sleep and SWS awakenings led to a significant reduction of the respective sleep stages, memory consolidation remained unaffected. We also found a significant correlation between the declarative task and sleep spindles in the undisturbed condition, especially the sleep spindles in the first third of the night. CONCLUSION: We suggest that word-pair learning relies on stage 2 sleep spindles and requires little SWS. Their sleep dependent consolidation is not affected by SWS deprivation. Simple motor tasks may either be consolidated in stage 2 sleep or depend on only small amounts of REM sleep. Their sleep dependent consolidation is not influenced by REM sleep deprivation.

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  • Indicators of sleep spindle expression consistently correlated with the amount of overnight retention of declarative memories.

    “Furthermore, indicators of sleep spindle expression consistently correlated with the amount of overnight retention of declarative memories (86,213,214,235,446,562,822,1016,1024,1037,1044,1057).”

    From About Sleep's Role in Memory (2013) · cites this paper as [446]

    The Results report correlations between spindle measures and declarative memory retention after an undisturbed night. The Caveats section says the correlation did not reach significance after REM sleep deprivation and was absent after slow-wave sleep deprivation, so this paper does not support calling its findings consistent across conditions. Page numbers are unavailable in our copy. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Genzel, L., Dresler, M., Wehrle, R., Grözinger, M., & Steiger, A.
Affiliations
  • Max Planck Society (DE)
  • Universitätsklinikum Aachen (DE)
Corresponding author
Genzel, Lisa
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2009-03
Volume
32
Issue
3
Pages
302-310
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/32.3.302
PMC
PMC2647784
OpenAlex
W1493193098
Cited by
107
References
19
Citations by year
2025: 1 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 9
FWCI
5.18
Type
journal article
Language
en
Open access
Locations
  • SLEEP (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
slow-wave sleep, REM sleep, sleep deprivation, sleep-dependent memory consolidation, declarative memory, procedural memory, sleep spindles, motor learning, paired-associate learning
MeSH terms
Adult, Attention, Circadian Rhythm, Humans, Male, Paired-Associate Learning, Psychomotor Performance, Mental Recall, Retention, Psychology, Sleep, Sleep Deprivation, Sleep, REM, Wakefulness, Single-Blind Method, Polysomnography, Young Adult

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