Robust stability of trait-like vulnerability or resilience to common types of sleep deprivation in a large sample of adults
Open accessAbstract
Study Objectives: Sleep loss produces large individual differences in neurobehavioral responses, with marked vulnerability or resilience among individuals. Such differences are stable with repeated exposures to acute total sleep deprivation (TSD) or chronic sleep restriction (SR) within short (weeks) and long (years) intervals. Whether trait-like responses are observed to commonly experienced types of sleep loss and across various demographically defined groups remains unknown. Methods: Eighty-three adults completed two baseline nights (10 h–12 h time-in-bed, TIB) followed by five 4 h TIB SR nights or 36 h TSD. Participants then received four 12-h TIB recovery nights followed by five SR nights or 36 h TSD, in counterbalanced order to the first sleep loss sequence. Neurobehavioral tests were completed every 2 h during wakefulness. Results: Participants who displayed neurobehavioral vulnerability to TSD displayed vulnerability to SR, evidenced by substantial to near perfect intraclass correlation coefficients (ICCs; 78%–91% across measures). Sex, race, age, body mass index (BMI), season, and sleep loss order did not impact ICCs significantly. Individuals exhibited significant consistency of responses within, but not between, performance and self-reported domains. Conclusions: Using the largest, most diverse sample to date, we demonstrate for the first time the remarkable stability of phenotypic neurobehavioral responses to commonly experienced sleep loss types, across demographic variables and different performance and self-reported measures. Since sex, race, age, BMI, and season did not affect ICCs, these variables are not useful for determining stability of responses to sleep loss, underscoring the criticality of biological predictors. Our findings inform mathematical models and are relevant for the general population and military and health professions.
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The degree of performance impairment in response to sleep loss is subject to substantial inter-individual differences that are stable and trait-like.
“The degree of performance impairment in response to sleep loss is subject to substantial inter-individual differences that are stable and trait-like36,51–54.”
From Effects of total sleep deprivation on performance in a manual spacecraft docking task (2024) · cites this paper as [53]
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Effects of total sleep deprivation on performance in a manual spacecraft docking task
Piechowski, S., Kalkoffen, L. J., Benderoth, S., Wolf, O. T., Rittweger, J., Aeschbach, D., & Mühl, C. (2024) · npj Microgravity · doi:10.1038/s41526-024-00361-z · Cited by 12 · see citing works
- Authors
- Yamazaki, E. M., & Goel, N.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- Goel, Namni
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-11-30
- Volume
- 43
- Issue
- 6
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC8152927
- OpenAlex
- W2993532314
- Cited by
- 44
- References
- 60
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 2
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Department of the Navy, Office of Naval Research (N00014-11-1-0361)
- National Aeronautics and Space Administration (NNX14AN49G)
- Clinical and Translational Research Center (UL1TR000003)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep deprivation, total sleep deprivation, chronic sleep restriction, resilience, neurobehavioral performance, intraclass correlation coefficient, sex differences, race, body mass index, seasonal variation, recovery sleep, military personnel
- MeSH terms
- Adult, Humans, Neuropsychological Tests, Psychomotor Performance, Sleep, Sleep Deprivation, Time Factors, Wakefulness
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