Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss
Open accessAbstract
BACKGROUND: The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel marker in healthy adults of differential vulnerability to chronic partial sleep deprivation (PSD), a condition distinct from total sleep loss and one experienced by millions on a daily and persistent basis. METHODOLOGY/PRINCIPAL FINDINGS: 20 Met/Met, 64 Val/Met, and 45 Val/Val subjects participated in a protocol of two baseline 10h time in bed (TIB) nights followed by five consecutive 4 h TIB nights. Met/Met subjects showed differentially steeper declines in non-REM EEG slow-wave energy (SWE)-the putative homeostatic marker of sleep drive-during PSD, despite comparable baseline SWE declines. Val/Val subjects showed differentially smaller increases in slow-wave sleep and smaller reductions in stage 2 sleep during PSD, and had more stage 1 sleep across nights and a shorter baseline REM sleep latency. The genotypes, however, did not differ in performance across various executive function and cognitive tasks and showed comparable increases in subjective and physiological sleepiness in response to chronic sleep loss. Met/Met genotypic and Met allelic frequencies were higher in whites than African Americans. CONCLUSIONS/SIGNIFICANCE: The COMT Val158Met polymorphism may be a genetic biomarker for predicting individual differences in sleep physiology-but not in cognitive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult population of men and women. Beyond healthy sleepers, our results may also provide insight for predicting sleep loss responses in patients with schizophrenia and other psychiatric disorders, since these groups repeatedly experience chronically-curtailed sleep and demonstrate COMT-related treatment responses and risk factors for symptom exacerbation.
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There are large and highly replicable, trait-like individual differences in the magnitude of fatigue, sleepiness, sleep homeostatic, and cognitive performance vulnerability to acute total sleep deprivation and to chronic sleep restriction.
“We have repeatedly demonstrated that there are large and highly replicable, trait-like individual differences in the magnitude of fatigue, sleepiness, sleep homeostatic, and cognitive performance vulnerability to acute total sleep deprivation170,171 and to chronic sleep restriction.32,148,172,173”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [173]
The catechol-O-methyltransferase Val158Met polymorphism predicted individual differences in sleep homeostatic responses to chronic sleep restriction.
“we found that the catechol-O-methyltransferase Val158Met polymorphism predicted individual differences in sleep homeostatic responses to chronic sleep restriction,173”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [173]
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Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173 · see citing works
Self-citationEffect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works
Self-citationSchizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788 · see citing works
Belenky, G., Wesensten, N. J., Thorne, D. R., Thomas, M. L., Sing, H. C., Redmond, D. P., Russo, M. B., & Balkin, T. J. (2003) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2003.00337.x · Cited by 1,436 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
Tunbridge, E. M., Harrison, P. J., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.024 · Cited by 685 · see citing works
PER3 polymorphism predicts sleep structure and waking performance
Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520 · see citing works
Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.005 · Cited by 412 · see citing works
Systematic Trends Across the Night in Human Sleep Cycles
Feinberg, I., & Floyd, T. C. (1979) · Psychophysiology · doi:10.1111/j.1469-8986.1979.tb02991.x · Cited by 394 · see citing works
The molecular genetics of cognition: dopamine, COMT and BDNF
Savitz, J. B., Solms, M., & Ramesar, R. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00163.x · Cited by 326 · see citing works
Banks, S., Van Dongen, H. P. A., Maislin, G., & Dinges, D. F. (2010) · Sleep · doi:10.1093/sleep/33.8.1013 · Cited by 295 · see citing works
Self-citationRétey, J. V., Adam, M., Khatami, R., Luhmann, U. F. O., Jung, H. H., Berger, W., & Landolt, H.-P. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100102 · Cited by 278 · see citing works
Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001973 · Cited by 274 · see citing works
Genes, cognition and brain through a COMT lens
Dickinson, D., & Elvevåg, B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.014 · Cited by 253 · see citing works
Effects of rapid versus slow accumulation of eight hours of sleep loss
Drake, C. L., Roehrs, T. A., Burduvali, E., Bonahoom, A., Rosekind, M., & Roth, T. (2001) · Psychophysiology · doi:10.1111/1469-8986.3860979 · Cited by 231 · see citing works
John A. Groeger, P., Viola, A., June C.Y. Lo, M., Malcolm von Schantz, P., Simon N. Archer, P., & Derk-Jan Dijk, P. (2008) · SLEEP · doi:10.5665/sleep/31.8.1159 · Cited by 160 · see citing works
Goel, N., Banks, S., Mignot, E., & Dinges, D. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005874 · Cited by 154 · see citing works
Self-citationSpronk, D. B., Arns, M., Barnett, K. J., Cooper, N. J., & Gordon, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.021 · Cited by 147 · see citing works
Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression
Ohara, K., Nagai, M., Suzuki, Y., & Ohara, K. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00009 · Cited by 145 · see citing works
Association of the COMT val158met Variant with Antidepressant Treatment Response in Major Depression
Baune, B. T., Hohoff, C., Berger, K., Neumann, A., Mortensen, S., Roehrs, T., Deckert, J., Arolt, V., & Domschke, K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301462 · Cited by 145 · see citing works
Association studies of bipolar disorder
Craddock, N. J., Dave, S., & Greening, J. (2001) · Bipolar Disorders · doi:10.1034/j.1399-5618.2001.30604.x · Cited by 118 · see citing works
Beersma, D. G. M., & Achermann, P. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00147.x · Cited by 112 · see citing works
MAO-A and COMT polymorphisms and gene effects in narcolepsy
Dauvilliers, Y. A., Neidhart, E., Lecendreux, M., Billiard, M. M., & Tafti, M. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000911 · Cited by 110 · see citing works
Bodenmann, S., Rusterholz, T., Dürr, R., Stoll, C., Bachmann, V., Geißler, E. M., Jaggi-Schwarz, K., & Landolt, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1427-09.2009 · Cited by 107 · see citing works
Al-Hendy, A. A., & Salama, S. A. (2006) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2005.10.007 · Cited by 103 · see citing works
<i>DQB1*0602</i> predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
Goel, N., Banks, S., Mignot, E., & Dinges, D. F. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f9615d · Cited by 92 · see citing works
Self-citationLi, T., Vallada, H., Curtis, D., Arranz, M. J., Xu, K., Cai, G., Deng, H., Liu, J., Murray, R. M., Liu, X., et al. (1997) · Pharmacogenetics · doi:10.1097/00008571-199710000-00002 · Cited by 91 · see citing works
Time of day effects on neurobehavioral performance during chronic sleep restriction
Mollicone, D. J., Van Dongen, H. P. A., Rogers, N. L., Banks, S., & Dinges, D. F. (2010) · Aviation, Space, and Environmental Medicine · doi:10.3357/asem.2756.2010 · Cited by 91 · see citing works
Self-citationBodenmann, S., Xu, S., Luhmann, U., Arand, M., Berger, W., Jung, H., & Landolt, H. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.222 · Cited by 85 · see citing works
COMT genotype, gender and cognition in community-dwelling, older adults
O'Hara, R. M., Miller, E., Liao, C.-P., Way, N., Lin, X., & Hallmayer, J. F. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.09.047 · Cited by 72 · see citing works
Benedetti, F., Dallaspezia, S., Colombo, C., Lorenzi, C., Pirovano, A., & Smeraldi, E. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2009.12.007 · Cited by 71 · see citing works
Goghari, V. M., & Sponheim, S. R. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.05.015 · Cited by 69 · see citing works
Benedetti, F., Barbini, B., Bernasconi, A., Fulgosi, M. C., Dallaspezia, S., Gavinelli, C., Locatelli, C., Lorenzi, C., Pirovano, A., & Radaelli, D. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.05.017 · Cited by 69 · see citing works
Dauvilliers, Y. A., Neidhart, E., Billiard, M. M., & Tafti, M. (2002) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500088 · Cited by 67 · see citing works
COMT Val108/158 Met Genotype Affects Neural but not Cognitive Processing in Healthy Individuals
Dennis, N. A., Need, A. C., LaBar, K. S., Waters, S., Cirulli, E. T., Kragel, J. E., Goldstein, D. B., & Cabeza, R. E. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp132 · Cited by 52 · see citing works
Benedetti, F., Dallaspezia, S., Colombo, C., Lorenzi, C., Pirovano, A., & Smeraldi, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.01.005 · Cited by 50 · see citing works
Zhang, Z., Lindpaintner, K., Che, R., He, Z., Wang, P., Yang, P., Feng, G., He, L., & Shi, Y. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0260-7 · Cited by 49 · see citing works
Effects of Modafinil on the Sleep EEG Depend on Val158Met Genotype of COMT
Bodenmann, S., & Landolt, H. (2010) · SLEEP · doi:10.1093/sleep/33.8.1027 · Cited by 49 · see citing works
Wirgenes, K. V., Djurovic, S., Sundet, K. S., Agartz, I., Mattingsdal, M., Athanasiu, L., Melle, I. S., & Andreassen, O. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.007 · Cited by 42 · see citing works
Mikołajczyk, E., Grzywacz, A., & Samochowiec, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.035 · Cited by 40 · see citing works
Frauscher, B., Högl, B., Maret, S., Wolf, E., Brandauer, E., Wenning, G. K., Kronenberg, M. F., Kronenberg, F., Tafti, M., & Poewe, W. H. (2004) · SLEEP · doi:10.1093/sleep/27.4.733 · Cited by 38 · see citing works
Daytime Sleepiness and the COMT val158met Polymorphism in Patients with Parkinson Disease
Rissling, I., Frauscher, B., Kronenberg, F., Tafti, M., Stiasny‐Kolster, K., Robyr, M. A.-C., Körner, Y., Oertel, W. H., Poewe, W. H., Högl, B., et al. (2006) · SLEEP · doi:10.1093/sleep/29.1.108 · Cited by 25 · see citing works
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“We have repeatedly demonstrated that there are large and highly replicable, trait-like individual differences in the magnitude of fatigue, sleepiness, sleep homeostatic, and cognitive performance vulnerability to acute total sleep deprivation(170,171) and to chronic sleep restriction.(32,148,172,173) Some individuals…”
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Fernández‐Mendoza, J., Vgontzas, A. N., Kritikou, I., Calhoun, S. L., Liao, D., & Bixler, E. O. (2015) · SLEEP · doi:10.5665/sleep.4488 · Cited by 146 · see citing works
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Zhang, S. L., Bai, L., Goel, N., Bailey, A., Jang, C. J., Bushman, F. D., Meerlo, P., Dinges, D. F., & Sehgal, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620673114 · Cited by 139 · see citing works
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Palma, J., Urrestarazu, E., & Iriarte, J. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2012.11.019 · Cited by 124 · see citing works
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Wu, B., Wang, Y., Wu, X., Liu, D., Xu, D., & Wang, F. (2018) · Military Medical Research · doi:10.1186/s40779-018-0165-6 · Cited by 94 · see citing works
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Chua, E. C.-P., Yeo, S. C., Lee, I. T.-G., Tan, L.-C., Lau, P., Cai, S., Zhang, X., Puvanendran, K., & Gooley, J. J. (2014) · SLEEP · doi:10.5665/sleep.3302 · Cited by 80 · see citing works
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- Authors
- Goel, N., Banks, S., Lin, L., Mignot, E., & Dinges, D. F.
- Affiliations
- University of Pennsylvania (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Goel, Namni
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-12-27
- Volume
- 6
- Issue
- 12
- Pages
- e29283
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3246458
- OpenAlex
- W2033650004
- Cited by
- 58
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 6 · 2012: 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- National Aeronautics and Space Administration (NCC958)
- Institute for Translational Medicine and Therapeutics (UL1-RR024134)
- National Space Biomedical Research Institute (NR004281, NCC 9‐58)
- National Institutes of Health (NCC9-58)
- National Institute of Nursing Research (NR004281, R01NR004281)
- National Institute of Neurological Disorders and Stroke (P50NS023724, NS-23724)
- National Center for Research Resources (UL1RR024134)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- COMT Val158Met polymorphism, sleep physiology, individual differences, slow-wave sleep, REM latency, stage 2 sleep, sleep drive, genetic biomarkers, executive function, sleepiness, schizophrenia
- MeSH terms
- Adult, Catechol O-Methyltransferase, Chronic Disease, Electroencephalography, Female, Humans, Male, Methionine, Polymorphism, Genetic, Sleep Deprivation, Sleep, REM, Valine, Polysomnography
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