Aβ peptide immunization restores blood‐brain barrier integrity in Alzheimer disease

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

Austyn, J. M., & Gordon, S. (1981) · European Journal of Immunology · doi:10.1002/eji.1830111013 · Cited by 1,580 · see citing works

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L. C., Jouanny, P., Dubois, B., Eisner, L., Flitman, S., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000073623.84147.a8 · Cited by 1,356 · see citing works

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298 · see citing works

Reactive microgliosis

Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096 · see citing works

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Dodart, J.-C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn842 · Cited by 858 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

Höck, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Müller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00294-0 · Cited by 777 · see citing works

β-Amyloid-mediated vasoactivity and vascular endothelial damage

Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703 · see citing works

Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia?

Wardlaw, J. M., Sandercock, P. A. G., Dennis, M. S., & Starr, J. (2003) · Stroke · doi:10.1161/01.str.0000058480.77236.b3 · Cited by 628 · see citing works

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

Ferrer, I., Boada, M., Guerra, M. L. S., Rey, M. J., & Costa‐Jussà, F. R. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00493.x · Cited by 567 · see citing works

Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M., & Holtzman, D. M. (2002) · Science · doi:10.1126/science.1067568 · Cited by 563 · see citing works

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Hsiao, K., Borchelt, D., Olson, K., Johannsdottir, R., Kitt, C. A., Yunis, W. S., Xu, S., Eckman, C., Younkin, S. G., Price, D., et al. (1995) · Neuron · doi:10.1016/0896-6273(95)90107-8 · Cited by 519 · see citing works

Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer’s disease and vascular dementia

Tarkowski, E., Issa, R., Sjögren, M., Wallin, A., Blennow, K., Tarkowski, A., & Kumar, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00285-8 · Cited by 360 · see citing works

Blood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model

UJIIE, M., DICKSTEIN, D. L., CARLOW, D. A., & JEFFERIES, W. A. (2003) · Microcirculation · doi:10.1038/sj.mn.7800212 · Cited by 351 · see citing works

Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β

Racke, M. M., Boone, L. I., Hepburn, D. L., Parsadainian, M., Bryan, M. T., Ness, D. K., Piroozi, K. S., Jordan, W. H., Brown, D. D., Hoffman, W. P., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4337-04.2005 · Cited by 320 · see citing works

Inflammatory factors are elevated in brain microvessels in Alzheimer's disease

Grammas, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00276-7 · Cited by 292 · see citing works

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

Wong, M.-L., Rettori, V., AL-Shekhlee, A., Bongiorno, P. B., Canteros, G., McCann, S. M., Gold, P. W., & Licinio, J. (1996) · Nature Medicine · doi:10.1038/nm0596-581 · Cited by 286 · see citing works

Quantitative Evaluation of Vascular Permeability in the Gerbil Brain after Transient Ischemia Using Evans Blue Fluorescence

Uyama, O., Okamura, N., Yanase, M., Narita, M., Kawabata, K., & Sugita, M. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.59 · Cited by 275 · see citing works

Alzheimer's disease and angiogenesis

Vagnucci, A. H., & Li, W. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12521-4 · Cited by 267 · see citing works

Alzheimer's disease and angiogenesis

Agorogiannis, E. I., & Agorogiannis, G. I. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13000-0 · Cited by 224 · see citing works

Microglia in diseases of the central nervous system

Nelson, P. T., Soma, L. A., & Lavi, E. (2002) · Annals of Medicine · doi:10.1080/078538902321117698 · Cited by 222 · see citing works

β-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1

Giri, R., Shen, Y., Stins, M., Du Yan, S., Schmidt, A. M., Stern, D., Kim, K.-S., Zlokovic, B., & Kalra, V. K. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1772 · Cited by 218 · see citing works

The relationship between senile plaques and cerebral blood vessels in Alzheimer’s disease and senile dementia

Miyakawa, T., Shimoji, A., Kuramoto, R., & Higuchi, Y. (1982) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02932857 · Cited by 217 · see citing works

Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/-Knock-Out Mice

Das, P., HOWARD, V. G., Loosbrock, N., Dickson, D. W., Murphy, M. P., & Golde, T. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08532.2003 · Cited by 212 · see citing works

Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

Dickson, D. W. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22317 · Cited by 201 · see citing works

Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia

Kalaria, R. N., Cohen, D., Premkumar, D. R., Nag, S., LaManna, J. C., & Lust, W. D. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00190-9 · Cited by 190 · see citing works

Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells

Blanc, E. M., Toborek, M. J., Mark, R. J., Hennig, B., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68051870.x · Cited by 174 · see citing works

Inflammation-Dependent Cerebral Deposition of Serum Amyloid A Protein in a Mouse Model of Amyloidosis

Guo, J.-T., Yu, J., Grass, D., de Beer, F. C., & Kindy, M. S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05900.2002 · Cited by 153 · see citing works

ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150 · see citing works

The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease.

Kawai, M., Kalaria, R. N., Harik, S. I., & Perry, G. L. (1990) · PubMed Central · Cited by 141 · see citing works

Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice

Lemere, C. A. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00044-5 · Cited by 138 · see citing works

Amyloid β Peptide–Induced Cerebral Endothelial Cell Death Involves Mitochondrial Dysfunction and Caspase Activation

Xu, J., Chen, S., Ku, G., Ahmed, S. H., Xu, J., Chen, H., & Hsu, C. Y. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200106000-00008 · Cited by 127 · see citing works

Amyloid-β Induces Smac Release via AP-1/Bim Activation in Cerebral Endothelial Cells

Yin, K., Lee, J., Chen, S., Xu, J., & Hsu, C. Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09764.2002 · Cited by 117 · see citing works

Autoimmunity in Alzheimer’s disease: increased levels of circulating IgGs binding Aβ and RAGE peptides

Mruthinti, S., Buccafusco, J. J., Hill, W., Waller, J. L., Jackson, T. W., ZAMRINI, E. Y., & Schade, R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.001 · Cited by 113 · see citing works

Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats

Ueno, M., Sakamoto, H., Liao, Y., Onodera, M., Huang, C., Miyanaka, H., & Nakagawa, T. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0684-y · Cited by 90 · see citing works

Aβ42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3β signaling-dependent mechanism

Suhara, T. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00135-5 · Cited by 66 · see citing works

The integrity of the blood—Brain barrier in Alzheimer's type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid

Leonardi, A., Gandolfo, C., Caponnetto, C., Arata, L., & Vecchia, R. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90121-2 · Cited by 65 · see citing works

Angiogenic signaling in Alzheimer's disease

Pogue, A. I., & Lukiw, W. J. (2004) · Neuroreport · doi:10.1097/01.wnr.0000130539.39937.1d · Cited by 65 · see citing works

Soluble β-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway

Paris, D., Town, T., Mori, T., Parker, T. A., Humphrey, J., & MULLAN, M. J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00111-6 · Cited by 64 · see citing works

Passive Immunization against β-Amyloid Peptide Protects Central Nervous System (CNS) Neurons from Increased Vulnerability Associated with an Alzheimer’s Disease-causing Mutation

Mohajeri, M. H., Saini, K., Schultz, J. G., Wollmer, M. A., Höck, C., & Nitsch, R. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203193200 · Cited by 59 · see citing works

Activation of vascular endothelial cells and perivascular cells by systemic inflammation?an immunohistochemical study of postmortem human brain tissues

Uchikado, H., Akiyama, H., Kondo, H., Ikeda, K., Tsuchiya, K., Kato, M., Oda, T., Togo, T., Iseki, E., & Kosaka, K. (2004) · Acta Neuropathologica · doi:10.1007/s00401-003-0815-x · Cited by 58 · see citing works

Evidence of Blood-Cerebrospinal Fluid-Barrier Impairment in a Subgroup of Patients with Dementia of the Alzheimer Type and Major Depression: A Possible Indicator for Immunoactivation

Hampel, H. J., Müller-Spahn, F., Berger, C., Haberl, A., Ackenheil, M., & Hock, C. (1995) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106969 · Cited by 48 · see citing works

Anti‐amyloid activity of neprilysin in plaque‐bearing mouse models of Alzheimer's disease

Mohajeri, M. H., Kuehnle, K., Li, H., Poirier, R., Tracy, J., & Nitsch, R. M. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00169-3 · Cited by 42 · see citing works

Amyloid-Beta Immunization in Alzheimer's Disease Transgenic Mouse Models and Wildtype Mice

Lemere, C. A., Spooner, E. T., Leverone, J. F., Mori, C., Iglesias, M., Bloom, J. K., & Seabrook, T. J. (2003) · Neurochemical Research · doi:10.1023/a:1023203122036 · Cited by 25 · see citing works

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 881 · see citing works

Apolipoprotein E in Alzheimer’s disease and other neurological disorders

Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · see citing works

The impact of microglial activation on blood-brain barrier in brain diseases

da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572 · see citing works

Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy

Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339 · see citing works

The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat

Kanoski, S. E., Zhang, Y., Zheng, W., & Davidson, T. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091414 · Cited by 324 · see citing works

Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease

Biron, K. E., Dickstein, D. L., Gopaul, R., & Jefferies, W. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023789 · Cited by 300 · see citing works

Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

Paul, J., Strickland, S., & Melchor, J. P. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070304 · Cited by 319 · see citing works

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?

Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050651 · Cited by 271 · see citing works

Microglia and neuroprotection: From in vitro studies to therapeutic applications

Polazzi, E., & Monti, B. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.009 · Cited by 260 · see citing works

Review: Role of developmental inflammation and blood–brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

Stolp, H. B., & Dzięgielewska, K. M. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01005.x · Cited by 259 · see citing works

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model

Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G., & Michikawa, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225532 · Cited by 275 · see citing works

Blood-brain barrier alterations in ageing and dementia

Popescu, B. O., Toescu, E. C., Popescu, L. M., Bajenaru, O. A., Muresanu, D. F., Schultzberg, M., & Bogdanović, N. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.321 · Cited by 235 · see citing works

Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models

Raymond, S. B., Treat, L. H., Dewey, J. D., McDannold, N. J., Hynynen, K., & Bacskai, B. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002175 · Cited by 227 · see citing works

Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice

Lee, C., Hsu, L., Wu, I.-L., Wang, Y., Chen, W.-C., Liu, Y., Yang, L.-T., Tan, C.-L., Luo, Y.-H., Wang, C.-C., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128431 · Cited by 235 · see citing works

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

Takeda, S., Sato, N., & Morishita, R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00171 · Cited by 226 · see citing works

Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

Dickstein, D. L., Walsh, J. J., Brautigam, H., Stockton, S. D., Gandy, S., & Hof, P. R. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20155 · Cited by 206 · see citing works

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ 1–40 Peptides

Xiong, H., Callaghan, D., Jones, A., Bai, J., Rasquinha, I., Smith, C., Pei, K., Walker, D. G., Lue, L., Stanimirovic, D. B., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5103-08.2009 · Cited by 202 · see citing works

Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

Wang, D., Chen, F., Han, Z., Yin, Z., Ge, X., & Lei, P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695479 · Cited by 201 · see citing works

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 192 · see citing works

Drug delivery to the brain in Alzheimer's disease: Consideration of the blood–brain barrier

Banks, W. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.005 · Cited by 184 · see citing works

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Li, J., Zheng, M., Shimoni, O., Banks, W. A., Bush, A. I., Gamble, J. R., & Shi, B. (2021) · Advanced Science · doi:10.1002/advs.202101090 · Cited by 202 · see citing works

Transcriptomic profiling of microglia and astrocytes throughout aging

Pan, J., Ma, N., Yu, B., Zhang, W., & Wan, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01774-9 · Cited by 188 · see citing works

Clearance of Amyloid-β Peptides By Microglia and Macrophages: the Issue of What, When and Where

Lai, A. Y., & McLaurin, J. (2012) · Future Neurology · doi:10.2217/fnl.12.6 · Cited by 161 · see citing works

Blood brain barrier: A review of its anatomy and physiology in health and disease

Sharif, Y., Jumah, F., Coplan, L., Krosser, A., Sharif, Κ., & Tubbs, R. S. (2018) · Clinical Anatomy · doi:10.1002/ca.23083 · Cited by 143 · see citing works

Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

Takeda, S., Sato, N., Ikimura, K., Nishino, H., Rakugi, H., & Morishita, R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.010 · Cited by 135 · see citing works

Immunotherapy Reduces Vascular Amyloid- in PDAPP Mice

Schroeter, S., Khan, K., Barbour, R., Doan, M., Chen, M., Guido, T., Gill, D., Basi, G., Schenk, D., Seubert, P., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2377-07.2008 · Cited by 133 · see citing works

Caffeine Protects Against Disruptions of the Blood-Brain Barrier in Animal Models of Alzheimer's and Parkinson's Diseases

Chen, X., Ghribi, O., & Geiger, J. D. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1376 · Cited by 133 · see citing works

Alzheimer's Mechanisms in Ischemic Brain Degeneration

Pluta, R. M., Ułamek, M., & Jabłoński, M. (2009) · The Anatomical Record · doi:10.1002/ar.21018 · Cited by 132 · see citing works

Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes

Afergan, E., Epstein-Barash, H., Dahan, R., Koroukhov, N., Rohekar, K., Danenberg, H. D., & Golomb, G. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.08.017 · Cited by 125 · see citing works

Developmental and pathological angiogenesis in the central nervous system

Vallon, M., Chang, J., Zhang, J. H., & Kuo, C. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1625-0 · Cited by 124 · see citing works

Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

Tai, L. M., Holloway, K., Male, D. K., Loughlin, J., & Romero, I. A. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00717.x · Cited by 115 · see citing works

Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

Takeuchi, H., Natsume, A., Wakabayashi, T., Aoshima, C., Shimato, S., Ito, M., Ishii, J., Maeda, Y., Hara, M., Kim, S. U., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.08.048 · Cited by 115 · see citing works

Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: Autoantibodies to Aβ(25–35) oligomers, S100b and neurotransmitters

Алексеевна, Г. М., Davidova, T. B., Mališauskas, M., Sewell, R. D. E., Voskresenskaya, N. I., Wilhelm, K., Elistratova, E. I., Sherstnev, V. V., & Morozova‐Roche, L. A. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.03.023 · Cited by 112 · see citing works

Aβ plaque-selective NIR fluorescence probe to differentiate Alzheimer's disease from tauopathies

Rajasekhar, K., Narayanaswamy, N., Murugan, N. A., Viccaro, K., Lee, H., Shah, K., & Govindaraju, T. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.06.030 · Cited by 99 · see citing works

Neuronal histamine and cognitive symptoms in Alzheimer's disease

Zlomuzica, A., Dere, D., Binder, S., Silva, M. A. D. S., Huston, J. P., & Dere, E. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.05.007 · Cited by 99 · see citing works

Pathophysiology of the Blood–Brain Barrier: Animal Models and Methods

Hawkins, B. T., & Egleton, R. D. (2007) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)80007-x · Cited by 96 · see citing works

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques

Kumar‐Singh, S. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00380.x · Cited by 94 · see citing works

Angiotensin II AT2 Receptor Oligomers Mediate G-protein Dysfunction in an Animal Model of Alzheimer Disease

AbdAlla, S., Lother, H., el Missiry, A., Langer, A., Sergeev, P., el Faramawy, Y., & Quitterer, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807746200 · Cited by 89 · see citing works

Caveolin-1 in the Anterior Cingulate Cortex Modulates Chronic Neuropathic Pain via Regulation of NMDA Receptor 2B Subunit

Yang, J., Hua, L., Li, Y., Jiang, Y., Han, D. K., Liu, H., Tang, Q., Yang, X.-N., Cui, Y., Hao, L.-Y., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1161-14.2015 · Cited by 90 · see citing works

Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease

Jefferies, W. A., Price, K. A., Biron, K. E., Fenninger, F., Pfeifer, C. G., & Dickstein, D. L. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt230 · Cited by 85 · see citing works

Apolipoprotein E, Amyloid-β, and Blood-Brain Barrier Permeability in Alzheimer Disease

Donahue, J. E., & Johanson, C. E. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31816a0dc8 · Cited by 86 · see citing works

Spatial Frequency Domain Imaging of Intrinsic Optical Property Contrast in a Mouse Model of Alzheimer’s Disease

Lin, A. J., Koike, M. A., Green, K. N., Kim, J. G., Mazhar, A., Rice, T. B., LaFerla, F. M., & Tromberg, B. J. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0269-6 · Cited by 75 · see citing works

Chronic Intranasal Treatment with an Anti-Aβ30-42 scFv Antibody Ameliorates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Cattepoel, S., Hanenberg, M., Kulic, L., & Nitsch, R. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018296 · Cited by 73 · see citing works

Central and Peripheral Administration of Antisense Oligonucleotide Targeting Amyloid-β Protein Precursor Improves Learning and Memory and Reduces Neuroinflammatory Cytokines in Tg2576 (AβPPswe) Mice

Farr, S. A., Erickson, M. A., Niehoff, M. L., Banks, W. A., & Morley, J. E. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131883 · Cited by 72 · see citing works

Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy

Allen, B. D., Alaghband, Y., Kramár, E. A., Ru, N., Petit, B., Grilj, V., Petronek, M. S., Pulliam, C. F., Kim, R. Y., Doan, N.-L., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac248 · Cited by 63 · see citing works

Peripheral Inflammation, Apolipoprotein E4 , and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction

Marottoli, F. M., Katsumata, Y., Koster, K. P., Thomas, R., Fardo, D. W., & Tai, L. M. (2017) · ASN NEURO · doi:10.1177/1759091417719201 · Cited by 68 · see citing works

Soluble aggregates of the amyloid‐β protein selectively stimulate permeability in human brain microvascular endothelial monolayers

Gonzalez‐Velasquez, F. J., Kotarek, J. A., & Moss, M. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05618.x · Cited by 65 · see citing works

Aβ Immunotherapy Protects Morphology and Survival of Adult-Born Neurons in Doubly Transgenic APP/PS1 Mice

Biscaro, B., Lindvall, O., Höck, C., Ekdahl, C. T., & Nitsch, R. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2055-09.2009 · Cited by 64 · see citing works

Transcutaneous β-amyloid immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage

Nikolic, W. V., Bai, Y., Obregon, D. F., Hou, H., Mori, T., Zeng, J., Ehrhart, J. C., Shytle, R. D., Giunta, B. N., Morgan, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609377104 · Cited by 63 · see citing works

Metallothionein and brain inflammation

Manso, Y., Adlard, P. A., Carrasco, J., Vašák, M., & Hidalgo, J. (2011) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-011-0802-y · Cited by 62 · see citing works

Chronic Sleep Restriction Induces Aβ Accumulation by Disrupting the Balance of Aβ Production and Clearance in Rats

Zhao, B., Liu, P., Wei, M., Li, Y., Liu, J., Ma, L., Shang, S., Jiang, Y., Huo, K., Wang, J., et al. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02719-2 · Cited by 61 · see citing works

Cerebral Amyloid Angiopathy and Blood-Brain Barrier Dysfunction

Gireud, M., Mack, A. F., McCullough, L. D., & Urayama, A. (2020) · The Neuroscientist · doi:10.1177/1073858420954811 · Cited by 61 · see citing works

Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?

Meyer‐Luehmann, M., & Prinz, M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.011 · Cited by 57 · see citing works

A New Hypothesis for Alzheimer’s Disease: The Lipid Invasion Model

Rudge, J. D. (2022) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-210299 · Cited by 58 · see citing works

Glial and endothelial blood-retinal barrier responses to amyloid-β in the neural retina of the rat

Anderson, P. J. (2008) · Clinical ophthalmology · doi:10.2147/opth.s3967 · Cited by 56 · see citing works

Characterization of the role of metallothionein-3 in an animal model of Alzheimer’s disease

Manso, Y., Carrasco, J., Comes, G., Meloni, G., Adlard, P. A., Bush, A. I., Vašák, M., & Hidalgo, J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1047-9 · Cited by 55 · see citing works

MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1

Liu, W., Cai, H., Lin, M., Zhu, L., Gao, L., Zhong, R., Bi, S., Xue, Y., & Shang, X. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.03.026 · Cited by 56 · see citing works

Multifunctional Effect of Human Serum Albumin Reduces Alzheimer’s Disease Related Pathologies in the 3xTg Mouse Model

Ezra, A., Rabinovich-Nikitin, I., Rabinovich‐Toidman, P., & Solomon, B. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150694 · Cited by 50 · see citing works

Delivery of Therapeutic Peptides and Proteins to the CNS

Salameh, T. S., & Banks, W. A. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.06.004 · Cited by 49 · see citing works

Factors in Creepy Delayed Neuronal Death in Hippocampus Following Brain Ischemia–Reperfusion Injury with Long-Term Survival

Pluta, R. M., Januszewski, S., Jabłoński, M., & Ułamek, M. (2009) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-98811-4_5 · Cited by 49 · see citing works

Peripheral Transgene Expression of Plasma Gelsolin Reduces Amyloid in Transgenic Mouse Models of Alzheimer's Disease

Hirko, A. C., Meyer, E. M., King, M. A., & Hughes, J. A. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300253 · Cited by 48 · see citing works

Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury

Zhang, Q., Chen, Q., Kang, J., Liu, C., Dong, N., Zhu, X., Sheng, Z.-Y., & Yao, Y.-M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-118 · Cited by 47 · see citing works

Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia

Nägga, K., Hansson, O., van Westen, D., Minthon, L., & Wennström, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141200 · Cited by 45 · see citing works

Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy

Gustafsson, S. S., Gustavsson, T., Roshanbin, S., Hultqvist, G., Hammarlund‐Udenaes, M., Sehlin, D., & Syvänen, S. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.001 · Cited by 42 · see citing works

Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2

Schultz, N., Nielsen, H. M., Minthon, L., & Wennström, M. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000084 · Cited by 43 · see citing works

Alzheimer’s Disease and the Blood–Brain Barrier: Past, Present and Future

Bowman, G. L., & Quinn, J. F. (2008) · Aging Health · doi:10.2217/1745509x.4.1.47 · Cited by 42 · see citing works

Control of the blood–brain barrier function in cancer cell metastasis

Blecharz, K., Colla, R., Rohde, V., & Vajkoczy, P. (2015) · Biology of the Cell · doi:10.1111/boc.201500011 · Cited by 42 · see citing works

Epidermal growth factor prevents APOE4 -induced cognitive and cerebrovascular deficits in female mice

Thomas, R., Morris, A. W. J., & Tai, L. M. (2017) · Heliyon · doi:10.1016/j.heliyon.2017.e00319 · Cited by 41 · see citing works

Hereditary and Sporadic Forms of Aβ-Cerebrovascular Amyloidosis and Relevant Transgenic Mouse Models

Kumar‐Singh, S. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041872 · Cited by 38 · see citing works

Nanoparticles as Contrast Agents for The Diagnosis of Alzheimer’s Disease: A Systematic Review

Ulanova, M., Poljak, A., Wen, W. X., Bongers, A., Gloag, L., Gooding, J. J., Tilley, R. D., Sachdev, P. S., & Braidy, N. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0316 · Cited by 38 · see citing works

Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics

Singh, C. S. B., Choi, K. B., Munro, L., Wang, H. Y., Pfeifer, C. G., & Jefferies, W. A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103503 · Cited by 36 · see citing works

Atorvastatin partially prevents an inflammatory barrier breakdown of cultured human brain endothelial cells at a pharmacologically relevant concentration

Buttmann, M., Lorenz, A., Weishaupt, A., & Rieckmann, P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04563.x · Cited by 35 · see citing works

Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain

Lyons, A., Murphy, K. J., Clarke, R. M., & Lynch, M. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-27 · Cited by 34 · see citing works

Immunotherapy as treatment for Alzheimer’s disease

Hawkes, C. A., & McLaurin, J. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.11.1535 · Cited by 33 · see citing works

Vascular Endothelial Barrier Dysfunction Mediated by Amyloid-β Proteins

Nagababu, E., Usatyuk, P. V., Enika, D., Natarajan, V., & Rifkind, J. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1104 · Cited by 32 · see citing works

Cessation of Neoangiogenesis in Alzheimer's Disease Follows Amyloid-beta Immunization

Biron, K. E., Dickstein, D. L., Gopaul, R., Fenninger, F., & Jefferies, W. A. (2013) · Scientific Reports · doi:10.1038/srep01354 · Cited by 32 · see citing works

Brain ischemia and ischemic blood–brain barrier as etiological factors in sporadic Alzheimer’s disease

Pluta, R. M. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s3739 · Cited by 32 · see citing works

Protein markers of cerebrovascular disruption of neurovascular unit: immunohistochemical and imaging approaches

Amtul, Z., & Hepburn, J. D. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0041 · Cited by 30 · see citing works

The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison

Jeynes, B., & Provias, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0099-z · Cited by 31 · see citing works

Consideration of the ischaemic basis and treatment of Alzheimer's disease.

Pluta, R. M., Ułamek, M., & Jabłoński, M. (2010) · PubMed · Cited by 29 · see citing works

Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo

Ryu, J., Tran, K., & McLarnon, J. (2007) · Glia · doi:10.1002/glia.20479 · Cited by 30 · see citing works

Immunotherapy in Alzheimer's Disease: Where Do We Stand? Where Should We Go?

Rommy von Bernhardi, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1248 · Cited by 28 · see citing works

The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer’s disease

Brock, A. J., Kasus‐Jacobi, A., Lerner, M. R., Logan, S., Adesina, A. M., & Pereira, H. A. (2015) · Histochemistry and Cell Biology · doi:10.1007/s00418-015-1347-x · Cited by 26 · see citing works

Pathological Changes in Microvascular Morphology, Density, Size and Responses Following Comorbid Cerebral Injury

Amtul, Z., Yang, J., Lee, T., & Cechetto, D. F. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00047 · Cited by 26 · see citing works

Novel therapeutic opportunities for neurodegenerative diseases with mesenchymal stem cells: the focus on modulating the blood-brain barrier

Vargas-Rodríguez, P., Cuenca-Martagón, A., Castillo-González, J., Serrano-Martínez, I., Luque, R. M., Delgado, M., & González-Rey, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814117 · Cited by 25 · see citing works

Engineering of structural and functional properties of nanotherapeutics and nanodiagnostics for intranasal brain targeting in Alzheimer's

Hinge, N. S., Kathuria, H., & Pandey, M. M. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101303 · Cited by 25 · see citing works

Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: a nano-anatomical perspective of barrier genesis

Mentor, S., & Fisher, D. W. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.938315 · Cited by 24 · see citing works

Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy

Finke, J. M., & Banks, W. A. (2016) · Human Antibodies · doi:10.3233/hab-160306 · Cited by 22 · see citing works

Post-Ischemic Permeability of the Blood–Brain Barrier to Amyloid and Platelets as a Factor in the Maturation of Alzheimer’s Disease-Type Brain Neurodegeneration

Pluta, R. M., Miziak, B., & Czuczwar, S. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310739 · Cited by 22 · see citing works

miR-424–5p maybe regulate blood-brain barrier permeability in a model in vitro with Abeta incubated endothelial cells

Lin, M., Zhu, L., Wang, J., Xue, Y., & Shang, X. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.075 · Cited by 21 · see citing works

VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult

Ryu, J. K., & McLarnon, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-18 · Cited by 626 · see citing works

Immunotherapy and Neuroimmunology in Alzheimer‘s Disease: a Perspective from The Blood–Brain Barrier

Banks, W. A. (2009) · Immunotherapy · doi:10.2217/imt.09.72 · Cited by 15 · see citing works

Conclusive demonstration of iatrogenic Alzheimer’s disease transmission in a model of stem cell transplantation

Singh, C. S. B., Johns, K. M., Kari, S., Munro, L., Mathews, A., Fenninger, F., Pfeifer, C. G., & Jefferies, W. A. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.02.012 · Cited by 13 · see citing works

Development of vaccination approaches for the treatment of neurological diseases

Federoff, H. J. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22034 · Cited by 13 · see citing works

Neuroprotective responses of quercetin in regulation of biochemical, structural, and neurobehavioral effects in 28-day oral exposure of iron in rats

Anuradha, U., Angati, A., Gautam, A. S., Dey, M., Pandey, S. K., & Singh, R. K. (2023) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2023.2256840 · Cited by 9 · see citing works

Alzheimer's Factors in Ischemic Brain Injury

Pluta, R. M., & Jaboski, M. (2012) · InTech eBooks · doi:10.5772/27205 · Cited by 9 · see citing works

Oxidative Changes and Possible Effects of Polymorphism of Antioxidant Enzymes in Neurodegenerative Disease

Babušíková, E., Evinová, A., Hatok, J., Dobrota, D., & Jurecekov, J. (2013) · InTech eBooks · doi:10.5772/54619 · Cited by 7 · see citing works

Evaluation of blood-brain barrier permeability in tryptophan hydroxylase 2-knockout mice

Xu, C., PengZhang, DAI, T.-L., Niu, X., Wang, J., Jin, M.-S., & Min-Liao (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1938 · Cited by 6 · see citing works

How to Stabilize Both the Proteins and the Membranes: Diverse Effects of sHsps in Neuroprotection

Tóth, M. E., Sántha, M., Penke, B., & Vı́gh, L. (2015) · Heat shock proteins · doi:10.1007/978-3-319-16077-1_23 · Cited by 5 · see citing works

Active Immunization with DNA Vaccine Reduced Cerebral Inflammation and Improved Cognitive Ability in APP/PS1 Transgenic Mice by In Vivo Electroporation

Xing, X., Sha, S., Chen, X.-H., Guo, W., Guo, R., Jiang, T., & Cao, Y. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1559-4 · Cited by 5 · see citing works

Amyloid β peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood–brain barrier

Poduslo, J. F., & Curran, G. L. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00011 · Cited by 31 · see citing works

Aß peptide immunization restores blood‐brain barrier integrity in Alzheimer disease

(2006) · The FASEB Journal · doi:10.1096/fasebj.20.9.1573-c

Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy

Gustafsson, S. S., Gustavsson, T., Roshanbin, S., Hultqvist, G., Hammarlund‐Udenaes, M., Sehlin, D., & Syvänen, S. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.001 · Cited by 42 · see citing works

Reduction of amyloid β-peptide accumulation in Tg2576 transgenic mice by oral vaccination

Ishii-Katsuno, R., Nakajima, A., Katsuno, T., Nojima, J., Futai, E., Sasagawa, N., Yoshida, T., Watanabe, Y., & Ishiura, S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.120 · Cited by 19 · see citing works

Transcutaneous β-amyloid immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage

Nikolic, W. V., Bai, Y., Obregon, D. F., Hou, H., Mori, T., Zeng, J., Ehrhart, J. C., Shytle, R. D., Giunta, B. N., Morgan, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609377104 · Cited by 63 · see citing works