Estrogen receptor α is essential for induction of oxytocin receptor by estrogen
Abstract
The induction of oxytocin receptor (OTR) synthesis in the periphery and in the brain by estrogen is critical for reproductive success. Oxytocin receptors are involved in the control of parturition, milk ejection, and sexual and maternal behaviors. The discovery of a second estrogen receptor (ERbeta) in the brain and the failure of in vitro transcription studies using OTR promoter constructs to replicate the in vivo transcriptional regulation have raised questions regarding the molecular mechanisms involved in the regulation of the OTR gene by estrogen. Using mice genetically deficient in estrogen receptor alpha (ERalpha), we demonstrate that ERalpha is not necessary for basal OTR synthesis, but is absolutely necessary for the induction of OTR binding in the brain by estrogen.
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Estradiol treatment in mice and rats results in a several-fold increase in OXTR mRNA in the brain.
“an estradiol treatment in mice and rats results in a several-fold increase in OXTR mRNA in the brain (Quinones-Jenab et al., 1997;Young et al., 1998).”
From Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face (2016) · cites this paper as Young et al., 1998
BPA likely influenced ERα, because the oxytocin receptor is an ERα target gene and Oxtr mRNA was changed.
“In fact it is likely that BPA did influence ERα since the oxytocin receptor is an ERα target gene and we noted changes in Oxtr mRNA [59], [60].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [60]
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- Authors
- Young, L. J., Wang, Z., Donaldson, R., & Rissman, E. F.
- Affiliations
- Emory University (US)
- University of Virginia (US)
- Venue
- Neuroreport
- Published
- 1998-03
- Volume
- 9
- Issue
- 5
- Pages
- 933-936
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2051389962
- Cited by
- 198
- References
- 6
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 12 · 2012: 7
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh054554-06)
- National Institute of Mental Health (MH-01349, MH54554, K02MH001349, MH 56897)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor alpha, oxytocin receptor, estrogen regulation of gene expression, estrogen receptor beta, transcriptional regulation, estrogen receptor knockout mice
- MeSH terms
- Animals, Autoradiography, Central Nervous System, Estrogens, Female, Male, Mice, Inbred C57BL, Receptors, Estrogen, Receptors, Oxytocin, Mice
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