Sex-specific effects of pain-related anxiety on adjustment to chronic pain
Abstract
OBJECTIVE: Considerable research indicates that both high levels of anxiety and female sex are associated with increased sensitivity to experimental pain and greater experience of clinical pain. In general, however, previous research has not investigated the joint effects of sex and anxiety on pain responses. A single previous laboratory-based study indicated that anxiety was inversely related to pain thresholds among men but not among women. The present study examined the relation between pain-related anxiety and adjustment to chronic pain in a sex-dependent manner. DESIGN AND SETTING: A total of 215 (114 women, 101 men) chronic pain patients referred to a multidisciplinary treatment center completed questionnaires assessing anxiety and adjustment to chronic pain. RESULTS: Results generally supported the previous laboratory-based finding indicating that an inverse relation between anxiety and adjustment to chronic pain was present only among male patients. Although male patients with high pain-related anxiety reported greater pain severity, greater interference of pain, and lower levels of daily activity than male patients with low anxiety, this effect was not present among female patients. Moreover, the effects of pain-related anxiety on adjustment to chronic pain were not attributable to either hypervigilance or use of passive coping strategies. Potential explanations and implications for the present findings are discussed.
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The stress-buffering hypothesis holds that social support can buffer the negative health consequences of stressors.
“According to the stress-buffering hypothesis, negative consequences of stressors on health outcomes can be buffered by social support 86.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [86]
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Self-citation
- Authors
- Edwards, R., Augustson, E. M., & Fillingim, R.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Edwards, Robert
- Fillingim, Roger
- Venue
- The Clinical Journal of Pain
- Published
- 2000-03
- Volume
- 16
- Issue
- 1
- Pages
- 46-53
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2312918940
- Cited by
- 98
- References
- 55
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 4
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- pain-related anxiety, chronic pain, sex differences, pain intensity, pain interference, daily activities, hypervigilance, multidisciplinary pain management
- MeSH terms
- Activities of Daily Living, Adaptation, Psychological, Adult, Anxiety, Chronic Disease, Female, Humans, Male, Pain, Surveys and Questionnaires, Sex Characteristics, Sickness Impact Profile
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