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How to assess sympathetic activity in humans
Abstract
Sympathetic factors play a central role not only in cardiovascular homeostatic control but also in the pathogenesis and/or in the progression of several cardiovascular diseases, such as essential hypertension, myocardial infarction, cardiac arrhythmias and congestive heart failure. This explains why assessment of adrenergic neural function in humans has been, and certainly still remains, one of the major fields in cardiovascular research. The present paper will review in detail the haemodynamic, pharmacological, biochemical, neurophysiological, neurochemical and neural imaging techniques by which sympathetic activity is assessed in humans, highlighting the main advantages and limitations of each of them. Although plasma noradrenaline measurement represents a useful guide to assess sympathetic neural function, direct recording of sympathetic nerve traffic via microneurography and noradrenaline radiotracer methods have in recent years largely supplanted the plasma noradrenaline approach. This is because they allow (1) discrimination between the central or peripheral nature of increased plasma noradrenaline levels, and (2) precise estimation of the behaviour of regional sympathetic neural function both under physiological and pathological conditions. In contrast, the approach based on spectral analysis of heart rate and blood pressure signals has been shown to have important limitations which prevent the method from faithfully reflecting sympathetic cardiovascular drive. Neural imaging techniques, which require expensive technical support, allow direct visualization of sympathetic enervation of human organs, thus providing information on the 'in vivo' metabolism of noradrenaline in different cardiovascular districts. Although technical improvements have allowed a more precise assessment of human adrenergic function, no technique so far available can be viewed as a 'gold standard' with which the others might be compared. Limitations and disadvantages of the various techniques may be reduced if these methods are seen as being complementary and employed in combination, allowing more reliable information to be achieved on the sympathetic abnormalities characterizing cardiovascular diseases, and thus hopefully providing a stronger rationale for newer therapeutic approaches involving pharmacological modification of the sympathetic nervous system and adrenoreceptors.
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“In healthy humans there are good relationships between the microneurographic data collected in the peroneal nerve and the ones characterizing the cardiac or the renal neural network, but this may not pertain in pathologic states22,.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [22]
In the citing paper
“As a result of these complexities, there is no such thing as “overall” or “generalized” sympathetic nerve activity or tone, and one cannot obtain an overall assessment of the sympathetic nervous system with any single method.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [22]
In the citing paper
“However, the sensitivity and reproducibility of the measurements are far from optimal22.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [22]
In the citing paper
“Interestingly, studies of elderly hypertensives have not always documented an increase in renal norepinephrine spillover in contrast to the finding of increased sympathetic nerve traffic to the skeletal muscle circulation22,28,39,47.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [22]
In the citing paper
“This possibility can be definitively excluded, however, because the pattern of sympathetic activation in lean hypertensive patients differs materially from that seen in mental stress responses.”
From Phenotypic Evidence of Faulty Neuronal Norepinephrine Reuptake in Essential Hypertension (2000) · cites this paper as [18]
Citations
Cites
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., Sandrone, G., Malfatto, G., Dell'Orto, S., & Piccaluga, E. (1986) · Circulation Research · doi:10.1161/01.res.59.2.178 · Cited by 4,130
Cardiovascular neural regulation explored in the frequency domain.
Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991) · Circulation · doi:10.1161/01.cir.84.2.482 · Cited by 3,569
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198409273111303 · Cited by 3,125
Physiological aspects of primary hypertension.
Folkow, B. (1982) · Physiological Reviews · doi:10.1152/physrev.1982.62.2.347 · Cited by 1,768
Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves
Vallbo, A. B., Hagbarth, K. E., Torebjork, H. E., & Wallin, B. G. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.919 · Cited by 1,507
Swedberg, K. B., Eneroth, P. H. E., KJEKSHUS, J. K., & Wilhelmsen, L. (1990) · Circulation · doi:10.1161/01.cir.82.5.1730 · Cited by 1,147
Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man
Rowe, J. W., Young, J. B., Minaker, K. L., Stevens, A. L., Pallotta, J., & Landsberg, L. (1981) · Diabetes · doi:10.2337/diab.30.3.219 · Cited by 1,143
Sympathetic Overactivity in Patients with Chronic Renal Failure
Converse, R. L., Jacobsen, T. N., Toto, R. D., Jost, C. M. T., Cosentino, F., Fouad-Tarazi, F., & Victor, R. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272704 · Cited by 1,132
Montano, N., Ruscone, T. G., Porta, A., Lombardi, F., Pagani, M., & Malliani, A. (1994) · Circulation · doi:10.1161/01.cir.90.4.1826 · Cited by 1,108
Sympathovagal Balance: A Critical Appraisal
Eckberg, D. L. (1997) · Circulation · doi:10.1161/01.cir.96.9.3224 · Cited by 1,087
Hasking, G. J., Esler, M. D., Jennings, G. L., Burton, D., Johns, J. A., & Korner, P. I. (1986) · Circulation · doi:10.1161/01.cir.73.4.615 · Cited by 1,028
Self-citationParati, G., Saul, J. P., Di Rienzo, M., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1276 · Cited by 849
General Characteristics of Sympathetic Activity in Human Muscle Nerves
Delius, W., Hagbarth, K. ‐., Hongell, A., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05157.x · Cited by 831
Leimbach, W., Wallin, B. G., Victor, R. G., Aylward, P. E., Sundlöf, G., & Mark, A. L. (1986) · Circulation · doi:10.1161/01.cir.73.5.913 · Cited by 810
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794
Self-citationCardiovascular regulatory mechanisms in advanced age.
Lakatta, E. G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.413 · Cited by 791
Neural Activity and Ventricular Fibrillation
Bleich, H. L., Boro, E. S., Lown, B., & Verrier, R. L. (1976) · New England Journal of Medicine · doi:10.1056/nejm197605202942107 · Cited by 764
Mark, A. L., Victor, R. G., Nerhed, C., & Wallin, B. G. (1985) · Circulation Research · doi:10.1161/01.res.57.3.461 · Cited by 748
Saul, J. P., Arai, Y., Berger, R. D., Lilly, L. S., Colucci, W. S., & Cohen, R. J. (1988) · The American Journal of Cardiology · doi:10.1016/0002-9149(88)91172-1 · Cited by 706
General Characteristics of Sympathetic Activity in Human Skin Nerves
Hagbarth, K. E., Hallin, R. G., Hongell, A., Torebjörk, H. E., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05167.x · Cited by 689
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642
Self-citationAnderson, E. A., Sinkey, C. A., Lawton, W. J., & Mark, A. L. (1989) · Hypertension · doi:10.1161/01.hyp.14.2.177 · Cited by 632
Sympathetic Activation in Obese Normotensive Subjects
Grassi, G., Seravalle, G., Cattaneo, B. M., Bolla, G. B., Lanfranchi, A., Colombo, M., Giannattasio, C., Brunani, A., Cavagnini, F., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.560 · Cited by 614
Self-citationPlasma catecholamines and essential hypertension. An analytical review.
Goldstein, D. S. (1983) · Hypertension · doi:10.1161/01.hyp.5.1.86 · Cited by 598
Catecholamine metabolism: basic aspects and clinical significance.
Kopin, I. J. (1985) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06859-0 · Cited by 582
Baroreflex Control of Sympathetic Nerve Activity in Essential and Secondary Hypertension
Grassi, G., Cattaneo, B. M., Seravalle, G., Lanfranchi, A., & Mancia, G. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.68 · Cited by 526
Self-citationComparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Robertson, D., Johnson, G., Robertson, R. M., Nies, A. S., Shand, D. G., & Oates, J. A. (1979) · Circulation · doi:10.1161/01.cir.59.4.637 · Cited by 467
Age and gender influence muscle sympathetic nerve activity at rest in healthy humans.
Ng, A. V., Callister, R. J., Johnson, D. G., & Seals, D. R. (1993) · Hypertension · doi:10.1161/01.hyp.21.4.498 · Cited by 444
The variability of muscle nerve sympathetic activity in resting recumbent man
Sundlöf, G., & Wallin, B. G. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp012050 · Cited by 442
Sympathetic Activation and Loss of Reflex Sympathetic Control in Mild Congestive Heart Failure
Grassi, G. M., Seravalle, G., Cattaneo, B. M., Lanfranchi, A. K., Vailati, S., Giannattasio, C., Bo, A. D., Sala, C., Bolla, G. B., Pozzi, M., et al. (1995) · Circulation · doi:10.1161/01.cir.92.11.3206 · Cited by 431
Self-citationBrod, J., Fencl, V., Hejl, Z., & Jirka, J. (1959) · PubMed · Cited by 420
Meredith, I. T., Broughton, A., Jennings, G. L., & Esler, M. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250905 · Cited by 420
Self-citationGuzzetti, S., Piccaluga, E., Casati, R., Cerutti, S., Lombardi, F., Pagani, M., & Malliani, A. (1988) · Journal of Hypertension · doi:10.1097/00004872-198809000-00004 · Cited by 417
The output of sympathetic transmitter from the spleen of the cat
Brown, G. L., & Gillespie, J. S. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005839 · Cited by 414
Regional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
Vaz, M., Jennings, G., Turner, A., Cox, H., Lambert, G., & Esler, M. (1997) · Circulation · doi:10.1161/01.cir.96.10.3423 · Cited by 404
Self-citationKingwell, B. A., Thompson, J. M., Kaye, D. M., McPherson, G. A., Jennings, G., & Esler, M. (1994) · Circulation · doi:10.1161/01.cir.90.1.234 · Cited by 401
Self-citationCircadian Rhythms of Epinephrine and Norepinephrine in Man*
LINSELL, C. R., LIGHTMAN, S. L., MULLEN, P. E., BROWN, M. J., & CAUSON, R. C. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1210 · Cited by 399
Mechanisms responsible for sympathetic activation by cigarette smoking in humans.
Grassi, G., Seravalle, G., Calhoun, D. A., Bolla, G. B., Giannattasio, C., Marabini, M., Del Bo, A., & Mancia, G. (1994) · Circulation · doi:10.1161/01.cir.90.1.248 · Cited by 394
Self-citationBody fat and sympathetic nerve activity in healthy subjects.
Scherrer, U., Randin, D., Tappy, L., Vollenweider, P., Jéquier, E., & Nicod, P. (1994) · Circulation · doi:10.1161/01.cir.89.6.2634 · Cited by 383
Absence of Low-Frequency Variability of Sympathetic Nerve Activity in Severe Heart Failure
van de Borne, P., Montano, N., Pagani, M., Oren, R. M., & Somers, V. K. (1997) · Circulation · doi:10.1161/01.cir.95.6.1449 · Cited by 376
Lown, B., Temte, J. V., Reich, P., Gaughan, C. E., Regestein, Q. R., & Hai, H. A. (1976) · New England Journal of Medicine · doi:10.1056/nejm197603182941201 · Cited by 374
Scherrer, U., & Sartori, C. (1997) · Circulation · doi:10.1161/01.cir.96.11.4104 · Cited by 371
Grassi, G., Seravalle, G., Colombo, M., Bolla, G., Cattaneo, B. M., Cavagnini, F., & Mancia, G. (1998) · Circulation · doi:10.1161/01.cir.97.20.2037 · Cited by 364
Self-citationDetermination of norepinephrine apparent release rate and clearance in humans
Esler, M., Jackman, G. P., Bobik, A., Kelleher, D., Jennings, G., Leonard, P., Skews, H., & Korner, P. I. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90371-0 · Cited by 340
Self-citationCigarette Smoking Increases Sympathetic Outflow in Humans
Narkiewicz, K., van de Borne, P. J. H., Hausberg, M., Cooley, R. L., Winniford, M. D., Davison, D. E., & Somers, V. K. (1998) · Circulation · doi:10.1161/01.cir.98.6.528 · Cited by 338
Role of Parasympathetic Inhibition in the Hyperkinetic Type of Borderline Hypertension
Julius, S., PASCUAL, A. V., & London, R. L. (1971) · Circulation · doi:10.1161/01.cir.44.3.413 · Cited by 336
Manoeuvres Affecting Sympathetic Outflow in Human Skin Nerves
Delius, W., Hagbarth, K. E., Hongell, A., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05168.x · Cited by 334
Sympathetic outflow to muscles during vasovagal syncope
Wallin, B. G., & Sundlöf, G. (1982) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(82)90001-7 · Cited by 326
Sympathetic Cardioneuropathy in Dysautonomias
Goldstein, D. S., Holmes, C. S., Cannon, R. O., Eisenhofer, G., & Kopin, I. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703063361004 · Cited by 322
Wallin, B. G., Esler, M., Dorward, P., Eisenhofer, G., Ferrier, C., Westerman, R., & Jennings, G. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019217 · Cited by 298
Self-citationBerne, C., Fagius, J., Pollare, T., & Hjemdahl, P. (1992) · Diabetologia · doi:10.1007/bf00399935 · Cited by 293
Role of the sympathetic nervous system in human hypertension
Grassi, G. M. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816121-00019 · Cited by 286
Self-citationKaye, D. M., Lambert, G. W., Lefkovits, J., Morris, M. J., Jennings, G., & Esler, M. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90738-2 · Cited by 285
Self-citationVagal and sympathetic mechanisms in patients with orthostatic vasovagal syncope
Morillo, C. A., Eckberg, D. L., Ellenbogen, K. A., Beightol, L. A., Hoag, J. B., Tahvanainen, K. U. O., Kuusela, T. A., & Diedrich, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.8.2509 · Cited by 280
Heart rate as marker of sympathetic activity
Grassi, G., Vailati, S., Bertinieri, G., Seravalle, G., Stella, M. L., DellʼOro, R., & Mancia, G. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816110-00010 · Cited by 279
Self-citationGrassi, G., Colombo, M., Seravalle, G., Spaziani, D., & Mancia, G. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.64 · Cited by 256
Self-citationThe discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves
Macefield, V. G., Wallin, B. G., & Vallbo, A. B. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020482 · Cited by 248
Victor, R. G., Seals, D. R., & Mark, A. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112841 · Cited by 246
Effects of cardiac sympathetic innervation on coronary blood flow
Di Carli, M. F., Tobes, M. C., Mangner, T., Levine, A. B., Muzik, O., Chakroborty, P., & Levine, T. B. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361703 · Cited by 237
Karlsberg, R. P., Cryer, P. E., & Roberts, R. (1981) · American Heart Journal · doi:10.1016/0002-8703(81)90408-7 · Cited by 235
Welle, S. L., Lilavivat, U., & Campbell, R. G. (1981) · Metabolism · doi:10.1016/0026-0495(81)90092-5 · Cited by 233
Holmes, C. S., Eisenhofer, G., & Goldstein, D. S. (1994) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(93)e0430-x · Cited by 227
Fagius, J., & Wallin, B. G. (1993) · Clinical Autonomic Research · doi:10.1007/bf01826234 · Cited by 227
Meredith, I. T., Eisenhofer, G., Lambert, G. W., Dewar, E., Jennings, G., & Esler, M. (1993) · Circulation · doi:10.1161/01.cir.88.1.136 · Cited by 226
Self-citationAge-related changes in muscle sympathetic nerve activity in essential hypertension
Yamada, Y., Miyajima, E., Tochikubo, O., Matsukawa, T., & Ishii, M. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.870 · Cited by 220
Energy turnover of vascular endothelial cells
Culic, O., Gruwel, M. L. H., & Schrader, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.1.c205 · Cited by 220
Noradrenaline turnover during under- and over-eating in normal weight subjects
O’Dea, K., Esler, M., Leonard, P., Stockigt, J. R., & Nestel, P. J. (1982) · Metabolism · doi:10.1016/0026-0495(82)90178-0 · Cited by 189
Self-citationExercise training lowers resting renal but not cardiac sympathetic activity in humans.
Meredith, I. T., Friberg, P., Jennings, G. L., Dewar, E. M., Fazio, V. A., Lambert, G. W., & Esler, M. D. (1991) · Hypertension · doi:10.1161/01.hyp.18.5.575 · Cited by 189
Self-citationPhysical training and baroreceptor control of sympathetic nerve activity in humans.
Grassi, G., Seravalle, G., Calhoun, D. A., & Mancia, G. (1994) · Hypertension · doi:10.1161/01.hyp.23.3.294 · Cited by 187
Self-citationEffects of Aging on the Responsiveness of the Human Cardiac Sympathetic Nerves to Stressors
Esler, M. D., Thompson, J. M., Kaye, D. M., Turner, A. G., Jennings, G. L., Cox, H. S., Lambert, G. W., & Seals, D. R. (1995) · Circulation · doi:10.1161/01.cir.91.2.351 · Cited by 183
Self-citationMechanism of increased alpha adrenergic vasoconstriction in human essential hypertension.
Egan, B. M., Panis, R., Hinderliter, A. L., Schork, N. J., & Julius, S. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113138 · Cited by 183
Lipsitz, L. A., Ryan, S. M., Parker, J. A., Freeman, R. L., Wei, J. Y., & Goldberger, A. L. (1993) · Circulation · doi:10.1161/01.cir.87.2.391 · Cited by 183
Renin, norepinephrine, and epinephrine responses to graded exercise.
Kotchen, T. A., Hartley, L. H., Rice, T. W., Mougey, E. H., Jones, L. G., & Mason, J. W. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.2.178 · Cited by 168
RENAL VASCULAR TONE IN ESSENTIAL AND SECONDARY HYPERTENSION
Hollenberg, N. K., Adams, D., SOLOMON, H., CHENITZ, W. R., Burger, B. M., Abrams, H. L., & Merrill, J. P. (1975) · Medicine · doi:10.1097/00005792-197501000-00002 · Cited by 164
Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980.
Young, J. B., & Macdonald, I. A. (1992) · PubMed · Cited by 163
Plasma and urinary norepinephrine values at extremes of sodium intake in normal man.
Luft, F. C., Rankin, L. I., Henry, D. P., Bloch, R., Grim, C. E., Weyman, A. E., Murray, R. H., & Weinberger, M. H. (1979) · Hypertension · doi:10.1161/01.hyp.1.3.261 · Cited by 163
Renal noradrenaline spillover correlates with muscle sympathetic activity in humans.
Wallin, B. G., Thompson, J. M., Jennings, G., & Esler, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021265 · Cited by 160
Self-citationKaye, D. M., Esler, M., Kingwell, B. A., McPherson, G. E., Esmore, D. S., & Jennings, G. (1993) · Circulation · doi:10.1161/01.cir.88.3.1110 · Cited by 159
Self-citationAllman, K. C., Wieland, D. M., Muzik, O., DeGrado, T. R., Wolfe, E. R., & Schwaiger, M. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90039-4 · Cited by 155
Sympathoneural and haemodynamic characteristics of young subjects with mild essential hypertension
Floras, J. S., & Hara, K. (1993) · Journal of Hypertension · doi:10.1097/00004872-199306000-00009 · Cited by 137
Kang, J., Richards, E. M., Posner, P., & Sumners, C. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.1.c278 · Cited by 133
Grassi, G. M., Bolla, G., Seravalle, G., Turri, C., Lanfranchi, A. K., & Mancia, G. (1997) · Clinical Science · doi:10.1042/cs0920285 · Cited by 132
Self-citationSympathetics, insulin resistance and coronary risk in hypertension: the chicken-and-egg question
Julius, S., & Jamerson, K. (1994) · Journal of Hypertension · doi:10.1097/00004872-199405000-00001 · Cited by 127
Increased Sympathetic Outflow in Cirrhosis and Ascites: Direct Evidence from Intraneural Recordings
Floras, J. S., Legault, L., Morali, G. A., Hara, K., & Blendis, L. M. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-5-373 · Cited by 125
Positron emission tomographic imaging of cardiac sympathetic innervation and function.
Goldstein, D. S., Chang, P. C., Eisenhofer, G., Miletich, R. S., Finn, R., Bacher, J. D., Kirk, K. L., Bacharach, S. L., & Kopin, I. J. (1990) · Circulation · doi:10.1161/01.cir.81.5.1606 · Cited by 124
Esler, M., Dudley, F., Jennings, G., Debinski, H. S., Lambert, G. W., Jones, P., Crotty, B. J., Colman, J. C., & Willett, I. R. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-6-446 · Cited by 112
Self-citationRenal neurohormonal and vascular responses to dynamic exercise in humans
Tidgren, B., Hjemdahl, P., Theodorsson, E., & Nussberger, J. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.5.2279 · Cited by 112
Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart
Esler, M., Kaye, D. M., Thompson, J., Jennings, G., Cox, H. S., Turner, A., Lambert, G. W., & Seals, D. R. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852502 · Cited by 110
Self-citationSympathetic nerve discharge in normal pregnancy and pregnancy-induced hypertension
Greenwood, J. P., Stoker, J. B., Walker, J. J., & Mary, D. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816050-00009 · Cited by 110
Increase in Muscle Nerve Sympathetic Activity in Humans after Food Intake
Fagius, J., & Berne, C. (1994) · Clinical Science · doi:10.1042/cs0860159 · Cited by 109
Björn Folkow Award Lecture The sympathetic nervous system in hypertension
Mancia, G. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00056 · Cited by 107
Parati, G., Pomidossi, G. A., Casadei, R., Ravogli, A., Groppelli, A., Cesana, B. M., & Mancia, G. (1988) · Journal of Hypertension · doi:10.1097/00004872-198806000-00008 · Cited by 106
Goldstein, D. S., Eisenhofer, G., Dunn, B. B., Armando, I., Lenders, J. W. M., Grossman, E., Holmes, C. S., Kirk, K. L., Bacharach, S. L., Adams, R., et al. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90786-z · Cited by 106
Measurement of overall and cardiac norepinephrine release into plasma during cognitive challenge
Esler, M., Jennings, G., & Lambert, G. W. (1989) · Psychoneuroendocrinology · doi:10.1016/0306-4530(89)90047-4 · Cited by 101
Self-citationHasking, G. J., Esler, M., Jennings, G., Dewar, E., & Lambert, G. W. (1988) · Circulation · doi:10.1161/01.cir.78.3.516 · Cited by 98
Self-citationEffect of energy-restricted diet on sympathetic muscle nerve activity in obese women.
Andersson, B., Elam, M., Wallin, B. G., Björntorp, P. A., & Andersson, O. K. (1991) · Hypertension · doi:10.1161/01.hyp.18.6.783 · Cited by 98
Activation of neurohumoral systems following acute myocardial infarction
Rouleau, J. L., Moyé, L. A., de Champlain, J., Klein, M. D., Bichet, D. G., Packer, M., Sussex, B. A., Arnold, J. M. O., Sestier, F., Parker, J. O., et al. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90264-l · Cited by 96
Baroreflex control of muscle sympathetic nerve activity in borderline hypertension.
Rea, R. F., & Hamdan, M. (1990) · Circulation · doi:10.1161/01.cir.82.3.856 · Cited by 96
Regional Sympathetic Nervous Activation after a Large Meal in Humans
Cox, H. S., Kaye, D. M., Thompson, J. M., Turner, A., Jennings, G., Itsiopoulos, C., & Esler, M. (1995) · Clinical Science · doi:10.1042/cs0890145 · Cited by 95
Self-citationElevated sympathetic nerve activity in patients with accelerated essential hypertension.
Matsukawa, T., Mano, T., Gotoh, E., & Ishii, M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116558 · Cited by 94
Evidence for increased renal norepinephrine overflow during sodium restriction in humans.
Friberg, P., Meredith, I. T., Jennings, G., Lambert, G. W., Fazio, V., & Esler, M. D. (1990) · Hypertension · doi:10.1161/01.hyp.16.2.121 · Cited by 91
Self-citationTreatment of chronic heart failure
Packer, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)90406-s · Cited by 82
Reflex control of the human cardiovascular system
Shepherd, J. T., & Mancia, G. (2006) · Springer eBooks · doi:10.1007/bfb0034497 · Cited by 82
Plasma norepinephrine responses to head-up tilt are misleading in autonomic failure.
Meredith, I. T., Eisenhofer, G., Lambert, G. W., Jennings, G. L., Thompson, J., & Esler, M. D. (1992) · Hypertension · doi:10.1161/01.hyp.19.6.628 · Cited by 81
Self-citationWallin, B. G., Mörlin, C., & Hjemdahl, P. (1987) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1987.tb08088.x · Cited by 76
Central motor command activates sympathetic outflow to the cutaneous circulation in humans.
Vissing, S. F., & Hjortsø, E. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021359 · Cited by 75
Sympathetic nerve activity related to local fatigue sensation during static contraction
Saito, M., Mano, T., & Iwase, S. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.3.980 · Cited by 74
Bradley, T., & Hjemdahl, P. (1984) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1984.tb07521.x · Cited by 72
Arterial-venous differences of plasma catecholamines in man
Halter, J. B., Pflug, A. E., & Tolas, A. G. (1980) · Metabolism · doi:10.1016/0026-0495(80)90090-6 · Cited by 67
Sugenoya, J., Iwase, S., Mano, T., Sugiyama, Y., Ogawa, T., NISHIYAMA, T., Nishimura, N., & Kimura, T. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.603bt.x · Cited by 66
Manhem, P., LECEROF, H., & HÖKFELT, B. (1978) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1978.tb06288.x · Cited by 65
Shannon, J. R., Jordan, J., Black, B. K., Costa, F., & Robertson, D. (1998) · Hypertension · doi:10.1161/01.hyp.32.1.101 · Cited by 65
The Neurogenic Component in Hypertension
Doyle, A. E., & Smirk, F. H. (1955) · Circulation · doi:10.1161/01.cir.12.4.543 · Cited by 63
Independent control of skin and muscle sympathetic nerve activity in patients with heart failure.
Middlekauff, H. R., Hamilton, M. A., Stevenson, L. W., & Mark, A. L. (1994) · Circulation · doi:10.1161/01.cir.90.4.1794 · Cited by 62
Impaired Cardiovascular Autonomic Response to Passive Tilting in Cirrhosis With Ascites
Laffi, G., Lagi, A., Cipriani, M., Barletta, G., Bernardi, L., Fattorini, L., Melani, L., Riccardi, D., Bandinelli, G., Mannelli, M., et al. (1996) · Hepatology · doi:10.1053/jhep.1996.v24.pm0008903376 · Cited by 62
Assessment of norepinephrine secretion and production.
Hoeldtke, R. D., Cilmi, K. M., Reichard, G., Boden, G. H., & Owen, O. E. (1983) · PubMed · Cited by 61
Baroreflex Impairment by Low Sodium Diet in Mild or Moderate Essential Hypertension
Grassi, G., Cattaneo, B. M., Seravalle, G., Lanfranchi, A., Bolla, G., & Mancia, G. (1997) · Hypertension · doi:10.1161/01.hyp.29.3.802 · Cited by 60
Self-citationParati, G., Pomidossi, G. A., Ramirez, A. J., Cesana, B. M., & Mancia, G. (1985) · Clinical Science · doi:10.1042/cs0690533 · Cited by 53
Goldstein, D. S., Holmes, C. S., Stuhlmuller, J. E., Lenders, J. W. M., & Kopin, I. J. (1997) · Clinical Autonomic Research · doi:10.1007/bf02267622 · Cited by 51
Prospective study of symptoms after human microneurography
Eckberg, D. L., Wallin, B. G., Fagius, J., Lundberg, L. E. R., & Torebjörk, H. E. (1989) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1989.tb08804.x · Cited by 51
Baroreflex control of muscle sympathetic nerve activity is attenuated in the elderly
Matsukawa, T., Sugiyama, Y., Watanabe, T., Kobayashi, F., & Mano, T. (1998) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(98)00128-3 · Cited by 51
Skin nerve sympathetic activity during insulin-induced hypoglycaemia
Berne, C., & Fagius, J. (1986) · Diabetologia · doi:10.1007/bf00870140 · Cited by 48
Enhanced erythropoietin secretion in hepatoblastoma cells in response to hypoxia
Ueno, M. K., Seferyńska, I., Beckman, B. S., Brookins, J. W., Nakashima, J., & Fisher, J. W. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.257.4.c743 · Cited by 42
Clonidine and Sympathetic Activity during Sleep
Tj, M., Dollery, C. T., & Hamilton, C. (1979) · Clinical Science · doi:10.1042/cs0570509 · Cited by 36
ANDERSSON, B., WALLIN, G., HEDNER, T., AHLBERG, A., & ANDERSSON, O. K. (1988) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1988.tb17685.x · Cited by 35
Stables, R., Flather, M. D., & Sigwart, U. (1998) · European Heart Journal · doi:10.1053/euhj.1997.0816 · Cited by 34
Andersson, O. K., Persson, B., Hedner, T., Aurell, M., Berglund, G., & Fagerberg, B. (1986) · Journal of Hypertension · doi:10.1097/00004872-198602000-00016 · Cited by 33
Aono, T., Sato, T., Nishinaga, M., Kawamoto, A., & Ozawa, T. (1996) · Hypertension Research · doi:10.1291/hypres.19.9 · Cited by 31
Is adrenaline released by sympathetic nerves in man?
Esler, M., Eisenhofer, G., Chin, J. P. F., Jennings, G., Meredith, I. T., Cox, H. S., Lambert, G. W., Thompson, J. M., & Dart, A. M. (1991) · Clinical Autonomic Research · doi:10.1007/bf01826204 · Cited by 31
Self-citationLambert, G. W., Thompson, J. M., Turner, A., Cox, H. S., Wilkinson, D. J. C., Vaz, M. A. P., Kalff, V., KELLY, M. J., Jennings, G., & Esler, M. (1997) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(97)00018-0 · Cited by 30
Self-citationKohara, K., Igase, M., Maguchi, M., FUKUOKA, T., Kitami, Y., & Hiwada, K. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)00198-7 · Cited by 28
Demonstration of neuronal and extraneuronal uptake of circulating norepinephrine in the forearm.
Chang, P. C., Krogt, J. A. V. D., & van Brummelen, P. (1987) · Hypertension · doi:10.1161/01.hyp.9.6.647 · Cited by 24
Tidgren, B., & Hjemdahl, P. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08455.x · Cited by 19
Boulos, M., Barron, S. A., Nicolski, E., & Markiewicz, W. (2008) · Cardiology · doi:10.1159/000177056 · Cited by 18
Differential actions of desipramine on sympathoadrenal release of noradrenaline and adrenaline.
Eisenhofer, G., Friberg, P., Goldstein, D. S., & Esler, M. (1995) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1995.tb05782.x · Cited by 14
Self-citationObservations on some possible precursors of essential hypertension and coronary artery disease
Thomas, C. B., Stanley, J. A., & Kendrick, M. A. (1961) · Journal of Chronic Diseases · doi:10.1016/0021-9681(61)90094-7 · Cited by 12
Research works printed but not linked: 22
- Cyon, 1866, Ber Sachs Ges Akad Wiss, 18, 307
- Pavlov, 1887, Arch Anat Physiol, 452-, 468
- Brod, 1959, Clin Sci, 18, 269
- Hoeldtke, 1983, J Lab Clin Med, 101, 772
- Kopin, 1985, Pharmacol Rev, 37, 333
- Hjemdahl, 1993, Clin Endocrinol Metab, 7, 307
- Young, 1992, Int J Obes Relat Metab Disord, 16, 959
- Folkow, 1983, Hypertension, 5, 398
- Kopin, 1998, Am J Physiol, 275, R165
- Esler, 1984, Am J Physiol, 247, E21
- Eisenhofer, 1991, Am J Physiol, 261, E505
- Esler, 1991, Am J Physiol, 260, R817
- Cousineau, 1984, Am J Physiol, 246, H283
- Axelrod, 1985, Am J Physiol, 249, H867
- Arai, 1989, Am J Physiol, 256, H132
- Hoshikawa, 1997, Am J Physiol, 272, H1113
- Laffi, 1996, Hepatology, 24, 1063, 10.1002/hep.510240514 · DOI
- Tidgren, 1989, Am J Physiol, 257, F682
- Tidgren, 1990, Am J Physiol, 259, F253
- Anderson, 1989, Hypertension, 14, 177, 10.1161/01.HYP.14.2.177 · DOI · Paper page
- Young, 1984, Am J Physiol, 247, E35
- Esler, 1995, J Clin Endocrinol Metab, 80, 435, 10.1210/jc.80.2.435 · DOI
Cited by
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Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616
Self-citationThe human sympathetic nervous system: its relevance in hypertension and heart failure
Parati, G., & Esler, M. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs041 · Cited by 538
Self-citationZoccali, C., Mallamaci, F., Parlongo, S., Cutrupi, S., Benedetto, F. A., Tripepi, G., Bonanno, G., Rapisarda, F., Fatuzzo, P., Seminara, G., et al. (2002) · Circulation · doi:10.1161/hc1102.105261 · Cited by 519
Innovations in Electrodermal Activity Data Collection and Signal Processing: A Systematic Review
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Metadata
- Authors
- Grassi, G., & Esler, M.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Grassi, Guido
- Venue
- Journal of Hypertension
- Published
- 1999-06
- Volume
- 17
- Issue
- 6
- Pages
- 719-734
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2091732895
- Semantic Scholar
- bc74577c141bc3ba2446fc838afe6f049c0c2e1d
- Cited by
- 455
- References
- 137
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 22 · 2018: 12 · 2017: 11 · 2016: 22 · 2015: 21 · 2014: 19 · 2013: 17 · 2012: 23
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- sympathetic nervous system, plasma norepinephrine, microneurography, heart rate variability, blood pressure variability, spectral analysis, cardiovascular disease, essential hypertension, congestive heart failure, adrenergic receptors
- MeSH terms
- Cardiovascular System, Hemodynamics, Humans, Norepinephrine, Sympathetic Nervous System, Tomography, Emission-Computed
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