Cited by 113Pain Management and Placebo EffectPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 122 of the 124 references it cites were found in a registry or an index.

Placebo 2.0: the impact of expectations on analgesic treatment outcome

Bingel, Ulrike·2020·Pain

DOI 10.1097/j.pain.0000000000001981

Open this paper in CoChat — free account

Abstract

Klinik für Neurologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Duisburg, Germany Corresponding author. Address: Klinik für Neurologie, Universitätsklinikum Essen, Hufelandstr. 55, Essen 45147. Tel.: +49 201 723 2165. E-mail address: [email protected] (U. Bingel). Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Integrity signals

Registry

Crossref · 10.1097/j.pain.0000000000001981

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

View Through a Window May Influence Recovery from Surgery
Ulrich, R. S. (1984) · Science · doi:10.1126/science.6143402 · Cited by 5,341
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
An fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488
THE MECHANISM OF PLACEBO ANALGESIA
Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094
Corticostriatal functional connectivity predicts transition to chronic back pain
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050
Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899
Towards a theory of chronic pain
Apkarian, A. V., Baliki, M. N., & Geha, P. Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.018 · Cited by 876
Changing illness perceptions after myocardial infarction: an early intervention randomized controlled trial
Petrie, K. J., Cameron, L. D., Ellis, C. J., Buick, D., & Weinman, J. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200207000-00007 · Cited by 851
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839
Self-citation
The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil
Bingel, U., Wanigasekera, V., Wiech, K., Ni Mhuircheartaigh, R., Lee, M. C., Ploner, M., & Tracey, I. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001244 · Cited by 810
Self-citation
The subjective experience of pain: where expectations become reality
Koyama, T., McHaffie, J. G., Laurienti, P. J., & Coghill, R. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408576102 · Cited by 747
The placebo response in medicine: minimize, maximize or personalize?
Enck, P., Bingel, U., Schedlowski, M., & Rief, W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3923 · Cited by 671
Self-citation
Significance of the insula for the evolution of human awareness of feelings from the body
(Bud) Craig, A. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05990.x · Cited by 646
Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.34 · Cited by 637
Untitled work
(2020) · doi:10.1056/nejmra1907805 · Cited by 634
An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
Price, D. D., Milling, L. S., Kirsch, I., Duff, A., Montgomery, G. H., & Nicholls, S. S. (1999) · Pain · doi:10.1016/s0304-3959(99)00081-0 · Cited by 569
Overt versus covert treatment for pain, anxiety, and Parkinson's disease
Colloca, L., Lopiano, L., Lanotte, M., & Benedetti, F. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00908-1 · Cited by 565
TREATMENT OF EXCESSIVE AXILLARY SWEATING
Gibbs, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91979-5 · Cited by 560
Direct evidence for spinal cord involvement in placebo analgesia
Eippert, F., Finsterbusch, J., Bingel, U., & Büchel, C. (2009) · Science · doi:10.1126/science.1180142 · Cited by 512
Self-citation
Deconstructing the sensation of pain: The influence of cognitive processes on pain perception
Wiech, K. (2016) · Science · doi:10.1126/science.aaf8934 · Cited by 503
Placebo Effects in Medicine
Kaptchuk, T. J., & Miller, F. G. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1504023 · Cited by 500
Placebos and painkillers: is mind as real as matter?
Colloca, L., & Benedetti, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1705 · Cited by 465
Response variability to analgesics: a role for non-specific activation of endogenous opioids
Amanzio, M., Pollo, A., Maggi, G., & Benedetti, F. (2001) · Pain · doi:10.1016/s0304-3959(00)00486-3 · Cited by 429
The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect
Benedetti, F., Amanzio, M., Vighetti, S., & Asteggiano, G. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2947-06.2006 · Cited by 419
Placebo analgesia induced by social observational learning
Colloca, L., & Benedetti, F. (2009) · Pain · doi:10.1016/j.pain.2009.01.033 · Cited by 416
The role of learning in nocebo and placebo effects
Colloca, L., Sigaudo, M., & Benedetti, F. (2008) · Pain · doi:10.1016/j.pain.2008.02.006 · Cited by 411
Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks
Kam-Hansen, S., Jakubowski, M., Kelley, J. M., Kirsch, I., Hoaglin, D. C., Kaptchuk, T. J., & Burstein, R. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006175 · Cited by 399
Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination
Kucyi, A., Moayedi, M., Weissman-Fogel, I., Goldberg, M. B., Freeman, B. V., Tenenbaum, H. C., & Davis, K. D. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5055-13.2014 · Cited by 396
The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients
Vase, L., Robinson, M. E., Verne, N. G., & Price, D. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00073-3 · Cited by 377
Nocebo hyperalgesia: how anxiety is turned into pain
Colloca, L., & Benedetti, F. (2007) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3282b972fb · Cited by 350
Loss of expectation-related mechanisms in Alzheimer’s disease makes analgesic therapies less effective
Benedetti, F., Arduino, C., Costa, S., Vighetti, S., Tarenzi, L., Rainero, I., & Asteggiano, G. (2006) · Pain · doi:10.1016/j.pain.2005.12.016 · Cited by 347
Meta-analysis of the placebo response in antidepressant trials.
Rief, W., Nestoriuc, Y., Weiss, S., Welzel, E., Barsky, A. J., & Hofmann, S. G. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.01.029 · Cited by 346
Prefrontal cortex modulates placebo analgesia
Krummenacher, P., Candia, V., Folkers, G., Schedlowski, M., & Schönbächler, G. (2010) · Pain · doi:10.1016/j.pain.2009.09.033 · Cited by 337
Placebo Effects: From the Neurobiological Paradigm to Translational Implications
Benedetti, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.023 · Cited by 327
Nocebo effects, patient–clinician communication, and therapeutic outcomes
Colloca, L., & Finniss, D. (2012) · JAMA · doi:10.1001/jama.2012.115 · Cited by 326
Influence of the method of drug administration on analgesic response
Levine, J. D., & Gordon, N. C. (1984) · Nature · doi:10.1038/312755a0 · Cited by 324
Neuro-bio-behavioral mechanisms of placebo and nocebo responses: implications for clinical trials and clinical practice
Schedlowski, M., Enck, P., Rief, W., & Bingel, U. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009423 · Cited by 323
Self-citation
The balanced placebo design: Methodological considerations
Rohsenow, D. J., & Marlatt, G. A. (1981) · Addictive Behaviors · doi:10.1016/0306-4603(81)90003-4 · Cited by 310
Psychobiological mechanisms of placebo and nocebo effects: pathways to improve treatments and reduce side effects
Petrie, K. J., & Rief, W. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102907 · Cited by 309
Differential Effectiveness of Placebo Treatments
Meißner, K., Fässler, M., Rücker, G., Kleijnen, J., Hróbjartsson, A., Schneider, A., Antes, G., & Linde, K. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.10391 · Cited by 308
Nonconscious activation of placebo and nocebo pain responses
Jensen, K. B., Kaptchuk, T. J., Kirsch, I., Raicek, J., Lindstrom, K. M., Berna, C., Gollub, R. L., Ingvar, M., & Kong, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202056109 · Cited by 305
Finasteride 5 mg and Sexual Side Effects: How Many of these are Related to a Nocebo Phenomenon?
Mondaini, N., Gontero, P., Giubilei, G., Lombardi, G., Cai, T., Gavazzi, A., & Bartoletti, R. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00563.x · Cited by 300
Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
Benedetti, F., Amanzio, M., Rosato, R., & Blanchard, C. (2011) · Nature Medicine · doi:10.1038/nm.2435 · Cited by 289
Genetics and the placebo effect: the placebome
Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.009 · Cited by 281
A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
Kong, J., Gollub, R. L., Polich, G., Kirsch, I., LaViolette, P., Vangel, M., Rosen, B., & Kaptchuk, T. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2944-08.2008 · Cited by 263
Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial
Rief, W., Shedden-Mora, M. C., Laferton, J. A. C., Auer, C., Petrie, K. J., Salzmann, S., Schedlowski, M., & Moosdorf, R. (2017) · BMC Medicine · doi:10.1186/s12916-016-0767-3 · Cited by 261
Distorted Cognitive Processes in Major Depression: A Predictive Processing Perspective
Κube, T., Schwarting, R. K. W., Rozenkrantz, L., Glombiewski, J. A., & Rief, W. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.017 · Cited by 257
A systematic review of adverse events in placebo groups of anti-migraine clinical trials
Amanzio, M., Corazzini, L. L., Vase, L., & Benedetti, F. (2009) · Pain · doi:10.1016/j.pain.2009.07.010 · Cited by 232
Gray matter alterations in chronic pain: A network-oriented meta-analytic approach
Cauda, F., Palermo, S., Costa, T., Torta, R., Duca, S., Vercelli, U., Geminiani, G., & Torta, D. M. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.04.007 · Cited by 212
Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome
Hall, K. T., Lembo, A. J., Kirsch, I., Ziogas, D. C., Douaiher, J., Jensen, K. B., Conboy, L. A., Kelley, J. M., Kokkotou, E. G., & Kaptchuk, T. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048135 · Cited by 212
The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic response
Schweinhardt, P., Seminowicz, D. A., Jaeger, E., Duncan, G. H., & Bushnell, M. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5634-08.2009 · Cited by 210
Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia
Tinnermann, A., Geuter, S., Sprenger, C., Finsterbusch, J., & Büchel, C. (2017) · Science · doi:10.1126/science.aan1221 · Cited by 208
Expectations predict chronic pain treatment outcomes
Cormier, S., Lavigne, G. L., Choinière, M., & Rainville, P. (2015) · Pain · doi:10.1097/j.pain.0000000000000379 · Cited by 208
Patients’ Expectations Predict Surgery Outcomes: A Meta-Analysis
Auer, C. J., Glombiewski, J. A., Doering, B. K., Winkler, A., Laferton, J. A. C., Broadbent, E., & Rief, W. (2015) · International Journal of Behavioral Medicine · doi:10.1007/s12529-015-9500-4 · Cited by 204
Differences in Adverse Effect Reporting in Placebo Groups in SSRI and Tricyclic Antidepressant Trials: A Systematic Review and Meta-Analysis
Rief, W., Nestoriuc, Y., von Lilienfeld-Toal, A., Dogan, I., Schreiber, F., Hofmann, S. G., Barsky, A. J., & Avorn, J. (2009) · Drug Safety · doi:10.2165/11316580-000000000-00000 · Cited by 202
Avoiding Nocebo Effects to Optimize Treatment Outcome
Bingel, U. (2014) · JAMA · doi:10.1001/jama.2014.8342 · Cited by 191
Self-citation
Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF)
Witthöft, M., & Rubin, G. J. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.12.002 · Cited by 184
Functional dissociation of stimulus intensity encoding and predictive coding of pain in the insula
Geuter, S., Boll, S., Eippert, F., & Büchel, C. (2017) · eLife · doi:10.7554/elife.24770 · Cited by 184
Nocebo hyperalgesia induced by social observational learning
Vögtle, E., Barke, A., & Kröner‐Herwig, B. (2013) · Pain · doi:10.1016/j.pain.2013.04.041 · Cited by 180
Dissociable Influences of Opiates and Expectations on Pain
Atlas, L. Y., Whittington, R. A., Lindquist, M. A., Wielgosz, J., Sonty, N., & Wager, T. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0383-12.2012 · Cited by 177
Duloxetine use in chronic painful conditions – individual patient data responder analysis
Moore, A., Cai, N., Skljarevski, V., & Tölle, T. R. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00341.x · Cited by 169
Medication-Attributed Adverse Effects in Placebo Groups: Implications for Assessment of Adverse Effects
Rief, W., Avorn, J., & Barsky, A. J. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.2.155 · Cited by 167
Placebo Effects on the Neurologic Pain Signature
Zunhammer, M., Bingel, U., & Wager, T. D. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.2017 · Cited by 167
Self-citation
Opioid-Mediated Placebo Responses Boost Pain Endurance and Physical Performance: Is It Doping in Sport Competitions?
Benedetti, F., Pollo, A., & Colloca, L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3330-07.2007 · Cited by 162
A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses
Jensen, K. B., Kaptchuk, T. J., Chen, X., Kirsch, I., Ingvar, M., Gollub, R. L., & Kong, J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu275 · Cited by 152
Facilitation of Pain in the Human Spinal Cord by Nocebo Treatment
Geuter, S., & Büchel, C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2191-13.2013 · Cited by 152
A psychophysical analysis of experiential factors that selectively influence the affective dimension of pain
Price, D. D., Barrell, J. J., & Gracely, R. H. (1980) · Pain · doi:10.1016/0304-3959(88)90001-2 · Cited by 138
Placebo and nocebo effects in randomized double‐blind clinical trials of agents for the therapy for fatigue in patients with advanced cancer
de la Cruz, M., Hui, D., Parsons, H. A., & Bruera, E. D. (2009) · Cancer · doi:10.1002/cncr.24751 · Cited by 127
Utilizing placebo mechanisms for dose reduction in pharmacotherapy
Doering, B. K., & Rief, W. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.12.001 · Cited by 126
Harnessing the placebo effect: the need for translational research
Colloca, L., & Miller, F. G. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0399 · Cited by 125
Resting state connectivity correlates with drug and placebo response in fibromyalgia patients
Schmidt-Wilcke, T., Ichesco, E., Hampson, J. P., Kairys, A., Peltier, S., Harte, S., Clauw, D. J., & Harris, R. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.09.007 · Cited by 122
Predictors of the placebo analgesia response in randomized controlled trials of chronic pain
Vase, L., Vollert, J., Finnerup, N. B., Miao, X., Atkinson, G., Marshall, S. F., Németh, R., Lange, B., Liss, C., Price, D. D., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000217 · Cited by 121
White matter integrity of the descending pain modulatory system is associated with interindividual differences in placebo analgesia
Stein, N., Sprenger, C., Scholz, J., Wiech, K., & Bingel, U. (2012) · Pain · doi:10.1016/j.pain.2012.07.010 · Cited by 120
Self-citation
Prediction of nonspecific side effects in rheumatoid arthritis patients by beliefs about medicines
Nestoriuc, Y., Orav, E. J., Liang, M. H., Horne, R., & BARSKY, A. J. (2010) · Arthritis Care & Research · doi:10.1002/acr.20160 · Cited by 116
Brain networks predicting placebo analgesia in a clinical trial for chronic back pain
Hashmi, J. A., Baria, A. T., Baliki, M. N., Huang, L., Schnitzer, T. J., & Apkarian, V. A. (2012) · Pain · doi:10.1016/j.pain.2012.08.008 · Cited by 115
Variability in placebo analgesia and the role of fear of pain—an ERP study
Lyby, P. S., Aslaksen, P. M., & Flaten, M. A. (2011) · Pain · doi:10.1016/j.pain.2011.07.010 · Cited by 110
Nocebo and placebo modulation of hypobaric hypoxia headache involves the cyclooxygenase-prostaglandins pathway
Benedetti, F., Durando, J., & Vighetti, S. (2014) · Pain · doi:10.1016/j.pain.2014.01.016 · Cited by 109
Changing Mindsets to Enhance Treatment Effectiveness
Crum, A. J., & ZUCKERMAN, B. S. (2017) · JAMA · doi:10.1001/jama.2017.4545 · Cited by 108
Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana
Metrik, J., Rohsenow, D. J., Monti, P. M., McGeary, J., Cook, T. A. R., de Wit, H., Haney, M., & Kahler, C. W. (2009) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0016502 · Cited by 107
Pain-Related Expectation and Prediction Error Signals in the Anterior Insula Are Not Related to Aversiveness
Fazeli, S., & Büchel, C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-18.2018 · Cited by 105
The Effect of Treatment History on Therapeutic Outcome: An Experimental Approach
Kessner, S. S., Wiech, K., Forkmann, K., Ploner, M., & Bingel, U. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.6705 · Cited by 103
Self-citation
The hidden effects of blinded, placebo-controlled randomized trials: An experimental investigation
Rief, W., & Glombiewski, J. A. (2012) · Pain · doi:10.1016/j.pain.2012.09.007 · Cited by 102
Learned immunosuppressive placebo responses in renal transplant patients
Kirchhof, J., Petrakova, L., Brinkhoff, A., Benson, S., Schmidt, J., Unteroberdörster, M., Wilde, B., Kaptchuk, T. J., Witzke, O., & Schedlowski, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720548115 · Cited by 102
Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion
Bosma, R. L., Cheng, J. C., Rogachov, A., Kim, J. A., Hemington, K. S., Osborne, N. R., Venkatraghavan, L., Bhatia, A., & Davis, K. D. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002417 · Cited by 102
Is fear of pain related to placebo analgesia?
Lyby, P. S., Aslaksen, P. M., & Flaten, M. A. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.10.009 · Cited by 99
Induced fear reduces the effectiveness of a placebo intervention on pain
Lyby, P. S., Forsberg, J. T., Åsli, O., & Flaten, M. A. (2012) · Pain · doi:10.1016/j.pain.2012.02.042 · Cited by 98
The Effect of an Apparent Change to a Branded or Generic Medication on Drug Effectiveness and Side Effects
Faasse, K., Cundy, T., Gamble, G. D., & Petrie, K. J. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182738826 · Cited by 95
Different brain networks mediate the effects of social and conditioned expectations on pain
Koban, L., Jepma, M., López‐Solà, M., & Wager, T. D. (2019) · Nature Communications · doi:10.1038/s41467-019-11934-y · Cited by 95
Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients
Lee, H., Hsieh, J., Lu, C., Yeh, T., Tu, C., Cheng, C.-M., Niddam, D. M., Lin, H., Lee, F., & Chang, F.-Y. (2012) · Pain · doi:10.1016/j.pain.2012.03.018 · Cited by 93
Insular Cortex Activity Is Associated with Effects of Negative Expectation on Nociceptive Long-Term Habituation
Rodriguez‐Raecke, R., Doganci, B., Breimhorst, M., Stankewitz, A., Büchel, C., Birklein, F., & May, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2197-10.2010 · Cited by 89
Pavlovian Conditioning of Immunological and Neuroendocrine Functions
Hadamitzky, M., Lückemann, L., Pacheco‐López, G., & Schedlowski, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00033.2018 · Cited by 89
Are Blue Pills Better Than Green? How Treatment Features Modulate Placebo Effects
Meißner, K., & Linde, K. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.014 · Cited by 86
Functional Network Architecture Predicts Psychologically Mediated Analgesia Related to Treatment in Chronic Knee Pain Patients
Hashmi, J. A., Kong, J., Spaeth, R. B., Khan, S., Kaptchuk, T. J., & Gollub, R. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3155-13.2014 · Cited by 77
Fear of pain potentiates nocebo hyperalgesia
Aslaksen, P. M., & Lyby, P. S. (2015) · Journal of Pain Research · doi:10.2147/jpr.s91923 · Cited by 76
The effects of treatment failure generalize across different routes of drug administration
Zunhammer, M., Ploner, M., Engelbrecht, C., Bock, J., Kessner, S. S., & Bingel, U. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2999 · Cited by 76
Self-citation
The power of positive and negative expectations to influence reported symptoms and mood during exposure to wind farm sound.
Crichton, F., Dodd, G., Schmid, G., Gamble, G. D., Cundy, T., & Petrie, K. J. (2013) · Health Psychology · doi:10.1037/hea0000037 · Cited by 71
Neural underpinnings of nocebo hyperalgesia in visceral pain: A fMRI study in healthy volunteers
Schmid, J., Bingel, U., Ritter, C., Benson, S., Schedlowski, M., Gramsch, C., Forsting, M., & Elsenbruch, S. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.060 · Cited by 71
Self-citation
Using different expectation mechanisms to optimize treatment of patients with medical conditions: a systematic review
Kube, T., Glombiewski, J. A., & Rief, W. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000596 · Cited by 62
Cognitive Reversal of Expected Nitrous Oxide Analgesia for Acute Pain
Dworkin, S. F., Chen, A. C. N., LeResche, L., & Clark, D. W. (1983) · Anesthesia & Analgesia · doi:10.1213/00000539-198312000-00005 · Cited by 59
Suppression of Striatal Prediction Errors by the Prefrontal Cortex in Placebo Hypoalgesia
Schenk, L. A., Sprenger, C., Onat, S., Colloca, L., & Büchel, C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1101-17.2017 · Cited by 58
Cognitive Reversal of Expected Nitrous Oxide Analgesia for Acute Pain
Dworkin, S. F., Chen, A. C. N., LeResche, L., & Clark, D. W. (1984) · Survey of Anesthesiology · doi:10.1097/00132586-198408000-00072 · Cited by 57
Side effects can enhance treatment response through expectancy effects: an experimental analgesic randomized controlled trial
Berna, C., Kirsch, I., Zion, S. R., Lee, Y., Jensen, K. B., Sadler, P., Kaptchuk, T. J., & Edwards, R. R. (2017) · Pain · doi:10.1097/j.pain.0000000000000870 · Cited by 54
Framing and personalizing informed consent to prevent negative expectations: An experimental pilot study.
Heisig, S. R., Mora, M. C. S., Hidalgo, P., & Nestoriuc, Y. (2015) · Health Psychology · doi:10.1037/hea0000217 · Cited by 53
The early history of the placebo
Jütte, R. (2012) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2012.06.002 · Cited by 52
Haloperidol blocks dorsal striatum activity but not analgesia in a placebo paradigm
Wrobel, N., Wiech, K., Forkmann, K., Ritter, C., & Bingel, U. (2014) · Cortex · doi:10.1016/j.cortex.2014.02.023 · Cited by 45
Self-citation
Neurotransmitter systems involved in placebo and nocebo effects in healthy participants and patients with chronic pain: a systematic review
Skyt, I., Lunde, S. J., Baastrup, C., Svensson, P. J., Jensen, T. S., & Vase, L. (2019) · Pain · doi:10.1097/j.pain.0000000000001682 · Cited by 43
Brain mechanisms supporting violated expectations of pain
Zeidan, F., Lobanov, O. V., Kraft, R. A., & Coghill, R. C. (2015) · Pain · doi:10.1097/j.pain.0000000000000231 · Cited by 41
Drug Discontinuation in Studies Including a Switch From an Originator to a Biosimilar Monoclonal Antibody: A Systematic Literature Review
Bakalos, G., & Zintzaras, E. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.11.002 · Cited by 41
Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer
Benson, S., Hagen, S., Hoffmann, O., Pasler, A., Bingel, U., Schedlowski, M., Peters, J., Elsenbruch, S., & Frey, U. H. (2019) · Pain · doi:10.1097/j.pain.0000000000001546 · Cited by 32
Self-citation
The sustained influence of prior experience induced by social observation on placebo and nocebo responses
Zhang, H., Zhou, L., Wei, H., Lu, X., & Hu, L. (2017) · Journal of Pain Research · doi:10.2147/jpr.s147970 · Cited by 30
Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain
Skyt, I., Moslemi, K., Baastrup, C., Grosen, K., Benedetti, F., Petersen, G. L., Price, D. D., Hall, K. T., Kaptchuk, T. J., Svensson, P. J., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001089 · Cited by 29
Das Potenzial des analgetischen Plazeboeffektes – S3–Leitlinien–Empfehlung zur Behandlung akuter und perioperativer Schmerzen
Klinger, R. (2010) · AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie · doi:10.1055/s-0029-1243374 · Cited by 29
When Expectancies Are Violated: A Functional Magnetic Resonance Imaging Study
Colloca, L., Schenk, L. A., Nathan, D. E., Robinson, O. J., & Grillon, C. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1587 · Cited by 28
Placebo and Active Treatment Additivity in Placebo Analgesia: Research to Date and Future Directions
Coleshill, M. J., Sharpe, L., Colloca, L., Zachariae, R. H., & Colagiuri, B. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.021 · Cited by 27
Conditioned responses in pharmacotherapy research
Ader, R. (1993) · Psychological Medicine · doi:10.1017/s0033291700028361 · Cited by 26
Effects of subtle cognitive manipulations on placebo analgesia – An implicit priming study
Rosén, A., Yi, J., Kirsch, I., Kaptchuk, T. J., Ingvar, M., & Jensen, K. B. (2016) · European Journal of Pain · doi:10.1002/ejp.961 · Cited by 24
Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment
Belcher, A. M., Cole, T. O., Greenblatt, A. D., Hoag, S. W., Epstein, D. H., Wagner, M. A., Billing, A. S., Massey, E. C., Hamilton, K. R., Kozak, Z., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026604 · Cited by 20
Placebo effects on the neurologic pain signature: A meta-analysis of individual participant functional magnetic resonance imaging data
Zunhammer, M., Bingel, U., Wager, T., Atlas, L. Y., Benedetti, F., Büchel, C., Choi, J., L., C., Duzzi, D., Eippert, F., et al. (2018) · MPG.PuRe (Max Planck Society) · Cited by 12
Self-citation
Psychologische Faktoren im Kontext perioperativer Knie- und Gelenkschmerzen: die Rolle der Behandlungserwartungen für den Schmerzverlauf
Klinger, R., Stuhlreyer, J., Schmitz, J., Zöllner, C., Roder, C., & Krug, F. (2018) · Der Schmerz · doi:10.1007/s00482-018-0350-2 · Cited by 11
Medication-attributed adverse effects in placebo groups: Implications for assessment of adverse effects
Rief, W. (n.d.) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 7

Sorted by citations

Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement
Hohenschurz‐Schmidt, D., Vase, L., Scott, W., Annoni, M., Ajayi, O. K., Barth, J., Bennell, K. L., Berna, C., Bialosky, J. E., BRAITHWAITE, F., et al. (2023) · BMJ · doi:10.1136/bmj-2022-072108 · Cited by 110
Neural circuit basis of placebo pain relief
Chen, C., Niehaus, J. K., Dinç, F., Huang, K. L., Barnette, A. L., Tassou, A., Shuster, S. A., Wang, L., Lemire, A. L., Menon, V., et al. (2024) · Nature · doi:10.1038/s41586-024-07816-z · Cited by 91
Expectancy Effects in Psychedelic Trials
Szigeti, B., & Heifets, B. D. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.02.004 · Cited by 81
Placebo and nocebo effects and mechanisms associated with pharmacological interventions: an umbrella review
Frisaldi, E., Shaibani, A. I., Benedetti, F., & Pagnini, F. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-077243 · Cited by 54
Local brain oscillations and interregional connectivity differentially serve sensory and expectation effects on pain
Bott, F. S., Nickel, M. M., Hohn, V. D., May, E. S., Ávila, C. G., Tiemann, L., Groß, J., & Ploner, M. (2023) · Science Advances · doi:10.1126/sciadv.add7572 · Cited by 36

See all 113

Authors: Bingel, U.
Affiliations: Essen University Hospital (DE)
Corresponding author: Bingel, Ulrike
ORCID: Bingel, Ulrike
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2020-09
Volume: 161
Issue: Supplement 1
Pages: S48-S56
ISSN: 0304-3959 (ISSN-L)
1872-6623
DOI: 10.1097/j.pain.0000000000001981
OpenAlex: W3049305214
Cited by: 113
References: 124
Citations by year: 2026: 21 · 2025: 20 · 2024: 24 · 2023: 13 · 2022: 20 · 2021: 13 · 2020: 2
FWCI: 6.46
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: placebo effect, expectations, analgesic treatment, pain management, treatment outcomes
MeSH terms: Analgesics, Motivation, Placebo Effect, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Placebo 2.0: the impact of expectations on analgesic treatment outcome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks