The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Impact of Probiotics on Colonizing Microbiota of the Gut
Abstract
Although precise mechanisms responsible for all demonstrations of probiotic health benefits are not known, many lines of evidence suggest that probiotics function through direct or indirect impact on colonizing microbiota of the gut. Probiotics can directly influence colonizing microbes through multiple mechanisms, including the production of inhibitory compounds (bacteriocins, short chain fatty acids, and others), by producing substrates that might promote the growth of colonizing microbes (secreted exopolysaccharides, vitamins, fatty acids, sugars from undigested carbohydrates and others), and by promoting immune responses against specific microbes. Indirectly, probiotics can influence colonizing microbes by inhibiting attachment through stimulated mucin production, reinforcing gut barrier effects, and downregulation of gut inflammation, thereby promoting microbes that are associated with a healthier gut physiology. Although the value of targeted changes in populations of gut bacteria is a matter of debate, increased levels of Bifidobacterium and Lactobacillus in the gut correlate with numerous health endpoints. Microbiota changes due to probiotic intake include increased numbers of related phylotypes, decreasing pathogens and their toxins, altering bacterial community structure to enhance evenness, stabilizing bacterial communities when perturbed (eg, with antibiotics), or promoting a more rapid recovery from a perturbation. Further research will provide insight into the degree of permanence of probiotic-induced changes, although research to date suggests that continued probiotic consumption is needed for sustained impact.
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“It may change community structure in unexpected ways, and these changes may or may not alter community function.138”
From The Gut Microbiome and the Brain (2014) · cites this paper as [138]
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Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310
Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2
Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Corr, S. C., Li, Y., Riedel, C. U., O'Toole, P. W., Hill, C., & Gahan, C. G. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700440104 · Cited by 853
Mack, D. R., Michail, S. K., Wei, S. H., McDougall, L., & Hollingsworth, M. A. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g941 · Cited by 839
Dietary prebiotics: current status and new definition
Gibson, G. R., Scott, K. P., Rastall, R. A., Tuohy, K. M., Hotchkiss, A. T., Dubert‐Ferrandon, A., Gareau, M. G., Murphy, E. F., Saulnier, D. M. A., Loh, G., et al. (2010) · Food Science & Technology Bulletin Functional Foods · doi:10.1616/1476-2137.15880 · Cited by 820
Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
Macfarlane, G. T., Steed, H., & Macfarlane, S. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03520.x · Cited by 785
A meta‐analysis of the association between Caesarean section and childhood asthma
Thavagnanam, S., Fleming, J., Bromley, A., Shields, M. D., & Cardwell, C. R. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02780.x · Cited by 651
Wang, Y., Hoenig, J. D., Malin, K. J., Qamar, S., Petrof, E. O., Sun, J., Antonopoulos, D. A., Chang, E. B., & Claud, E. C. (2009) · The ISME Journal · doi:10.1038/ismej.2009.37 · Cited by 600
Probiotics—compensation for lactase insufficiency
de Vrese, M., Stegelmann, A., Richter, B., Fenselau, S., Laue, C., & Schrezenmeir, J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.421s · Cited by 521
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501
Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
Membrez, M., Blancher, F., Jaquet, M., Bibiloni, R., Cani, P. D., Burcelin, R. G., Corthesy, I., Macé, K., & Chou, C. J. (2008) · The FASEB Journal · doi:10.1096/fj.07-102723 · Cited by 493
Willing, B., Halfvarson, J., Dicksved, J., Rosenquist, M., Järnerot, G., Engstrand, L., Tysk, C., & Jansson, J. K. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20783 · Cited by 455
Fecal microbiota in early rheumatoid arthritis.
Vaahtovuo, J., Munukka, E., Korkeamäki, M., Luukkainen, R., & Toivanen, P. (2008) · PubMed · Cited by 426
Role of the gut microbiota in defining human health
Fujimura, K. E., Slusher, N. A., Cabana, M. D., & Lynch, S. V. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.14 · Cited by 421
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396
KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02579.x · Cited by 361
Mucosal damage and neutropenia are required for Candida albicans dissemination
Koh, A. Y., Köhler, J. R., Coggshall, K. T., Van Rooijen, N., & Pier, G. B. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040035 · Cited by 360
Metagenomics, biotechnology with non-culturable microbes
Schmeisser, C., Steele, H. L., & Streit, W. R. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0945-5 · Cited by 321
Veiga, P., Gallini, C. A., Beal, C., Michaud, M., Delaney, M. L., DuBois, A. M., Khlebnikov, A., Vlieg, J. E. T. V. H., Punit, S., Glickman, J. N., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011737107 · Cited by 233
Gori, A., Tincati, C., Rizzardini, G., Torti, C., Quirino, T., Haarman, M., Amor, K. B., van Schaik, J., Vriesema, A. J. M., Knol, J., et al. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01729-07 · Cited by 232
Probiotic Bacteria Influence the Composition and Function of the Intestinal Microbiota
O’Toole, P. W., & Cooney, J. C. (2008) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2008/175285 · Cited by 216
Immunomodulation by commensal and probiotic bacteria
Forsythe, P., & Bienenstock, J. (2010) · Immunological Investigations · doi:10.3109/08820131003667978 · Cited by 189
Dietary Modulation of Gut Functional Ecology Studied by Fecal Metabonomics
Martin, F., Sprenger, N., Montoliu, I., Rezzi, S., Kochhar, S., & Nicholson, J. K. (2010) · Journal of Proteome Research · doi:10.1021/pr100554m · Cited by 141
Matsumoto, K., Takada, T., Shimizu, K., Moriyama, K., Kawakami, K., Hirano, K., Kajimoto, O., & Nomoto, K. (2010) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2010.05.016 · Cited by 134
The putative role of the intestinal microbiota in the irritable bowel syndrome.
Collins, S., Denou, E., Verdú, E., & Bercik, P. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.023 · Cited by 130
Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome
Cox, M. J., Huang, Y. J., Fujimura, K. E., Liu, J. T., McKean, M., Boushey, H. A., Segal, M. R., Brodie, E., Cabana, M. D., & Lynch, S. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008745 · Cited by 129
Lyra, A., Krogius-Kurikka, L., Nikkilä, J., Malinen, E., Kajander, K., Kurikka, K., Korpela, R., & Palva, A. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-110 · Cited by 86
Probiotic Intervention in the First Months of Life
Rinne, M., Kalliomäki, M. A., Salminen, S., & Isolauri, E. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000228106.91240.5b · Cited by 78
Fujiwara, S., Seto, Y., Kimura, A., & Hashiba, H. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01205.x · Cited by 61
Lactobacillus strains stabilize intestinal microbiota in Japanese cedar pollinosis patients
Kubota, A., He, F., Kawase, M., Harata, G., Hiramatsu, M., Salminen, S., & Iino, H. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2009.00113.x · Cited by 22
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Möhle, L., Mattei, D., Heimesaat, M. M., Bereswill, S., Fischer, A., Alutis, M., French, T., Hambardzumyan, D., Matzinger, P., Dunay, I. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.074 · Cited by 470
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Metadata
- Authors
- Sanders, M. E.
- Corresponding author
- Sanders, Mary Ellen
- ORCID
- Sanders, Mary Ellen
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2011-11
- Volume
- 45
- Pages
- S115-S119
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W1966668014
- Cited by
- 153
- References
- 41
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 6 · 2021: 10 · 2020: 23 · 2019: 11 · 2018: 12 · 2017: 10 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 7 · 2012: 10
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, gut microbiota, bacteriocins, short-chain fatty acids, exopolysaccharides, mucin production, intestinal barrier, intestinal inflammation, Bifidobacterium, Lactobacillus, bacterial community structure, health benefits of probiotics
- MeSH terms
- Bacteria, Bifidobacterium, Humans, Intestines, Lactobacillus, Probiotics, Metagenome
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