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Cited by 76Mindfulness and Compassion InterventionsReligion, Spirituality, and PsychologyHIV/AIDS Research and Interventions

Randomized Controlled Trial of Mindfulness-Based Stress Reduction Delivered to Human Immunodeficiency Virus–Positive Patients in Iran: Effects on CD4+ T Lymphocyte Count and Medical and Psychological Symptoms

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SeyedAlinaghi, SeyedAhmad, Jam, Sara, Foroughi, Maryam, Imani, AmirHossein, Mohraz, Minoo, Djavid, Gholamreza Esmaeeli, Black, David S.·2012·Psychosomatic Medicine
DOI 10.1097/psy.0b013e31825abfaaPMC PMC3392542
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Abstract

OBJECTIVE: To evaluate the immediate and long-term effectiveness of mindfulness-based stress reduction (MBSR) on biological and symptomatological markers of health among human immunodeficiency virus-positive (HIV+) patients in Tehran, Iran. METHODS: Using a randomized controlled trial design, data from 173 HIV+ patients (CD4 count > 250) not yet receiving antiretroviral therapy, who participated in either an 8-week MBSR (n = 87) or a brief education and support condition (n = 86) at the Imam Khomeini Hospital, were analyzed. Assessments included CD4 count, Symptom Checklist-90-Revised (SCL-90R), and Medical Symptom Checklist (MSCL) at baseline, immediate post-treatment, and at the 3-, 6-, 9-, and 12-month follow-up periods. RESULTS: The treatment-adherent sample had a mean (standard deviation) age of 35.1 (6.5) years and 69% were male. Linear mixed-model estimates indicated that, in the MBSR condition, the mean CD4 count increased from baseline up to 9 months after treatment and then returned to baseline level at 12 months. Improvements in mean SCL-90R (up to 6 months) and MSCL (up to 12 months) scores were observed for the MBSR condition, whereas education and support condition scores remained the same over time; however, only MSCL improvements significantly differed between groups and these changes lasted up to the final assessment. CONCLUSIONS: Findings suggest that among treatment-adherent Iranian HIV+ patients not yet receiving antiretroviral drug treatment, MBSR seems to have the strongest potential to improve self-reported medical symptoms. TRIAL REGISTRATION: Iranian Registry of Clinical Trials: IRCT201106084076N2.

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  • SeyedAlinaghi et al. (2012) found that CD4 count increased following MBSR up to a nine-month follow up, surpassing effects on psychological well-being that only maintained through the six-month follow up.

    “SeyedAlinaghi et al. (2012) found that CD4 count increased following MBSR up to a nine-month follow up, surpassing effects on psychological well-being that only maintained through the six-month follow up.”

    From The Application of Mindfulness for Individuals Living with HIV in South Africa: a Hybrid Effectiveness-Implementation Pilot Study (2018) · cites this paper as SeyedAlinaghi et al., 2012

    The Results (Effect of Treatment on CD4 Count; no page provided) report an increase after MBSR lasting to the nine-month follow-up. The Results (Effect of Treatment on SCL-90R; no page provided) report improved psychological-symptom scores through six months, but the Abstract’s Results state that these improvements did not significantly differ between groups. The claim omits that qualification and presents the psychological change as an established treatment effect. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Some preliminary work has evaluated mindfulness-based interventions for individuals living with HIV in international settings, such as Iran, Canada, and Spain.

    “some preliminary work has evaluated mindfulness-based interventions for individuals living with HIV in international settings, such as Iran (Jam et al., 2010; SeyedAlinaghi et al., 2012), Canada (Gayner et al., 2012), and Spain (Gonzalez-Garcia et al., 2014)”

    From The Application of Mindfulness for Individuals Living with HIV in South Africa: a Hybrid Effectiveness-Implementation Pilot Study (2018) · cites this paper as SeyedAlinaghi et al., 2012

  • SeyedAlinaghi et al. (2012) found that CD4 count increased following MBSR through a nine-month follow up, before returning to baseline levels at one year, compared to a supportive education control.

    “SeyedAlinaghi et al. 2012 found that CD4 count increased following MBSR through a nine-month follow up, before returning to baseline levels at one year (compared to a supportive education control).”

    From The Application of Mindfulness for Individuals Living with HIV in South Africa: a Hybrid Effectiveness-Implementation Pilot Study (2018) · cites this paper as SeyedAlinaghi et al., 2012

  • Our findings are consistent with two studies from Iran that showed increases in CD4 count following MBSR.

    “Our findings are consistent with two studies from Iran that showed increases in CD4 count following MBSR: a small, single group pilot study (Jam et al., 2010) and a larger randomized clinical trial (SeyedAlinaghi et al., 2012).”

    From The Application of Mindfulness for Individuals Living with HIV in South Africa: a Hybrid Effectiveness-Implementation Pilot Study (2018) · cites this paper as SeyedAlinaghi et al., 2012

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Research works printed but not linked: 33

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Cited by

Sorted by citations

Authors
SeyedAlinaghi, S., Jam, S., Foroughi, M., Imani, A., Mohraz, M., Djavid, G. E., & Black, D. S.
Affiliations
  • Iranian Research Center for HIV/AIDS (IR)
  • University of California, Los Angeles (US)
Corresponding author
Foroughi, Maryam
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-07
Volume
74
Issue
6
Pages
620-627
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e31825abfaa
PMC
PMC3392542
OpenAlex
W2086816960
Cited by
76
References
12
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 12 · 2014: 7 · 2013: 2
FWCI
7.64
Type
journal article
Language
en
Open access
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG026364)
  • National Institute of Mental Health (T32MH019925)
  • National Cancer Institute (T32CA009492, 2T32CA9492-26)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Health › Religion, Spirituality, and Psychology
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
mindfulness-based stress reduction, HIV, CD4 count, psychological symptoms, clinical symptoms, medication adherence
MeSH terms
Adaptation, Psychological, Adult, Female, Follow-Up Studies, Humans, Iran, Male, Stress, Psychological, HIV Infections, Linear Models, Treatment Outcome, Disease Progression, CD4 Lymphocyte Count, Meditation, Self Report

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