Cited by 65Musculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsPain Management and Placebo Effect

Positive and Negative Affect Dimensions in Chronic Knee Osteoarthritis: Effects on Clinical and Laboratory Pain

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Finan, Patrick H., Quartana, Phillip J., Smith, Michael T.·2013·Psychosomatic Medicine

Abstract

OBJECTIVE: This study investigated whether daily and laboratory assessed pain differs as a function of the temporal stability and valence of affect in individuals with chronic knee osteoarthritis (KOA). METHODS: One hundred fifty-one men and women with KOA completed 14 days of electronic diaries assessing positive affect (PA), negative affect (NA), and clinical pain. A subset of participants (n =79) engaged in quantitative sensory testing (QST). State PA and NA were assessed prior to administration of stimuli that induced suprathreshold pain and temporal summation. Multilevel modeling and multiple regression evaluated associations of affect and pain as a function of valence (i.e., positive versus negative) and stability (i.e., stable versus state). RESULTS: In the diary, stable NA (B = -.63, standard error [SE] = .13, p < .001) was a stronger predictor of clinical KOA pain than stable PA (B = -.18, SE = .11, p = .091), and state PA (B = -.09, p < .001) was a stronger predictor of concurrent daily clinical pain than state NA (B = .04, SE = .02, p = .068). In the laboratory, state PA (B = -.05, SE = .02, p = .042), but not state NA (p = .46), predicted diminished temporal summation of mechanical pain. CONCLUSIONS: Stable NA is more predictive of clinical pain than stable PA, whereas state PA is more predictive of both clinical and laboratory pain than state NA. The findings suggest that dynamic affect-pain processes in the field may reflect individual differences in central pain facilitation.

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  • Parents' reactions to children's pain play an important determining role in children's pain responses.

    “parents’ reactions to children’s pain have also been shown to play an important determining role in children’s pain responses 110–114”

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  1. [14]Isen AM Positive affect Dalgleish T Power M Handbook of Cognition and Emotion New York Wiley 1999 521 39
  2. [48]Singer JD Willett JB Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence New York Oxford University Press 2003

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Authors
Finan, P. H., Quartana, P. J., & Smith, M. T.
Affiliations
Johns Hopkins University (US)
Corresponding author
Finan, Patrick H.
Venue
Psychosomatic Medicine
Published
2013-06
Volume
75
Issue
5
Pages
463-470
ISSN
0033-3174 (ISSN-L)
OpenAlex
W2032274433
Cited by
65
References
62
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 9 · 2016: 3 · 2015: 9 · 2014: 5 · 2013: 2
FWCI
4.65
Type
journal article
Language
en
Open access
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01ar059410-04)
  • National Institute on Drug Abuse (K23DA035915, R01DA032922)
  • National Institute of Neurological Disorders and Stroke (T32NS070201)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR-059410, R01 AR05487)
Topics
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords
knee osteoarthritis, positive affect, negative affect, affect valence, chronic pain, temporal summation, quantitative sensory testing
MeSH terms
Affect, Aged, Chronic Disease, Female, Humans, Male, Medical Records, Middle Aged, Pain, Pain Measurement, Regression Analysis, Severity of Illness Index, Temperament, Osteoarthritis, Knee, Multilevel Analysis, Resilience, Psychological, Diagnostic Self Evaluation

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