8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes–2024
Open accessAbstract
The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
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High-dose liraglutide (3 mg daily subcutaneously) is approved as an adjunctive medication for weight loss in adults with obesity or overweight-related comorbidities and for treatment of obese children and adolescents aged 12 years or older.
“The GLP-1 receptor agonist liraglutide at a high dose (administered as a single daily injection of 3 mg subcutaneously) has been approved as an adjunctive medication for weight loss achieved through a low-calorie diet and physical activity in adults with obesity or overweight-related comorbidities, as well as for the treatment of obese children and adolescents aged 12 years or older [70].”
From New Developments in Pharmacological Treatment of Obesity and Type 2 Diabetes—Beyond and within GLP-1 Receptor Agonists (2024) · cites this paper as [70]
The Approved Obesity Pharmacotherapy section describes FDA-approved weight-management medications as adjuncts to reduced-calorie diet and increased physical activity for adults with obesity or overweight-related comorbidities, and identifies liraglutide among them. Table 8.1 lists liraglutide at 3 mg daily, but this paper does not state that it is approved for children or adolescents aged 12 or older; it directs readers to a different section for adolescent approvals. (LLM, conf=0.87)
Experimental — accuracy not yet measuredCurrent clinical guidelines recommend a reduction in total body weight of approximately 3-7% to achieve improvements in metabolic parameters, including glycemic control and cardiovascular risk.
“Regarding adiposity, current clinical guidelines recommend a reduction in total body weight of approximately 3–7% to achieve improvements in metabolic parameters, including glycemic control and cardiovascular risk [196–198].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [196]
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Lap band outcomes from 19,221 patients across centers and over a decade within the state of New York
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A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss
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Obesity Treatment, Beyond the Guidelines
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Obesity Pharmacotherapy in Patients With Type 2 Diabetes
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Glycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB)
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Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
Aronne, L. J., Horn, D. B., le Roux, C. W., Ho, W., Falcon, B. L., Gomez Valderas, E., Das, S., Lee, C. J., Glass, L. C., Senyucel, C., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2416394 · Cited by 634 · see citing works
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Efficacy and Safety of Tirzepatide in Overweight and Obese Adult Patients with Type 1 Diabetes
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Scott Butsch, W., Sulo, S., Chang, A. T., Kim, J. A., Kerr, K. W., Williams, D. R., Hegazi, R., Panchalingam, T., Goates, S., & Heymsfield, S. B. (2025) · Obesity Pillars · doi:10.1016/j.obpill.2025.100186 · Cited by 58 · see citing works
Sztanek, F., Tóth, L. I., Pető, A., Hernyák, M., Diószegi, Á., & Harangi, M. (2024) · Biomedicines · doi:10.3390/biomedicines12061320 · Cited by 43 · see citing works
“…of 3 mg subcutaneously) has been approved as an adjunctive medication for weight loss achieved through a low-calorie diet and physical activity in adults with obesity or overweight-related comorbidities, as well as for the treatment of obese children and adolescents aged 12 years or older [70].”
BackgroundSilverii, G. A. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15749 · Cited by 33 · see citing works
Kong, F., Zhao, Y., Zhang, W., Wang, X., Wu, T., Zhou, Z., Xu, Y., Xia, L., & Sun, T. (2026) · Nature Communications · doi:10.1038/s41467-025-67701-9 · Cited by 29 · see citing works
Liu, L., Shi, H., Xie, M., Sun, Y., & Nahata, M. C. (2025) · Pharmaceuticals · doi:10.3390/ph18050668 · Cited by 19 · see citing works
Havers, T., Held, S., Schönfelder, M., Geisler, S., & Wackerhage, H. (2025) · Sports Medicine · doi:10.1007/s40279-025-02263-w · Cited by 19 · see citing works
Garg, S. K., Snell-Bergeon, J., Kaur, G., & Beatson, C. (2024) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2024.0023 · Cited by 15 · see citing works
Xu, Y., Echouffo Tcheugui, J. B., Coresh, J., Grams, M. E., Selvin, E., Fang, M., & Shin, J. (2025) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.16300 · Cited by 15 · see citing works
The Benefits of Exercise Training in Combination With Weight Loss Therapies
Jiang, B. C., & Villareal, D. T. (2025) · Diabetes · doi:10.2337/dbi25-0001 · Cited by 9 · see citing works
- Authors
- American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K., Kushner, R. F., Lingvay, I., Matfin, G., McCoy, R. G., Perry, M. L., Pilla, S. J., Polsky, S., Prahalad, P., Pratley, R. E., Segal, A. R., Seley, J. J., Stanton, R. C., & Gabbay, R. A.
- ORCID
- ElSayed, Nuha A.
- Aleppo, Grazia
- Bannuru, Raveendhara R.
- Bruemmer, Dennis
- Collins, Billy S.
- Ekhlaspour, Laya
- Hilliard, Marisa E.
- Johnson, Eric L.
- Khunti, Kamlesh
- Kushner, Robert F.
- Lingvay, Ildiko
- McCoy, Rozalina G.
- Perry, Mary Lou
- Pilla, Scott J.
- Polsky, Sarit
- Prahalad, Priya
- Pratley, Richard E.
- Segal, Alissa R.
- Seley, Jane Jeffrie
- Stanton, Robert C.
- Gabbay, Robert A.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2023-12-11
- Volume
- 47
- Issue
- Supplement_1
- Pages
- S145-S157
- ISSN
- 0149-5992 (ISSN-L)
- PMC
- PMC10725806
- OpenAlex
- W4389560512
- Cited by
- 213
- References
- 143
- Citations by year
- 2026: 51 · 2025: 97 · 2024: 65
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK121942)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- obesity, weight management, type 2 diabetes, diabetes prevention, diabetes treatment, clinical guidelines, American Diabetes Association standards of care
- MeSH terms
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Endocrinology, Humans, Obesity, Reference Standards, Societies, Medical, Standard of Care
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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