Cited by 295Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionPsychometric Methodologies and Testing

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The GRID-HAMD: standardization of the Hamilton Depression Rating Scale

Williams, Janet B.W., Kobak, Kenneth A., Bech, Per, Engelhardt, Nina, Evans, Ken, Lipsitz, Joshua, Olin, Jason, Pearson, Jay, Kalali, Amir·2008·International Clinical Psychopharmacology

DOI 10.1097/yic.0b013e3282f948f5

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Abstract

This report describes the GRID-Hamilton Depression Rating Scale (GRID-HAMD), an improved version of the Hamilton Depression Rating Scale that was developed through a broad-based international consensus process. The GRID-HAMD separates the frequency of the symptom from its intensity for most items, refines several problematic anchors, and integrates both a structured interview guide and consensus-derived conventions for all items. Usability was established in a small three-site sample of convenience, evaluating 29 outpatients, with most evaluators finding the scale easy to use. Test-retest (4-week) and interrater reliability were established in 34 adult outpatients with major depressive disorder, as part of an ongoing clinical trial. In a separate study, interrater reliability was found to be superior to the Guy version of the HAMD, and as good as the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D), across 30 interview pairs. Finally, using the SIGH-D as the criterion standard, the GRID-HAMD demonstrated high concurrent validity. Overall, these data suggest that the GRID-HAMD is an improvement over the original Guy version as well as the SIGH-D in its incorporation of innovative features and preservation of high reliability and validity.

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Authors: Williams, J. B. W., Kobak, K. A., Bech, P., Engelhardt, N., Evans, K., Lipsitz, J., Olin, J., Pearson, J., & Kalali, A.
Affiliations: Columbia University (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
University of California San Diego (US)
Corresponding author: Williams, Janet B.W.
ORCID: Williams, Janet B.W.
Kobak, Kenneth A.
Bech, Per
Lipsitz, Joshua
Olin, Jason
Venue: International Clinical Psychopharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-05
Volume: 23
Issue: 3
Pages: 120-129
ISSN: 0268-1315 (ISSN-L)
DOI: 10.1097/yic.0b013e3282f948f5
OpenAlex: W2030962294
Cited by: 295
References: 26
Citations by year: 2026: 17 · 2025: 18 · 2024: 18 · 2023: 26 · 2022: 25 · 2021: 19 · 2020: 25 · 2019: 29 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 14 · 2014: 16 · 2013: 8 · 2012: 8
FWCI: 10.43
Type: journal article
Language: en
Open access: closed
Locations: International Clinical Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
Keywords: Hamilton Depression Rating Scale, major depressive disorder, inter-rater reliability, test-retest reliability, concurrent validity, consensus building, outpatients
MeSH terms: Adult, Consensus Statements as Topic, Major Depressive Disorder, Humans, International Cooperation, Interview, Psychological, Pilot Projects, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychometrics, Surveys and Questionnaires, United States, Reproducibility of Results, Observer Variation, Treatment Outcome

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